@article{MTMT:34423770,
	title = {Protein engineering - a biológiai gyógyszerek racionális tervezése},
	url = {https://m2.mtmt.hu/api/publication/34423770},
	author = {Szakonyi, Gerda},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {6},
	unique-id = {34423770},
	issn = {0017-6036},
	year = {2023},
	pages = {294-303},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283}
}

@article{MTMT:33712712,
	title = {Structural Adaptation of the Single-Stranded DNA-Binding Protein C-Terminal to DNA Metabolizing Partners Guides Inhibitor Design},
	url = {https://m2.mtmt.hu/api/publication/33712712},
	author = {Tököli, Attila and Bodnár, Brigitta and Bogár, Ferenc and Paragi, Gábor and Hetényi, Anasztázia and Bartus, Éva and Wéber, Edit and Hegedüs, Zsófia and Szabó, Zoltán and Kecskeméti, Gábor and Szakonyi, Gerda and Martinek, Tamás},
	doi = {10.3390/pharmaceutics15041032},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {33712712},
	issn = {1999-4923},
	abstract = {Single-stranded DNA-binding protein (SSB) is a bacterial interaction hub and an appealing target for antimicrobial therapy. Understanding the structural adaptation of the disordered SSB C-terminus (SSB-Ct) to DNA metabolizing enzymes (e.g., ExoI and RecO) is essential for designing high-affinity SSB mimetic inhibitors. Molecular dynamics simulations revealed the transient interactions of SSB-Ct with two hot spots on ExoI and RecO. The residual flexibility of the peptide–protein complexes allows adaptive molecular recognition. Scanning with non-canonical amino acids revealed that modifications at both termini of SSB-Ct could increase the affinity, supporting the two-hot-spot binding model. Combining unnatural amino acid substitutions on both segments of the peptide resulted in enthalpy-enhanced affinity, accompanied by enthalpy–entropy compensation, as determined by isothermal calorimetry. NMR data and molecular modeling confirmed the reduced flexibility of the improved affinity complexes. Our results highlight that the SSB-Ct mimetics bind to the DNA metabolizing targets through the hot spots, interacting with both of segments of the ligands.},
	year = {2023},
	eissn = {1999-4923},
	orcid-numbers = {Tököli, Attila/0000-0001-8413-3182; Bogár, Ferenc/0000-0002-0611-1452; Paragi, Gábor/0000-0001-5408-1748; Hetényi, Anasztázia/0000-0001-8080-6992; Bartus, Éva/0000-0001-9976-6978; Wéber, Edit/0000-0002-5904-0619; Hegedüs, Zsófia/0000-0002-5546-8167; Szabó, Zoltán/0000-0001-8278-8038; Kecskeméti, Gábor/0000-0002-5584-6869; Szakonyi, Gerda/0000-0002-4366-4283; Martinek, Tamás/0000-0003-3168-8066}
}

@article{MTMT:33698459,
	title = {Az mRNS-vakcinák fejlesztése},
	url = {https://m2.mtmt.hu/api/publication/33698459},
	author = {Szakonyi, Gerda},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {66},
	unique-id = {33698459},
	issn = {0017-6036},
	year = {2022},
	pages = {454-459},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283}
}

@article{MTMT:32793624,
	title = {Recent insight into strategies for the design of antimicrobial peptides (AMPs)},
	url = {https://m2.mtmt.hu/api/publication/32793624},
	author = {Manteghi, Reihaneh and Kristó, Katalin and Szakonyi, Gerda and Pannonhalminé Csóka, Ildikó},
	doi = {10.33892/aph.2022.92.20-37},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {92},
	unique-id = {32793624},
	issn = {0001-6659},
	year = {2022},
	eissn = {1587-1495},
	pages = {20-37},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@{MTMT:32640325,
	title = {Strategies for development of antimicrobial peptides and proteins},
	url = {https://m2.mtmt.hu/api/publication/32640325},
	author = {Manteghi, Reihaneh and Kristó, Katalin and Szakonyi, Gerda and Csóka, Ildikó},
	booktitle = {III. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2021.op8},
	unique-id = {32640325},
	year = {2021},
	pages = {20-20},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:31781555,
	title = {PEGylation and formulation strategies of antimicrobial peptides and proteins development},
	url = {https://m2.mtmt.hu/api/publication/31781555},
	author = {Manteghi, Reihaneh and Kristó, Katalin and Szakonyi, Gerda and Pannonhalminé Csóka, Ildikó},
	booktitle = {III. Fiatal Technológusok Fóruma},
	doi = {10.14232/ftf.2020.op10},
	unique-id = {31781555},
	year = {2020},
	pages = {15-15},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:31598466,
	title = {Proteomimetic surface fragments distinguish targets by function},
	url = {https://m2.mtmt.hu/api/publication/31598466},
	author = {Tököli, Attila and Mag, Beáta Zsófia and Bartus, Éva and Wéber, Edit and Szakonyi, Gerda and Simon, Márton and Czibula, Ágnes and Monostori, Éva and Nyitray, László and Martinek, Tamás},
	doi = {10.1039/d0sc03525d},
	journal-iso = {CHEM SCI},
	journal = {CHEMICAL SCIENCE},
	volume = {11},
	unique-id = {31598466},
	issn = {2041-6520},
	year = {2020},
	eissn = {2041-6539},
	pages = {10390-10398},
	orcid-numbers = {Tököli, Attila/0000-0001-8413-3182; Bartus, Éva/0000-0001-9976-6978; Wéber, Edit/0000-0002-5904-0619; Szakonyi, Gerda/0000-0002-4366-4283; Czibula, Ágnes/0000-0003-4461-2773; Monostori, Éva/0000-0002-7442-3562; Nyitray, László/0000-0003-4717-5994; Martinek, Tamás/0000-0003-3168-8066}
}

@CONFERENCE{MTMT:31361067,
	title = {PEGylation and formulation strategies of antimicrobial peptides and proteins development},
	url = {https://m2.mtmt.hu/api/publication/31361067},
	author = {Manteghi, Reihaneh and Szakonyi, Gerda and Pannonhalminé Csóka, Ildikó},
	booktitle = {II. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science},
	unique-id = {31361067},
	year = {2020},
	pages = {42-42},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:30656319,
	title = {Formulation strategy of anti-microbial peptide (AMP) delivery systems},
	url = {https://m2.mtmt.hu/api/publication/30656319},
	author = {Manteghi, Reihaneh and Szakonyi, Gerda and Pallagi, Edina and Pannonhalminé Csóka, Ildikó},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {88},
	unique-id = {30656319},
	issn = {0001-6659},
	year = {2018},
	eissn = {1587-1495},
	pages = {192-192},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:3260664,
	title = {Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1},
	url = {https://m2.mtmt.hu/api/publication/3260664},
	author = {Oláh, Zoltán and Rédei, Dóra and Pecze, László and Vizler, Csaba and Jósvay, Katalin and Forgó, Péter and Winter, Zoltán and Dombi, György and Szakonyi, Gerda and Hohmann, Judit},
	doi = {10.1016/j.phymed.2017.06.006},
	journal-iso = {PHYTOMEDICINE},
	journal = {PHYTOMEDICINE: INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY},
	volume = {34},
	unique-id = {3260664},
	issn = {0944-7113},
	year = {2017},
	eissn = {1618-095X},
	pages = {44-49},
	orcid-numbers = {Rédei, Dóra/0000-0002-5013-247X; Forgó, Péter/0000-0002-0279-6896; Szakonyi, Gerda/0000-0002-4366-4283; Hohmann, Judit/0000-0002-2887-6392}
}