@article{MTMT:36914162, title = {Mozgásszervi eredetű mellkasi fájdalmat felismerő klinikai predikciós modell fejlesztése. Prospektív pilotvizsgálati elképzelés}, url = {https://m2.mtmt.hu/api/publication/36914162}, author = {Ádám, Kornél and Varga, Csaba and Fenyves, Bánk and Hegyi, Krisztina and Kostyál, László and Finta, Ervin and Kanizsai, Péter László and Lelovics, Zsuzsanna and Xantus, Gábor}, doi = {10.1556/650.2026.33484}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {167}, unique-id = {36914162}, issn = {0030-6002}, abstract = {Bevezetés: A sürgősségi osztályokra kis kockázatú mellkasi fájdalommal érkező betegek differenciáldiagnosztikája világszerte jelentős klinikai és egészség-gazdaságtani kihívást jelent. Bár a legtöbb esetben nem cardiopulmonalis eredetű kórképek állnak a tünetek hátterében, az ellátás elsődleges célja az életet veszélyeztető állapotok – elsősorban az akut coronariaszindróma és a tüdőembolia – gyors és biztonságos felismerése/kizárása. A túlzott diagnosztikus vizsgálatok ugyanakkor növelik az ellátási költségeket, és fokozzák az osztályok leterheltségét. Korábban publikált megfigyeléseink szerint a pleuriticus és/vagy mozgásszervi jellegű mellkasi fájdalommal jelentkező felnőtt betegek körében gyakrabban előfordul korábban fel nem ismert gerincaszimmetria, amely a bordaízületek (costosternalis, ritkábban costovertebralis) subluxatiójára hajlamosíthat. Célkitűzés: A tervezett multicentrikus, prospektív vizsgálat célja a gerincaszimmetria előfordulásának és klinikai jelentőségének meghatározása ambuláns, kis kockázatú, mellkasi fájdalommal jelentkező felnőttek körében, valamint egy új, mozgásszervi eredetű mellkasi fájdalmat azonosító klinikai predikciós modell fejlesztése. Módszerek: A vizsgálat elsődleges kimeneti változói a tüdőembolia és a major cardialis események (nem ST-elevációs myocardialis infarktus, instabil angina). Korábban validált számítás alapján 2500 beteg bevonása biztosítja a megfelelő statisztikai erőt a II. típusú hiba elkerülésére. A betegek 30, 90 és 365 napos utánkövetése során regisztráljuk a szövődményeket, az ismételt megjelenéseket, a major cardialis eseményeket és a mortalitást. Várható eredmények: Feltételezésünk szerint a gerincaszimmetria jelenléte oki összefüggést mutat az akut, mozgásszervi jellegű mellkasi fájdalommal, amely ebben a betegcsoportban nem jár együtt emelkedett mortalitási kockázattal. Egy újonnan kidolgozott predikciós eszköz feltehetően lehetővé teheti a mozgásszervi eredetű mellkasi fájdalom korai felismerését és biztonságos elkülönítését a cardiopulmonalis kórképektől. Következtetés: A vizsgálat eredményei hozzájárulhatnak a sürgősségi betegellátás diagnosztikus protokolljának finomításához, a szükségtelen vizsgálatok számának csökkentéséhez, valamint a költséghatékonyság és a betegelégedettség javításához. Orv Hetil. 2026; 167(5): 180–187. | Introduction: The diagnostic work-up of patients presenting to the emergency department with chest pain remains a major clinical and health-economic challenge worldwide. Although most cases are caused by benign, non-cardiopul- monary conditions, the primary goal of emergency care is the timeous, but safe exclusion of life-threatening disorders – mainly acute coronary syndrome and pulmonary embolism. Excessive diagnostic testing increases both healthcare costs and emergency department overcrowding. Preliminary observations suggest that previously unrecognized spi- nal asymmetry or scoliosis is more prevalent among ambulatory adults presenting with pleuritic or musculoskeletal- type chest pain, potentially predisposing to costosternal or costovertebral subluxation as a mechanical pain generator. Objective: The planned prospective, multicenter study aims to assess the prevalence and clinical significance of spinal asymmetry among ambulatory, low-risk adults presenting with chest pain, and to develop/validate a novel musculo- skeletal chest pain clinical prediction model. Methods: Primary outcome variables include pulmonary embolism and major cardiac events (non-ST-elevation myo- cardial infarction, unstable angina). Based on power calculations by Peduzzi et al. (1996), a total of 2,500 patients will provide adequate statistical power to avoid Type II error. Patients will be followed up at 30, 90, and 365 days for complications, recurrent visits, major adverse cardiac events, and mortality. Data will be analyzed using bootstrapping techniques for internal validation of the derived score. Expected results: We hypothesize that spinal asymmetry independently correlates with acute musculoskeletal chest pain but does not confer an increased risk of short- or long-term mortality. The newly developed musculoskeletal chest pain clinical prediction model may facilitate early recognition and safe management of musculoskeletal chest pain in the emergency department setting. Conclusion: This study is expected to refine diagnostic algorithms for low-risk chest pain, reduce unnecessary inves- tigations, improve cost-effectiveness, and enhance patient satisfaction.}, year = {2026}, eissn = {1788-6120}, pages = {180-187}, orcid-numbers = {Ádám, Kornél/0009-0003-7998-0258; Fenyves, Bánk/0000-0003-2374-7513; Kanizsai, Péter László/0000-0001-7896-2857; Xantus, Gábor/0000-0003-3060-0069} } @CONFERENCE{MTMT:36939214, title = {A váltott műszak terhei: komplex stresszvizsgálat sürgősségi ápolók körében}, url = {https://m2.mtmt.hu/api/publication/36939214}, author = {Suszter, Gergely and Závodi, Péter and Deák, András Sándor and Kanizsai, Péter László and Fusz, Katalin}, booktitle = {SZOFIKON 2026 – II. Szentágothai Felsőoktatási Interdiszciplináris Konferencia: Absztraktkötet = SZOFIKON 2026 – II. Szentágothai Higher Education Interdisciplinary Conference: Book of Abstracts}, unique-id = {36939214}, year = {2026}, pages = {223-223}, orcid-numbers = {Deák, András Sándor/0000-0003-3466-2865; Kanizsai, Péter László/0000-0001-7896-2857} } @article{MTMT:36947501, title = {Circadian patterns of patient symptoms in a tertiary university emergency department : a single-centre retrospective analysis}, url = {https://m2.mtmt.hu/api/publication/36947501}, author = {Fusz, Katalin and Deák, András Sándor and Závodi, Péter and Jónás, Bence and Szilber, Vilmos Dávid and Kanizsai, Péter László}, doi = {10.1136/bmjopen-2025-101295}, journal-iso = {BMJ OPEN}, journal = {BMJ OPEN}, volume = {16}, unique-id = {36947501}, issn = {2044-6055}, abstract = {To evaluate emergency patient care from a chronophysiological perspective, examining circadian variations in symptom presentations and physiological parameters.Single-centre retrospective analysis.SETTING: Department of Emergency Medicine, Clinical Centre, University of Pécs, Hungary (August 2022 to August 2023).Patient data including symptom categories, time of presentation (divided into eight 3-hour intervals), sex and age were collected. A total of 32 977 patient records were analysed. Symptoms were classified using the International Classification of Diseases, 10th Revision. For hypertension, random proportionally stratified sampling was performed (n=120).Primary outcomes were the circadian distribution of emergency presentations across 14 symptom categories and their variation by time of day, age and sex. Secondary outcomes included diurnal variation in hypertension-related cases, examining blood pressure, pulse rate, triage time and medication use.Cardiovascular cases peaked between 09:00 and 12:00 (p<0.001), toxicological emergencies between 18:00 and 21:00 (p<0.001) and endocrine-metabolic cases between 12:00 and 15:00 (p<0.001). In hypertensive patients, the lowest systolic pressure occurred between 12:00 and 15:00 (p=0.037). More patients presented on weekdays than weekends (p=0.013).Symptom presentations in emergency care follow distinct circadian patterns, highlighting the influence of biological rhythms on clinical demand. Recognition of these temporal trends may support more effective ED scheduling and resource allocation.}, keywords = {physiology; Emergency Service, Hospital; Epidemiologic Studies}, year = {2026}, eissn = {2044-6055}, orcid-numbers = {Deák, András Sándor/0000-0003-3466-2865; Jónás, Bence/0009-0003-1452-6230; Kanizsai, Péter László/0000-0001-7896-2857} } @article{MTMT:36059856, title = {Súlyos euglikémiás etoacidózis SGLT-2-gátló kezelés mellett - esetismertetés}, url = {https://m2.mtmt.hu/api/publication/36059856}, author = {Sütő, Zsófia and Böröcz, Attila and Merész, Márton and Rodek, Gyula and Cséke, Balázs and Budai, Bianka and Deli, Gabriella and Mühl, Diána and Horváth, Márk László and Kanizsai, Péter László and Janszky, József Vladimír and Csontos, Csaba and Wittmann, István and Kun, Szilárd}, doi = {10.24121/dh.2025.12}, journal-iso = {DIABETOLOGIA HUNGARICA}, journal = {DIABETOLOGIA HUNGARICA}, volume = {33}, unique-id = {36059856}, issn = {1217-372X}, year = {2025}, eissn = {2560-0168}, pages = {65-70}, orcid-numbers = {Kanizsai, Péter László/0000-0001-7896-2857; Janszky, József Vladimír/0000-0001-6100-832X} } @article{MTMT:36402348, title = {Chronotype, Night Shift Work, and Diurnal Salivary Cortisol Rhythms Among Healthcare Professionals}, url = {https://m2.mtmt.hu/api/publication/36402348}, author = {Fusz, Katalin and Deák, András Sándor and Závodi, Péter and Suszter, Gergely and Böröcz, Katalin and Szinger, Dávid and le, Roux Alain and Rozmann, Nóra and Kanizsai, Péter László}, doi = {10.3390/jcm14217630}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {14}, unique-id = {36402348}, abstract = {Background: Chronotype is a determinant of tolerance to shift work; however, its physiological and psychological correlates remain insufficiently explored in healthcare workers. This study investigated associations between chronotype, perceived stress, sleep quality, and health behaviours in a large cohort of shift-working nurses and physicians. Additionally, diurnal salivary cortisol patterns were characterised in a physiological subsample. Methods: A cross-sectional study was conducted with 451 participants (77% female; mean age 42 ± 11 years) completing validated instruments, including the Perceived Stress Scale (PSS), Athens Insomnia Scale (AIS), Patient Health Questionnaire Somatic Symptom Scale (PHQ-15), and reduced Morningness–Eveningness Questionnaire (rMEQ). In addition, a prospective pilot substudy was performed in a physiological subsample of nurses (n = 40), in which salivary cortisol was measured at three time points during both day and night shifts. Results: Evening chronotype exhibited a higher prevalence of insomnia (70%) and elevated AIS scores (8.2 ± 4.2, p < 0.001). In the physiological subsample, evening types demonstrated a significantly attenuated cortisol awakening response (6.5 ± 5.1 nmol/L, p = 0.02) and a flatter diurnal cortisol slope during day shifts (p = 0.01). Logistic regression indicated that increased age, somatic symptom burden, and perceived stress were significant risk factors for insomnia, whereas morningness was protective (OR = 0.89, p = 0.003). Conclusions: Evening chronotype among healthcare professionals is associated with altered hypothalamic–pituitary–adrenal axis regulation and impaired sleep quality. These findings highlight the potential utility of chronotype-based scheduling and behavioural interventions targeting circadian misalignment to improve occupational health outcomes in shift-working populations.}, keywords = {Insomnia; CORTISOL; Healthcare professionals; Perceived stress; shift work; Chronotype}, year = {2025}, eissn = {2077-0383}, orcid-numbers = {Deák, András Sándor/0000-0003-3466-2865; Rozmann, Nóra/0000-0002-5621-4935; Kanizsai, Péter László/0000-0001-7896-2857} } @misc{MTMT:36431408, title = {Jogi vonatkozások pro-con vita}, url = {https://m2.mtmt.hu/api/publication/36431408}, author = {Feith, Helga Judit and Kanizsai, Péter László}, unique-id = {36431408}, year = {2025}, orcid-numbers = {Feith, Helga Judit/0000-0001-8855-5059; Kanizsai, Péter László/0000-0001-7896-2857} } @article{MTMT:36604796, title = {Applied Improvisation to Improve Mental Health Training.}, url = {https://m2.mtmt.hu/api/publication/36604796}, author = {Fekete, Judit Diána and Hainselin, M. and Eklicsné Lepenye, Katalin and Kanizsai, Péter László and Jouin, M.}, doi = {10.1192/j.eurpsy.2025.1827}, journal-iso = {EUR PSYCHIAT}, journal = {EUROPEAN PSYCHIATRY}, volume = {68}, unique-id = {36604796}, issn = {0924-9338}, year = {2025}, eissn = {1778-3585}, pages = {S901-S901}, orcid-numbers = {Fekete, Judit Diána/0009-0004-6860-369X; Kanizsai, Péter László/0000-0001-7896-2857} } @{MTMT:34823706, title = {Az eszméletlenség differenciáldiagnosztikája}, url = {https://m2.mtmt.hu/api/publication/34823706}, author = {Kanizsai, Péter László}, booktitle = {Súlyos baleseti agysérültek ellátása}, unique-id = {34823706}, year = {2024}, pages = {85-92}, orcid-numbers = {Kanizsai, Péter László/0000-0001-7896-2857} } @{MTMT:34823836, title = {Kihűlt beteg}, url = {https://m2.mtmt.hu/api/publication/34823836}, author = {Kanizsai, Péter László}, booktitle = {Az intenzív terápia gyakorlata}, unique-id = {34823836}, year = {2024}, pages = {198}, orcid-numbers = {Kanizsai, Péter László/0000-0001-7896-2857} } @{MTMT:34823852, title = {Újraélesztés (legfrissebb ajánlás)}, url = {https://m2.mtmt.hu/api/publication/34823852}, author = {Kanizsai, Péter László}, booktitle = {Az intenzív terápia gyakorlata}, unique-id = {34823852}, year = {2024}, pages = {259}, orcid-numbers = {Kanizsai, Péter László/0000-0001-7896-2857} }