TY - JOUR AU - Stefanics, Gábor AU - Hangya, Balázs AU - Hernádi, István AU - Winkler, István AU - Lakatos, Péter AU - Ulbert, István TI - Phase Entrainment of Human Delta Oscillations Can Mediate the Effects of Expectation on Reaction Speed (October, pg 13578, 2010) JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 31 PY - 2011 IS - 4 SP - 1559 EP - 1559 PG - 1 SN - 0270-6474 UR - https://m2.mtmt.hu/api/publication/1609777 ID - 1609777 LA - English DB - MTMT ER - TY - JOUR AU - Stefanics, Gábor AU - Hangya, Balázs AU - Hernádi, István AU - Winkler, István AU - Lakatos, Péter AU - Ulbert, István TI - Phase Entrainment of Human Delta Oscillations Can Mediate the Effects of Expectation on Reaction Speed JF - JOURNAL OF NEUROSCIENCE J2 - J NEUROSCI VL - 30 PY - 2010 IS - 41 SP - 13578 EP - 13585 PG - 8 SN - 0270-6474 DO - 10.1523/JNEUROSCI.0703-10.2010 UR - https://m2.mtmt.hu/api/publication/1384665 ID - 1384665 AB - The more we anticipate a response to a predictable stimulus, the faster we react. This empirical observation has been confirmed and quantified by many investigators suggesting that the processing of behaviorally relevant stimuli is facilitated by probability-based confidence of anticipation. However, the exact neural mechanisms underlying this phenomenon are largely unknown. Here we show that performance changes related to different levels of expectancy originate in dynamic modulation of delta oscillation phase. Our results obtained in rhythmic auditory target detection tasks indicated significant entrainment of the EEG delta rhythm to the onset of the target tones with increasing phase synchronization at higher levels of predictability. Reaction times correlated with the phase of the delta band oscillation at target onset. The fastest reactions occurred during the delta phase that most commonly coincided with the target event in the high expectancy conditions. These results suggest that low-frequency oscillations play a functional role in human anticipatory mechanisms, presumably by modulating synchronized rhythmic fluctuations in the excitability of large neuronal populations and by facilitating efficient task-related neuronal communication among brain areas responsible for sensory processing and response execution. LA - English DB - MTMT ER - TY - JOUR AU - Falchier, A AU - Schroeder, CE AU - Hackett, TA AU - Lakatos, Péter AU - Nascimento-Silva, S AU - Ulbert, István AU - Karmos, György AU - Smiley, JF TI - Projection from Visual Areas V2 and Prostriata to Caudal Auditory Cortex in the Monkey. JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 20 PY - 2010 IS - 7 SP - 1529 EP - 1538 PG - 10 SN - 1047-3211 DO - 10.1093/cercor/bhp213 UR - https://m2.mtmt.hu/api/publication/1275705 ID - 1275705 N1 - Megjegyzés-21070452 PubMed ID: 19875677 Chemicals/CAS: Amidines; Cholera Toxin, 9012-63-9; Fluorescent Dyes; diamidino compound 253/50 Megjegyzés-22307270 Chemicals/CAS: Amidines; Cholera Toxin, 9012-63-9; Fluorescent Dyes; diamidino compound 253/50 AB - Studies in humans and monkeys report widespread multisensory interactions at or near primary visual and auditory areas of neocortex. The range and scale of these effects has prompted increased interest in interconnectivity between the putatively "unisensory" cortices at lower hierarchical levels. Recent anatomical tract-tracing studies have revealed direct projections from auditory cortex to primary visual area (V1) and secondary visual area (V2) that could serve as a substrate for auditory influences over low-level visual processing. To better understand the significance of these connections, we looked for reciprocal projections from visual cortex to caudal auditory cortical areas in macaque monkeys. We found direct projections from area prostriata and the peripheral visual representations of area V2. Projections were more abundant after injections of temporoparietal area and caudal parabelt than after injections of caudal medial belt and the contiguous areas near the fundus of the lateral sulcus. Only one injection was confined to primary auditory cortex (area A1) and did not demonstrate visual connections. The projections from visual areas originated mainly from infragranular layers, suggestive of a "feedback"-type projection. The selective localization of these connections to peripheral visual areas and caudal auditory cortex suggests that they are involved in spatial localization. LA - English DB - MTMT ER - TY - JOUR AU - Rajkai, Csaba AU - Lakatos, Péter AU - Chen, CM AU - Pincze, Zsuzsa AU - Karmos, György AU - Schroeder, CE TI - Transient cortical excitation at the onset of visual fixation JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 18 PY - 2008 IS - 1 SP - 200 EP - 209 PG - 10 SN - 1047-3211 DO - 10.1093/cercor/bhm046 UR - https://m2.mtmt.hu/api/publication/1252669 ID - 1252669 N1 - ISI:000251505900020 Megjegyzés-22361420 Z9: 41 WC: Neurosciences AB - Primates actively examine the visual world by rapidly shifting gaze (fixation) over the elements in a scene. Despite this fact, we typically study vision by presenting stimuli with gaze held constant. To better understand the dynamics of natural vision, we examined how the onset of visual fixation affects ongoing neuronal activity in the absence of visual stimulation. We used multiunit activity and current source density measurements to index neuronal firing patterns and underlying synaptic processes in macaque V1. Initial averaging of neural activity synchronized to the onset of fixation suggested that a brief period of cortical excitation follows each fixation. Subsequent single-trial analyses revealed that 1) neuronal oscillation phase transits from random to a highly organized state just after the fixation onset, 2) this phase concentration is accompanied by increased spectral power in several frequency bands, and 3) visual response amplitude is enhanced at the specific oscillatory phase associated with fixation. We hypothesize that nonvisual inputs are used by the brain to increase cortical excitability at fixation onset, thus "priming" the system for new visual inputs generated at fixation. Despite remaining mechanistic questions, it appears that analysis of fixation-related responses may be useful in studying natural vision. LA - English DB - MTMT ER - TY - JOUR AU - Lakatos, Péter AU - Karmos, György AU - Mehta, AD AU - Ulbert, István AU - Schroeder, CE TI - Entrainment of neuronal oscillations as a mechanism of attentional selection. JF - SCIENCE J2 - SCIENCE VL - 320 PY - 2008 IS - 5872 SP - 110 EP - 113 PG - 4 SN - 0036-8075 DO - 10.1126/science.1154735 UR - https://m2.mtmt.hu/api/publication/1121165 ID - 1121165 N1 - Funding Agency and Grant Number: NIMH NIH HHS [MH060358] Funding Source: Medline; NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH060358] Funding Source: NIH RePORTER AB - Whereas gamma-band neuronal oscillations clearly appear integral to visual attention, the role of lower-frequency oscillations is still being debated. Mounting evidence indicates that a key functional property of these oscillations is the rhythmic shifting of excitability in local neuronal ensembles. Here, we show that when attended stimuli are in a rhythmic stream, delta-band oscillations in the primary visual cortex entrain to the rhythm of the stream, resulting in increased response gain for task-relevant events and decreased reaction times. Because of hierarchical cross-frequency coupling, delta phase also determines momentary power in higher-frequency activity. These instrumental functions of low-frequency oscillations support a conceptual framework that integrates numerous earlier findings. LA - English DB - MTMT ER - TY - JOUR AU - Schroeder, CE AU - Lakatos, Péter AU - Kajikawa, Y AU - Partan, S AU - Puce, A TI - Neuronal oscillations and visual amplification of speech JF - TRENDS IN COGNITIVE SCIENCES J2 - TRENDS COGN SCI VL - 12 PY - 2008 IS - 3 SP - 106 EP - 113 PG - 8 SN - 1364-6613 DO - 10.1016/j.tics.2008.01.002 UR - https://m2.mtmt.hu/api/publication/208000 ID - 208000 LA - English DB - MTMT ER - TY - JOUR AU - Hackett, TA AU - Smiley, JF AU - Ulbert, István AU - Karmos, György AU - Lakatos, Péter AU - de la, Mothe LA AU - Schroeder, CE TI - Sources of somatosensory input to the caudal belt areas of auditory cortex. JF - PERCEPTION J2 - PERCEPTION VL - 36 PY - 2007 IS - 10 SP - 1419 EP - 1430 PG - 12 SN - 0301-0066 DO - 10.1068/p5841 UR - https://m2.mtmt.hu/api/publication/1121162 ID - 1121162 AB - The auditory cortex of nonhuman primates is comprised of a constellation of at least twelve interconnected areas distributed across three major regions on the superior temporal gyrus: core, belt, and parabelt. Individual areas are distinguished on the basis of unique profiles comprising architectonic features, thalamic and cortical connections, and neuron response properties. Recent demonstrations of convergent auditory-somatosensory interactions in the caudomedial (CM) and caudolateral (CL) belt areas prompted us to pursue anatomical studies to identify the source(s) of somatic input to auditory cortex. Corticocortical and thalamocortical connections were revealed by injecting neuroanatomical tracers into CM, CL, and adjoining fields of marmoset (Callithrix jacchus jacchus) and macaque (Macaca mulatta) monkeys. In addition to auditory cortex, the cortical connections of CM and CL included somatosensory (retroinsular, Ri; granular insula, Ig) and multisensory areas (temporal parietal occipital, temporal parietal temporal). Thalamic inputs included the medial geniculate complex and several multisensory nuclei (suprageniculate, posterior, limitans, medial pulvinar), but not the ventroposterior complex. Injections of the core (A1, R) and rostromedial areas of auditory cortex revealed sparse multisensory connections. The results suggest that areas Ri and Ig are the principle sources of somatosensory input to the caudal belt, while multisensory regions of cortex and thalamus may also contribute. The present data add to growing evidence of multisensory convergence in cortical areas previously considered to be 'unimodal', and also indicate that auditory cortical areas differ in this respect. LA - English DB - MTMT ER - TY - JOUR AU - Smiley, JF AU - Hackett, TA AU - Ulbert, István AU - Karmos, György AU - Lakatos, Péter AU - Javitt, DC AU - Schroeder, CE TI - Multisensory convergence in auditory cortex, I. Cortical connections of the caudal superior temporal plane in macaque monkeys. JF - JOURNAL OF COMPARATIVE NEUROLOGY J2 - J COMP NEUROL VL - 502 PY - 2007 IS - 6 SP - 894 EP - 923 PG - 30 SN - 0021-9967 DO - 10.1002/cne.21325 UR - https://m2.mtmt.hu/api/publication/1121160 ID - 1121160 N1 - Megjegyzés-20332966 Cited By (since 1996): 6 AB - The caudal medial auditory area (CM) has anatomical and physiological features consistent with its role as a first-stage (or "belt") auditory association cortex. It is also a site of multisensory convergence, with robust somatosensory and auditory responses. In this study, we investigated the cerebral cortical sources of somatosensory and auditory inputs to CM by injecting retrograde tracers in macaque monkeys. A companion paper describes the thalamic connections of CM (Hackett et al., J. Comp. Neurol. [this issue]). The likely cortical sources of somatosensory input to CM were the adjacent retroinsular cortex (area Ri) and granular insula (Ig). In addition, CM had reliable connections with areas Tpt and TPO, which are sites of multisensory integration. CM also had topographic connections with other auditory areas. As expected, connections with adjacent caudal auditory areas were stronger than connections with rostral areas. Surprisingly, the connections with the core were concentrated along its medial side, suggesting that there may be a medial-lateral division of function within the core. Additional injections into caudal lateral auditory area (CL) and Tpt showed similar connections with Ri, Ig, and TPO. In contrast to CM injections, these lateral injections had inputs from parietal area 7a and had a preferential connection with the lateral (gyral) part of Tpt. Taken together, the findings indicate that CM may receive somatosensory input from nearby areas along the fundus of the lateral sulcus. The differential connections of CM compared with adjacent areas provide additional evidence for the functional specialization of the individual auditory belt areas. LA - English DB - MTMT ER - TY - JOUR AU - Chen, CM AU - Lakatos, Péter AU - Shah, AS AU - Mehta, AD AU - Givre, SJ AU - Javitt, DC AU - Schroeder, CE TI - Functional anatomy and interaction of fast and slow visual pathways in macaque monkeys. JF - CEREBRAL CORTEX J2 - CEREB CORTEX VL - 17 PY - 2007 IS - 7 SP - 1561 EP - 1569 PG - 9 SN - 1047-3211 DO - 10.1093/cercor/bhl067 UR - https://m2.mtmt.hu/api/publication/207828 ID - 207828 LA - English DB - MTMT ER - TY - JOUR AU - Lakatos, Péter AU - Chen, CM AU - O'Connell, MN AU - Mills, A AU - Schroeder, CE TI - Neuronal oscillations and multisensory interaction in primary auditory cortex JF - NEURON J2 - NEURON VL - 53 PY - 2007 IS - 2 SP - 279 EP - 292 PG - 14 SN - 0896-6273 DO - 10.1016/j.neuron.2006.12.011 UR - https://m2.mtmt.hu/api/publication/207692 ID - 207692 LA - English DB - MTMT ER -