@article{MTMT:34093583,
	title = {Synaptic alterations and neuronal firing in human epileptic neocortical excitatory networks},
	url = {https://m2.mtmt.hu/api/publication/34093583},
	author = {Bod, Réka and Tóth, Kinga and Essam, Nour and Tóth, Estilla Zsófia and Erőss, Loránd and Entz, László and Bagó, Attila György and Fabó, Dániel and Ulbert, István and Wittner, Lucia},
	doi = {10.3389/fnsyn.2023.1233569},
	journal-iso = {FRONT SYNAPTIC NEURO},
	journal = {FRONTIERS IN SYNAPTIC NEUROSCIENCE},
	volume = {15},
	unique-id = {34093583},
	abstract = {Epilepsy is a prevalent neurological condition, with underlying neuronal mechanisms involving hyperexcitability and hypersynchrony. Imbalance between excitatory and inhibitory circuits, as well as histological reorganization are relatively well-documented in animal models or even in the human hippocampus, but less is known about human neocortical epileptic activity. Our knowledge about changes in the excitatory signaling is especially scarce, compared to that about the inhibitory cell population. This study investigated the firing properties of single neurons in the human neocortex in vitro , during pharmacological blockade of glutamate receptors, and additionally evaluated anatomical changes in the excitatory circuit in tissue samples from epileptic and non-epileptic patients. Both epileptic and non-epileptic tissues exhibited spontaneous population activity (SPA), NMDA receptor antagonization reduced SPA recurrence only in epileptic tissue, whereas further blockade of AMPA/kainate receptors reversibly abolished SPA emergence regardless of epilepsy. Firing rates did not significantly change in excitatory principal cells and inhibitory interneurons during pharmacological experiments. Granular layer (L4) neurons showed an increased firing rate in epileptic compared to non-epileptic tissue. The burstiness of neurons remained unchanged, except for that of inhibitory cells in epileptic recordings, which decreased during blockade of glutamate receptors. Crosscorrelograms computed from single neuron discharge revealed both mono- and polysynaptic connections, particularly involving intrinsically bursting principal cells. Histological investigations found similar densities of SMI-32-immunopositive long-range projecting pyramidal cells in both groups, and shorter excitatory synaptic active zones with a higher proportion of perforated synapses in the epileptic group. These findings provide insights into epileptic modifications from the perspective of the excitatory system and highlight discrete alterations in firing patterns and synaptic structure. Our data suggest that NMDA-dependent glutamatergic signaling, as well as the excitatory synaptic machinery are perturbed in epilepsy, which might contribute to epileptic activity in the human neocortex.},
	year = {2023},
	eissn = {1663-3563},
	orcid-numbers = {Bod, Réka/0000-0001-9744-9282; Tóth, Kinga/0000-0002-8751-8499; Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351; Ulbert, István/0000-0001-9941-9159; Wittner, Lucia/0000-0001-6800-0953}
}

@{MTMT:33194844,
	title = {Pszichiátriai kórképek idegsebészeti kezelése},
	url = {https://m2.mtmt.hu/api/publication/33194844},
	author = {Entz, László and Erőss, Loránd},
	booktitle = {Az idegsebészet alapjai},
	unique-id = {33194844},
	year = {2022},
	pages = {521-523},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546}
}

@{MTMT:33194829,
	title = {A spaszticitás idegsebészeti kezelése},
	url = {https://m2.mtmt.hu/api/publication/33194829},
	author = {Entz, László and Erőss, Loránd},
	booktitle = {Az idegsebészet alapjai},
	unique-id = {33194829},
	year = {2022},
	pages = {517-521},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546}
}

@article{MTMT:33075628,
	title = {A humán agykéreg elektromos ingerlésével kiváltott válaszok alatti lokális hálózati és egysejt-szintű aktivitásváltozásainak vizsgálata},
	url = {https://m2.mtmt.hu/api/publication/33075628},
	author = {Hajnal, Boglárka Zsófia and Entz, László and Tóth, Emília and Wittner, Lucia and Ulbert, István and Erőss, Loránd and Fabó, Dániel},
	journal-iso = {IDEGGYÓGY SZEMLE PROC},
	journal = {IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS},
	volume = {7},
	unique-id = {33075628},
	issn = {2498-6240},
	year = {2022},
	pages = {18},
	orcid-numbers = {Wittner, Lucia/0000-0001-6800-0953; Ulbert, István/0000-0001-9941-9159; Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351}
}

@article{MTMT:32785453,
	title = {Bursting of excitatory cells is linked to interictal epileptic discharge generation in humans.},
	url = {https://m2.mtmt.hu/api/publication/32785453},
	author = {Hofer, Katharina and Kandrács, Ágnes and Tóth, Kinga and Hajnal, Boglárka Zsófia and Bokodi, Virág and Tóth, Estilla Zsófia and Erőss, Loránd and Entz, László and Bagó, Attila György and Fabó, Dániel and Ulbert, István and Wittner, Lucia},
	doi = {10.1038/s41598-022-10319-4},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {12},
	unique-id = {32785453},
	issn = {2045-2322},
	abstract = {Knowledge about the activity of single neurons is essential in understanding the mechanisms of synchrony generation, and particularly interesting if related to pathological conditions. The generation of interictal spikes-the hypersynchronous events between seizures-is linked to hyperexcitability and to bursting behaviour of neurons in animal models. To explore its cellular mechanisms in humans we investigated the activity of clustered single neurons in a human in vitro model generating both physiological and epileptiform synchronous events. We show that non-epileptic synchronous events resulted from the finely balanced firing of excitatory and inhibitory cells, which was shifted towards an enhanced excitability in epileptic tissue. In contrast, interictal-like spikes were characterised by an asymmetric overall neuronal discharge initiated by excitatory neurons with the presumptive leading role of bursting pyramidal cells, and possibly terminated by inhibitory interneurons. We found that the overall burstiness of human neocortical neurons is not necessarily related to epilepsy, but the bursting behaviour of excitatory cells comprising both intrinsic and synaptically driven bursting is clearly linked to the generation of epileptiform synchrony.},
	year = {2022},
	eissn = {2045-2322},
	orcid-numbers = {Kandrács, Ágnes/0000-0002-6408-2397; Tóth, Kinga/0000-0002-8751-8499; Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351; Ulbert, István/0000-0001-9941-9159; Wittner, Lucia/0000-0001-6800-0953}
}

@article{MTMT:32548110,
	title = {Local neuronal network and single unit changes evoked by single and paired pulse cortical stimulation in humans},
	url = {https://m2.mtmt.hu/api/publication/32548110},
	author = {Hajnal, Boglárka Zsófia and Entz, László and Tóth, Emília and Ulbert, István and Erőss, Loránd and Fabó, Dániel},
	journal-iso = {EPILEPSIA},
	journal = {EPILEPSIA},
	volume = {62},
	unique-id = {32548110},
	issn = {0013-9580},
	year = {2021},
	eissn = {1528-1167},
	pages = {264-265},
	orcid-numbers = {Ulbert, István/0000-0001-9941-9159; Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351}
}

@misc{MTMT:32173211,
	title = {Alterations in perisomatic inhibition contributes to the higher synchrony in human epileptic neocortical tissues},
	url = {https://m2.mtmt.hu/api/publication/32173211},
	author = {Zsófia Tóth, Estilla and Erőss, Loránd and Entz, László and Bagó, Attila György and Fabó, Dániel and Ulbert, István and Wittner, Lucia and Tóth, Kinga},
	unique-id = {32173211},
	year = {2020},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351}
}

@misc{MTMT:32173181,
	title = {Interictal epileptic discharges associated with sleep spindles in the anterior and mediodorsal thalamus},
	url = {https://m2.mtmt.hu/api/publication/32173181},
	author = {Szalárdy, Orsolya and Simor, Péter and Ujma, Przemyslaw Péter and Jordán, Zsófia and Borbély, Csaba and Halász, László and Erőss, Loránd and Entz, László and Halász, Péter and Fabó, Dániel and Bódizs, Róbert},
	unique-id = {32173181},
	year = {2020},
	orcid-numbers = {Ujma, Przemyslaw Péter/0000-0002-7981-3009; Erőss, Loránd/0000-0002-5796-5546; Fabó, Dániel/0000-0001-5141-5351; Bódizs, Róbert/0000-0001-5341-060X}
}

@article{MTMT:30868010,
	title = {Reorganization of Large-Scale Functional Networks during Low-Frequency Electrical Stimulation of the Cortical Surface},
	url = {https://m2.mtmt.hu/api/publication/30868010},
	author = {File, Bálint and Nánási, Tibor and Tóth, E. and Bokodi, Virág and Tóth, Brigitta and Hajnal, Boglárka Zsófia and Balogh-Kardos, Zsófia Klára and Entz, László and Erőss, Loránd and Ulbert, István and Fabó, Dániel},
	doi = {10.1142/S0129065719500229},
	journal-iso = {INT J NEURAL SYST},
	journal = {INTERNATIONAL JOURNAL OF NEURAL SYSTEMS},
	volume = {30},
	unique-id = {30868010},
	issn = {0129-0657},
	year = {2020},
	eissn = {1793-6462},
	orcid-numbers = {Erőss, Loránd/0000-0002-5796-5546; Ulbert, István/0000-0001-9941-9159; Fabó, Dániel/0000-0001-5141-5351}
}

@misc{MTMT:32235256,
	title = {Probabilistic tractography shows correlation with cortico-cortical evoked potentials (ccep) over ictal areas},
	url = {https://m2.mtmt.hu/api/publication/32235256},
	author = {Barnaföldi, Luca and Halász, László and Emília, Tóth and Virág, Bokodi and Boglárka, Hajnal and Fabó, Dániel and Erőss, Loránd and Entz, László},
	unique-id = {32235256},
	year = {2019},
	orcid-numbers = {Fabó, Dániel/0000-0001-5141-5351; Erőss, Loránd/0000-0002-5796-5546}
}