@CONFERENCE{MTMT:34526563, title = {A keton táplálékkiegészítők izoflurán által indukált vércukorszint-emelkedésre gyakorolt hatása hím és nőstény WAG/Rij patkányokban}, url = {https://m2.mtmt.hu/api/publication/34526563}, author = {Rauch, Enikő and Kovács, Zsolt}, booktitle = {Program és az előadások összefoglalói}, unique-id = {34526563}, year = {2024}, pages = {4-4}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @misc{MTMT:34204869, title = {Review of exogenous ketone supplements with enantiomer and concentration dependent effects}, url = {https://m2.mtmt.hu/api/publication/34204869}, author = {Csilla, Ari and Dominic, P. D’Agostino and Kovács, Zsolt}, unique-id = {34204869}, year = {2023}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @article{MTMT:34204821, title = {Dose-Dependent Beneficial Effect of Ketone Supplement-Evoked Ketosis on Anxiety Level in Female WAG/Rij Rats: Sometimes Less Is More}, url = {https://m2.mtmt.hu/api/publication/34204821}, author = {Rauch, Enikő and Ari, Csilla and Kovács, Zsolt}, doi = {10.3390/nu15204412}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {15}, unique-id = {34204821}, abstract = {While one-third of the population can be affected by anxiety disorders during their lifetime, our knowledge of the pathophysiology of these disorders is far from complete. Previously, it has been demonstrated in male animals that exogenous ketone supplement-evoked ketosis can decrease anxiety levels in preclinical rodent models, such as Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats. Thus, in this study, we investigated whether intragastric gavage of the exogenous ketone supplement KEMCT (mix of 1,3-butanediol-acetoacetate diester/ketone ester/KE and medium-chain triglyceride/MCT oil in 1:1 ratio) for 7 days can alter the anxiety levels of female WAG/Rij rats using the light–dark box (LDB) test. We demonstrated that a lower dose of KEMCT (3 g/kg/day) increased blood R-βHB (R-β-hydroxybutyrate) levels and significantly decreased anxiety levels (e.g., increased the time spent in the light compartment) in female WAG/Rij rats on the seventh day of administration. Although the higher KEMCT dose (5 g/kg/day) increased blood R-βHB levels more effectively, compared with the lower KEMCT dose, anxiety levels did not improve significantly. We conclude that ketone supplementation might be an effective strategy to induce anxiolytic effects not only in male but also in female WAG/Rij rats. However, these results suggest that the optimal level may be moderately, not highly, elevated blood R-βHB levels when the goal is to alleviate symptoms of anxiety. More studies are needed to understand the exact mechanism of action of ketone supplementation on anxiety levels and to investigate their use in other animal models and humans for the treatment of anxiety disorders and other mental health conditions.}, keywords = {anxiety; mental health; exogenous ketone supplement; LDB test; female WAG/Rij rat}, year = {2023}, eissn = {2072-6643}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @misc{MTMT:33669033, title = {Az adenozin receptorok modulátoros hatása a keton táplálékkiegészítők kiváltotta rohamszám csökkenésben WAG/Rij patkányokban.}, url = {https://m2.mtmt.hu/api/publication/33669033}, author = {Brunner, Brigitta and Kovács, Zsolt}, unique-id = {33669033}, year = {2023}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @CONFERENCE{MTMT:33669006, title = {Antiepileptic effect of the GABA precursor putrescine in early termination of seizures.}, url = {https://m2.mtmt.hu/api/publication/33669006}, author = {Saif, Qahtan and Márton, Péter and Kovács, Zsolt and Serguei, Skatchkov and Zsolt, Szabó and Julianna, Kardos and László, Héja}, booktitle = {Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA)}, unique-id = {33669006}, year = {2023}, pages = {63}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @article{MTMT:33668972, title = {Ketone supplementation abolished isoflurane anesthesia-induced elevation in blood glucose level and increased recovery time from anesthesia in Wistar Albino Glaxo Rijswijk rats}, url = {https://m2.mtmt.hu/api/publication/33668972}, author = {Kovács, Zsolt and D’Agostino, Dominic P. and Ari, Csilla}, doi = {10.1186/s12871-023-02000-8}, journal-iso = {BMC ANESTHESIOL}, journal = {BMC ANESTHESIOLOGY}, volume = {23}, unique-id = {33668972}, issn = {1471-2253}, year = {2023}, eissn = {1471-2253}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @CONFERENCE{MTMT:33212674, title = {Influence of ketone supplements on epileptic seizures and anxiety in WAG/Rij rats}, url = {https://m2.mtmt.hu/api/publication/33212674}, author = {Kovács, Zsolt}, booktitle = {ESMED 2022 GENERAL ASSEMBY ABSTRACT BOOK}, unique-id = {33212674}, year = {2022}, pages = {138-139}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @CONFERENCE{MTMT:33212671, title = {Effect of ketone supplements on absence epileptic seizures in the WAG/Rij rat model}, url = {https://m2.mtmt.hu/api/publication/33212671}, author = {Kovács, Zsolt}, booktitle = {World Brain Disorders and Neuroscience Summit 2022}, unique-id = {33212671}, year = {2022}, pages = {&}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} } @article{MTMT:33031938, title = {Putrescine Intensifies Glu/GABA Exchange Mechanism and Promotes Early Termination of Seizures}, url = {https://m2.mtmt.hu/api/publication/33031938}, author = {Kovács, Zsolt and Skatchkov, Serguei N. and Szabó, Zsolt and Qahtan, Saif and Méndez-González, Miguel P. and Malpica-Nieves, Christian J. and Eaton, Misty J. and Kardos, Julianna and Héja, László}, doi = {10.3390/ijms23158191}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {33031938}, issn = {1661-6596}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686; Szabó, Zsolt/0000-0002-2902-743X; Méndez-González, Miguel P./0000-0003-0079-4042; Malpica-Nieves, Christian J./0000-0001-6778-408X} } @misc{MTMT:32897157, title = {Concentration Dependent Effect of Ketone Bodies: Cell, Animal and Human Studies - Higher is Not Always Better}, url = {https://m2.mtmt.hu/api/publication/32897157}, author = {Csilla, Ari and Collin, Park and John, Vallas and Raquel, Sanford and Sahil, Bharwani and Dominic, P. D’Agostino and Kovács, Zsolt}, unique-id = {32897157}, year = {2022}, orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686} }