TY - JOUR AU - Mezőlaki, Noémi AU - Baltás, Eszter AU - Ócsai, Henriette AU - Varga, Anita AU - Korom, Irma AU - Varga, Erika AU - Németh, István Balázs AU - Kis, Erika AU - Varga, János AU - Kocsis, Ádám László AU - Gyulai, Rolland Péter AU - Bukva, Mátyás AU - Kemény, Lajos AU - Oláh, Judit Magdolna TI - Tumour regression predicts better response to interferon therapy in melanoma patients. a retrospective single centre study. TS - a retrospective single centre study. JF - MELANOMA RESEARCH J2 - MELANOMA RES VL - 34 PY - 2024 IS - 1 SP - 54 EP - 62 PG - 9 SN - 0960-8931 DO - 10.1097/CMR.0000000000000935 UR - https://m2.mtmt.hu/api/publication/34523817 ID - 34523817 AB - We hypothesise that regression may have an impact on the effectiveness of adjuvant IFN therapy, based on its role in the host immune response. Our purpose is to investigate regression and ulceration as prognostic factors in case of interferon-alpha (IFN)-treated melanoma patients. We followed 357 IFN-treated melanoma patients retrospectively, investigating progression-free survival (PFS) and overall survival (OS) depending on the presence of ulceration and regression. A Kaplan-Meier analysis was performed, and we used a Cox regression analysis to relate risk factors. The survival function of the Cox regression was used to measure the effect of regression and ulceration on PFS and OS depending on the Breslow thickness (T1-T4) of the primary tumour. Regression was significantly positively related to PFS ( P = 0.0018, HR = 0.352) and OS ( P = 0.0112, HR = 0.380), while ulceration showed a negative effect (PFS: P = 0.0001, HR = 2.629; OS: P = 0.0003, HR = 2.388). They influence survival independently. The most favourable outcome was measured in the regressed/non-ulcerated group, whereas the worse was in the non-regressed/ulcerated one. Of risk factors, Breslow thickness is the most significant predictor. The efficacy of regression is regardless of Breslow thickness, though the more favourable the impact of regression was in the thicker primary lesions. Our results indicate that regression is associated with a more favourable outcome for IFN-treated melanoma patients, whereas ulceration shows an inverse relation. Further studies are needed to analyse the survival benefit of regression in relation to innovative immune checkpoint inhibitors. LA - English DB - MTMT ER - TY - JOUR AU - Hánis, Csilla AU - Csányi, Ildikó AU - Ócsai, Henriette AU - Németh, István Balázs AU - Bende, Balázs AU - Besenyi, Zsuzsanna AU - Hideghéty, Katalin AU - Kemény, Lajos AU - Gyulai, Rolland Péter AU - Oláh, Judit Magdolna AU - Baltás, Eszter TI - Sarcoid-like reakciók előfordulása metasztatikus melanoma miatt immunterápiával kezelt betegnél JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 99 PY - 2023 IS - 6 SP - 438 EP - 438 PG - 1 SN - 0006-7768 UR - https://m2.mtmt.hu/api/publication/34513890 ID - 34513890 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Varga, Ákos AU - Németh, István Balázs AU - Kemény, Lajos AU - Varga, János AU - Tiszlavicz, László AU - Kumar, D. AU - Dodd, S. AU - Simpson, A.W.M. AU - Buknicz, Tünde AU - Beynon, R. AU - Simpson, D. AU - Krenács, Tibor AU - Dockray, G.J. AU - Varro, A. TI - Elevated serum gastrin is associated with melanoma progression: putative role in increased migration and invasion of melanoma cells JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 23 PG - 16 SN - 1661-6596 DO - 10.3390/ijms242316851 UR - https://m2.mtmt.hu/api/publication/34443653 ID - 34443653 LA - English DB - MTMT ER - TY - GEN AU - Szadai, Leticia AU - Bartha, Áron AU - Parada, Pla Indira AU - Lakatos, Alexandra AU - Pál, Dorottya AU - Lengyel, Sára Anna AU - Almeida, Natália AU - Jánosi, Ágnes Judit AU - Nogueira, Fábio AU - Szeitz, Beáta AU - Doma, Viktória AU - Woldmar, Nicole AU - Guedes, Jéssica AU - Újfaludi, Zsuzsanna AU - Kim, Yonghyo AU - Páhi, Gábor Zoltán AU - Pankotai, Tibor AU - Győrffy, Balázs AU - Ingvar, C AU - Ekedahl, H AU - Jundgren, L AU - Baldetorp, B AU - Welinder, C AU - Szász, Marcell AU - Betancourt, Lazaro AU - Gil, Jeovanis AU - Appelqvist, Roger AU - Kwon, Jeong AU - Kárpáti, Sarolta AU - Németh, István Balázs AU - Malm, Johan AU - Fenyő, Dávid AU - Pawlowski, Krzysztof AU - Horvatovich, Péter AU - Wieslander, Elisabet AU - Marko-Varga, György AU - Kemény, Lajos Vince AU - Domont, Gilberto AU - Sanchez, Aniel TI - Six potential proteins predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts PY - 2023 UR - https://m2.mtmt.hu/api/publication/34437156 ID - 34437156 LA - English DB - MTMT ER - TY - JOUR AU - Szadai, Leticia AU - Guedes, Jessica AU - Gil, Jeovanis AU - Marko-Varga, György AU - Németh, István Balázs TI - Quantitative proteomics on laser microdissected early-stage melanomas reveals a mitochondrial involvement in the disease progression JF - ARCHIVES OF THE HUNGARIAN MEDICAL ASSOCIATION OF AMERICA J2 - ARCH HUNG MED ASSOC AM VL - 29 PY - 2023 IS - 1 SP - 36 EP - 36 PG - 1 SN - 1070-0773 UR - https://m2.mtmt.hu/api/publication/34437117 ID - 34437117 LA - English DB - MTMT ER - TY - JOUR AU - Szadai, Leticia AU - Guedes, Jéssica de Siqueira AU - Woldmar, Nicole AU - de Almeida, Natália Pinto AU - Jánosi, Ágnes Judit AU - Rajeh, Ahmad AU - Kovács, Ferenc AU - Kriston, András AU - Migh, Ede AU - Wan, Guihong AU - Nguyen, Nga AU - Oskolás, Henriett AU - Appelqvist, Roger AU - Nogueira, Fábio Cn AU - Domont, Gilberto B AU - Yu, Kun-Hsing AU - Semenov, Eugene R AU - Malm, Johan AU - Rezeli, Melinda AU - Wieslander, Elisabet AU - Fenyö, David AU - Kemény, Lajos AU - Horváth, Péter AU - Németh, István Balázs AU - Marko-Varga, György AU - Gil, Jeovanis TI - Mitochondrial and immune response dysregulation in melanoma recurrence JF - CLINICAL AND TRANSLATIONAL MEDICINE J2 - CLIN TRANSL MED VL - 13 PY - 2023 IS - 11 PG - 7 SN - 2001-1326 DO - 10.1002/ctm2.1495 UR - https://m2.mtmt.hu/api/publication/34436978 ID - 34436978 N1 - Besorolása szakcikk a központi MTMT adminisztrátorokkal történt egyeztetés és az MTA V. Osztályának képviselője által végzett tartalmi vizsgálat alapján. (BCS, SZTE admin4, 2024-01-03) LA - English DB - MTMT ER - TY - JOUR AU - Tabár, László AU - Bozó, Renáta AU - Dean, Peter B AU - Ormándi, Katalin AU - Puchkova, Olga AU - Oláh, Orsolya AU - Németh, István Balázs AU - Veréb, Zoltán AU - Yen, Ming-Fang AU - Chen, Li-Sheng AU - Chen, Hsiu-Hsi AU - Vörös, András TI - Does Diffusely Infiltrating Lobular Carcinoma of the Breast Arise from Epithelial-Mesenchymal Hybrid Cells? JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 13 PG - 15 SN - 1661-6596 DO - 10.3390/ijms241310752 UR - https://m2.mtmt.hu/api/publication/34068499 ID - 34068499 AB - Classic diffusely infiltrating lobular carcinoma has imaging features divergent from the breast cancers originating from the terminal ductal lobular units and from the major lactiferous ducts. Although the term "invasive lobular carcinoma" implies a site of origin within the breast lobular epithelium, we were unable to find evidence supporting this assumption. Exceptional excess of fibrous connective tissue and the unique cell architecture combined with the aberrant features at breast imaging suggest that this breast malignancy has not originated from cells lining the breast ducts and lobules. The only remaining relevant component of the fibroglandular tissue is the mesenchyme. The cells freshly isolated and cultured from diffusely infiltrating lobular carcinoma cases contained epithelial-mesenchymal hybrid cells with both epithelial and mesenchymal properties. The radiologic and histopathologic features of the tumours and expression of the mesenchymal stem cell positive markers CD73, CD90, and CD105 all suggest development in the direction of mesenchymal transition. These hybrid cells have tumour-initiating potential and have been shown to have poor prognosis and resistance to therapy targeted for malignancies of breast epithelial origin. Our work emphasizes the need for new approaches to the diagnosis and therapy of this highly fatal breast cancer subtype. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Erika AU - Horváth, Zsófia AU - Németh, István Balázs AU - Korom, Irma TI - Biológiai és célzott terápiák bőrpathologiai vonatkozásai a mindennapi gyakorlatban JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 99 PY - 2023 IS - 2 SP - 125 EP - 131 PG - 7 SN - 0006-7768 DO - 10.7188/bvsz.2023.99.2.7 UR - https://m2.mtmt.hu/api/publication/33928967 ID - 33928967 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Varga, Ákos AU - Bende, Balázs AU - Baltás, Eszter AU - Németh, István Balázs AU - Varga, Erika AU - Vass, Gábor AU - Kis, Erika AU - Oláh, Judit Magdolna AU - Varga, János AU - Kocsis, Ádám László TI - Az SZTE Bőrgyógyászati és Allergológiai Klinikán a melanoma malignum sebészi kezelésében történt változások az elmúlt évtizedben [Changes in the surgical treatment of melanoma malignum at the Department of Dermatology and Allergology University of Szeged over the last decade] JF - BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE J2 - BVSZ VL - 99 PY - 2023 IS - 2 SP - 122 EP - 124 PG - 3 SN - 0006-7768 DO - 10.7188/bvsz.2023.99.2.6 UR - https://m2.mtmt.hu/api/publication/33928935 ID - 33928935 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Germán, P. AU - Veréb, Zoltán AU - Bozó, Renáta AU - Flink, Lili Borbála AU - Erdei, Lilla AU - Groma, Gergely AU - Szebeni, Gábor AU - Csörgő Sándorné Bata, Zsuzsanna AU - Kemény, Lajos AU - Németh, István Balázs TI - Morphologic variants of cell cannibalism in the spontaneous human melanoma-fibroblast hybrids using high-content fluorescent microscope imaging JF - JOURNAL OF INVESTIGATIVE DERMATOLOGY J2 - J INVEST DERMATOL VL - 143 PY - 2023 IS - Suppl. 5 SP - S219 EP - S219 PG - 1 SN - 0022-202X DO - 10.1016/j.jid.2023.03.1290 UR - https://m2.mtmt.hu/api/publication/33927401 ID - 33927401 N1 - HCEMM-USZ Skin Research Group, Szeged, Hungary LA - English DB - MTMT ER -