TY - JOUR AU - Perlaki, Gábor AU - Darnai, Gergely AU - Arató, Ákos AU - Alhour, Husamalddin Ali Mohammad AU - Szente, Anna Tímea AU - Áfra, Eszter AU - Nagy, Szilvia Anett AU - Horváth, Réka AU - Kovács, Norbert AU - Dóczi, Tamás Péter AU - Orsi, Gergely AU - Janszky, József Vladimír TI - Gray Matter Changes Following Mild COVID-19 : An MR Morphometric Study in Healthy Young People JF - JOURNAL OF MAGNETIC RESONANCE IMAGING J2 - JMRI - J MAGN RESON IM VL - 59 PY - 2024 IS - 6 SP - 2152 EP - 2161 PG - 10 SN - 1053-1807 DO - 10.1002/jmri.28970 UR - https://m2.mtmt.hu/api/publication/34113102 ID - 34113102 N1 - * Megosztott szerzőség AB - Although COVID-19 is primarily an acute respiratory infection, 5%-40% of patients develop late and prolonged symptoms with frequent neurological complaints, known as long COVID syndrome. The presentation of the disease suggests that COVID infection may cause functional and/or morphological central nervous system alterations, but studies published in the literature report contradictory findings.To investigate the chronic effects of COVID-19 on cerebral grey matter in a group of young patients without comorbidities, with mild course of COVID infection and no medical complaints at the time of examination.Prospective.Thirty-eight young (age = 26.6 ± 5.0 years; male/female = 14/24), adult participants who recovered from mild COVID infection without a history of clinical long COVID and 37 healthy control subjects (age = 25.9 ± 2.8 years; male/female = 14/23).Three Tesla, 3D T1-weighted magnetization-prepared rapid gradient-echo, 2D T2-weighted turbo spin-echo.MRI-based morphometry and volumetry along with neuropsychological testing and self-assessed questionnaire.Fisher's exact test, Mann-Whitney U-test, and multiple linear regression analyses were used to assess differences between COVID and healthy control groups. P < 0.05 was used as cutoff for significance.In the COVID group, significantly lower bilateral mean cortical thickness (left/right-hemisphere: 2.51 ± 0.06 mm vs. 2.56 ± 0.07 mm, η2 p = 0.102/2.50 ± 0.06 mm vs. 2.54 ± 0.07 mm, η2 p = 0.101), lower subcortical gray matter (57881 ± 3998 mm3 vs. 60470 ± 5211 mm3 , η2 p = 0.100) and lower right olfactory bulb volume (52.28 ± 13.55 mm3 vs. 60.98 ± 15.8 mm3 , η2 p = 0.078) were found. In patients with moderate to severe anosmia, cortical thickness was significantly lower bilaterally, as compared to patients without olfactory function loss (left/right-hemisphere: 2.50 ± 0.06 mm vs. 2.56 ± 0.05 mm, η2 = 0.173/2.49 ± 0.06 mm vs. 2.55 ± 0.05 mm, η2 = 0.189). Using further exploratory analysis, significantly reduced cortical thickness was detected locally in the right lateral orbitofrontal cortex in the COVID group (2.53 ± 0.10 mm vs. 2.60 ± 0.09 mm, η2 p = 0.112).Even without any subjective or objective neurological complaints at the time of the MR scan, subjects in the COVID group showed gray matter alterations in cortical thickness and subcortical gray matter volume.2 TECHNICAL EFFICACY: Stage 3. LA - English DB - MTMT ER - TY - JOUR AU - Darnai, Gergely AU - Perlaki, Gábor AU - Orsi, Gergely AU - Arató, Ákos AU - Szente, Anna Tímea AU - Horváth, Réka AU - Áfra, Eszter AU - Nagy, Szilvia Anett AU - Kovács, Norbert AU - Dóczi, Tamás Péter AU - Janszky, József Vladimír TI - Language processing in Internet use disorder : Task-based fMRI study JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 6 PG - 14 SN - 1932-6203 DO - 10.1371/journal.pone.0269979 UR - https://m2.mtmt.hu/api/publication/32907490 ID - 32907490 N1 - Funding Agency and Grant Number: Hungarian Brain Research Program [20017-1.2.1-NKP-2017-00002]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765/3/2018/FEKUSTRAT]; National Research, Development and Innovation Fund of Hungary [TKP2021-EGA-16] Funding text: This study was supported by the Hungarian Brain Research Program 20017-1.2.1-NKP-2017-00002 government-based fund. Our research was partly financed by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the 5th thematic program of the University of Pe ' cs, Hungary (20765/3/2018/FEKUSTRAT) and by the National Research, Development and Innovation Fund of Hungary (TKP2021-EGA-16). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. AB - Internet use disorder (IUD) is generally conceptualized as a fast-growing behavioral addiction. Several structural and functional brain alterations have been revealed in this condition, but previous behavioral studies indicated that language systems may also be impaired. We used a silent word generation task to induce brain activation in Broca's area and other parts of the language system. Blood-oxygen-level-dependent activation analysis and psychophysiological interaction analysis were applied to assess functional brain changes. IUD was measured by the Problematic Internet Use Questionnaire and two additional questions concerning usage time and subjective rating of addiction. According to our key findings, areas strongly related to the default mode network were altered in IUD during the task. Moreover, Broca's area showed altered functional connectivity with other language network and occipital areas in IUD. These findings may address the neural background of decreased verbal fluency performance previously reported in the literature, and we emphasize that beside the brain's reward and inhibitory control systems, the language system is the next candidate to be involved in the pathogenesis of IUD. LA - English DB - MTMT ER - TY - JOUR AU - Trischlerné Gyimesi, Csilla AU - Barsi, Péter AU - Bóné, Beáta AU - Dóczi, Tamás Péter AU - Horváth, Réka AU - Horváth, Zsolt AU - Komoly, Sámuel AU - Lőrincz, Katalin Nóra AU - Tóth, Márton AU - Janszky, József Vladimír TI - Epilepsziasebészet a pécsi epilepsziacentrumban JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 17 EP - 17 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893951 ID - 32893951 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ábrahám, Hajnalka AU - Sóki, Noémi AU - Richter, Zsófia AU - Karádi, Kázmér AU - Lőrincz, Katalin AU - Horváth, Réka AU - Trischlerné Gyimesi, Csilla AU - Szekeres-Paraczky, Cecília AU - Sétáló, György (ifj.) AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Seress, László TI - Fehérállományi neuronok és szerepük a temporalislebeny-epilepsziában JF - IDEGGYÓGYÁSZATI SZEMLE PROCEEDINGS / CLINICAL NEUROSCIENCE PROCEEDINGS J2 - IDEGGYÓGY SZEMLE PROC VL - 7 PY - 2022 IS - 1 SP - 8 EP - 8 PG - 1 SN - 2498-6240 UR - https://m2.mtmt.hu/api/publication/32893852 ID - 32893852 LA - Hungarian DB - MTMT ER - TY - GEN AU - Geiger, Lili AU - Horváth, Réka AU - Janszky, József Vladimír AU - Kecskés, Miklós AU - Orsi, Gergely AU - Tóth, Márton AU - Miseta, Attila János AU - Illés, Zsolt László AU - Gombos, Katalin AU - Czéh, Boldizsár TI - Extracellular circulating miRNAs as potential biomarkers in multiple sclerosis and epilepsy PY - 2022 UR - https://m2.mtmt.hu/api/publication/32635269 ID - 32635269 LA - English DB - MTMT ER - TY - JOUR AU - Sóki, Noémi AU - Richter, Zsófia AU - Karádi, Kázmér AU - Lőrincz, Katalin AU - Horváth, Réka AU - Trischlerné Gyimesi, Csilla AU - Szekeres-Paraczky, Cecília Kata AU - Horváth, Zsolt AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Seress, László AU - Ábrahám, Hajnalka TI - Investigation of synapses in the cortical white matter in human temporal lobe epilepsy JF - BRAIN RESEARCH J2 - BRAIN RES VL - 1779 PY - 2022 PG - 12 SN - 0006-8993 DO - 10.1016/j.brainres.2022.147787 UR - https://m2.mtmt.hu/api/publication/32598077 ID - 32598077 N1 - Department of Medical Biology and Central Electron Microscopic Laboratory, University of Pécs Medical School, Szigeti u. 12, Pécs, 7643, Hungary Neuromorphology and Cellular Neurobiology Research Group, Center for Neuroscience, University of Pécs, Ifjúság u. 20, Pécs, 7624, Hungary Department of Behavioral Sciences, University of Pécs Medical School, Szigeti u. 12, Pécs, 7624, Hungary Department of Neurology, University of Pécs Medical School, Rét u. 2, Pécs, 7623, Hungary Human Brain Research Laboratory, Institute of Experimental Medicine, ELKH, Szigony u. 43, Budapest, 1083, Hungary Department of Neurosurgery, University of Pécs Medical School, Rét u. 2, Pécs, 7623, Hungary MTA-PTE Clinical Neuroscience MR Research Group, Center for Neuroscience, University of Pécs, Ifjúság u 20, Pécs, 7624, Hungary Cited By :2 Export Date: 5 March 2024 CODEN: BRREA Correspondence Address: Ábrahám, H.; Department of Medical Biology and Central Electron Microscopic Laboratory, Szigeti u. 12, Hungary; email: hajnalka.abraham@aok.pte.hu Chemicals/CAS: Synaptophysin; SYP protein, human Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, -16-2016-00004, 2020-4.1.1-TKP2020, K125436, TKP2020-IKA-08 Funding details: Innovációs és Technológiai Minisztérium, GINOP-2.3.3-15-2016-00026 Funding text 1: This work was supported by the Hungarian Brain Research Program NAP 2.0 (2017-1.2.1-NKP-2017-00002), by National Research, Development and Innovation Fund of Hungary (NKFIH) K125436, by PTE EFOP-3.6.1.-16-2016-00004 and by project no. TKP2020-IKA-08 that has been implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the 2020-4.1.1-TKP2020 funding scheme and by the Thematic Excellence Program 2021 Health Sub-programme of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of the Pécs of University. JEOL JEM-1400Flash TEM electron microscope was funded by the GINOP-2.3.3-15-2016-00026 (New generation electron microscope: 3D ultrastructure). LA - English DB - MTMT ER - TY - JOUR AU - Horváth, Réka AU - Sütő, Zsófia AU - Cséke, Balázs AU - Schranz, Dániel AU - Darnai, Gergely AU - Kovács, Norbert AU - Janszky, Imre AU - Janszky, József Vladimír TI - Epilepsy is overrepresented among young people who died from COVID-19 : Analysis of nationwide mortality data in Hungary JF - SEIZURE-EUROPEAN JOURNAL OF EPILEPSY J2 - SEIZURE-EUR J EPILEP VL - 94 PY - 2022 SP - 136 EP - 141 PG - 6 SN - 1059-1311 DO - 10.1016/j.seizure.2021.11.013 UR - https://m2.mtmt.hu/api/publication/32543751 ID - 32543751 AB - Studies examining epilepsy as a COVID-related death risk have come to conflicting conclusions. Our aim was to assess the prevalence of epilepsy among COVID-related deaths in Hungary.Each COVID-19 infection case is required to be reported on a daily basis to the National Public Health Center of Hungary. This online report includes the beginning and end of the infection, as well as information on comorbidities. Death during infection is regarded as COVID-related. The anonymized data of each deceased patient are published on an information website (www.koronavirus.gov.hu) and provides up-to-date information on each patient with the date of death, the patient's sex, age, and chronic illness.There were 11,968 patients who died of COVID-19 in Hungary between 13 March 2020 and 23 January 2021. Among 11,686 patients with no missing values for comorbidities, 255 patients had epilepsy (2.2%). Epilepsy was much more common among those who died at a young age: 9.3% of those who died under the age of 50 had epilepsy, compared with only 1.3% in those over the age of 80. The younger an age group was, the higher was the prevalence of epilepsy.Patients who died of COVID-19 under the age of 50 were 10 to 20 times more likely to have epilepsy than what would have been expected from epidemiological data. Our results highlight the need for increased protection of young people with epilepsy from COVID-19 infection and the development of a vaccination strategy accordingly. LA - English DB - MTMT ER - TY - CHAP AU - Geiger, Lili AU - Horváth, Réka AU - Kecskés, Miklós AU - Orsi, Gergely AU - M., Tóth AU - Miseta, Attila János AU - Illés, Zsolt László AU - Gombos, Katalin AU - Czéh, Boldizsár ED - Kajos, Luca Fanni ED - Bali, Cintia ED - Preisz, Zsolt ED - Polgár, Petra Ibolya ED - Glázer-Kniesz, Adrienn ED - Tislér, Ádám ED - Szabó, Rebeka TI - Az extracellulárisan keringő miRNS-ek, mint potenciális biomarkerek neuropszichiátriai rendellenességekben: Előzetes tanulmány T2 - 10th Jubilee Interdisciplinary Doctoral Conference : Book of Abstracts = 10. Jubileumi Interdiszciplináris Doktorandusz Konferencia : Absztraktkötet PB - Pécsi Tudományegyetem Doktorandusz Önkormányzat CY - Pécs SN - 9789634298205 PY - 2021 SP - 304 EP - 304 PG - 1 UR - https://m2.mtmt.hu/api/publication/32643372 ID - 32643372 N1 - Poszter LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Márton AU - Barsi, Péter AU - Tóth, Zoltán AU - Borbély, Katalin AU - Lückl, János AU - Emri, Miklós AU - Repa, Imre AU - Janszky, József Vladimír AU - Dóczi, Tamás Péter AU - Horváth, Zsolt AU - Halász, Péter AU - Juhos, Vera AU - Trischlerné Gyimesi, Csilla AU - Bóné, Beáta AU - Kuperczkó, Diána AU - Horváth, Réka AU - Nagy, Ferenc AU - Kelemen, Anna AU - Jordán, Zsófia AU - Újvári, Ákos AU - Hagiwara, Koichi AU - Isnard, Jean AU - Pál, Endre AU - Fekésházy, Attila AU - Fabó, Dániel AU - Vajda, Zsolt TI - The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy JF - BMC NEUROLOGY J2 - BMC NEUROL VL - 21 PY - 2021 IS - 1 PG - 20 SN - 1471-2377 DO - 10.1186/s12883-021-02352-z UR - https://m2.mtmt.hu/api/publication/32219141 ID - 32219141 N1 - * Megosztott szerzőség AB - When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20-65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients.In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI.The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention.The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.Trial registry: Scientific Research Ethics Committee of the Medical Research Council of Hungary.008899/2016/OTIG . Date of registration: 08 February 2016. LA - English DB - MTMT ER - TY - JOUR AU - Bóné, Beáta AU - Kovács, Norbert AU - Balás, István AU - Horváth, Réka AU - Dóczi, Tamás Péter AU - Janszky, József Vladimír TI - Pregnancy and deep brain stimulation therapy for epilepsy JF - EPILEPTIC DISORDERS J2 - EPILEPTIC DISORD VL - 23 PY - 2021 IS - 4 SP - 633 EP - 638 PG - 6 SN - 1294-9361 DO - 10.1684/epd.2021.1304 UR - https://m2.mtmt.hu/api/publication/32107761 ID - 32107761 N1 - Funding Agency and Grant Number: Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; NKFIH [EFOP-3.6.2-16-2017-00008]; Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary [20765/3/2018/FEKUSTRAT] Funding text: This article was supported by the Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002), NKFIH EFOP-3.6.2-16-2017-00008 government-based funds. Our research was partly financed by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the 5th thematic program of the University of Pecs, Hungary (20765/3/2018/FEKUSTRAT). AB - Neuromodulation therapy -vagus nerve stimulation (VNS) and deep brain stimulation (DBS)- is one of the therapeutic options for drug-resistant epilepsy. With the increasing number of DBS implantations in women with epilepsy, it has become a burning issue whether DBS is safe in pregnancy. We report here two women with epilepsy who gave birth to healthy children with DBS therapy. We describe two cases, a 30-year-old woman and a 37-year-old woman. Both were implanted with DBS due to drug-resistant epilepsy. Both of our patients showed a significant improvement after DBS implantation and thereafter gave birth to a healthy child with DBS treatment. The severity and frequency of epileptic seizures did not change during pregnancy and after childbirth. Although a Caesarean section was performed in one case, pregnancies and births were essentially problem-free. At present, the two- and four-year-old children are healthy. Considering these cases, previously described VNS cases, and DBS cases with non-epileptic indications; we suggest that pregnancy and childbirth are safe in epilepsy patients with DBS, moreover, DBS treatment has probably no effect on foetal abnormalities or breastfeeding. LA - English DB - MTMT ER -