@article{MTMT:34729015, title = {Új minimálinvazív kezelési lehetőségek jó- és rosszindulatú fül-orr-gégészeti betegségekben nanoszerkezetű hatóanyag-leadó rendszerek alkalmazásával = New minimally invasive treatment options in benign and malignant otorhinolaryngological diseases using nanostructured drug delivery systems}, url = {https://m2.mtmt.hu/api/publication/34729015}, author = {Szabó, Diána and Janovák, László and Abdelghafour, Mohamed M. and Takács, Tamás and Csanády, Miklós ifj. and Spengler, Gabriella and Szakács, László and Csanády, Miklós and Rovó, László}, doi = {10.1556/650.2024.32978}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {165}, unique-id = {34729015}, issn = {0030-6002}, year = {2024}, eissn = {1788-6120}, pages = {370-378}, orcid-numbers = {Janovák, László/0000-0002-2066-319X; Abdelghafour, Mohamed M./0000-0002-7895-4555; Spengler, Gabriella/0000-0001-8085-0950; Rovó, László/0000-0003-1782-1756} } @article{MTMT:34728990, title = {A biomarkerek szerepe a fej-nyaki daganatok diagnosztikájában}, url = {https://m2.mtmt.hu/api/publication/34728990}, author = {Ambrus , Andrea and Csanády, Miklós and Rovó, László and Bach, Ádám}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {70}, unique-id = {34728990}, issn = {0016-237X}, year = {2024}, pages = {22-25}, orcid-numbers = {Rovó, László/0000-0003-1782-1756; Bach, Ádám/0000-0001-9265-1043} } @article{MTMT:34515707, title = {Comparison between Baha® 5 and the new Baha 6 Max sound processors: results among Baha attract users}, url = {https://m2.mtmt.hu/api/publication/34515707}, author = {Bere, Zsófia and Nagy, Roland and Molnár , Fiona Anna and Kiss, József Géza and Rovó, László}, doi = {10.1080/2050571X.2024.2304998}, journal-iso = {Speech, Language and Hearing}, journal = {Speech, Language and Hearing}, unique-id = {34515707}, issn = {2050-571X}, year = {2024}, eissn = {2050-5728}, orcid-numbers = {Bere, Zsófia/0000-0002-8342-1059; Rovó, László/0000-0003-1782-1756} } @article{MTMT:34402412, title = {Marószer okozta hallójárati sérülés következtében kialakult atrézia kombinált lebenyes megoldása. Esettanulmány.}, url = {https://m2.mtmt.hu/api/publication/34402412}, author = {Szalenko-Tőkés, Ágnes and Vass, Gábor and Jóri, József and Rovó, László and Bere, Zsófia and Bella, Zsolt}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {69}, unique-id = {34402412}, issn = {0016-237X}, year = {2023}, pages = {12-16}, orcid-numbers = {Vass, Gábor/0000-0003-0787-8679; Rovó, László/0000-0003-1782-1756; Bere, Zsófia/0000-0002-8342-1059} } @article{MTMT:34402216, title = {A Da Vinci operációs robot szerepe az ismeretlen primer fej-nyaki tumorok diagnosztikájában - A Groningeni Egyetem tapasztalatai}, url = {https://m2.mtmt.hu/api/publication/34402216}, author = {Szalenko-Tőkés, Ágnes and Wisse, van der Laan and Rovó, László and Halmos, György}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {69}, unique-id = {34402216}, issn = {0016-237X}, year = {2023}, pages = {140-145}, orcid-numbers = {Rovó, László/0000-0003-1782-1756} } @article{MTMT:34391980, title = {Fiberoszkóppal végzett funkcionális nyelésvizsgálat bevezetése és indikációs körének kiterjesztése klinikánkon [Introduction of fiberoptic endoscopic evaluation of swallowing and increase of the range of indications in our department]}, url = {https://m2.mtmt.hu/api/publication/34391980}, author = {Ambrus , Andrea and Rovó, László and Sztanó, Balázs and Burián, András and Tóth, Alinka and Bach, Ádám}, doi = {10.1556/650.2023.32912}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {164}, unique-id = {34391980}, issn = {0030-6002}, abstract = {A dysphagia a nyelési folyamat előkészítő vagy transzportzavaraiból adódó betegség. A laesio helye szerint oropharyngealis és oesophagealis dysphagiát különböztetünk meg. A fül-orr-gégészeti szakvizsgálat az oropharyngealis fázist érintő eltérésekre koncentrálódik, ugyanakkor fontos hangsúlyozni, hogy a dysphagia okának differenciáldiagnosztikája, kivizsgálása és kezelése sokszor multidiszciplináris szemléletet és együttműködést igénylő, komplex feladat. A Szegedi Tudományegyetem Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinikáján fiberoszkóppal végzett funkcionális nyelésvizsgálati módszer (FEES) került bevezetésre, melynek segítségével a fül-orr-gégészeti és a neurológiai eredetű nyelészavarok vizsgálata, illetve a betegek nyelésminőségének objektív elemzése is lehetővé vált. A FEES olyan, minimálisan invazív eljárás, melynek segítségével a nyelés oropharyngealis fázisa vizualizálható, a dysphagiát okozó anatómiai eltérések vagy beidegzési zavarok is azonosíthatók, így a vizsgálat a későbbi betegrehabilitációban szintén meghatározó szerepet játszhat. Közleményünkben fej-nyaki daganat miatt parciális gége- és garatműtéten átesett és légúti szűkület miatt operált betegeinknek, illetve a Neurológiai Klinikával létrejött együttműködéssel a különböző neurológiai eredetű, oropharyngealis nyelészavarral küzdő pácienseknek a vizsgálatai során szerzett tapasztalatainkról számolunk be. Orv Hetil. 2023; 164(46): 1817–1823.}, year = {2023}, eissn = {1788-6120}, pages = {1817-1823}, orcid-numbers = {Rovó, László/0000-0003-1782-1756; Sztanó, Balázs/0000-0002-9925-4849; Bach, Ádám/0000-0001-9265-1043} } @article{MTMT:34299490, title = {Extended partial laryngectomy with functional preservation using the rotational crico-thyrotracheopexy}, url = {https://m2.mtmt.hu/api/publication/34299490}, author = {Rovó, László and Szakács, László and Castellanos, Paul F. and Tóbiás, Zoltán and Pfiszterer, Péter and Ambrus , Andrea and Csanády, Miklós and Bach, Ádám}, doi = {10.1002/lio2.1155}, journal-iso = {LARYNGOSCOPE INVEST}, journal = {LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY}, volume = {8}, unique-id = {34299490}, issn = {2378-8038}, abstract = {ObjectivesGlottic tumors with infiltration of the anterior/posterior commissure, and lesions with subglottic, cricoid, or cricoarytenoid joint infiltration have been highly controversial in the past, from the perspective of oncological safety. Although conservation laryngeal resection options exist, most are limited by the extent of resection proscribed by the technique and the postoperative functional results. Oncologically speaking, extended vertical hemilaryngectomy is often the optimal solution. However, limited reconstruction methods often compel total laryngectomy.MethodsEight patients with vocal fold malignancy, which infiltrated the anterior and sometimes the posterior commissure and with subglottic extension and resultant uni/bilateral vocal fold motion impairment, were treated by single stage extended vertical partial laryngectomy with rotational crico-thyrotracheopexy as a functional reconstruction of the laryngeal framework. Patients were evaluated with objective and subjective function tests.ResultsHistologic examination demonstrated tumor-free margins in every case. Definitive decannulation was successful in all cases within 2 weeks. All patients had a stable and adequate airway during follow-up and reported socially acceptable voice. Oral feeding was possible in seven patients.ConclusionRotational crico-thyrotracheopexy, as a single stage reconstruction technique, is based on well-vascularized, readily available, appropriately shaped local tissues, without significant donor site morbidity or need for long-term stenting to reconstruct large laryngeal defects after extended vertical hemilaryngectomy for advanced unilateral glottic tumors and is applicable even with supra/subglottic invasion or infiltration of the contralateral vocal fold. An adequate airway can be achieved with socially acceptable voice and safe swallowing without compromising oncologic reliability.Level of Evidence4 (retrospective case series review).The study evaluated the effectiveness of rotational crico-thyrotracheopexy as a functional reconstruction technique for the laryngeal framework in patients with advanced unilateral glottic tumors after extended vertical hemilaryngectomy.image}, keywords = {glottic cancer; extended vertical hemilaryngectomy; rotational crico-thyrotracheopexy; single-stage reconstructive surgery; tracheal graft}, year = {2023}, eissn = {2378-8038}, pages = {1328-1336}, orcid-numbers = {Rovó, László/0000-0003-1782-1756; Bach, Ádám/0000-0001-9265-1043} } @article{MTMT:34154074, title = {Mitomycin loaded self-assembled colloidal prodrug nanoparticles for magnetic drug targeting}, url = {https://m2.mtmt.hu/api/publication/34154074}, author = {Amin, Keristina and Abdelghafour, Mohamed M. and Varga, Viktória and Kiss, Tamás and Szabó, Diána and Rovó, László and Janovák, László}, doi = {10.1016/j.jddst.2023.104948}, journal-iso = {J DRUG DELIV SCI TEC}, journal = {JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY}, volume = {88}, unique-id = {34154074}, issn = {1773-2247}, year = {2023}, eissn = {2588-8943}, orcid-numbers = {Abdelghafour, Mohamed M./0000-0002-7895-4555; Varga, Viktória/0000-0001-9933-7604; Rovó, László/0000-0003-1782-1756; Janovák, László/0000-0002-2066-319X} } @article{MTMT:34152481, title = {Quality by Design-based optimization of in situ ionic-sensitive gels of amoxicillin-loaded bovine serum albumin nanoparticles for enhanced local nasal delivery}, url = {https://m2.mtmt.hu/api/publication/34152481}, author = {Mardikasari, Sandra Aulia and Katona, Gábor and Budai-Szűcs, Mária and Sipos, Bence and Orosz, László and Burián, Katalin and Rovó, László and Pannonhalminé Csóka, Ildikó}, doi = {10.1016/j.ijpharm.2023.123435}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {645}, unique-id = {34152481}, issn = {0378-5173}, year = {2023}, eissn = {1873-3476}, orcid-numbers = {Mardikasari, Sandra Aulia/0000-0001-6771-0208; Katona, Gábor/0000-0003-1564-4813; Budai-Szűcs, Mária/0000-0001-5187-5702; Sipos, Bence/0000-0002-0131-4728; Burián, Katalin/0000-0003-1300-2374; Rovó, László/0000-0003-1782-1756; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781} } @article{MTMT:33764466, title = {Genetic Etiology of Nonsyndromic Hearing Loss in Hungarian Patients}, url = {https://m2.mtmt.hu/api/publication/33764466}, author = {Pál, Margit and Nagy, Dóra and Neller, Alexandra and Farkas, Katalin and Török, Dóra and Nagy, Nikoletta and Füstös, Dalma and Nagy, Roland and Németh, Adrienn and Szilvássy, Judit and Rovó, László and Kiss, József Géza and Széll, Márta}, doi = {10.3390/ijms24087401}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {33764466}, issn = {1661-6596}, abstract = {Hearing loss is the most prevalent sensory disorder worldwide. The majority of congenital nonsyndromic hearing loss (NSHL) cases are caused by hereditary factors. Previously, the majority of NSHL studies focused on the GJB2 gene; however, with the availability of next-generation sequencing (NGS) methods, the number of novel variants associated with NSHL has increased. The purpose of this study was to design effective genetic screening for a Hungarian population based on a pilot study with 139 NSHL patients. A stepwise, comprehensive genetic approach was developed, including bidirectional capillary sequencing, multiplex ligation-dependent probe amplification (MLPA), and an NGS panel of 108 hearing loss genes. With our results, a genetic diagnosis was possible for 92 patients. Sanger sequencing and MLPA identified the genetic background of 50% of these diagnosed cases, and the NGS panel identified another 16%. The vast majority (92%) of the diagnosed cases showed autosomal recessive inheritance and 76% were attributed to GJB2. The implementation of this stepwise analysis markedly increased our diagnostic yield and proved to be cost-effective as well.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Pál, Margit/0000-0003-3662-0837; Nagy, Dóra/0000-0002-6224-1972; Nagy, Nikoletta/0000-0001-8576-7953; Németh, Adrienn/0000-0001-9965-0609; Rovó, László/0000-0003-1782-1756; Széll, Márta/0000-0002-0730-714X} }