TY - JOUR AU - Fekete, Szilvia AU - Juhász, János AU - Makra, Nóra AU - Dunai, Zsuzsanna AU - Kristóf, Katalin AU - Ostorházi, Eszter AU - Tamás, László AU - Szabó, Dóra AU - Kecskeméti, Nóra AU - Polony, Gábor TI - Middle ear microbiome in otitis media with effusion, the role of Alloiococcus otitidis JF - HELIYON J2 - HELIYON VL - in press PY - 2024 PG - 27 SN - 2405-8440 DO - 10.2139/ssrn.4693874 UR - https://m2.mtmt.hu/api/publication/34656287 ID - 34656287 LA - English DB - MTMT ER - TY - GEN AU - Cakir, Ugur AU - Ostorházi, Eszter AU - Kovács, Tibor AU - Belsőné, Ocsovai Ildikó AU - Falucskainé, Juhász Katalin AU - Tóth, Béla AU - Tamási, Béla AU - Holló, Péter TI - Neurosyphilis esetek a SE Bőr-, Nemikórtani és Bőronkológiai Klinikán, 2012-2022 között PY - 2023 UR - https://m2.mtmt.hu/api/publication/34406907 ID - 34406907 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Lőrincz, Eszter Boglárka AU - Tóth, Gergely AU - Spolárics, Júlia AU - Herczeg, Mihály AU - Hodek, Jan AU - Zupkó, István AU - Minorics, Renáta AU - Ádám, Dorottya AU - Oláh, Attila AU - Zouboulis, Christos C. AU - Weber, Jan AU - Nagy, Lajos AU - Ostorházi, Eszter AU - Bácskay, Ildikó AU - Borbás, Anikó AU - Herczegh, Pál AU - Bakai-Bereczki, Ilona TI - Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 20 SN - 2045-2322 DO - 10.1038/s41598-023-45565-7 UR - https://m2.mtmt.hu/api/publication/34316518 ID - 34316518 AB - (−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral bioavailability is moderate, which is unfavorable for medicinal use. Therefore, there is a great need for appropriate chemical modifications to improve their physicochemical and biological properties. In this study, Mannich-type reaction was used for the synthetic modification of CBD and CBG for the first time, and thus fifteen new cannabinoid derivatives containing one or two tertiary amino groups were prepared. Thereafter the antiviral, antiproliferative and antibacterial properties of the derivatives and their effects on certain skin cells were investigated. Some modified CBD derivatives showed remarkable antiviral activity against SARS-CoV-2 without cytotoxic effect, while synthetic modifications on CBG resulted in a significant increase in antiproliferative activity in some cases compared to the parent compound. LA - English DB - MTMT ER - TY - JOUR AU - Kushkevych, Ivan AU - Dordević, Dani AU - Alberfkani, Mohammad I. AU - Gajdács, Márió AU - Ostorházi, Eszter AU - Vítězová, Monika AU - Rittmann, Simon K.-M. R. TI - NADH and NADPH peroxidases as antioxidant defense mechanisms in intestinal sulfate-reducing bacteria JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 11 SN - 2045-2322 DO - 10.1038/s41598-023-41185-3 UR - https://m2.mtmt.hu/api/publication/34110888 ID - 34110888 AB - Animal and human feces typically include intestinal sulfate-reducing bacteria (SRB). Hydrogen sulfide and acetate are the end products of their dissimilatory sulfate reduction and may create a synergistic effect. Here, we report NADH and NADPH peroxidase activities from intestinal SRB Desulfomicrobium orale and Desulfovibrio piger . We sought to compare enzymatic activities under the influence of various temperature and pH regimes, as well as to carry out kinetic analyses of enzymatic reaction rates, maximum amounts of the reaction product, reaction times, maximum rates of the enzyme reactions, and Michaelis constants in cell-free extracts of intestinal SRB, D. piger Vib-7, and D. orale Rod-9, collected from exponential and stationary growth phases. The optimal temperature (35 °C) and pH (7.0) for both enzyme’s activity were determined. The difference in trends of Michaelis constants ( K m ) during exponential and stationary phases are noticeable between D. piger Vib-7 and D. orale Rod-9; D. orale Rod-9 showed much higher K m (the exception is NADH peroxidase of D. piger Vib-7: 1.42 ± 0.11 mM) during the both monitored phases. Studies of the NADH and NADPH peroxidases—as putative antioxidant defense systems of intestinal SRB and detailed data on the kinetic properties of this enzyme, as expressed by the decomposition of hydrogen peroxide—could be important for clarifying evolutionary mechanisms of antioxidant defense systems, their etiological role in the process of dissimilatory sulfate reduction, and their possible role in the development of bowel diseases. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Dóra AU - Ostorházi, Eszter AU - Stercz, Balázs AU - Makra, Nóra AU - Pénzes, Kinga AU - Kristóf, Katalin AU - Antal, István AU - Réthelyi, János AU - Zsigmond, Réka Ildikó AU - Birtalan, Ede AU - Merkely, Béla Péter AU - Tamás, László TI - Specific nasopharyngeal Corynebacterium strains serve as gatekeepers against SARS-CoV-2 infection JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 45 PY - 2023 IS - 5 SP - 2927 EP - 2938 PG - 12 SN - 2509-2715 DO - 10.1007/s11357-023-00850-1 UR - https://m2.mtmt.hu/api/publication/34026885 ID - 34026885 AB - The SARS-CoV-2 virus is still causing a worldwide problem. The virus settles primarily on the nasal mucosa, and the infection and its course depend on individual susceptibility. Our aim was to investigate the nasopharynx composition’s role in the individual susceptibility. During the first phase of SARS-CoV-2 pandemic, nasopharyngeal microbiome samples of close contact unvaccinated patients were investigated by 16S rRNA analysis and by culturing. The whole genome of cultured Corynebacteria was sequenced. The relative expression of ACE2, TMPRSS2, and cathepsin L on Caco-2 cells and the strength of S1-ACE2 binding were determined in the presence of Corynebacteria . From 55 close contacts exposed to identical SARS-CoV-2 exposure, 26 patients became infected and 29 remained uninfected. The nasopharyngeal microbiome analysis showed significantly higher abundance of Corynebacteria in uninfected group. Corynebacterium accolens could be cultivated only from uninfected individuals and Corynebacterium propinquum from both infected and uninfected. Corynebacteria from uninfected patient significantly reduced the ACE2 and cathepsin L expression. C. accolens significantly reduced the TMPRSS2 expression compared to other Corynebacteria . Furthermore, Corynebacterium spp. weakened the binding of the S1-ACE2. Most C. accolens isolates harbored the TAG lipase LipS1 gene. Based on these results, the presence of Corynebacterium spp. in the nasopharyngeal microbiota, especially C. accolens strains, could reduce the individual susceptibility to SARS-CoV-2 infection by several mechanisms: by downregulation the ACE2, the TMPRSS2 receptors, and cathepsin L in the host; through the inhibition of S1-ACE2 binding; and lipase production. These results suggest the use of C. accolens strains as probiotics in the nasopharynx in the future. LA - English DB - MTMT ER - TY - BOOK ED - Szabó, Dóra AU - Dobay, Orsolya AU - Ghidán, Ágoston AU - Horváth, Andrea AU - Kádár, Béla AU - Kis, Zoltán AU - Kocsis, Béla AU - Nagy, Orsolya AU - Ostorházi, Eszter AU - Stercz, Balázs AU - Szabó, Dóra AU - Takács, Mária TI - Az orvosi mikrobiológia alapja – e-tankönyv ET - 2 PB - Semmelweis Kiadó CY - Budapest PY - 2022 SP - 397 SN - 9789633315705 UR - https://m2.mtmt.hu/api/publication/34494073 ID - 34494073 N1 - 2. bővített kiadás LA - Hungarian DB - MTMT ER - TY - BOOK ED - Szabó, Dóra AU - Dobay, Orsolya AU - Ghidán, Ágoston AU - Horváth, Andrea AU - Kádár, Béla AU - Kiss, Zoltán AU - Kocsis, Béla AU - Nagy, Orsolya AU - Ostorházi, Eszter AU - Stercz, Balázs AU - Szabó, Dóra AU - Takács, Mária TI - Grundlagen der medizinischen mikrobiologie - e-Lehrbuch - másodközlés német nyelven PB - Semmelweis Kiadó CY - Budapest PY - 2022 SP - 418 SN - 9789633315620 UR - https://m2.mtmt.hu/api/publication/34494032 ID - 34494032 N1 - Eredeti közlemény: [34494073] LA - German DB - MTMT ER - TY - BOOK AU - Dobay, Orsolya AU - Ghidán, Ágoston AU - Horváth, Andrea AU - Kádár, Béla AU - Kis, Zoltán AU - Kocsis, Béla AU - Nagy, Orsolya AU - Ostorházi, Eszter AU - Stercz, Balázs AU - Szabó, Dóra AU - Takács, Mária ED - Szabó, Dóra TI - Basics of Medical Microbiology - másodközlés angol nyelven PB - Semmelweis Kiadó CY - Budapest PY - 2022 SP - 387 SN - 9789633315712 UR - https://m2.mtmt.hu/api/publication/34034597 ID - 34034597 N1 - Eredeti közlemény: [34494073] LA - English DB - MTMT ER - TY - GEN AU - Farkas, Enikő AU - Tarr, Robert AU - Gerecsei, Tamás AU - Saftics, András AU - Kovács, Kinga Dóra AU - Stercz, Balázs AU - Domokos, Judit AU - Péter, Beatrix AU - Kurunczi, Sándor AU - Székács, Inna AU - Bonyár, Attila AU - Bányai, Anita AU - Fürjes, Péter AU - Ruszkai-Szaniszló, Szilvia AU - Varga, Máté AU - Szabó, Barnabás AU - Ostorházi, Eszter AU - Szabó, Dóra AU - Horváth, Róbert TI - Label-free optical biosensor method for detailed analysis of bacteria repellent and adhesive surfaces PY - 2022 UR - https://m2.mtmt.hu/api/publication/33548127 ID - 33548127 LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Bálint Gergely AU - Kiss, Rebeka AU - Makra, Nóra AU - Pénzes, Kinga AU - Vad, Eszter AU - Kamotsay, Katalin AU - Szabó, Dóra AU - Ostorházi, Eszter TI - Composition and changes of blood microbiota in adult patients with community-acquired sepsis: A pilot study from bench to bedside JF - FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY J2 - FRONT CELL INFECT MI VL - 12 PY - 2022 PG - 13 SN - 2235-2988 DO - 10.3389/fcimb.2022.1067476 UR - https://m2.mtmt.hu/api/publication/33336220 ID - 33336220 N1 - South Pest Central Hospital, National Institute of Hematology and Infectious Diseases, Budapest, Hungary Departmental Group of Infectious Diseases, Department of Haematology and Internal Medicine, Semmelweis University, Budapest, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary Export Date: 13 June 2023 Correspondence Address: Ostorházi, E.; Institute of Medical Microbiology, Hungary; email: ostorhazi.eszter@med.semmelweis-univ.hu LA - English DB - MTMT ER -