@article{MTMT:34656287, title = {Middle ear microbiome in otitis media with effusion, the role of Alloiococcus otitidis}, url = {https://m2.mtmt.hu/api/publication/34656287}, author = {Fekete, Szilvia and Juhász, János and Makra, Nóra and Dunai, Zsuzsanna and Kristóf, Katalin and Ostorházi, Eszter and Tamás, László and Szabó, Dóra and Kecskeméti, Nóra and Polony, Gábor}, doi = {10.2139/ssrn.4693874}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {in press}, unique-id = {34656287}, year = {2024}, eissn = {2405-8440}, orcid-numbers = {Kristóf, Katalin/0000-0002-5189-4636; Ostorházi, Eszter/0000-0002-9459-7316; Tamás, László/0000-0003-3723-9149; Szabó, Dóra/0000-0002-8601-3923; Kecskeméti, Nóra/0000-0003-1886-5021; Polony, Gábor/0000-0001-5236-8139} } @misc{MTMT:34406907, title = {Neurosyphilis esetek a SE Bőr-, Nemikórtani és Bőronkológiai Klinikán, 2012-2022 között}, url = {https://m2.mtmt.hu/api/publication/34406907}, author = {Cakir, Ugur and Ostorházi, Eszter and Kovács, Tibor and Belsőné, Ocsovai Ildikó and Falucskainé, Juhász Katalin and Tóth, Béla and Tamási, Béla and Holló, Péter}, unique-id = {34406907}, year = {2023}, orcid-numbers = {Cakir, Ugur/0000-0001-8270-1430; Ostorházi, Eszter/0000-0002-9459-7316; Tóth, Béla/0000-0003-0498-0387; Tamási, Béla/0000-0002-7247-2491; Holló, Péter/0000-0002-0744-8989} } @article{MTMT:34316518, title = {Mannich-type modifications of (−)-cannabidiol and (−)-cannabigerol leading to new, bioactive derivatives}, url = {https://m2.mtmt.hu/api/publication/34316518}, author = {Lőrincz, Eszter Boglárka and Tóth, Gergely and Spolárics, Júlia and Herczeg, Mihály and Hodek, Jan and Zupkó, István and Minorics, Renáta and Ádám, Dorottya and Oláh, Attila and Zouboulis, Christos C. and Weber, Jan and Nagy, Lajos and Ostorházi, Eszter and Bácskay, Ildikó and Borbás, Anikó and Herczegh, Pál and Bakai-Bereczki, Ilona}, doi = {10.1038/s41598-023-45565-7}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34316518}, issn = {2045-2322}, abstract = {(−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids that have many beneficial biological properties. However, due to their low water solubility and prominent first-pass metabolism, their oral bioavailability is moderate, which is unfavorable for medicinal use. Therefore, there is a great need for appropriate chemical modifications to improve their physicochemical and biological properties. In this study, Mannich-type reaction was used for the synthetic modification of CBD and CBG for the first time, and thus fifteen new cannabinoid derivatives containing one or two tertiary amino groups were prepared. Thereafter the antiviral, antiproliferative and antibacterial properties of the derivatives and their effects on certain skin cells were investigated. Some modified CBD derivatives showed remarkable antiviral activity against SARS-CoV-2 without cytotoxic effect, while synthetic modifications on CBG resulted in a significant increase in antiproliferative activity in some cases compared to the parent compound.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Herczeg, Mihály/0000-0002-7938-9789; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Oláh, Attila/0000-0003-4122-5639; Ostorházi, Eszter/0000-0002-9459-7316; Borbás, Anikó/0000-0001-8462-4547; Bakai-Bereczki, Ilona/0000-0003-4601-7257} } @article{MTMT:34110888, title = {NADH and NADPH peroxidases as antioxidant defense mechanisms in intestinal sulfate-reducing bacteria}, url = {https://m2.mtmt.hu/api/publication/34110888}, author = {Kushkevych, Ivan and Dordević, Dani and Alberfkani, Mohammad I. and Gajdács, Márió and Ostorházi, Eszter and Vítězová, Monika and Rittmann, Simon K.-M. R.}, doi = {10.1038/s41598-023-41185-3}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34110888}, issn = {2045-2322}, abstract = {Animal and human feces typically include intestinal sulfate-reducing bacteria (SRB). Hydrogen sulfide and acetate are the end products of their dissimilatory sulfate reduction and may create a synergistic effect. Here, we report NADH and NADPH peroxidase activities from intestinal SRB Desulfomicrobium orale and Desulfovibrio piger . We sought to compare enzymatic activities under the influence of various temperature and pH regimes, as well as to carry out kinetic analyses of enzymatic reaction rates, maximum amounts of the reaction product, reaction times, maximum rates of the enzyme reactions, and Michaelis constants in cell-free extracts of intestinal SRB, D. piger Vib-7, and D. orale Rod-9, collected from exponential and stationary growth phases. The optimal temperature (35 °C) and pH (7.0) for both enzyme’s activity were determined. The difference in trends of Michaelis constants ( K m ) during exponential and stationary phases are noticeable between D. piger Vib-7 and D. orale Rod-9; D. orale Rod-9 showed much higher K m (the exception is NADH peroxidase of D. piger Vib-7: 1.42 ± 0.11 mM) during the both monitored phases. Studies of the NADH and NADPH peroxidases—as putative antioxidant defense systems of intestinal SRB and detailed data on the kinetic properties of this enzyme, as expressed by the decomposition of hydrogen peroxide—could be important for clarifying evolutionary mechanisms of antioxidant defense systems, their etiological role in the process of dissimilatory sulfate reduction, and their possible role in the development of bowel diseases.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Ostorházi, Eszter/0000-0002-9459-7316} } @article{MTMT:34026885, title = {Specific nasopharyngeal Corynebacterium strains serve as gatekeepers against SARS-CoV-2 infection}, url = {https://m2.mtmt.hu/api/publication/34026885}, author = {Szabó, Dóra and Ostorházi, Eszter and Stercz, Balázs and Makra, Nóra and Pénzes, Kinga and Kristóf, Katalin and Antal, István and Réthelyi, János and Zsigmond, Réka Ildikó and Birtalan, Ede and Merkely, Béla Péter and Tamás, László}, doi = {10.1007/s11357-023-00850-1}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {45}, unique-id = {34026885}, issn = {2509-2715}, abstract = {The SARS-CoV-2 virus is still causing a worldwide problem. The virus settles primarily on the nasal mucosa, and the infection and its course depend on individual susceptibility. Our aim was to investigate the nasopharynx composition’s role in the individual susceptibility. During the first phase of SARS-CoV-2 pandemic, nasopharyngeal microbiome samples of close contact unvaccinated patients were investigated by 16S rRNA analysis and by culturing. The whole genome of cultured Corynebacteria was sequenced. The relative expression of ACE2, TMPRSS2, and cathepsin L on Caco-2 cells and the strength of S1-ACE2 binding were determined in the presence of Corynebacteria . From 55 close contacts exposed to identical SARS-CoV-2 exposure, 26 patients became infected and 29 remained uninfected. The nasopharyngeal microbiome analysis showed significantly higher abundance of Corynebacteria in uninfected group. Corynebacterium accolens could be cultivated only from uninfected individuals and Corynebacterium propinquum from both infected and uninfected. Corynebacteria from uninfected patient significantly reduced the ACE2 and cathepsin L expression. C. accolens significantly reduced the TMPRSS2 expression compared to other Corynebacteria . Furthermore, Corynebacterium spp. weakened the binding of the S1-ACE2. Most C. accolens isolates harbored the TAG lipase LipS1 gene. Based on these results, the presence of Corynebacterium spp. in the nasopharyngeal microbiota, especially C. accolens strains, could reduce the individual susceptibility to SARS-CoV-2 infection by several mechanisms: by downregulation the ACE2, the TMPRSS2 receptors, and cathepsin L in the host; through the inhibition of S1-ACE2 binding; and lipase production. These results suggest the use of C. accolens strains as probiotics in the nasopharynx in the future.}, year = {2023}, eissn = {2509-2723}, pages = {2927-2938}, orcid-numbers = {Szabó, Dóra/0000-0002-8601-3923; Ostorházi, Eszter/0000-0002-9459-7316; Stercz, Balázs/0000-0002-9585-8397; Kristóf, Katalin/0000-0002-5189-4636; Antal, István/0000-0002-5434-201X; Réthelyi, János/0000-0002-3641-012X; Zsigmond, Réka Ildikó/0000-0002-7019-6761; Birtalan, Ede/0000-0002-5699-3545; Merkely, Béla Péter/0000-0001-6514-0723; Tamás, László/0000-0003-3723-9149} } @book{MTMT:34494073, title = {Az orvosi mikrobiológia alapja – e-tankönyv}, url = {https://m2.mtmt.hu/api/publication/34494073}, isbn = {9789633315705}, author = {Dobay, Orsolya and Ghidán, Ágoston and Horváth, Andrea and Kádár, Béla and Kis, Zoltán and Kocsis, Béla and Nagy, Orsolya and Ostorházi, Eszter and Stercz, Balázs and Szabó, Dóra and Takács, Mária}, editor = {Szabó, Dóra}, publisher = {Semmelweis Kiadó és Multimédia Stúdió}, unique-id = {34494073}, year = {2022}, orcid-numbers = {Szabó, Dóra/0000-0002-8601-3923; Dobay, Orsolya/0000-0001-7094-2288; Ghidán, Ágoston/0000-0002-2397-1809; Horváth, Andrea/0000-0003-4208-3417; Kádár, Béla/0000-0002-7126-5415; Kocsis, Béla/0000-0002-7067-7055; Ostorházi, Eszter/0000-0002-9459-7316; Stercz, Balázs/0000-0002-9585-8397; Szabó, Dóra/0000-0002-8601-3923} } @book{MTMT:34494032, title = {Grundlagen der medizinischen mikrobiologie - e-Lehrbuch - másodközlés német nyelven}, url = {https://m2.mtmt.hu/api/publication/34494032}, isbn = {9789633315620}, author = {Dobay, Orsolya and Ghidán, Ágoston and Horváth, Andrea and Kádár, Béla and Kiss, Zoltán and Kocsis, Béla and Nagy, Orsolya and Ostorházi, Eszter and Stercz, Balázs and Szabó, Dóra and Takács, Mária}, editor = {Szabó, Dóra}, publisher = {Semmelweis Kiadó és Multimédia Stúdió}, unique-id = {34494032}, year = {2022}, orcid-numbers = {Szabó, Dóra/0000-0002-8601-3923; Dobay, Orsolya/0000-0001-7094-2288; Ghidán, Ágoston/0000-0002-2397-1809; Horváth, Andrea/0000-0003-4208-3417; Kádár, Béla/0000-0002-7126-5415; Kocsis, Béla/0000-0002-7067-7055; Ostorházi, Eszter/0000-0002-9459-7316; Stercz, Balázs/0000-0002-9585-8397; Szabó, Dóra/0000-0002-8601-3923} } @book{MTMT:34034597, title = {Basics of Medical Microbiology - másodközlés angol nyelven}, url = {https://m2.mtmt.hu/api/publication/34034597}, isbn = {9789633315712}, author = {Dobay, Orsolya and Ghidán, Ágoston and Horváth, Andrea and Kádár, Béla and Kis, Zoltán and Kocsis, Béla and Nagy, Orsolya and Ostorházi, Eszter and Stercz, Balázs and Szabó, Dóra and Takács, Mária}, editor = {Szabó, Dóra}, publisher = {Semmelweis Kiadó és Multimédia Stúdió}, unique-id = {34034597}, year = {2022}, orcid-numbers = {Dobay, Orsolya/0000-0001-7094-2288; Ghidán, Ágoston/0000-0002-2397-1809; Horváth, Andrea/0000-0003-4208-3417; Kádár, Béla/0000-0002-7126-5415; Kocsis, Béla/0000-0002-7067-7055; Ostorházi, Eszter/0000-0002-9459-7316; Stercz, Balázs/0000-0002-9585-8397; Szabó, Dóra/0000-0002-8601-3923; Szabó, Dóra/0000-0002-8601-3923} } @misc{MTMT:33548127, title = {Label-free optical biosensor method for detailed analysis of bacteria repellent and adhesive surfaces}, url = {https://m2.mtmt.hu/api/publication/33548127}, author = {Farkas, Enikő and Tarr, Robert and Gerecsei, Tamás and Saftics, András and Kovács, Kinga Dóra and Stercz, Balázs and Domokos, Judit and Péter, Beatrix and Kurunczi, Sándor and Székács, Inna and Bonyár, Attila and Bányai, Anita and Fürjes, Péter and Ruszkai-Szaniszló, Szilvia and Varga, Máté and Szabó, Barnabás and Ostorházi, Eszter and Szabó, Dóra and Horváth, Róbert}, unique-id = {33548127}, year = {2022}, orcid-numbers = {Stercz, Balázs/0000-0002-9585-8397; Domokos, Judit/0000-0002-0238-105X; Kurunczi, Sándor/0000-0002-6567-5231; Bonyár, Attila/0000-0002-6976-7846; Fürjes, Péter/0000-0002-8022-4367; Ostorházi, Eszter/0000-0002-9459-7316; Szabó, Dóra/0000-0002-8601-3923; Horváth, Róbert/0000-0001-8617-2302} } @article{MTMT:33336220, title = {Composition and changes of blood microbiota in adult patients with community-acquired sepsis: A pilot study from bench to bedside}, url = {https://m2.mtmt.hu/api/publication/33336220}, author = {Szabó, Bálint Gergely and Kiss, Rebeka and Makra, Nóra and Pénzes, Kinga and Vad, Eszter and Kamotsay, Katalin and Szabó, Dóra and Ostorházi, Eszter}, doi = {10.3389/fcimb.2022.1067476}, journal-iso = {FRONT CELL INFECT MI}, journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}, volume = {12}, unique-id = {33336220}, issn = {2235-2988}, year = {2022}, eissn = {2235-2988}, orcid-numbers = {Szabó, Bálint Gergely/0000-0003-1775-1356; Szabó, Dóra/0000-0002-8601-3923; Ostorházi, Eszter/0000-0002-9459-7316} }