TY - JOUR AU - Tóth, Gábor AU - Lukács, Andrea AU - Stachon, Tanja AU - Schirra, Frank AU - Sándor, Gábor László AU - Nagy, Zoltán Zsolt AU - Szentmáry, Nóra TI - Clinical Characteristics and Treatment of Ophthalmic Sequelae of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis at a Tertiary Eyecare Centre in Hungary JF - OPHTHALMOLOGY AND THERAPY J2 - OPHTHALMOL THERAP VL - 13 PY - 2024 IS - 5 SP - 1343 EP - 1356 PG - 14 SN - 2193-8245 DO - 10.1007/s40123-024-00924-z UR - https://m2.mtmt.hu/api/publication/34755441 ID - 34755441 AB - This study analysed the causative factors and clinical characteristics of acute and chronic ocular sequelae of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) treated at a large third-referral centre in a developed country (Hungary) over a 15-year period.This was a retrospective review of patients with acute and/or chronic SJS/TEN who were managed between 2006 and 2020 at the Department of Ophthalmology of Semmelweis University in Budapest, Hungary. For each subject, clinical data, including patient demographics, clinical history, causative agents of SJS/TEN, and conservative and surgical treatment details, were reviewed.Ninety-six eyes of 48 patients were included (28 female; 58.3%); the age at disease onset was 32.1 ± 22.4 years. The most common causative factors were medicines (n = 36; 75.0%). Among these drugs, 29.2% were nonsteroidal anti-inflammatory drugs (NSAIDs) (n = 14), 20.8% were antibiotics (n = 10) and 14.6% were antiepileptic drugs (n = 7). In patients with chronic SJS/TEN, the most commonly found ocular sequelae were conjunctival hyperaemia in 45 (56.3%) eyes, symblepharon in 38 (47.5%) eyes, trichiasis/distichiasis in 37 (46.3%) eyes, corneal neovascularization in 31 (38.8%) eyes and corneal scarring in 29 (36.3%) eyes. In patients with chronic SJS/TEN, the most frequently used topical conservative treatment included antibiotics in 53 (66.3%) eyes, preservative-free artificial tears in 50 (62.5%) eyes and topical corticosteroids in 42 (52.5%) eyes of 40 patients. The most frequently performed ocular surgeries for managing chronic ocular sequelae in patients with SJS/TEN were epilation for trichiasis (n = 27; 33.8%), cataract surgery (n = 14; 17.5%), entropion surgery (n = 12; 15.0%), penetrating keratoplasty (PK) (n = 11; 13.8%) and amniotic membrane transplantation (n = 4; 5.0%).Our results suggest that NSAIDs, antibiotics and antiepileptic drugs are the most common causative factors for SJS/TEN in Hungary. Like in other countries, in Hungary, the ocular management of patients with acute and chronic SJS/TEN is heterogeneous, and most cases do not follow modern therapeutic guidelines. LA - English DB - MTMT ER - TY - JOUR AU - Volek, Eva AU - Sándor, Gábor László AU - Nagy, Zoltán Zsolt AU - Schneider, Miklós TI - Anterior segment optical coherence tomography-assisted surgical planning of an organic intralamellar corneal foreign body removal: a case report JF - SPEKTRUM DER AUGENHEILKUNDE J2 - SPEKTRUM AUGENHEILKD PY - 2023 PG - 4 SN - 0930-4282 DO - 10.1007/s00717-023-00551-2 UR - https://m2.mtmt.hu/api/publication/34237412 ID - 34237412 AB - BackgroundCorneal foreign bodies have been reported to be the second most common type of ocular injury. We report a case of an organic intralamellar foreign body in which noninvasive anterior segment optical coherence tomography (AS-OCT) was used to assist the diagnosis, plan the surgery, and monitor the progress of treatment.Case presentationA 37-year-old male patient presented with an intracorneal reed foreign body in his right eye. It was challenging to assess whether the foreign body perforated the cornea. Slit-lamp examination and AS-OCT were performed. The latter showed that the foreign body had not completely perforated the cornea. Removal of the foreign body via the entry wound was not possible due to the structure of the reed. Extraction was performed via an incision along the foreign body. During the postoperative period, the patient's visual acuity was 20/20 on the right eye with minimal astigmatism, despite a scar tissue formation.ConclusionsIn our case, AS-OCT facilitated the localization of the corneal foreign body and was useful in planning the surgery. HintergrundEs ist bekannt, dass Verletzungen mit Hornhautfremdkorper die zweithaufigste Art von Augenverletzungen sind. Es wird uber den Fall eines organischen intralamellaren Fremdkorpers berichtet, bei dem eine nichtinvasive optische Koharenztomographie des vorderen Augenabschnitts (AS-OCT) zur Feststellung der Diagnose, Planung der Operation und uberwachung des Behandlungsfortschritts durchgefuhrt wurde.FalldarstellungEin 37-jahriger Patient mit einem intrakornealen Schilfrohr-Fremdkorper im rechten Auge wurde untersucht. Es war schwierig zu beurteilen, ob der Fremdkorper die Hornhaut perforierte oder nicht. Spaltlampenuntersuchung und AS-OCT wurden durchgefuhrt. Letztere zeigte, dass der Fremdkorper die Hornhaut nicht vollstandig perforiert hatte. Die Entfernung des Fremdkorpers uber die Eintrittswunde war aber aufgrund der Schilfstruktur nicht moglich. Die Extraktion erfolgte uber einen Schnitt entlang des Fremdkorpers. Wahrend der postoperativen Phase betrug die Sehscharfe des Patienten trotz Narbenbildung 20/20 auf dem rechten Auge bei minimalem Astigmatismus.SchlussfolgerungIm vorliegenden Fall erleichterte die AS-OCT die Lokalisierung des Hornhautfremdkorpers und war hilfreich bei der Planung der Operation. LA - English DB - MTMT ER - TY - JOUR AU - Czakó, Cecilia Nóra AU - Gerencsér, D. AU - Kormányos, Kitti AU - Kovács, Klaudia AU - Németh, Orsolya AU - Tóth, Gábor AU - Sándor, Gábor László AU - Csorba, Anita AU - Langenbucher, Achim AU - Nagy, Zoltán Zsolt AU - Varga, Gergely AU - Gopcsa, László AU - Mikala, Gábor AU - Kovács, Illés AU - Szentmáry, Nóra TI - Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 12 PY - 2023 IS - 16 PG - 8 SN - 2077-0383 DO - 10.3390/jcm12165227 UR - https://m2.mtmt.hu/api/publication/34125474 ID - 34125474 N1 - Department of Ophthalmology, Semmelweis University, Budapest, 1085, Hungary Department of Ophthalmology, Markusovszky University Teaching Hospital, Szombathely, 9700, Hungary Experimental Ophthalmology, Saarland University, Homburg, 66424, Germany 3rd Department of Internal Medicine and Haematology, Semmelweis University, Budapest, 1085, Hungary Department of Haematology and Stem Cell-Transplantation, South-Pest Central Hospital-National Institute for Hematology and Infectious Diseases, Budapest, 1097, Hungary Department of Ophthalmology, Weill Cornell Medical College, New York, NY 10065, United States Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, Homburg, 66424, Germany Export Date: 1 October 2023 Correspondence Address: Czakó, C.; Department of Ophthalmology, Hungary; email: cecilia.czako@gmail.com AB - Background: Monoclonal gammopathy (MG) is characterized by monoclonal protein overproduction, potentially leading to the development of hyperviscosity syndrome. Objective: To assess retinal circulation using optical coherence tomography angiography (OCTA) parameters in patients with monoclonal gammopathy. Methods: OCTA measurements were performed using the Optovue AngioVue system by examining 44 eyes of 27 patients with MG and 62 eyes of 36 control subjects. Superficial and deep retinal capillary vessel density (VD SVP and DVP) in the whole 3 × 3 mm macular and parafoveal area, foveal avascular zone (FAZ) area, and central retinal thickness (CRT) were measured using the AngioAnalytics software. The OCTA parameters were evaluated in both groups using a multivariate regression model, after controlling for the effect of imaging quality (SQ). Results: There was no significant difference in age between the subjects with monoclonal gammopathy and the controls (63.59 ± 9.33 vs. 58.01 ± 11.46 years; p > 0.05). Taking into account the effect of image quality, the VD SVP was significantly lower in the MG group compared to the control group (44.54 ± 3.22% vs. 46.62 ± 2.84%; p < 0.05). No significant differences were found between the two groups regarding the other OCTA parameters (p > 0.05). Conclusions: A decreased superficial retinal capillary vessel density measured using OCTA in patients with MG suggests a slow blood flow, reduced capillary circulation, and consequent tissue hypoperfusion. An evaluation of retinal circulation using OCTA in cases of monoclonal gammopathy may be a sensitive method for the non-invasive detection and follow-up of early microcirculatory dysfunction caused by increased viscosity. © 2023 by the authors. LA - English DB - MTMT ER - TY - JOUR AU - Németh, János Tibor AU - Daiki, Tennó AU - Sándor, Gábor László AU - Keve, Hajnalka AU - Szabó, Dorottya AU - Tóth, Gábor AU - Dankovics, Gergely AU - Barna, István AU - Limburg, Hans AU - Nagy, Zoltán Zsolt TI - Uncorrected refractive errors are important causes of avoidable visual impairment in Hungary. re-evaluation of two existing national data sets TS - re-evaluation of two existing national data sets JF - INTERNATIONAL JOURNAL OF OPHTHALMOLOGY (ENGLISH EDITION) J2 - INT J OPHTHALMOL (ENGLISH EDITION) VL - 16 PY - 2023 IS - 6 SP - 955 EP - 961 PG - 7 SN - 2222-3959 DO - 10.18240/ijo.2023.06.19 UR - https://m2.mtmt.hu/api/publication/34032432 ID - 34032432 N1 - Funding Agency and Grant Number: Lions Clubs International Foundation (LCIF) SightFirst Research Grant Program [SF 1825/UND] Funding text: The RAAB survey was supported by the Lions Clubs International Foundation (LCIF) SightFirst Research Grant Program (No.SF 1825/UND) . AB - To review existing data for the prevalence of corrected, uncorrected, and inadequately corrected refractive errors and spectacle wear in Hungary.Data from two nationwide cross-sectional studies were analysed. The Rapid Assessment of Avoidable Blindness study collected population-based representative national data on the prevalence of visual impairment due to uncorrected refractive errors and spectacle coverage in 3523 people aged ≥50y (Group I). The Comprehensive Health Test Program of Hungary provided data on the use of spectacles in 80 290 people aged ≥18y (Group II).In Group I, almost half of the survey population showed refractive errors for distant vision, about 10% of which were uncorrected (3.2% of all male participants and 5.0% of females). The distance spectacle coverage was 90.7% (91.9% in males; 90.2% in females). The proportion of inadequate distance spectacles was found to be 33.1%. Uncorrected presbyopia was found in 15.7% of participants. In all age groups (Group II), 65.4% of females and 56.0% of males used distance spectacles, and approximately 28.9% of these spectacles were found to be inappropriate for dioptric power (with 0.5 dioptres or more). The prevalence of inaccurate distance spectacles was significantly higher in older age groups (71y and above) in both sexes.According to this population-based data, uncorrected refractive errors are not rare in Hungary. Despite recent national initiatives, further steps are required to reduce uncorrected refractive errors and associated negative effects on vision, such as avoidable visual impairment. LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Gábor AU - Lukács, Andrea AU - Schirra, F. AU - Sándor, Gábor László AU - Killik, Petra AU - Maneschg, Otto AU - Nagy, Zoltán Zsolt AU - Szentmáry, Nóra TI - Ophthalmic Aspects of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Narrative Review JF - OPHTHALMOLOGY AND THERAPY J2 - OPHTHALMOL THERAP VL - 12 PY - 2023 IS - 4 SP - 1795 EP - 1811 PG - 17 SN - 2193-8245 DO - 10.1007/s40123-023-00725-w UR - https://m2.mtmt.hu/api/publication/33845677 ID - 33845677 N1 - Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University, Kirrberger Str. 100, Homburg/Saar, 66424, Germany Department of Ophthalmology, Semmelweis University, Mária Utca 39, Budapest, 1085, Hungary Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária Utca 41, Budapest, 1085, Hungary Argos Augenzentrum, Faktoreistraße 4, Saarbrücken, 66111, Germany Export Date: 14 July 2023 Correspondence Address: Tóth, G.; Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Kirrberger Str. 100, Germany; email: gabortothgabor@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Lukacs, R. AU - Schneider, Miklós AU - Nagy, Zoltán Zsolt AU - Sándor, Gábor László AU - Kaan, K. AU - Asztalos, A. AU - Enyedi, L. AU - Pek, G. AU - Barcsay, György AU - Szabó, Antal AU - Borbándy, Ágnes AU - Kovács, Illés AU - Resch, Miklós AU - Papp, András TI - Seven-year outcomes following intensive anti-vascular endothelial growth factor therapy in patients with exudative age-related macular degeneration JF - BMC OPHTHALMOLOGY J2 - BMC OPHTHALMOL VL - 23 PY - 2023 IS - 1 PG - 9 SN - 1471-2415 DO - 10.1186/s12886-023-02843-2 UR - https://m2.mtmt.hu/api/publication/33718042 ID - 33718042 LA - English DB - MTMT ER - TY - JOUR AU - Németh, János Tibor AU - Nyitrai, Beatrix AU - Karacs, Kristóf AU - Szabó, Dorottya AU - Ecsedy, Mónika AU - Szalai, Irén AU - Tóth, Gábor AU - Sándor, Gábor László AU - Magyar, Márton AU - Benyó, Fruzsina AU - Papp, András TI - OCT-leletek telemedicinális értékelésének pontossága cukorbetegekben JF - SZEMÉSZET J2 - SZEMÉSZET VL - 159 PY - 2022 IS - 2 SP - 64 EP - 68 PG - 5 SN - 0039-8101 DO - 10.55342/szemhungarica.2022.159.2.64 UR - https://m2.mtmt.hu/api/publication/33039528 ID - 33039528 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Magyar, Márton AU - Sándor, Gábor László AU - Ujváry, László AU - Nagy, Zoltán Zsolt AU - Tóth, Gábor TI - Szürkehályog-műtétek során fellépő intraoperatív szövődmények rezidenseknél és szakorvosoknál JF - SZEMÉSZET J2 - SZEMÉSZET VL - 159 PY - 2022 IS - 2 SP - 86 EP - 90 PG - 5 SN - 0039-8101 DO - 10.55342/SZEMHUNGARICA.2022.159.2.86 UR - https://m2.mtmt.hu/api/publication/32990563 ID - 32990563 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Magyar, Márton AU - Sándor, Gábor László AU - Ujváry, László AU - Nagy, Zoltán Zsolt AU - Tóth, Gábor TI - Intraoperative complication rates in cataract surgery performed by resident trainees and staff surgeons in a tertiary eyecare center in Hungary JF - INTERNATIONAL JOURNAL OF OPHTHALMOLOGY (ENGLISH EDITION) J2 - INT J OPHTHALMOL (ENGLISH EDITION) VL - 15 PY - 2022 IS - 4 SP - 586 EP - 590 PG - 5 SN - 2222-3959 DO - 10.18240/ijo.2022.04.10 UR - https://m2.mtmt.hu/api/publication/32818876 ID - 32818876 N1 - Export Date: 23 July 2022 Correspondence Address: Toth, G.; Department of Ophthalmology, Maria u. 39., Hungary; email: gabortothgabor@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Gábor AU - Sándor, Gábor László AU - Geiszelhardt, Balázs AU - Mohammadpour, Behnam AU - Resch, Miklós AU - Nagy, Zoltán Zsolt AU - Papp, András TI - Direkt orális antikoaguláns profilaxis mellett kialakult kétoldali retinalis vénás ágelzáródás COVID-19-fertőzést követően JF - SZEMÉSZET J2 - SZEMÉSZET VL - 159 PY - 2022 IS - 1 SP - 40 EP - 43 PG - 4 SN - 0039-8101 DO - 10.55342/szemhungarica.2022.159.1.40 UR - https://m2.mtmt.hu/api/publication/32786297 ID - 32786297 LA - Hungarian DB - MTMT ER -