@article{MTMT:34728998, title = {Bőrön elhelyezkedő, metasztatizáló fej-nyaki laphámkarcinómák onkológiai szemléletű kezelésének jelentősége}, url = {https://m2.mtmt.hu/api/publication/34728998}, author = {Égi, Fruzsina and Greksa, Dávid and Halmos, Réka and Cifra, János and Kravják, András and Kálmán, Endre and Molnár, Krisztián and Móricz, Péter}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {70}, unique-id = {34728998}, issn = {0016-237X}, year = {2024}, pages = {26-30}, orcid-numbers = {Móricz, Péter/0000-0001-8815-0625} } @article{MTMT:33255083, title = {Tág aquaeductus vestibuli okozta harmadikablak-szindróma komplex sebészeti ellátása}, url = {https://m2.mtmt.hu/api/publication/33255083}, author = {Szabó, Éva and Molnár, Krisztián and Kovács, Márton and Németh, Adrienn and Beke, Zsolt and Gerlinger, Imre and Szanyi, István and Bakó, Péter}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {68}, unique-id = {33255083}, issn = {0016-237X}, year = {2022}, pages = {153-155} } @article{MTMT:33130331, title = {A szervezett lakossági mammográfiás emlőszűrés részvételi mutatói 2012–2021 között Magyarországon}, url = {https://m2.mtmt.hu/api/publication/33130331}, author = {Laczó, Andrea and Bódis, József and Bogner, Péter and Molnár, Krisztián and Vajda, Réka and Pónusz-Kovács, Dalma and Elmer, Diána and Kajos, Luca Fanni and Csákvári, Tímea and Kívés, Zsuzsanna and Boncz, Imre}, journal-iso = {MAGYAR ONKOLÓGIA}, journal = {MAGYAR ONKOLÓGIA}, volume = {66}, unique-id = {33130331}, issn = {0025-0244}, abstract = {The aim of our study is to analyze the participation indicators of screening rounds Nr. 6-10 (2012-2021) of the organized nationwide mammography screening program. Data derived from the nationwide financing database of the Hungarian National Health Insurance Fund Management and covered the period 2012-2021. We analyzed both diagnostic and screening mammography examinations. Between 2012 and 2019 the coverage (screening and diagnostic mammography) varied between 48.1-51.5, which decreased to 31.8% in 2020-2021. Within total coverage, the organized screening rate declined from 30.3-31.2 to 20.0, while the diagnostic mammography rate decreased from 17.7-20.7% to 11.8%. We can conclude that the number of both the diagnostic and screening mammography declined. In order to reduce the mortality of breast cancer, participation rate of mammography screening program should be increased.}, year = {2022}, eissn = {2060-0399}, pages = {195-200}, orcid-numbers = {Kajos, Luca Fanni/0000-0002-0574-5787; Csákvári, Tímea/0000-0002-3339-4953; Kívés, Zsuzsanna/0000-0002-3698-8466; Boncz, Imre/0000-0003-3699-6236} } @article{MTMT:33026634, title = {Hemizygous nonsense variant in the moesin gene (MSN) leads to a new autoimmune phenotype of Immunodeficiency 50}, url = {https://m2.mtmt.hu/api/publication/33026634}, author = {Kovács, László András and Kárteszi, Judit and Prohászka, Zoltán and Kalmár, Tibor and Késmárky, Gábor and Koltai, Katalin and Nagy, Zsuzsanna and Sebők, Judit and Vas, Tibor and Molnár, Krisztián and Berki, Tímea and Böröcz, Katalin and Gyömörei, Csaba and Szalma, József and Egyed, Miklós and Horváth, Szabina and Oláh, Péter and Csuka, Dorottya and Németh, Viktória and Gyulai, Rolland Péter}, doi = {10.3389/fimmu.2022.919411}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {13}, unique-id = {33026634}, issn = {1664-3224}, abstract = {Here we describe the investigation of two male siblings with juvenile total loss of teeth, early onset chronic leg ulcers and autoimmune thyroiditis in both patients, as well as focal segmental glomerulosclerosis with associated pulmonal emphysema in one and diabetes mellitus in the other patient. The clinical picture and lupus anticoagulant, cryoglobulin and cold agglutinin positivity suggested the diagnosis of antiphospholipid syndrome. Flow cytometry analysis showed immunophenotypes consistent with immune dysregulation: low number of naive T cells, elevated CD4+ T cell counts and decreased CD8+ T cell counts were detected, and more than half of the T helper population was activated. Because of the siblings’ almost identical clinical phenotype genetic alteration was suspected in the background of the immunodeficiency. Whole exome sequencing identified a previously not described hemizygous nonsense variant (c.650G>A, p.W217X) within exon 6 of the moesin gene (MSN) localized on chromosome X, resulting in significantly decreased MSN mRNA expression compared to healthy controls. We present a putative new autoimmune phenotype of Immunodeficiency 50 (MIM300988) characterized by antiphospholipid syndrome, Hashimoto’s thyroiditis, leg ulcer and juvenile loss of teeth, associated with W217X mutation of the MSN gene.}, year = {2022}, eissn = {1664-3224}, orcid-numbers = {Prohászka, Zoltán/0000-0003-1761-7982; Kalmár, Tibor/0000-0002-0419-2009; Berki, Tímea/0000-0002-0134-8127; Szalma, József/0000-0002-6006-8758; Csuka, Dorottya/0000-0003-3610-9852; Gyulai, Rolland Péter/0000-0002-3286-8846} } @article{MTMT:31383610, title = {Parotistumorok extrakapszuláris disszekciója: egy új szemlélet bevezetésével nyert tapasztalataink}, url = {https://m2.mtmt.hu/api/publication/31383610}, author = {Greksa, Dávid and Járai, Tamás and Magyarosi, István and Cifra, János and Kravják, András and Kálmán, Endre and Molnár, Krisztián and Tóth, Arnold and Móricz, Péter}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {66}, unique-id = {31383610}, issn = {0016-237X}, year = {2020}, pages = {36-40}, orcid-numbers = {Móricz, Péter/0000-0001-8815-0625} } @article{MTMT:31341936, title = {False-Positive Malignant Diagnosis of Nodule Mimicking Lesions by Computer-Aided Thyroid Nodule Analysis in Clinical Ultrasonography Practice}, url = {https://m2.mtmt.hu/api/publication/31341936}, author = {Molnár, Krisztián and Kálmán, Endre and Hári, Zsófia and Giyab, Omar and Gáspár, Tamás and Rucz, Károly and Bogner, Péter and Tóth, Arnold}, doi = {10.3390/diagnostics10060378}, journal-iso = {DIAGNOSTICS}, journal = {DIAGNOSTICS}, volume = {10}, unique-id = {31341936}, issn = {2075-4418}, abstract = {This study aims to test computer-aided diagnosis (CAD) for thyroid nodules in clinical ultrasonography (US) practice with a focus towards identifying thyroid entities associated with CAD system misdiagnoses. Two-hundred patients referred to thyroid US were prospectively enrolled. An experienced radiologist evaluated the thyroid nodules and saved axial images for further offline blinded analysis using a commercially available CAD system. To represent clinical practice, not only true nodules, but mimicking lesions were also included. Fine needle aspiration biopsy (FNAB) was performed according to present guidelines. US features and thyroid entities significantly associated with CAD system misdiagnosis were identified along with the diagnostic accuracy of the radiologist and the CAD system. Diagnostic specificity regarding the radiologist was significantly (p < 0.05) higher than when compared with the CAD system (88.1% vs. 40.5%) while no significant difference was found in the sensitivity (88.6% vs. 80%). Focal inhomogeneities and true nodules in thyroiditis, nodules with coarse calcification and inspissated colloid cystic nodules were significantly (p < 0.05) associated with CAD system misdiagnosis as false-positives. The commercially available CAD system is promising when used to exclude thyroid malignancies, however, it currently may not be able to reduce unnecessary FNABs, mainly due to the false-positive diagnoses of nodule mimicking lesions.}, keywords = {Diagnostic Errors; Ultrasonography; thyroid cancer; thyroid nodule; computer-assisted diagnosis}, year = {2020}, eissn = {2075-4418} } @article{MTMT:31273676, title = {Author Correction: Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas: combined genomic and radiology based 3D model (Scientific Reports, (2020), 10, 1, (40), 10.1038/s41598-019-56429-4)}, url = {https://m2.mtmt.hu/api/publication/31273676}, author = {Orosz, Éva and Gombos, Katalin and Petrevszky, N. and Csonka, Dávid Ciprián and Háber, István Ervin and Kaszas, B. and Tóth, Arnold and Molnár, Krisztián and Kalacs, K. and Piski, Zalán and Gerlinger, Imre and Burián, András and Bellyei, Szabolcs and Szanyi, István}, doi = {10.1038/s41598-020-62491-0}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {10}, unique-id = {31273676}, issn = {2045-2322}, year = {2020}, eissn = {2045-2322}, orcid-numbers = {Csonka, Dávid Ciprián/0000-0002-6140-6878; Piski, Zalán/0000-0003-2592-9652} } @article{MTMT:31269089, title = {Subtotalis petrosectomia – javallatok, műtéti technika, pécsi tapasztalatok}, url = {https://m2.mtmt.hu/api/publication/31269089}, author = {Gerlinger, Imre and Molnár, Krisztián and Nepp, Nelli and Tóth, István and Tóth, Tamás Ferenc and Szanyi, István and Bakó, Péter and Pap, István}, doi = {10.1556/650.2020.31691}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {161}, unique-id = {31269089}, issn = {0030-6002}, abstract = {Introduction: Subtotal petrosectomy (STP) has been known for decades and it is considered being on the borderline between ear and skull-base surgery. Due to its excessive radicalism and adverse effects on hearing, it has been a forgotten surgical technique until recently. Over the last decade, due to its many benefits and the ability to combine it with modern hearing rehabilitation methods, STP has reappeared, providing a definitive solution to a number of problematic middl-ear disorders. Aim: In our retrospective clinical study, we wanted to highlight the effectiveness of STP, analyzing the efficiency of this surgery for the first time in domestic patient records, and to report our own experiences to date. Method: We processed data from 45 surgeries on our 44 patients. In addition to presenting the various surgical indications, we review the steps of the operation, analyze the audiological results, including the various methods of hearing rehabilitation, and also analyze the complications that have occurred. Our results are also summarized in the light of international professional literature. Results: Of our 44 patients, 23 were female and 21 were male. Patients had a mean age of 44.6 ± 20.5 years and a mean follow-up of 23 ± 16 months. Of our patients, 25 (57%) had undergone at least two previous unsuccessful ear operations, and 6 (14%) had deafness before surgery. The most common indication was chronic otitis media with cholesteatoma. 13 patients underwent 14 cochlear implantations (23%), in addition 6 patients received bone anchored hearing aids (BAHA) (14%), and 2 patients (5%) underwent VSB (Vibrant Soundbridge) placement against the round window membrane. Complications occurred in 11 of our patients, the most common of which was cerebrospinal fluid leak (5 cases, 11%) and wound dehiscence (3 cases, 7%). Data from 3 patients were available for processing the audiological results. Conclusion: STP is an extremely favorable surgical solution for a number of middle-ear pathologies that have previously caused major problems. The main reason for its growing popularity is that it can be combined with a number of modern, effective methods of hearing rehabilitation. Orv Hetil. 2020; 161(14): 544-553.}, keywords = {cholesteatoma; Subtotal petrosectomy; hallásrehabilitáció; hearing rehabilitation; closure of external ear canal; hallójárat lezárása; műtéti üreg obliterációja; subtotalis petrosectomia; surgical cavity obliteration}, year = {2020}, eissn = {1788-6120}, pages = {544-553} } @article{MTMT:30932623, title = {Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas: combined genomic and radiology based 3D model}, url = {https://m2.mtmt.hu/api/publication/30932623}, author = {Orosz, Éva and Gombos, Katalin and Petrevszky, Nerina and Csonka, Dávid Ciprián and Háber, István Ervin and Kaszas, Balint and Tóth, Arnold and Molnár, Krisztián and Kalacs, Krisztina and Piski, Zalán and Gerlinger, Imre and Burián, András and Bellyei, Szabolcs and Szanyi, István}, doi = {10.1038/s41598-019-56429-4}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {10}, unique-id = {30932623}, issn = {2045-2322}, year = {2020}, eissn = {2045-2322}, orcid-numbers = {Csonka, Dávid Ciprián/0000-0002-6140-6878; Piski, Zalán/0000-0003-2592-9652} } @article{MTMT:30936919, title = {Cochleáris implantációval szerzett tapasztalataink MELAS-szindrómás betegeinknél - Esteismertetés}, url = {https://m2.mtmt.hu/api/publication/30936919}, author = {Németh, Adrienn and Bocskai, Tímea and Tóth, Tamás Ferenc and Molnár, Krisztián and Gerlinger, Imre}, journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT}, volume = {65}, unique-id = {30936919}, issn = {0016-237X}, year = {2019}, pages = {135-137} }