@article{MTMT:32823615,
	title = {Early prediction of acute necrotizing pancreatitis by artificial intelligence : a prospective cohort-analysis of 2387 cases},
	url = {https://m2.mtmt.hu/api/publication/32823615},
	author = {Kiss, Szabolcs and Pintér, József and Molontay, Roland and Nagy, Marcell and Borbásné Farkas, Kornélia and Sipos, Zoltán and Fehérvári, Péter and Pecze, László and Földi, Mária and Vincze, Áron and Takács, Tamás and Czakó, László and Szabó-Halász, Adrienn and Boros, Eszter and Hamvas, József and Varga, Márta and Mickevicius, Artautas and Faluhelyi, Nándor and Farkas, Orsolya and Váncsa, Szilárd and Nagy, Rita and Bunduc, Stefania and Hegyi, Péter Jenő and Márta, Katalin and Borka, Katalin and Doros, Attila and Hosszúfalusi, Nóra and Zubek, László and Erőss, Bálint Mihály and Molnár, Zsolt and Párniczky, Andrea and Hegyi, Péter and Szentesi, Andrea Ildikó and Izbéki, Ferenc},
	doi = {10.1038/s41598-022-11517-w},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {12},
	unique-id = {32823615},
	issn = {2045-2322},
	abstract = {Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or lack sufficient predictive value. We therefore aimed to develop a tool to aid in necrosis prediction. The XGBoost machine learning algorithm processed data from 2387 patients with AP. The confidence of the model was estimated by a bootstrapping method and interpreted via the 10th and the 90th percentiles of the prediction scores. Shapley Additive exPlanations (SHAP) values were calculated to quantify the contribution of each variable provided. Finally, the model was implemented as an online application using the Streamlit Python-based framework. The XGBoost classifier provided an AUC value of 0.757. Glucose, C-reactive protein, alkaline phosphatase, gender and total white blood cell count have the most impact on prediction based on the SHAP values. The relationship between the size of the training dataset and model performance shows that prediction performance can be improved. This study combines necrosis prediction and artificial intelligence. The predictive potential of this model is comparable to the current clinical scoring systems and has several advantages over them.},
	year = {2022},
	eissn = {2045-2322},
	orcid-numbers = {Molontay, Roland/0000-0002-0666-5279; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Sipos, Zoltán/0000-0001-7845-8116; Vincze, Áron/0000-0003-2217-7686; Czakó, László/0000-0002-6331-0802; Váncsa, Szilárd/0000-0002-9347-8163; Nagy, Rita/0000-0002-2663-4912; Márta, Katalin/0000-0002-2213-4865; Borka, Katalin/0000-0002-8956-0770; Doros, Attila/0000-0002-6496-9895; Hosszúfalusi, Nóra/0000-0002-9469-372X; Zubek, László/0000-0003-0583-3290; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Németh, Balázs/0000-0001-5338-7577; Papp, Mária/0000-0003-3662-4010; Szakács, Zsolt/0000-0002-7035-941X; Izbéki, Ferenc/0000-0001-7767-4319}
}

@article{MTMT:32546426,
	title = {Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality},
	url = {https://m2.mtmt.hu/api/publication/32546426},
	author = {Ocskay, Klementina and Vinkó, Zsófia and Németh, Dávid and Szabó, László and Bajor, Judit and Gódi, Szilárd and Sarlós, Patrícia and Czakó, László and Izbéki, Ferenc and Hamvas, József and Papp, Mária and Varga, Márta and Török, Imola and Mickevicius, Artautas and Sallinen, Ville and Maldonado, Elena Ramirez and Galeev, Shamil and Mikó, Alexandra and Erőss, Bálint Mihály and Imrei, Marcell and Hegyi, Péter Jenő and Faluhelyi, Nándor and Farkas, Orsolya and Kanizsai, Péter László and Miseta, Attila János and Nagy, Tamás and Hágendorn, Roland and Márton, Zsolt and Szakács, Zsolt and Szentesi, Andrea Ildikó and Hegyi, Péter and Párniczky, Andrea},
	doi = {10.1038/s41598-021-03449-8},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {11},
	unique-id = {32546426},
	issn = {2045-2322},
	abstract = {The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the first 48 h (n = 1149) and anytime during hospitalization (n = 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (< 35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (< 25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276-98.908) and mortality (OR 16.83; CI 8.32-35.13). Albumin loss during AP was strongly associated with severity (p < 0.001) and mortality (p = 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay.},
	year = {2021},
	eissn = {2045-2322},
	orcid-numbers = {Ocskay, Klementina/0000-0001-5848-2506; Sarlós, Patrícia/0000-0002-5086-9455; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Imrei, Marcell/0000-0003-0175-7462; Kanizsai, Péter László/0000-0001-7896-2857; Miseta, Attila János/0000-0002-7984-3347; Nagy, Tamás/0000-0001-5437-1411; Szakács, Zsolt/0000-0002-7035-941X; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:32091062,
	title = {Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases},
	url = {https://m2.mtmt.hu/api/publication/32091062},
	author = {Nagy, Anikó and Juhász, Márk Félix and Görbe, Anikó and Váradi, Alex and Izbéki, Ferenc and Vincze, Áron and Sarlós, Patrícia and Czimmer, József and Szepes, Zoltán and Takács, Tamás and Papp, Mária and Fehér, Eszter and Hamvas, József and Kárász, Klaudia and Török, Imola and Stimac, Davor and Poropat, Goran and Ince, Ali Tüzün and Erőss, Bálint Mihály and Márta, Katalin and Pécsi, Dániel and Illés, Dóra and Váncsa, Szilárd and Földi, Mária and Faluhelyi, Nándor and Farkas, Orsolya and Nagy, Tamás and Kanizsai, Péter László and Márton, Zsolt and Szentesi, Andrea Ildikó and Hegyi, Péter and Párniczky, Andrea},
	doi = {10.1016/j.pan.2021.06.003},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {21},
	unique-id = {32091062},
	issn = {1424-3903},
	year = {2021},
	eissn = {1424-3911},
	pages = {1237-1246},
	orcid-numbers = {Váradi, Alex/0000-0001-8229-6340; Izbéki, Ferenc/0000-0001-7767-4319; Vincze, Áron/0000-0003-2217-7686; Sarlós, Patrícia/0000-0002-5086-9455; Czimmer, József/0000-0001-7831-3523; Szepes, Zoltán/0000-0002-9466-8719; Papp, Mária/0000-0003-3662-4010; Ince, Ali Tüzün/0000-0002-1627-4829; Erőss, Bálint Mihály/0000-0003-3658-8427; Márta, Katalin/0000-0002-2213-4865; Pécsi, Dániel/0000-0003-0499-6004; Váncsa, Szilárd/0000-0002-9347-8163; Nagy, Tamás/0000-0001-5437-1411; Kanizsai, Péter László/0000-0001-7896-2857; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:32053186,
	title = {Early occurrence of pseudocysts in acute pancreatitis - A multicenter international cohort analysis of 2275 cases},
	url = {https://m2.mtmt.hu/api/publication/32053186},
	author = {Szakó, Lajos and Gede, Noémi and Váradi, Alex and Tinusz, Benedek and Vörhendi, Nóra and Mosztbacher, Dóra and Vincze, Áron and Takács, Tamás and Czakó, László and Izbéki, Ferenc and Gajdán, László and Dunás-Varga, Veronika and Hamvas, József and Papp, Mária and Fehér, Krisztina Eszter and Varga, Márta and Mickevicius, Artautas and Török, Imola and Ocskay, Klementina and Juhász, Márk Félix and Váncsa, Szilárd and Faluhelyi, Nándor and Farkas, Orsolya and Miseta, Attila János and Vereczkei, András and Mikó, Alexandra and Hegyi, Péter Jenő and Szentesi, Andrea Ildikó and Párniczky, Andrea and Erőss, Bálint Mihály and Hegyi, Péter},
	doi = {10.1016/j.pan.2021.05.007},
	journal-iso = {PANCREATOLOGY},
	journal = {PANCREATOLOGY},
	volume = {21},
	unique-id = {32053186},
	issn = {1424-3903},
	abstract = {Pseudocysts being the most frequent local complications of acute pancreatitis (AP) have substantial effect on the disease course, hospitalization and quality of life of the patient. Our study aimed to understand the effects of pre-existing (OLD-P) and newly developed (NEW-P) pseudocysts on AP.Data were extracted from the Acute Pancreatitis Registry organized by the Hungarian Pancreatic Study Group (HPSG). 2275 of 2461 patients had uploaded information concerning pancreatic morphology assessed by imaging technique. Patients were divided into "no pseudocyst" (NO-P) group, "old pseudocyst" (OLD-P) group, or "newly developed pseudocyst" (NEW-P) groups.The median time of new pseudocyst development was nine days from hospital admission and eleven days from the beginning of the abdominal pain. More NEW-P cases were severe (15.9% vs 4.7% in the NO-P group p < 0.001), with longer length of hospitalization (LoH) (median: 14 days versus 8 days, p < 0.001), and were associated with several changed laboratory parameters. OLD-P was associated with male gender (72.2% vs. 56.1%, p = 0.0014), alcoholic etiology (35.2% vs. 19.8% in the NO-P group), longer hospitalization (median: 10 days, p < 0.001), a previous episode of AP (p < 0.001), pre-existing diagnosis of chronic pancreatitis (CP) (p < 0.001), current smoking (p < 0.001), and increased alcohol consumption (unit/week) (p = 0.014).Most of the new pseudocysts develop within two weeks. Newly developing pseudocysts are associated with a more severe disease course and increased length of hospitalization. Pre-existing pseudocysts are associated with higher alcohol consumption and smoking. Because CP is more frequently associated with a pre-existing pseudocyst, these patients need closer attention after AP.},
	keywords = {PANCREAS; Pancreatic Pseudocyst; Acute pancreatitis; Pancreatic Fluid Collection; Pancreatic local complication},
	year = {2021},
	eissn = {1424-3911},
	pages = {1161-1172},
	orcid-numbers = {Váradi, Alex/0000-0001-8229-6340; Mosztbacher, Dóra/0000-0002-2446-9247; Vincze, Áron/0000-0003-2217-7686; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Papp, Mária/0000-0003-3662-4010; Ocskay, Klementina/0000-0001-5848-2506; Váncsa, Szilárd/0000-0002-9347-8163; Miseta, Attila János/0000-0002-7984-3347; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:30789520,
	title = {Observational longitudinal multicentre investigation of acute pancreatitis (GOULASH PLUS) : follow-up of the GOULASH study, protocol},
	url = {https://m2.mtmt.hu/api/publication/30789520},
	author = {Mikó, Alexandra and Erőss, Bálint Mihály and Sarlós, Patrícia and Hegyi, Péter Jenő and Márta, Katalin and Pécsi, Dániel and Vincze, Áron and Bódis, Beáta and Nemes, Orsolya and Faluhelyi, Nándor and Farkas, Orsolya and Papp, Róbert and Kelemen, Dezső and Szentesi, Andrea Ildikó and Hegyi, Eszter and Papp, Mária and Czakó, László and Izbéki, Ferenc and Gajdán, László and Novák, János and Sahin-Tóth, Miklós and Lerch, Markus M and Neoptolemos, John and Petersen, Ole H and Hegyi, Péter},
	doi = {10.1136/bmjopen-2018-025500},
	journal-iso = {BMJ OPEN},
	journal = {BMJ OPEN},
	volume = {9},
	unique-id = {30789520},
	issn = {2044-6055},
	abstract = {Acute pancreatitis (AP) is an inflammatory condition that can lead to late consequences. Recurrent AP (RAP) develops in 20% of patients and chronic pancreatitis (CP) occurs in 7%-12.8%. However, we do not have sufficient information to establish an evidence-based statement to define early CP, or how to prevent its development.The aim of this study was to understand the influencing factors and to determine which parameters should be measured or used as a biomarker to detect the early phase of CP.This is an observational prospective follow-up study of the GOULASH-trial (ISRTCN 63827758) in which (1) all severity of pancreatitis are included; (2) patients receive only therapeutic modalities which are accepted by the evidence based medicine (EBM) guideline; (3) whole blood, serum and plasma samples are stored in our biobank; and (4) large amount of variables are collected and kept in our electronic database including anamnestic data, physical examination, laboratory parameters, imaging, therapy and complications. Therefore, this fully characterised patient cohort are well suitable for this longitudinal follow-up study. Patients' selection: patients enrolled in the GOULASH study will be offered to join to the longitudinal study. The follow-up will be at 1, 2, 3, 4, 5 and 6 years after the episode of AP. Anamnestic data will be collected by questionnaires: (1) diet history questionnaire, (2) 36-Item Short-Form Health Survey, (3) physical activity questionnaire and (4) stress questionnaire. Genetic tests will be performed for the genes associated with CP. The exocrine and endocrine pancreatic, liver and kidney functions will be determined by laboratory tests, stool sample analyses and imaging. Cost-effectiveness will be analysed to examine the relationship between events of interest and health-related quality of life or to explore subgroup differences.This study will provide information about the risk and influencing factors leading to CP and identify the most useful measurable parameters.ISRCTN63396106.},
	keywords = {FOLLOW-UP; risk factor; chronic pancreatitis; Acute pancreatitis; PANCREATIC DISEASE},
	year = {2019},
	eissn = {2044-6055},
	orcid-numbers = {Erőss, Bálint Mihály/0000-0003-3658-8427; Sarlós, Patrícia/0000-0002-5086-9455; Márta, Katalin/0000-0002-2213-4865; Pécsi, Dániel/0000-0003-0499-6004; Vincze, Áron/0000-0003-2217-7686; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Papp, Mária/0000-0003-3662-4010; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:2202895,
	title = {Multi-modal magnetic resonance imaging in the acute and sub-acute phase of mild traumatic brain injury: Can we see the difference?},
	url = {https://m2.mtmt.hu/api/publication/2202895},
	author = {Tóth, Arnold and Kovács, Noémi and Perlaki, Gábor and Orsi, Gergely and Aradi, Mihály and Komáromy, Hedvig and Ezer, Erzsébet and Bukovics, Péter and Farkas, Orsolya and Janszky, József Vladimír and Dóczi, Tamás Péter and Büki, András and Schwarcz, Attila},
	doi = {10.1089/neu.2012.2486},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {30},
	unique-id = {2202895},
	issn = {0897-7151},
	year = {2013},
	eissn = {1557-9042},
	pages = {2-10},
	orcid-numbers = {Janszky, József Vladimír/0000-0001-6100-832X}
}

@article{MTMT:1352887,
	title = {Update on protein biomarkers in traumatic brain injury with emphasis on clinical use in adults and pediatrics.},
	url = {https://m2.mtmt.hu/api/publication/1352887},
	author = {Kövesdi, Erzsébet and Lückl, János and Bukovics, Péter and Farkas, Orsolya and Pál, József and Czeiter, Endre and Szellar, D and Dóczi, Tamás Péter and Komoly, Sámuel and Büki, András},
	doi = {10.1007/s00701-009-0463-6},
	journal-iso = {ACTA NEUROCHIR},
	journal = {ACTA NEUROCHIRURGICA},
	volume = {152},
	unique-id = {1352887},
	issn = {0001-6268},
	abstract = {This review summarizes protein biomarkers in mild and severe traumatic brain injury in adults and children and presents a strategy for conducting rationally designed clinical studies on biomarkers in head trauma. We performed an electronic search of the National Library of Medicine's MEDLINE and Biomedical Library of University of Pennsylvania database in March 2008 using a search heading of traumatic head injury and protein biomarkers. The search was focused especially on protein degradation products (spectrin breakdown product, c-tau, amyloid-beta(1-42)) in the last 10 years, but recent data on "classical" markers (S-100B, neuron-specific enolase, etc.) were also examined. We identified 85 articles focusing on clinical use of biomarkers; 58 articles were prospective cohort studies with injury and/or outcome assessment. We conclude that only S-100B in severe traumatic brain injury has consistently demonstrated the ability to predict injury and outcome in adults. The number of studies with protein degradation products is insufficient especially in the pediatric care. Cohort studies with well-defined end points and further neuroproteomic search for biomarkers in mild injury should be triggered. After critically reviewing the study designs, we found that large homogenous patient populations, consistent injury, and outcome measures prospectively determined cutoff values, and a combined use of different predictors should be considered in future studies.},
	year = {2010},
	eissn = {0942-0940},
	pages = {1-17},
	orcid-numbers = {Lückl, János/0000-0001-8094-771X; Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:1352882,
	title = {Calpain inhibition reduces axolemmal leakage in traumatic axonal injury.},
	url = {https://m2.mtmt.hu/api/publication/1352882},
	author = {Czeiter, Endre and Bukovics, Péter and Farkas, Orsolya and Pál, József and Kövesdi, Erzsébet and Dóczi, Tamás Péter and Povlishock, JT and Büki, András and Sándor, János},
	doi = {10.3390/molecules14125115},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {14},
	unique-id = {1352882},
	issn = {1420-3049},
	year = {2009},
	eissn = {1420-3049},
	pages = {5115-5123},
	orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944}
}

@mastersthesis{MTMT:2239273,
	title = {A KOPONYATRAUMA ÁLTAL KIVÁLTOTT DIFFÚZ AXONÁLIS ÉS NEURONÁLIS KÁROSODÁS PATHOMECHANIZMUSÁNAK VIZSGÁLATA ÉS TERÁPIÁS BEFOLYÁSOLÁSÁNAK LEHETŐSÉGEI},
	url = {https://m2.mtmt.hu/api/publication/2239273},
	author = {Farkas, Orsolya},
	unique-id = {2239273},
	year = {2008}
}

@article{MTMT:1166819,
	title = {Posttraumatic administration of pituitary adenylate cyclase activating polypeptide in central fluid percussion injury in rats},
	url = {https://m2.mtmt.hu/api/publication/1166819},
	author = {Kövesdi, Erzsébet and Tamás, Andrea and Reglődi, Dóra and Farkas, Orsolya and Pál, József and Tóth, Gábor and Bukovics, Péter and Dóczi, Tamás Péter and Büki, András},
	doi = {10.1007/BF03033558},
	journal-iso = {NEUROTOX RES},
	journal = {NEUROTOXICITY RESEARCH},
	volume = {13},
	unique-id = {1166819},
	issn = {1029-8428},
	abstract = {Several in vitro and in vivo experiments have demonstrated the 
		neuroprotective effects of pituitary adenylate cyclase 
		activating polypeptide (PACAP) in focal cerebral ischemia, 
		Parkinson's disease and traumatic brain injury (TBI). The aim 
		of the present study was to analyze the effect of PACAP 
		administration on diffuse axonal injury (DAI), an important 
		contributor to morbidity and mortality associated with TBI, in a 
		central fluid percussion (CFP) model of TBI. Rats were 
		subjected to moderate (2 Atm) CFP injury. Thirty min after 
		injury, 100 microg PACAP was administered 
		intracerebroventricularly. DAI was assessed by 
		immunohistochemical detection of beta-amyloid precursor protein, 
		indicating impaired axoplasmic transport, and RMO-14 antibody, 
		representing foci of cytoskeletal alterations (neurofilament 
		compaction), both considered classical markers of axonal damage. 
		Analysis of damaged, immunoreactive axonal profiles revealed 
		significant axonal protection in the PACAP-treated versus 
		vehicle-treated animals in the corticospinal tract, as far as 
		traumatically induced disturbance of axoplasmic transport and 
		cytoskeletal alteration were considered. Similarly to our former 
		observations in an impact acceleration model of diffuse TBI, 
		the present study demonstrated that PACAP also inhibits DAI in 
		the CFP injury model. The finding indicates that PACAP and 
		derivates can be considered potential candidates for further 
		experimental studies, or purportedly for clinical trials in the 
		therapy of TBI.},
	keywords = {VASOACTIVE-INTESTINAL-PEPTIDE; HIPPOCAMPAL-NEURONS; SPINAL-CORD; PACAP; AMYLOID PRECURSOR PROTEIN; traumatic brain injury; APP; TRANSDUCTION PATHWAYS; HEAD-INJURY; INDUCED RETINAL LESION; INTRAAXONAL NEUROFILAMENT COMPACTION; INDUCED AXONAL INJURY; TRAUMATIC BRAIN-INJURY; RMO; axonoprotection},
	year = {2008},
	eissn = {1476-3524},
	pages = {71-78},
	orcid-numbers = {Tóth, Gábor/0000-0002-3604-4385}
}