TY  - JOUR
AU  - Oláh, Zoltán
AU  - Rédei, Dóra
AU  - Pecze, László
AU  - Vizler, Csaba
AU  - Jósvay, Katalin
AU  - Forgó, Péter
AU  - Winter, Zoltán
AU  - Dombi, György
AU  - Szakonyi, Gerda
AU  - Hohmann, Judit
TI  - Pellitorine, an extract of Tetradium daniellii, is an antagonist of the ion channel TRPV1
JF  - PHYTOMEDICINE: INTERNATIONAL JOURNAL OF PHYTOTHERAPY AND PHYTOPHARMACOLOGY
J2  - PHYTOMEDICINE
VL  - 34
PY  - 2017
SP  - 44
EP  - 49
PG  - 6
SN  - 0944-7113
DO  - 10.1016/j.phymed.2017.06.006
UR  - https://m2.mtmt.hu/api/publication/3260664
ID  - 3260664
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hetényi, Anasztázia
AU  - Németh, Lukács
AU  - Wéber, Edit
AU  - Szakonyi, Gerda
AU  - Winter, Zoltán
AU  - Jósvay, Katalin
AU  - Bartus, Éva
AU  - Oláh, Zoltán
AU  - Martinek, Tamás
TI  - Competitive inhibition of TRPV1 – calmodulin interaction by vanilloids
JF  - FEBS LETTERS
J2  - FEBS LETT
VL  - 590
PY  - 2016
IS  - 16
SP  - 2768
EP  - 2775
PG  - 8
SN  - 0014-5793
DO  - 10.1002/1873-3468.12267
UR  - https://m2.mtmt.hu/api/publication/3087152
ID  - 3087152
N1  - Funding Agency and Grant Number: Hungarian Academy of Sciences; Lendulet Program [LP-2011-009]; MTA Postdoctoral Fellowship E.W., Gedeon Richter Plc. [TP7-017]; Hungarian Research Foundation [OTKA K112442]; Richter Gedeon Talentum Alapitvany; European Union; State of Hungary; European Social Fund [TAMOP-4.2.4.A/ 2-11/1-2012-0001]\n Funding text: This work was supported by the Hungarian Academy of Sciences, Lendulet Program (LP-2011-009), MTA Postdoctoral Fellowship E.W., Gedeon Richter Plc. (TP7-017), the Hungarian Research Foundation (OTKA K112442) and Financial support from Richter Gedeon Talentum Alapitvany (Ph.D. Scholarship to E.B.). This research was supported by the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TAMOP-4.2.4.A/ 2-11/1-2012-0001 'National Excellence Program'.\n
Funding Agency and Grant Number: Hungarian Academy of Sciences; Lendulet Program [LP-2011-009]; MTA Postdoctoral Fellowship E.W., Gedeon Richter Plc. [TP7-017]; Hungarian Research Foundation [OTKA K112442]; Richter Gedeon Talentum Alapitvany; European Union; State of Hungary; European Social Fund [TAMOP-4.2.4.A/ 2-11/1-2012-0001]
            Funding text: This work was supported by the Hungarian Academy of Sciences, Lendulet Program (LP-2011-009), MTA Postdoctoral Fellowship E.W., Gedeon Richter Plc. (TP7-017), the Hungarian Research Foundation (OTKA K112442) and Financial support from Richter Gedeon Talentum Alapitvany (Ph.D. Scholarship to E.B.). This research was supported by the European Union and the State of Hungary, cofinanced by the European Social Fund in the framework of TAMOP-4.2.4.A/ 2-11/1-2012-0001 'National Excellence Program'.
AB  - There is enormous interest toward vanilloid agonists of the pain receptor TRPV1 in analgesic therapy, but the mechanisms of their sensory neuron-blocking effects at high or repeated doses are still a matter of debate. Our results have demonstrated that capsaicin and resiniferatoxin form nanomolar complexes with calmodulin, and competitively inhibit TRPV1-calmodulin interaction. These interactions involve the protein recognition interface of calmodulin, which is responsible for all of the cell-regulatory calmodulin-protein interactions. These results draw attention to a previously unknown vanilloid target, which may contribute to the explanation of the paradoxical pain-modulating behavior of these important pharmacons.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jósvay, Katalin
AU  - Winter, Zoltán
AU  - Katona, Róbert László
AU  - Pecze, László
AU  - Marton, Annamária
AU  - Buhala, Andrea
AU  - Szakonyi, Gerda
AU  - Oláh, Zoltán
AU  - Vizler, Csaba
TI  - Besides neuro-imaging, the Thy1-YFP mouse could serve for visualizing experimental tumours, inflammation and wound-healing
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 4
PY  - 2014
SP  - 6776
PG  - 7
SN  - 2045-2322
DO  - 10.1038/srep06776
UR  - https://m2.mtmt.hu/api/publication/2763894
ID  - 2763894
AB  - The B6.Cg-Tg(Thy1-YFP)16Jrs/J transgenic mouse strain, widely used to study neuronal development and regeneration, expresses the yellow fluorescent protein (YFP) in the peripheral nerves and the central nervous system under the control of regulatory sequences of the Thy1 gene. The Thy1 (CD90) cell surface glycoprotein is present on many cell types besides neurons, and is known to be involved in cell adhesion, migration and signal transduction. We hypothesized that Thy1-activating conditions could probably activate the truncated Thy1 regulatory sequences used in the Thy1-YFP construct, resulting in YFP transgene expression outside the nervous system. We demonstrated that the stroma of subcutaneous tumours induced by the injection of 4T1 or MC26 carcinoma cells into BALB/c(Thy1-YFP) mice, carrying the same construct, indeed expressed the YFP transgene. In the tumour mass, the yellow-green fluorescent stromal cells were clearly distinguishable from 4T1 carcinoma cells stably transfected with red fluorescent protein. Local inflammation induced by subcutaneous injection of complete Freund's adjuvant, as well as the experimental wound-healing milieu, also triggered YFP fluorescence in both the BALB/c(Thy1-YFP) and B6.Cg-Tg(Thy1-YFP)16Jrs/J mice, pointing to eventual overlapping pathways of wound-healing, inflammation and tumour growth.
LA  - English
DB  - MTMT
ER  - 

TY  - THES
AU  - Winter, Zoltán
TI  - Investigation of the transient receptor potential vanilloid 1 (TRPV1) ion channel
PB  - Szegedi Tudományegyetem (SZTE)
PY  - 2013
SP  - 58
DO  - 10.14232/phd.1885
UR  - https://m2.mtmt.hu/api/publication/2852024
ID  - 2852024
N1  - 3. Témavezető: Oláh Zoltán (biokémia)
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Winter, Zoltán
AU  - Buhala, Andrea
AU  - Ötvös, Ferenc
AU  - Jósvay, Katalin
AU  - Vizler, Csaba
AU  - Dombi, György
AU  - Szakonyi, Gerda
AU  - Oláh, Zoltán
TI  - Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel – an overview of the current mutational data
JF  - MOLECULAR PAIN
J2  - MOL PAIN
VL  - 9
PY  - 2013
IS  - 1
PG  - 29
SN  - 1744-8069
DO  - 10.1186/1744-8069-9-30
UR  - https://m2.mtmt.hu/api/publication/2341377
ID  - 2341377
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Pecze, László
AU  - Winter, Zoltán
AU  - Jósvay, Katalin
AU  - Ötvös, Ferenc
AU  - Kolozsi, Csongor
AU  - Vizler, Csaba
AU  - Budai, D
AU  - Letoha, Tamás
AU  - Dombi, György
AU  - Szakonyi, Gerda
AU  - Oláh, Zoltán
TI  - Divalent Heavy Metal Cations Block the TRPV1 Ca2+ Channel
JF  - BIOLOGICAL TRACE ELEMENT RESEARCH
J2  - BIOL TRACE ELEM RES
VL  - 151
PY  - 2013
IS  - 3
SP  - 451
EP  - 461
PG  - 11
SN  - 0163-4984
DO  - 10.1007/s12011-012-9570-y
UR  - https://m2.mtmt.hu/api/publication/2192154
ID  - 2192154
N1  - Received: 4 May 2012 / Accepted: 3 December 2012
AB  - Transient receptor potential vanilloid 1 (TRPV1) is a non-
selective cation channel involved in pain sensation and in a 
wide range of non-pain-related physiological and pathological 
conditions. The aim of the present study was to explore the 
effects of selected heavy metal cations on the function of 
TRPV1. The cations ranked in the following sequence of pore-
blocking activity: Co(2+) [half-maximal inhibitory concentration 
(IC(50)) = 13 muM] > Cd(2+) (IC(50) = 38 muM) > Ni(2+) (IC(50) = 
62 muM) > Cu(2+) (IC(50) = 200 muM). Zn(2+) proved to be a weak 
(IC(50) = 27 muM) and only partial inhibitor of the channel 
function, whereas Mg(2+), Mn(2+) and La(3+) did not exhibit any 
substantial effect. Co(2+), the most potent channel blocker, was 
able not only to compete with Ca(2+) but also to pass with it 
through the open channel of TRPV1. In response to heat 
activation or vanilloid treatment, Co(2+) accumulation was 
verified in TRPV1-transfected cell lines and in the TRPV1+ 
dorsal root ganglion neurons. The inhibitory effect was also 
demonstrated in vivo. Co(2+) applied together with vanilloid 
agonists attenuated the nocifensive eye wipe response in mice. 
Different rat TRPV1 pore point mutants (Y627W, N628W, D646N and 
E651W) were created that can validate the binding site of 
previously used channel blockers in agonist-evoked (45)Ca(2+) 
influx assays in cells expressing TRPV1. The IC(50) of Co(2+) 
on these point mutants were determined to be reasonably 
comparable to those on the wild type, which suggests that 
divalent cations passing through the TRPV1 channel use the same 
negatively charged amino acids as Ca(2+).
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Pecze, László
AU  - Pelsőczi, Péter
AU  - Kecskés, Miklós
AU  - Winter, Zoltán
AU  - Papp, András
AU  - Kaszas, K
AU  - Letoha, Tamás
AU  - Vizler, Csaba
AU  - Oláh, Zoltán
TI  - Resiniferatoxin mediated ablation of TRPV1+ neurons removes TRPA1 as well
JF  - CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES / JOURNAL CANADIEN DES SCIENCES NEUROLOGIQUES
J2  - CAN J NEUROL SCI
VL  - 36
PY  - 2009
IS  - 2
SP  - 234
EP  - 241
PG  - 8
SN  - 0317-1671
DO  - 10.1017/S0317167100006600
UR  - https://m2.mtmt.hu/api/publication/1918262
ID  - 1918262
LA  - English
DB  - MTMT
ER  -