@article{MTMT:1321061, title = {Galectin-1-Asialofetuin Interaction Is Inhibited by Peptides Containing the Tyr-Xxx-Tyr Motif Acting on the Glycoprotein}, url = {https://m2.mtmt.hu/api/publication/1321061}, author = {Wéber, Edit and Hetényi, Anasztázia and Váczi, Balázs and Szolnoki, Éva Tünde and Fajka-Boja, Roberta and Tubak, Vilmos and Monostori, Éva and Martinek, Tamás}, doi = {10.1002/cbic.200900502}, journal-iso = {CHEMBIOCHEM}, journal = {CHEMBIOCHEM}, volume = {11}, unique-id = {1321061}, issn = {1439-4227}, abstract = {Galectin-1 (Gal-1), a ubiquitous P-galactoside-binding protein expressed by various normal and pathological tissues, has been implicated in cancer and autoimmune/inflammatory diseases in consequence of its regulatory role in adhesion, cell viability, proliferation, and angiogenesis. The functions of Gal-1 depend on its affinity for P-galactoside-containing glycoconjugates; accordingly, the inhibition of sugar binding blocks its functions, hence promising potential therapeutic tools. The Tyr-Xxx-Tyr peptide motifs have been reported to be glycomimetic sequences, mainly on the basis of their inhibitory effect on the Gal-1-asialofetuin (ASF) interaction. However, the results regarding the efficacy of the Tyr-Xxx-Tyr motif as a glycomimetic inhibitor are still controversial. The present STD and trNOE NMR experiments reveal that the Tyr-Xxx-Tyr peptides studied do not bind to Gal-1, whereas their binding to ASF is clearly detected. N-15,H-1 HSQC titrations with N-15-labeled Gal-1 confirm the absence of any peptide-Gal-1 interaction. These data indicate that the Tyr-Xxx-Tyr peptides tested in this work are not glycomimetics as they interact with ASF via an unrevealed molecular linkage.}, keywords = {CROSS-LINKING; LIGAND-BINDING; NMR-SPECTROSCOPY; NMR spectroscopy; galectins; Biochemistry & Molecular Biology; glycomimetics; lectin mimetics; (GLYCO)PEPTIDE LIBRARIES; RECOMBINANT GALECTIN-1; CARBOHYDRATE-BINDING; MAMMALIAN GALECTINS; CYTOKINE SECRETION; CELL APOPTOSIS}, year = {2010}, eissn = {1439-7633}, pages = {228-234}, orcid-numbers = {Wéber, Edit/0000-0002-5904-0619; Hetényi, Anasztázia/0000-0001-8080-6992; Fajka-Boja, Roberta/0000-0001-5331-8280; Tubak, Vilmos/0000-0002-6141-3920; Monostori, Éva/0000-0002-7442-3562; Martinek, Tamás/0000-0003-3168-8066} } @article{MTMT:1915261, title = {Definition of Drosophila hemocyte subsets by cell-type specific antigens}, url = {https://m2.mtmt.hu/api/publication/1915261}, author = {Kurucz, Judit Éva and Váczi, Balázs and Márkus, Róbert and Laurinyecz, Barbara and Vilmos, Péter and Zsámboki, János and Csorba, Kinga and Gateff, E and Hultmark, D and Andó, István}, doi = {10.1556/ABiol.58.2007.Suppl.8}, journal-iso = {ACTA BIOL HUNG}, journal = {ACTA BIOLOGICA HUNGARICA (1983-2018)}, volume = {58}, unique-id = {1915261}, issn = {0236-5383}, abstract = {We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria. Oil the basis of the expression or the lack of expression of blood cell antigens the following hemocyte populations have been defined: crystal cells, plasmalocytes, lamellocytes and precursor cells. The expression of the antigens and thus the different cell types are developmentally regulated. The hemocytes are arranged ill four main compartments: the circulating blood cells, the sessile tissue, the lymph glands and the posterior hematopoietic tissue. Each hemocyte compartment has a specific and characteristic composition of the various cell types. The described markers represent the first successful attempt to define hemocyte lineages by immunological markers in Drosophila and help to define morphologically, functionally, spatially and developmentally distinct subsets of hemocyles.}, year = {2007}, eissn = {1588-256X}, pages = {95-111}, orcid-numbers = {Laurinyecz, Barbara/0000-0003-0620-2239; Andó, István/0000-0002-4648-9396} } @article{MTMT:1913689, title = {Ősi örökségünk a veleszületett immunitás : a Drosophila immunrendszere}, url = {https://m2.mtmt.hu/api/publication/1913689}, author = {Andó, István and Laurinyecz, Barbara and Márkus, Róbert and Rus, Florentina and Váczi, Balázs and Zsámboki, János and Kurucz, Judit Éva}, journal-iso = {MAGYAR TUDOMÁNY}, journal = {MAGYAR TUDOMÁNY}, volume = {111}, unique-id = {1913689}, issn = {0025-0325}, year = {2004}, eissn = {1588-1245}, pages = {1080-1089}, orcid-numbers = {Andó, István/0000-0002-4648-9396; Laurinyecz, Barbara/0000-0003-0620-2239} } @article{MTMT:1912996, title = {Ősi örökségünk a veleszületett immunitás. A Drosophila immunrendszere}, url = {https://m2.mtmt.hu/api/publication/1912996}, author = {Andó, István and Laurinyecz, Barbara and Nagy, István and Márkus, Róbert and FLORENTINA, R and Váczi, Balázs and Zsámboki, János and FEHER, L and GATEFF, E and Kurucz, Judit Éva}, journal-iso = {MAGYAR IMMUNOLÓGIA}, journal = {MAGYAR IMMUNOLÓGIA}, volume = {2}, unique-id = {1912996}, issn = {1588-3280}, year = {2003}, pages = {39-45}, orcid-numbers = {Andó, István/0000-0002-4648-9396; Laurinyecz, Barbara/0000-0003-0620-2239} }