TY - JOUR AU - Walter, Fruzsina AU - Harazin, András AU - Tóth, Andrea AU - Veszelka, Szilvia AU - Santa Maria, Anaraquel AU - Barna, Lilla AU - Kincses, András AU - Biczo, G AU - Balla, Zsolt AU - Kui, Balázs AU - Maléth, József AU - Cervenak, László AU - Tubak, Vilmos AU - Kittel, Ágnes AU - Rakonczay, Zoltán AU - Deli, Mária Anna TI - Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells JF - FLUIDS AND BARRIERS OF THE CNS J2 - FLUIDS BARRIERS CNS VL - 19 PY - 2022 IS - 1 PG - 20 SN - 2045-8118 DO - 10.1186/s12987-022-00308-0 UR - https://m2.mtmt.hu/api/publication/32667372 ID - 32667372 N1 - Institute of Biophysics, Biological Research Centre, Temesvári krt. 62, Szeged, 6726, Hungary Department of Medicine, University of Szeged, Kálvária sgt 57, Szeged, 6725, Hungary Department of Pathophysiology, University of Szeged, Semmelweis u. 1, Szeged, 6701, Hungary HAS-USZ Momentum Epithelial Cell Signaling and Secretion Research Group, University of Szeged, Dóm sqr. 10, Szeged, 6720, Hungary HCEMM-SZTE Molecular Gastroenterology Research Group, University of Szeged, Dóm sqr. 10, Szeged, 6720, Hungary Department of Internal Medicine and Hematology, Research Laboratory, Semmelweis University, Üllői út 26, Budapest, 1085, Hungary Creative Laboratory Ltd, Temesvári krt. 62, Szeged, 6726, Hungary Institute of Experimental Medicine, Eötvös Loránd Research Network, Szigony u. 43, Budapest, 1083, Hungary Wyss Institute for Biologically Inspired Engineering at Harvard University, 3 Blackfan Circle, Boston, MA 02115, United States Department of Biomedicine, Faculty of Health, Aarhus University, Høegh-Guldbergs Gade 10, Aarhus C, 8000, Denmark Institute of Applied Sciences, Department of Environmental Biology and Education, Juhász Gyula Faculty of Education, University of Szeged, Boldogasszony sgt. 6, Szeged, 6725, Hungary Cited By :1 Export Date: 23 November 2022 Correspondence Address: Deli, M.A.; Institute of Biophysics, Temesvári krt. 62, Hungary; email: deli.maria@brc.hu LA - English DB - MTMT ER - TY - JOUR AU - Balla, Zsolt AU - Kormányos, Eszter Sára AU - Kui, Balázs AU - Bálint, Emese Réka AU - Fűr, Gabriella AU - Orján, Erik Márk AU - Iványi, Béla AU - Vécsei, László AU - Fülöp, Ferenc AU - Varga, Gabriella AU - Harazin, András AU - Tubak, Vilmos AU - Deli, Mária Anna AU - Papp, Csaba Gergő AU - Gácser, Attila AU - Madácsy, Tamara AU - Venglovecz, Viktória AU - Maléth, József AU - Hegyi, Péter AU - Kiss, Lóránd AU - Rakonczay, Zoltán TI - Kynurenic acid and its analogue SZR-72 ameliorate the severity of experimental acute necrotizing pancreatitis JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 12 PY - 2021 PG - 15 SN - 1664-3224 DO - 10.3389/fimmu.2021.702764 UR - https://m2.mtmt.hu/api/publication/32258744 ID - 32258744 LA - English DB - MTMT ER - TY - JOUR AU - Barna, Lilla AU - Walter, Fruzsina AU - Harazin, András AU - Bocsik, Alexandra AU - Kincses, András AU - Tubak, Vilmos AU - Jósvay, Katalin AU - Zvara, Ágnes AU - Campos-Bedolla, Patricia AU - Deli, Mária Anna TI - Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage. JF - FLUIDS AND BARRIERS OF THE CNS J2 - FLUIDS BARRIERS CNS VL - 17 PY - 2020 IS - 1 PG - 13 SN - 2045-8118 DO - 10.1186/s12987-019-0166-1 UR - https://m2.mtmt.hu/api/publication/31181444 ID - 31181444 N1 - Lilla Barna, Fruzsina R. Walter and András Harazin contributed equally to the manuscript. AB - Excitotoxicity is a central pathological pathway in many neurological diseases with blood-brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effect of kainate on brain endothelial cells has not been studied in detail. Our aim was to examine the direct effects of kainate on cultured cells of the BBB and to test three anti-inflammatory and antioxidant drugs used in clinical practice, simvastatin, edaravone and dexamethasone, to protect against kainate-induced changes.Primary rat brain endothelial cell, pericyte and astroglia cultures were used to study cell viability by impedance measurement. BBB permeability was measured on a model made from the co-culture of the three cell types. The production of nitrogen monoxide and reactive oxygen species was followed by fluorescent probes. The mRNA expression of kainate receptors and nitric oxide synthases were studied by PCR.Kainate damaged brain endothelial cells and made the immunostaining of junctional proteins claudin-5 and zonula occludens-1 discontinuous at the cell border indicating the opening of the barrier. The permeability of the BBB model for marker molecules fluorescein and albumin and the production of nitric oxide in brain endothelial cells were increased by kainate. Simvastatin, edaravone and dexamethasone protected against the reduced cell viability, increased permeability and the morphological changes in cellular junctions caused by kainate. Dexamethasone attenuated the elevated nitric oxide production and decreased the inducible nitric oxide synthase (NOS2/iNOS) mRNA expression increased by kainate treatment.Kainate directly damaged cultured brain endothelial cells. Simvastatin, edaravone and dexamethasone protected the BBB model against kainate-induced changes. Our results confirmed the potential clinical usefulness of these drugs to attenuate BBB damage. LA - English DB - MTMT ER - TY - JOUR AU - Fajka-Boja, Roberta AU - Marton, Annamária AU - Tóth, Anna AU - Blazsó, Péter AU - Tubak, Vilmos AU - Bálint, Balázs AU - Nagy, István AU - Hegedűs, Zoltán AU - Vizler, Csaba AU - Katona, Róbert László TI - Adipose stem cells may promote cancer progression JF - RESEARCH OUTREACH J2 - RO VL - 2019 PY - 2019 SP - 6 EP - 9 PG - 4 SN - 2517-701X DO - 10.32907/RO-106-110113 UR - https://m2.mtmt.hu/api/publication/30693937 ID - 30693937 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, András Attila AU - Popovics, Nikoletta AU - Tubak, Vilmos AU - Boldogkői, Zsolt AU - Csiszár, Katalin AU - Mink, Mátyás TI - Novel Phenotypic Elements of Type IV Collagenopathy Revealed by the Drosophila Model JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 9 PY - 2019 IS - 10 PG - 11 SN - 2076-3417 DO - 10.3390/app9102083 UR - https://m2.mtmt.hu/api/publication/30686350 ID - 30686350 LA - English DB - MTMT ER - TY - JOUR AU - Ocskó, Tímea AU - Tóth, Dániel Márton AU - Hoffmann, Gyula AU - Tubak, Vilmos AU - Glant, Tibor T. AU - Rauch, Tibor TI - Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis JF - BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS J2 - BBA-GENE REGUL MECH VL - 1861 ET - 0 PY - 2018 IS - 11 SP - 1040 EP - 1047 PG - 8 SN - 1874-9399 DO - 10.1016/j.bbagrm.2018.09.007 UR - https://m2.mtmt.hu/api/publication/30318636 ID - 30318636 LA - English DB - MTMT ER - TY - JOUR AU - Fajka-Boja, Roberta AU - Marton, Annamária AU - Tóth, Anna AU - Blazsó, Péter AU - Tubak, Vilmos AU - Bálint, Balázs AU - Nagy, István AU - Hegedűs, Zoltán AU - Vizler, Csaba AU - Katona, Róbert László TI - Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells JF - BMC CANCER J2 - BMC CANCER VL - 18 PY - 2018 PG - 12 SN - 1471-2407 DO - 10.1186/s12885-018-4781-z UR - https://m2.mtmt.hu/api/publication/3411662 ID - 3411662 LA - English DB - MTMT ER - TY - JOUR AU - Harazin, András AU - Bocsik, Alexandra AU - Barna, Lilla AU - Kincses, András AU - Váradi, Judit AU - Fenyvesi, Ferenc AU - Tubak, Vilmos AU - Deli, Mária Anna AU - Vecsernyés, Miklós TI - Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone JF - PEERJ J2 - PEERJ VL - 6 PY - 2018 PG - 22 SN - 2167-8359 DO - 10.7717/peerj.4774 UR - https://m2.mtmt.hu/api/publication/3371756 ID - 3371756 N1 - These authors have contributed equally to this work: András Harazin​, Alexandra Bocsik​. LA - English DB - MTMT ER - TY - JOUR AU - Marton, Annamária AU - Kusz, Erzsébet AU - Kolozsi, Csongor AU - Tubak, Vilmos AU - Zagotto, G AU - Buzás, Krisztina AU - Quintieri, L AU - Vizler, Csaba TI - Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NF kappa B Activation and Suppress Growth of A375 Human Melanoma JF - ANTICANCER RESEARCH J2 - ANTICANCER RES VL - 36 PY - 2016 IS - 11 SP - 5743 EP - 5750 PG - 8 SN - 0250-7005 DO - 10.21873/anticanres.11157 UR - https://m2.mtmt.hu/api/publication/3157889 ID - 3157889 N1 - : ATHENS 19014, GREECE Hungarian Academy of Sciences, Biological Research Centre, Temesvári krt. 62, Szeged, H-6726, Hungary Creative Laboratory Ltd., Szeged, Hungary Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Largo Meneghetti 2, Padova, 35131, Italy Cited By :4 Export Date: 14 January 2020 CODEN: ANTRD Correspondence Address: Vizler, C.; Hungarian Academy of Sciences, Biological Research Centre, Temesvári krt. 62, Hungary; email: vizler.csaba@brc.mta.hu Chemicals/CAS: cyclophosphamide, 50-18-0; doxorubicin, 23214-92-8, 25316-40-9; perfosfamide, 39800-16-3, 62435-42-1; 2,4,6-trihydroxybenzaldehyde; 2-vanillin; Benzaldehydes; NF-kappa B AB - Background/Aim: Constitutive activation of nuclear factor kappa-B (NF kappa B) is a hallmark of various cancer types, including melanoma. Chemotherapy may further increase tumour NF kappa B activity, a phenomenon that, in turn, exacerbates drug resistance. This study aimed at preliminary screening of a panel of aromatic aldehydes, including vanillin, for cytotoxicity and suppression of tumour cell NF kappa B activity. Materials and Methods: The cytotoxic and NF kappa B-inhibitory effects of 10 aromatic aldehydes, including vanillin, were investigated in cultured A375 human melanoma cells. Each compound was assayed alone and in combination with the model NF kappa B-activating drug doxorubicin. The most promising analogues were then tested alone and in combination with 4-hydroperoxycyclophosphamide in vitro, and with cyclophosphamide in mice bearing A375 xenografts. Results: The vanillin analogues o-vanillin and 2,4,6-trihydroxybenzaldehyde exhibited cytotoxicity against cultured A375 cells, and inhibited doxorubicin-and 4-hydroperoxycyclophosphamide-induced NF kappa B activation. They also suppressed A375 cell growth in mice. Conclusion: o-vanillin and 2,4,6-trihydroxybenzaldehyde deserve further evaluation as potential anticancer drugs. LA - English DB - MTMT ER - TY - JOUR AU - Oláh, Attila AU - Ambrus, Lídia AU - Nicolussi, Simon AU - Gertsch, Jürg AU - Tubak, Vilmos AU - Kemény, Lajos AU - Soeberdt, Michael AU - Abels, Christoph AU - Bíró, Tamás TI - Inhibition of fatty acid amide hydrolase exerts cutaneousanti-inflammatory effects both in vitro and in vivo JF - EXPERIMENTAL DERMATOLOGY J2 - EXP DERMATOL VL - 25 PY - 2016 IS - 4 SP - 328 EP - 330 PG - 3 SN - 0906-6705 DO - 10.1111/exd.12930 UR - https://m2.mtmt.hu/api/publication/3019591 ID - 3019591 LA - English DB - MTMT ER -