@article{MTMT:32667372, title = {Blood–brain barrier dysfunction in l-ornithine induced acute pancreatitis in rats and the direct effect of l-ornithine on cultured brain endothelial cells}, url = {https://m2.mtmt.hu/api/publication/32667372}, author = {Walter, Fruzsina and Harazin, András and Tóth, Andrea and Veszelka, Szilvia and Santa Maria, Anaraquel and Barna, Lilla and Kincses, András and Biczo, G and Balla, Zsolt and Kui, Balázs and Maléth, József and Cervenak, László and Tubak, Vilmos and Kittel, Ágnes and Rakonczay, Zoltán and Deli, Mária Anna}, doi = {10.1186/s12987-022-00308-0}, journal-iso = {FLUIDS BARRIERS CNS}, journal = {FLUIDS AND BARRIERS OF THE CNS}, volume = {19}, unique-id = {32667372}, issn = {2045-8118}, year = {2022}, eissn = {2045-8118}, orcid-numbers = {Walter, Fruzsina/0000-0001-8145-2823; Harazin, András/0000-0002-0904-5606; Santa Maria, Anaraquel/0000-0003-3505-5477; Maléth, József/0000-0001-5768-3090; Cervenak, László/0000-0003-0166-8697; Tubak, Vilmos/0000-0002-6141-3920; Rakonczay, Zoltán/0000-0002-1499-3416; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:32258744, title = {Kynurenic acid and its analogue SZR-72 ameliorate the severity of experimental acute necrotizing pancreatitis}, url = {https://m2.mtmt.hu/api/publication/32258744}, author = {Balla, Zsolt and Kormányos, Eszter Sára and Kui, Balázs and Bálint, Emese Réka and Fűr, Gabriella and Orján, Erik Márk and Iványi, Béla and Vécsei, László and Fülöp, Ferenc and Varga, Gabriella and Harazin, András and Tubak, Vilmos and Deli, Mária Anna and Papp, Csaba Gergő and Gácser, Attila and Madácsy, Tamara and Venglovecz, Viktória and Maléth, József and Hegyi, Péter and Kiss, Lóránd and Rakonczay, Zoltán}, doi = {10.3389/fimmu.2021.702764}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {12}, unique-id = {32258744}, issn = {1664-3224}, year = {2021}, eissn = {1664-3224}, orcid-numbers = {Orján, Erik Márk/0000-0003-4176-0834; Vécsei, László/0000-0001-8037-3672; Fülöp, Ferenc/0000-0003-1066-5287; Varga, Gabriella/0000-0003-1888-8629; Harazin, András/0000-0002-0904-5606; Tubak, Vilmos/0000-0002-6141-3920; Deli, Mária Anna/0000-0001-6084-6524; Papp, Csaba Gergő/0000-0003-4450-0667; Madácsy, Tamara/0000-0001-5598-9723; Venglovecz, Viktória/0000-0002-2316-7247; Maléth, József/0000-0001-5768-3090; Hegyi, Péter/0000-0003-0399-7259; Rakonczay, Zoltán/0000-0002-1499-3416} } @article{MTMT:31181444, title = {Simvastatin, edaravone and dexamethasone protect against kainate-induced brain endothelial cell damage.}, url = {https://m2.mtmt.hu/api/publication/31181444}, author = {Barna, Lilla and Walter, Fruzsina and Harazin, András and Bocsik, Alexandra and Kincses, András and Tubak, Vilmos and Jósvay, Katalin and Zvara, Ágnes and Campos-Bedolla, Patricia and Deli, Mária Anna}, doi = {10.1186/s12987-019-0166-1}, journal-iso = {FLUIDS BARRIERS CNS}, journal = {FLUIDS AND BARRIERS OF THE CNS}, volume = {17}, unique-id = {31181444}, issn = {2045-8118}, abstract = {Excitotoxicity is a central pathological pathway in many neurological diseases with blood-brain barrier (BBB) dysfunction. Kainate, an exogenous excitotoxin, induces epilepsy and BBB damage in animal models, but the direct effect of kainate on brain endothelial cells has not been studied in detail. Our aim was to examine the direct effects of kainate on cultured cells of the BBB and to test three anti-inflammatory and antioxidant drugs used in clinical practice, simvastatin, edaravone and dexamethasone, to protect against kainate-induced changes.Primary rat brain endothelial cell, pericyte and astroglia cultures were used to study cell viability by impedance measurement. BBB permeability was measured on a model made from the co-culture of the three cell types. The production of nitrogen monoxide and reactive oxygen species was followed by fluorescent probes. The mRNA expression of kainate receptors and nitric oxide synthases were studied by PCR.Kainate damaged brain endothelial cells and made the immunostaining of junctional proteins claudin-5 and zonula occludens-1 discontinuous at the cell border indicating the opening of the barrier. The permeability of the BBB model for marker molecules fluorescein and albumin and the production of nitric oxide in brain endothelial cells were increased by kainate. Simvastatin, edaravone and dexamethasone protected against the reduced cell viability, increased permeability and the morphological changes in cellular junctions caused by kainate. Dexamethasone attenuated the elevated nitric oxide production and decreased the inducible nitric oxide synthase (NOS2/iNOS) mRNA expression increased by kainate treatment.Kainate directly damaged cultured brain endothelial cells. Simvastatin, edaravone and dexamethasone protected the BBB model against kainate-induced changes. Our results confirmed the potential clinical usefulness of these drugs to attenuate BBB damage.}, keywords = {DEXAMETHASONE; Permeability; Blood-Brain Barrier; Reactive oxygen species; nitric oxide synthase; SIMVASTATIN; kainate; Edaravone; Brain endothelial cells}, year = {2020}, eissn = {2045-8118}, orcid-numbers = {Walter, Fruzsina/0000-0001-8145-2823; Harazin, András/0000-0002-0904-5606; Tubak, Vilmos/0000-0002-6141-3920; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:30693937, title = {Adipose stem cells may promote cancer progression}, url = {https://m2.mtmt.hu/api/publication/30693937}, author = {Fajka-Boja, Roberta and Marton, Annamária and Tóth, Anna and Blazsó, Péter and Tubak, Vilmos and Bálint, Balázs and Nagy, István and Hegedűs, Zoltán and Vizler, Csaba and Katona, Róbert László}, doi = {10.32907/RO-106-110113}, journal-iso = {RO}, journal = {RESEARCH OUTREACH}, volume = {2019}, unique-id = {30693937}, issn = {2517-701X}, year = {2019}, eissn = {2517-7028}, pages = {6-9}, orcid-numbers = {Blazsó, Péter/0000-0003-4404-8068; Tubak, Vilmos/0000-0002-6141-3920} } @article{MTMT:30686350, title = {Novel Phenotypic Elements of Type IV Collagenopathy Revealed by the Drosophila Model}, url = {https://m2.mtmt.hu/api/publication/30686350}, author = {Kiss, András Attila and Popovics, Nikoletta and Tubak, Vilmos and Boldogkői, Zsolt and Csiszár, Katalin and Mink, Mátyás}, doi = {10.3390/app9102083}, journal-iso = {APPL SCI-BASEL}, journal = {APPLIED SCIENCES-BASEL}, volume = {9}, unique-id = {30686350}, year = {2019}, eissn = {2076-3417}, orcid-numbers = {Kiss, András Attila/0000-0003-2633-292X; Tubak, Vilmos/0000-0002-6141-3920; Boldogkői, Zsolt/0000-0003-1184-7293} } @article{MTMT:30318636, title = {Transcription factor Zbtb38 downregulates the expression of anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis}, url = {https://m2.mtmt.hu/api/publication/30318636}, author = {Ocskó, Tímea and Tóth, Dániel Márton and Hoffmann, Gyula and Tubak, Vilmos and Glant, Tibor T. and Rauch, Tibor}, doi = {10.1016/j.bbagrm.2018.09.007}, journal-iso = {BBA-GENE REGUL MECH}, journal = {BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS}, volume = {1861}, unique-id = {30318636}, issn = {1874-9399}, year = {2018}, eissn = {1876-4320}, pages = {1040-1047}, orcid-numbers = {Hoffmann, Gyula/0000-0002-2206-6997; Tubak, Vilmos/0000-0002-6141-3920} } @article{MTMT:3411662, title = {Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells}, url = {https://m2.mtmt.hu/api/publication/3411662}, author = {Fajka-Boja, Roberta and Marton, Annamária and Tóth, Anna and Blazsó, Péter and Tubak, Vilmos and Bálint, Balázs and Nagy, István and Hegedűs, Zoltán and Vizler, Csaba and Katona, Róbert László}, doi = {10.1186/s12885-018-4781-z}, journal-iso = {BMC CANCER}, journal = {BMC CANCER}, volume = {18}, unique-id = {3411662}, issn = {1471-2407}, year = {2018}, eissn = {1471-2407}, orcid-numbers = {Fajka-Boja, Roberta/0000-0001-5331-8280; Blazsó, Péter/0000-0003-4404-8068; Tubak, Vilmos/0000-0002-6141-3920} } @article{MTMT:3371756, title = {Protection of cultured brain endothelial cells from cytokine-induced damage by α-melanocyte stimulating hormone}, url = {https://m2.mtmt.hu/api/publication/3371756}, author = {Harazin, András and Bocsik, Alexandra and Barna, Lilla and Kincses, András and Váradi, Judit and Fenyvesi, Ferenc and Tubak, Vilmos and Deli, Mária Anna and Vecsernyés, Miklós}, doi = {10.7717/peerj.4774}, journal-iso = {PEERJ}, journal = {PEERJ}, volume = {6}, unique-id = {3371756}, issn = {2167-8359}, year = {2018}, eissn = {2167-8359}, orcid-numbers = {Harazin, András/0000-0002-0904-5606; Tubak, Vilmos/0000-0002-6141-3920; Deli, Mária Anna/0000-0001-6084-6524} } @article{MTMT:3157889, title = {Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NF kappa B Activation and Suppress Growth of A375 Human Melanoma}, url = {https://m2.mtmt.hu/api/publication/3157889}, author = {Marton, Annamária and Kusz, Erzsébet and Kolozsi, Csongor and Tubak, Vilmos and Zagotto, G and Buzás, Krisztina and Quintieri, L and Vizler, Csaba}, doi = {10.21873/anticanres.11157}, journal-iso = {ANTICANCER RES}, journal = {ANTICANCER RESEARCH}, volume = {36}, unique-id = {3157889}, issn = {0250-7005}, abstract = {Background/Aim: Constitutive activation of nuclear factor kappa-B (NF kappa B) is a hallmark of various cancer types, including melanoma. Chemotherapy may further increase tumour NF kappa B activity, a phenomenon that, in turn, exacerbates drug resistance. This study aimed at preliminary screening of a panel of aromatic aldehydes, including vanillin, for cytotoxicity and suppression of tumour cell NF kappa B activity. Materials and Methods: The cytotoxic and NF kappa B-inhibitory effects of 10 aromatic aldehydes, including vanillin, were investigated in cultured A375 human melanoma cells. Each compound was assayed alone and in combination with the model NF kappa B-activating drug doxorubicin. The most promising analogues were then tested alone and in combination with 4-hydroperoxycyclophosphamide in vitro, and with cyclophosphamide in mice bearing A375 xenografts. Results: The vanillin analogues o-vanillin and 2,4,6-trihydroxybenzaldehyde exhibited cytotoxicity against cultured A375 cells, and inhibited doxorubicin-and 4-hydroperoxycyclophosphamide-induced NF kappa B activation. They also suppressed A375 cell growth in mice. Conclusion: o-vanillin and 2,4,6-trihydroxybenzaldehyde deserve further evaluation as potential anticancer drugs.}, keywords = {EXPRESSION; IN-VIVO; TRANSCRIPTION FACTOR; PATHWAY; CHEMOTHERAPY; ESCHERICHIA-COLI; BREAST-CANCER; CANCER-CELLS; INDUCED APOPTOSIS; cinnamaldehyde; Chemoresistance; vanillin; NF kappa B; Melanomas}, year = {2016}, eissn = {1791-7530}, pages = {5743-5750}, orcid-numbers = {Tubak, Vilmos/0000-0002-6141-3920; Buzás, Krisztina/0000-0001-8933-2033} } @article{MTMT:3019591, title = {Inhibition of fatty acid amide hydrolase exerts cutaneousanti-inflammatory effects both in vitro and in vivo}, url = {https://m2.mtmt.hu/api/publication/3019591}, author = {Oláh, Attila and Ambrus, Lídia and Nicolussi, Simon and Gertsch, Jürg and Tubak, Vilmos and Kemény, Lajos and Soeberdt, Michael and Abels, Christoph and Bíró, Tamás}, doi = {10.1111/exd.12930}, journal-iso = {EXP DERMATOL}, journal = {EXPERIMENTAL DERMATOLOGY}, volume = {25}, unique-id = {3019591}, issn = {0906-6705}, year = {2016}, eissn = {1600-0625}, pages = {328-330}, orcid-numbers = {Oláh, Attila/0000-0003-4122-5639; Tubak, Vilmos/0000-0002-6141-3920; Kemény, Lajos/0000-0002-2119-9501} }