TY - JOUR AU - Inczefi, Orsolya AU - Eutamene, Hélène AU - Placide, Fanny AU - Tondereau, Valérie AU - Pallagi, Petra AU - Bagyánszki, Mária AU - Bódi, Nikolett AU - Gémes, Nikolett AU - Szebeni, Gábor AU - Molnár, Tamás AU - Theodorou, Vassilia AU - Róka, Richárd László TI - Translational evaluation of Gelsectan® effects on gut barrier dysfunction and visceral pain in animal models and irritable bowel syndrome with diarrhoea JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 12 PY - 2024 IS - 8 SP - 1102 EP - 1113 PG - 12 SN - 2050-6406 DO - 10.1002/ueg2.12625 UR - https://m2.mtmt.hu/api/publication/35162166 ID - 35162166 N1 - Department of Medicine, Centre for Gastroenterology, University of Szeged, Szeged, Hungary UMR 1331, Toxalim (Research Centre in Food Toxicology), INRAE, Université de Toulouse III, ENVT, Toulouse, France Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary Department of Internal Medicine, Hematology Centre, Faculty of Medicine, University of Szeged, Szeged, Hungary Cited By :1 Export Date: 7 December 2024 Correspondence Address: Inczefi, O.; Department of Medicine, Hungary; email: inczefi@gmail.com Chemicals/CAS: acepromazine, 61-00-7; chromium 51, 14392-02-0; ethylenediamine, 107-15-3; gamma interferon, 82115-62-6; ketamine, 1867-66-9, 6740-88-1, 81771-21-3; protein glutamine gamma glutamyltransferase, 80146-85-6; protein glutamine gamma glutamyltransferase 2; glucan, 9012-72-0, 9037-91-6; xylan, 9014-63-5; Glucans; Oligosaccharides; Xylans; xyloglucan Tradenames: calmivet, Vetoquinol, France; gelsectan; imalgene1000, Rhone Merieux, FranceCLARIOstar, BMG Labtech, Germany; Cobra II, Packard; Fogarty, Edward sLaboratories; powerlab Chart 5, AdInstruments, United States Manufacturers: Rhone Merieux, France; Vetoquinol, FranceBMG Labtech, Germany; AdInstruments, United States; Edward sLaboratories; Packard LA - English DB - MTMT ER - TY - JOUR AU - Ruppert, Zsófia AU - Neuperger, Patricia AU - Rákóczi, Bettina AU - Gémes, Nikolett AU - Dukay, Brigitta AU - Hajdu, Petra AU - Péter, Mária AU - Balogh, Gábor AU - Tiszlavicz, László AU - Vigh, László AU - Török, Zsolt AU - Puskás, László AU - Szebeni, Gábor AU - Tóth, Erzsébet Melinda TI - Characterization of obesity-related diseases and inflammation using single cell immunophenotyping in two different diet-induced obesity models JF - INTERNATIONAL JOURNAL OF OBESITY J2 - INT J OBES (LOND) VL - 48 PY - 2024 IS - 11 SP - 1568 EP - 1576 PG - 9 SN - 0307-0565 DO - 10.1038/s41366-024-01584-6 UR - https://m2.mtmt.hu/api/publication/35133023 ID - 35133023 N1 - Laboratory of Molecular Stress Biology, Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, Hungary PhD School in Biology, University of Szeged, Szeged, Hungary Laboratory of Functional Genomics, Core Facility, HUN-REN Biological Research Centre, Szeged, Hungary Department of Pathology, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Internal Medicine, Hematology Centre, Faculty of Medicine, University of Szeged, Szeged, H6725, Hungary Export Date: 2 August 2024 CODEN: IJOBD Correspondence Address: Tóth, M.E.; Laboratory of Molecular Stress Biology, Hungary; email: toth.erzsebetmelinda@brc.hu Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Hungary; email: szebeni.gabor@brc.hu A közlemény a Bolyai János Kutatási Ösztöndíj (BO/00582/22/8) segítségével jött létre. LA - English DB - MTMT ER - TY - CONF AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba AU - Szabó, Renáta ED - Pap, Péter László ED - László, Zoltán TI - A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében T2 - 24. Kolozsvári Biológus Napok PB - Szervezők/Organizers: Babeș-Bolyai Tudományegyetem, Magyar Biológiai és Ökológiai Intézet (MBÖI) Apáthy István Egyesület BÖSZ (KMDSZ Biológia-Ökológia Szakosztály) Kolozsvári Akadémiai Bizottság (KAB) C1 - Kolozsvár PY - 2024 SP - 48 UR - https://m2.mtmt.hu/api/publication/35054657 ID - 35054657 N1 - Előadás LA - Hungarian DB - MTMT ER - TY - CHAP AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba AU - Szabó, Renáta ED - Hajdú, Péter TI - A BGP-15 hatása imatinib-indukált szívkárosodás kezelésében T2 - XXVII. Tavaszi Szél Konferencia 2024 - Absztraktkötet PB - Doktoranduszok Országos Szövetsége (DOSZ) C1 - Budapest SN - 9786156457523 PY - 2024 SP - 651 UR - https://m2.mtmt.hu/api/publication/35054634 ID - 35054634 N1 - Poszter szekció előadással LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szabó, Renáta AU - Nagy, András Levente AU - Börzsei, Denise AU - Nagyné Hoffmann, Alexandra AU - Kiss, Viktória AU - Toldi, Éva AU - Almási, Nikoletta AU - Török, Szilvia AU - Veszelka, Médea AU - Neuperger, Patricia AU - Szebeni, Gábor AU - Varga, Csaba TI - Therapeutic effect of BGP-15 in the treatment of imatinib-induced cardiotoxicity in a rat model JF - CARDIOLOGIA HUNGARICA J2 - CARDIOL HUNG VL - 54. évfolyam (1-2) PY - 2024 SP - 263 SN - 0133-5596 UR - https://m2.mtmt.hu/api/publication/35054510 ID - 35054510 N1 - Poszter szekció előadással LA - English DB - MTMT ER - TY - JOUR AU - Szebeni, Gábor AU - Balog, Attila TI - Closing Editorial: Immunophenotyping in Autoimmune Diseases and Cancer 3.0 JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 12 PG - 5 SN - 1661-6596 DO - 10.3390/ijms25126311 UR - https://m2.mtmt.hu/api/publication/34959555 ID - 34959555 N1 - Funding Agency and Grant Number: National Research, Development, and Innovation Office (NKFI), Hungary [GINOP-2.3.2-15-2016-00030, 2020-1.1.6-JOVO-2021-00003, 2022-1.2.6-TET-IPARI-TR-2022-00023, 142877 FK22]; SZTE OK-KKA Hetenyi 2020 grant; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00582/22/8]; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-23-5-SZTE-694] Funding text: This research was funded by the GINOP-2.3.2-15-2016-00030, 2020-1.1.6-JOVO-2021-00003, 2022-1.2.6-TET-IPARI-TR-2022-00023 and 142877 FK22 grants from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by an SZTE OK-KKA Hetenyi 2020 grant (AB). This work was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GJS) and the UNKP-23-5-SZTE-694 New National Excellence Program of the Ministry for Innovation and Technology (GJS). AB - The mammalian immune system is a Janus-faced network of well-coordinated highly specialized cells and biomolecules [...] LA - English DB - MTMT ER - TY - JOUR AU - Balog, József Ágoston AU - Horti-Oravecz, Klaudia AU - Kövesdi, Dorottya AU - Bozsik, Anikó AU - Papp, János AU - Butz, Henriett AU - Patócs, Attila Balázs AU - Szebeni, Gábor AU - Grolmusz, Vince Kornél TI - Peripheral immunophenotyping reveals lymphocyte stimulation in healthy women living with hereditary breast and ovarian cancer syndrome JF - ISCIENCE J2 - ISCIENCE VL - 27 PY - 2024 IS - 6 PG - 15 SN - 2589-0042 DO - 10.1016/j.isci.2024.109882 UR - https://m2.mtmt.hu/api/publication/34840271 ID - 34840271 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program (National Tumor Biology Laboratory) [2022-2.1.1-NL-2022-00010]; Hungarian Thematic Excellence Program [TKP2021-EGA-44]; National Research, Development and Innovation Office [2020-1.1.6-JOVO -2021-00003, 2020-1.1.6-JOVO -2021-00008, NKFIH-FK-142877, NKFIH-FK-138377]; Janos Bolyai Postdoctoral Scholarship [BO/00582/22/8, BO/00141/21]; New National Excellence Program Bolyai+ Scholarship [UNKP-23-5-SZTE-694, UNKP-22-5-SE-25]; COST Action [CA20122] Funding text: The project was implemented with the support from the National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program (National Tumor Biology Laboratory (2022-2.1.1-NL-2022-00010) ) and the Hungarian Thematic Excellence Program (under project TKP2021-EGA-44) Grant Agreements with the National Research, Development and Innovation Office. The authors would like to acknowledge the financial support of the National Research, Development and Innovation Office under grants Investment into Future (2020-1.1.6-JOVO -2021-00003 and 2020-1.1.6-JOVO -2021-00008) , NKFIH-FK-142877, and NKFIH-FK-138377. G.J.S. is the recipient of the Janos Bolyai Postdoctoral Scholarship (BO/00582/22/8) and the New National Excellence Program Bolyai+ Scholarship (UNKP-23-5-SZTE-694) . V.K.G. is the recipient of the Janos Bolyai Postdoctoral Scholarship (BO/00141/21) and the New National Excellence Program Bolyai+ Scholarship (UNKP-22-5-SE-25, UNKP-23-5-SE-16) . V.K.G. is supported by COST Action CA20122 Harmonisation. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Enikő AU - Faragó, Anna AU - Bodor, Gergely AU - Gémes, Nikolett AU - Puskás, László AU - Kovács, László AU - Szebeni, Gábor TI - Identification of immune subsets with distinct lectin binding signatures using multi-parameter flow cytometry: correlations with disease activity in systemic lupus erythematosus JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 15 PY - 2024 PG - 22 SN - 1664-3224 DO - 10.3389/fimmu.2024.1380481 UR - https://m2.mtmt.hu/api/publication/34840255 ID - 34840255 N1 - Funding Agency and Grant Number: Nemzeti Kutatsi Fejlesztsi s Innovcis Hivatal10.13039/501100011019 Funding text: No Statement Available A közlemény a Bolyai János Kutatási Ösztöndíj (BO/00582/22/8) segítségével jött létre. LA - English DB - MTMT ER - TY - JOUR AU - Balog, József Ágoston AU - Zvara, Ágnes AU - Bukovinszki, Vivien AU - Puskás, László AU - Balog, Attila AU - Szebeni, Gábor TI - Comparative single-cell multiplex immunophenotyping of therapy-naive patients with rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus shed light on disease-specific composition of the peripheral immune system JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 15 PY - 2024 PG - 22 SN - 1664-3224 DO - 10.3389/fimmu.2024.1376933 UR - https://m2.mtmt.hu/api/publication/34829278 ID - 34829278 N1 - Funding Agency and Grant Number: National Research, Development, and Innovation Office (NKFI), Hungary [GINOP-2.3.2-15-2016-00030, 2020-1.1.6-JVOdblac;-2021-00003, 2022-1.2.6-TT-IPARI-TR-2022-00023, 142877 FK22]; Jnos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00582/22/8, NKP-23-5-SZTE-694]; New National Excellence Program of the Ministry for Innovation and Technology Funding text: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This research was funded by the GINOP-2.3.2-15-2016-00030, 2020-1.1.6-JOV & Odblac;-2021-00003, 2022-1.2.6-TET-IPARI-TR-2022-00023, and 142877 FK22 grants from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by an SZTE OK-KKA Hetenyi 2020 grant (AB). This work was supported by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GS) and the & Uacute;NKP-23-5-SZTE-694 New National Excellence Program of the Ministry for Innovation and Technology (GS). LA - English DB - MTMT ER - TY - JOUR AU - Faragó, Anna AU - Zvara, Ágnes AU - Tiszlavicz, László AU - Hunyadi-Gulyás Éva, Csilla AU - Darula, Zsuzsanna AU - Hegedűs, Zoltán AU - Szabó, Enikő AU - Surguta, Sára Eszter AU - Tóvári, József AU - Puskás, László AU - Szebeni, Gábor TI - Lectin-Based Immunophenotyping and Whole Proteomic Profiling of CT-26 Colon Carcinoma Murine Model JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 7 PG - 21 SN - 1661-6596 DO - 10.3390/ijms25074022 UR - https://m2.mtmt.hu/api/publication/34790193 ID - 34790193 N1 - * Megosztott szerzőség A közlemény a Bolyai János Kutatási Ösztöndíj (BO/00582/22/8) segítségével jött létre. AB - A murine colorectal carcinoma (CRC) model was established. CT26 colon carcinoma cells were injected into BALB/c mice's spleen to study the primary tumor and the mechanisms of cell spread of colon cancer to the liver. The CRC was verified by the immunohistochemistry of Pan Cytokeratin and Vimentin expression. Immunophenotyping of leukocytes isolated from CRC-bearing BALB/c mice or healthy controls, such as CD19+ B cells, CD11+ myeloid cells, and CD3+ T cells, was carried out using fluorochrome-labeled lectins. The binding of six lectins to white blood cells, such as galectin-1 (Gal1), siglec-1 (Sig1), Sambucus nigra lectin (SNA), Aleuria aurantia lectin (AAL), Phytolacca americana lectin (PWM), and galectin-3 (Gal3), was assayed. Flow cytometric analysis of the splenocytes revealed the increased binding of SNA, and AAL to CD3 + T cells and CD11b myeloid cells; and increased siglec-1 and AAL binding to CD19 B cells of the tumor-bearing mice. The whole proteomic analysis of the established CRC-bearing liver and spleen versus healthy tissues identified differentially expressed proteins, characteristic of the primary or secondary CRC tissues. KEGG Gene Ontology bioinformatic analysis delineated the established murine CRC characteristic protein interaction networks, biological pathways, and cellular processes involved in CRC. Galectin-1 and S100A4 were identified as upregulated proteins in the primary and secondary CT26 tumor tissues, and these were previously reported to contribute to the poor prognosis of CRC patients. Modelling the development of liver colonization of CRC by the injection of CT26 cells into the spleen may facilitate the understanding of carcinogenesis in human CRC and contribute to the development of novel therapeutic strategies. LA - English DB - MTMT ER -