@article{MTMT:34444932,
	title = {Gyermekkori agydaganatok: diagnózis és terápia – komprehenzív genomikai profilozás},
	url = {https://m2.mtmt.hu/api/publication/34444932},
	author = {Brückner, Edit and Bedics, Gábor and Reiniger, Lilla and Rajnai, Hajnalka and Jakab, Zsuzsanna and Bödör, Csaba and Scheich, Bálint and Garami, Miklós},
	journal-iso = {MAGYAR ONKOLÓGIA},
	journal = {MAGYAR ONKOLÓGIA},
	volume = {67},
	unique-id = {34444932},
	issn = {0025-0244},
	abstract = {With the advancement of molecular oncology, numerous new opportunities are available for the effective and efficient treatment of patients diagnosed with childhood brain tumors. This includes gene panel analysis aiding personalized treatment used in clinical trials, and the application of targeted therapy independent of tissue type (tumor agnostic therapy). Most personalized therapies inhibit certain kinases. In our review, we present the modern pathological diagnosis of childhood brain tumors, as well as the complex intracellular regulation of signal transduction pathways important from the point of view of clinical practice, and we describe their further targets defined on the basis of pharmacological characteristics of the pathway, based on international and our own results. Despite common mutations affecting kinases, personalized therapy is not available in many types of tumors. Through the example of childhood brain tumors, we demonstrate the expected future therapeutic significance of tyrosine kinases.},
	year = {2023},
	eissn = {2060-0399},
	pages = {315-320},
	orcid-numbers = {Brückner, Edit/0000-0002-2140-3357; Bedics, Gábor/0000-0003-4628-2384; Reiniger, Lilla/0000-0003-2248-4264; Rajnai, Hajnalka/0000-0003-0934-5366; Jakab, Zsuzsanna/0000-0002-8231-0357; Bödör, Csaba/0000-0002-0729-692X; Garami, Miklós/0000-0003-4298-2746}
}

@article{MTMT:34258190,
	title = {Novel, clinically relevant genomic patterns identified by comprehensive genomic profiling in ATRX-deficient IDH-wildtype adult high-grade gliomas},
	url = {https://m2.mtmt.hu/api/publication/34258190},
	author = {Bedics, Gábor and Szőke, P. and Bátai, Bence and Nagy, Tibor and Papp, Gergő and Kránitz, N. and Rajnai, Hajnalka and Reiniger, Lilla and Bödör, Csaba and Scheich, Bálint},
	doi = {10.1038/s41598-023-45786-w},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {34258190},
	issn = {2045-2322},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Bedics, Gábor/0000-0003-4628-2384; Nagy, Tibor/0000-0002-4451-0796; Papp, Gergő/0000-0001-5840-2369; Rajnai, Hajnalka/0000-0003-0934-5366; Reiniger, Lilla/0000-0003-2248-4264; Bödör, Csaba/0000-0002-0729-692X}
}

@article{MTMT:33999222,
	title = {PD-1 and PD-L1 expression in rare lung tumors},
	url = {https://m2.mtmt.hu/api/publication/33999222},
	author = {Gyulai, Márton and Megyesfalvi, Zsolt and Reiniger, Lilla and Harko, Tunde and Ferencz, Bence and Karsko, Luca and Agócs, László and Fillinger, Janos and Döme, Balázs and Szállási, Zoltán and Moldvay, Judit},
	doi = {10.3389/pore.2023.1611164},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {29},
	unique-id = {33999222},
	issn = {1219-4956},
	abstract = {Background: Our knowledge is still limited about the characteristics and treatment of rare lung tumors. The aim of our study was to determine programmed cell death ligand-1 (PD-L1) and programmed cell death-1 (PD-1) expression in rare pulmonary tumors to assess the potential role of immunotherapy.},
	year = {2023},
	eissn = {1532-2807},
	orcid-numbers = {Megyesfalvi, Zsolt/0000-0001-8552-6500; Reiniger, Lilla/0000-0003-2248-4264; Ferencz, Bence/0000-0001-9820-2441; Agócs, László/0000-0002-5578-4100; Döme, Balázs/0000-0001-8799-8624; Szállási, Zoltán/0000-0001-5395-7509}
}

@article{MTMT:33364842,
	title = {Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases},
	url = {https://m2.mtmt.hu/api/publication/33364842},
	author = {Woldmar, N and Schwendenwein, A and Kuras, M and Szeitz, Beáta and Boettiger, K and Sólyom-Tisza, Anna and Laszlo, Viktoria and Reiniger, Lilla and Bagó, Attila György and Szállási, Zoltán and Moldvay, Judit and Szász, Attila Marcell and Malm, J and Horvatovich, P and Pizzatti, L and Domont, G B and Rényi-Vámos, Ferenc István and Hoetzenecker, K and Hoda, M A and Marko-Varga, G and Schelch, K and Megyesfalvi, Zsolt and Rezeli, M and Döme, Balázs},
	doi = {10.1016/j.esmoop.2022.100741},
	journal-iso = {ESMO OPEN},
	journal = {ESMO OPEN},
	volume = {8},
	unique-id = {33364842},
	issn = {2059-7029},
	abstract = {Background
		Brain metastases are associated with considerable negative effects on patients’ outcome in lung adenocarcinoma (LADC). Here, we investigated the proteomic landscape of primary LADCs and their corresponding brain metastases.
		
		Materials and methods
		Proteomic profiling was conducted on 20 surgically resected primary and brain metastatic LADC samples via label-free shotgun proteomics. After sample processing, peptides were analyzed using an Ultimate 3000 pump coupled to a QExactive HF-X mass spectrometer. Raw data were searched using PD 2.4. Further data analyses were carried out using Perseus, RStudio and GraphPad Prism. Proteomic data were correlated with clinical and histopathological parameters and the timing of brain metastases. Mass spectrometry-based proteomic data are available via ProteomeXchange with identifier PXD027259.
		
		Results
		Out of the 6821 proteins identified and quantified, 1496 proteins were differentially expressed between primary LADCs and corresponding brain metastases. Pathways associated with the immune system, cell-cell/matrix interactions and migration were predominantly activated in the primary tumors, whereas pathways related to metabolism, translation or vesicle formation were overrepresented in the metastatic tumors. When comparing fast- versus slow-progressing patients, we found 454 and 298 differentially expressed proteins in the primary tumors and brain metastases, respectively. Metabolic reprogramming and ribosomal activity were prominently up-regulated in the fast-progressing patients (versus slow-progressing individuals), whereas expression of cell-cell interaction- and immune system-related pathways was reduced in these patients and in those with multiple brain metastases.
		
		Conclusions
		This is the first comprehensive proteomic analysis of paired primary tumors and brain metastases of LADC patients. Our data suggest a malfunction of cellular attachment and an increase in ribosomal activity in LADC tissue, promoting brain metastasis. The current study provides insights into the biology of LADC brain metastases and, moreover, might contribute to the development of personalized follow-up strategies in LADC.},
	keywords = {brain metastasis; lung adenocarcinoma; CLINICAL PROTEOMICS; Intertumoral heterogeneity},
	year = {2023},
	eissn = {2059-7029},
	orcid-numbers = {Szeitz, Beáta/0000-0001-6414-0537; Sólyom-Tisza, Anna/0000-0001-5871-2930; Reiniger, Lilla/0000-0003-2248-4264; Szállási, Zoltán/0000-0001-5395-7509; Szász, Attila Marcell/0000-0003-2739-4196; Rényi-Vámos, Ferenc István/0000-0002-0555-2096; Megyesfalvi, Zsolt/0000-0001-8552-6500; Döme, Balázs/0000-0001-8799-8624}
}

@article{MTMT:33283318,
	title = {Novel actionable ROS1::GIT2 fusion in non-Langerhans cell histiocytosis with central nervous system involvement},
	url = {https://m2.mtmt.hu/api/publication/33283318},
	author = {Bedics, Gábor and Csóka, Monika and Reiniger, Lilla and Varga, Edit and Liptai, Zoltán and Papp, Gergő and Bekő, Anna and Cervi, Catherine and Bödör, Csaba and Scheich, Bálint},
	doi = {10.1007/s00401-022-02520-6},
	journal-iso = {ACTA NEUROPATHOL},
	journal = {ACTA NEUROPATHOLOGICA},
	volume = {145},
	unique-id = {33283318},
	issn = {0001-6322},
	year = {2023},
	eissn = {1432-0533},
	pages = {153-156},
	orcid-numbers = {Bedics, Gábor/0000-0003-4628-2384; Csóka, Monika/0000-0003-4202-891X; Reiniger, Lilla/0000-0003-2248-4264; Varga, Edit/0000-0002-0215-0702; Papp, Gergő/0000-0001-5840-2369; Bödör, Csaba/0000-0002-0729-692X}
}

@article{MTMT:32827525,
	title = {Germline MUTYH mutations and high-grade gliomas: Novel evidence for a potential association},
	url = {https://m2.mtmt.hu/api/publication/32827525},
	author = {Bedics, Gábor and Kotmayer, Lili and Zajta, Erik and Hegyi, Lajos László and Brückner, Edit and Rajnai, Hajnalka and Reiniger, Lilla and Bödör, Csaba and Garami, Miklós and Scheich, Bálint},
	doi = {10.1002/gcc.23054},
	journal-iso = {GENE CHROMOSOME CANC},
	journal = {GENES CHROMOSOMES & CANCER},
	volume = {61},
	unique-id = {32827525},
	issn = {1045-2257},
	year = {2022},
	eissn = {1098-2264},
	pages = {622-628},
	orcid-numbers = {Bedics, Gábor/0000-0003-4628-2384; Zajta, Erik/0000-0001-5258-2506; Brückner, Edit/0000-0002-2140-3357; Rajnai, Hajnalka/0000-0003-0934-5366; Reiniger, Lilla/0000-0003-2248-4264; Bödör, Csaba/0000-0002-0729-692X; Garami, Miklós/0000-0003-4298-2746}
}

@article{MTMT:32816292,
	title = {An Implantable Magneto-Responsive Poly(aspartamide) Based Electrospun Scaffold for Hyperthermia Treatment},
	url = {https://m2.mtmt.hu/api/publication/32816292},
	author = {Veres, T. and Voniatis, Constantinos and Molnár, Kristóf and Nesztor, D. and Fehér, Daniella and Ferencz, Andrea and Gresits, Iván and Thuróczy, G. and Márkus, Bence Gábor and Simon, Ferenc and Nemes, N.M. and García-Hernández, M. and Reiniger, Lilla and Horváth, I. and Máthé, Domokos and Szigeti, Krisztián and Csákiné Tombácz, Etelka and Jedlovszky-Hajdú, Angéla},
	doi = {10.3390/nano12091476},
	journal-iso = {NANOMATERIALS-BASEL},
	journal = {NANOMATERIALS},
	volume = {12},
	unique-id = {32816292},
	abstract = {When exposed to an alternating magnetic field, superparamagnetic nanoparticles can elicit the required hyperthermic effect while also being excellent magnetic resonance imaging (MRI) contrast agents. Their main drawback is that they diffuse out of the area of interest in one or two days, thus preventing a continuous application during the typical several-cycle multi-week treatment. To solve this issue, our aim was to synthesise an implantable, biodegradable membrane infused with magnetite that enabled long-term treatment while having adequate MRI contrast and hyperthermic capabilities. To immobilise the nanoparticles inside the scaffold, they were synthesised inside hydrogel fibres. First, polysuccinimide (PSI) fibres were produced by electrospinning and crosslinked, and then, magnetitc iron oxide nanoparticles (MIONs) were synthesised inside and in-between the fibres of the hydrogel membranes with the well-known co-precipitation method. The attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR) investigation proved the success of the chemical synthesis and the presence of iron oxide, and the superconducting quantum interference device (SQUID) study revealed their superparamagnetic property. The magnetic hyperthermia efficiency of the samples was significant. The given alternating current (AC) magnetic field could induce a temperature rise of 5 degrees C (from 37 degrees C to 42 degrees C) in less than 2 min even for five quick heat-cool cycles or for five consecutive days without considerable heat generation loss in the samples. Short-term (1 day and 7 day) biocompatibility, biodegradability and MRI contrast capability were investigated in vivo on Wistar rats. The results showed excellent MRI contrast and minimal acute inflammation.},
	keywords = {MRI; HYPERTHERMIA; Electrospinning; Polysuccinimide; Theranostics; Magnetic iron oxide nanoparticles},
	year = {2022},
	eissn = {2079-4991},
	orcid-numbers = {Molnár, Kristóf/0000-0002-5393-2130; Ferencz, Andrea/0000-0002-1623-9783; Márkus, Bence Gábor/0000-0003-1472-0482; Reiniger, Lilla/0000-0003-2248-4264; Csákiné Tombácz, Etelka/0000-0002-2068-0459; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X}
}

@article{MTMT:32551575,
	title = {Distinct miRNA expression signatures of primary and secondary central nervous system lymphomas},
	url = {https://m2.mtmt.hu/api/publication/32551575},
	author = {Sebestyén, Endre and Nagy, Ákos and Marosvári, Dóra and Rajnai, Hajnalka and Kajtár, Béla and Deák, Beáta and Matolcsy, András and Brandner, Sebastian and Storhoff, James and Chen, Ning and Bagó, Attila György and Bödör, Csaba and Reiniger, Lilla},
	doi = {10.1016/j.jmoldx.2021.11.005},
	journal-iso = {J MOL DIAGN},
	journal = {JOURNAL OF MOLECULAR DIAGNOSTICS},
	volume = {24},
	unique-id = {32551575},
	issn = {1525-1578},
	abstract = {Central nervous system (CNS) lymphoma is a rare and aggressive non-Hodgkin lymphoma that might arise in the CNS (primary CNS lymphoma, PCNSL) or disseminates from a systemic lymphoma to the CNS (secondary CNS lymphoma, SCNSL). Dysregulated expression of microRNAs (miRNAs) is associated with various pathological processes and miRNA expression patterns may have diagnostic, prognostic and therapeutic implications. However, miRNA expression is understudied in CNS lymphomas. We performed expression analysis of 798 miRNAs in 73 CNS lymphoma samples using the NanoString platform, followed by an analysis to identify potential diagnostic biomarkers characterizing subgroups and to examine differences based on their primary and secondary nature, molecular subtype, mutational patterns and survival. We identified 31 differentially expressed miRNAs between primary and secondary groups. Additionally, we identified 7 more miRNAs associated with a molecular subtype and 25 associated with mutation status. Using unsupervised clustering methods, we defined a small but distinct primary CNS lymphoma subgroup, with characteristically different expression patterns compared to the rest of the cases. Finally, we identified differentially regulated pathways in the above comparisons and assessed the utility of miRNA expression patterns in predicting survival. Our study identifies a novel CNS lymphoma subgroup defined by distinct miRNAs, proves the importance of specific miRNAs and pathways in their pathogenesis, and provides the basis for future research in defining potential biomarkers.},
	keywords = {microRNA; Molecular subtype; NanoString; Brain lymphoma; PCNSL},
	year = {2022},
	eissn = {1943-7811},
	pages = {224-240},
	orcid-numbers = {Sebestyén, Endre/0000-0001-5470-2161; Rajnai, Hajnalka/0000-0003-0934-5366; Kajtár, Béla/0000-0001-5551-3709; Matolcsy, András/0000-0002-5382-2150; Bödör, Csaba/0000-0002-0729-692X; Reiniger, Lilla/0000-0003-2248-4264}
}

@article{MTMT:32304658,
	title = {Az interleukin-6-expresszió vizsgálata colorectalis adenocarcinomában szenvedő betegeken},
	url = {https://m2.mtmt.hu/api/publication/32304658},
	author = {Jósa, Valéria and Féderer, Krisztina and Zrubka, Zsombor and Reiniger, Lilla and Baranyai, Zsolt},
	doi = {10.1556/650.2021.32206},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {162},
	unique-id = {32304658},
	issn = {0030-6002},
	year = {2021},
	eissn = {1788-6120},
	pages = {1502-1507},
	orcid-numbers = {Zrubka, Zsombor/0000-0002-1992-6087; Reiniger, Lilla/0000-0003-2248-4264}
}

@article{MTMT:32153027,
	title = {Poly(amino acid) based fibrous membranes with tuneable in vivo biodegradation},
	url = {https://m2.mtmt.hu/api/publication/32153027},
	author = {Molnár, Kristóf and Voniatis, Constantinos and Fehér, Daniella and Szabó, Györgyi and Pázmány, Rita and Reiniger, Lilla and Juriga, Dávid and Kiss, Zoltan and Molnárné Krisch, Enikő and Wéber, György and Ferencz, Andrea and Varga, Gábor and Zrínyi, Miklós and S. Nagy, Krisztina and Jedlovszky-Hajdú, Angéla},
	doi = {10.1371/journal.pone.0254843},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {16},
	unique-id = {32153027},
	issn = {1932-6203},
	year = {2021},
	eissn = {1932-6203},
	orcid-numbers = {Molnár, Kristóf/0000-0002-5393-2130; Szabó, Györgyi/0000-0002-3290-0797; Reiniger, Lilla/0000-0003-2248-4264; Juriga, Dávid/0000-0003-2655-5584; Wéber, György/0000-0003-3802-5812; Ferencz, Andrea/0000-0002-1623-9783; Varga, Gábor/0000-0002-5506-8198; Zrínyi, Miklós/0000-0002-9362-3199; S. Nagy, Krisztina/0000-0002-4942-2947; Jedlovszky-Hajdú, Angéla/0000-0003-2720-783X}
}