@article{MTMT:3104826, title = {Atypical teratoid/rhabdoid tumor arising in a malignant glioma}, url = {https://m2.mtmt.hu/api/publication/3104826}, author = {Bozzai, Barbara and Hasselblatt, M and Turányi, Eszter and Fruhwald, MC and Siebert, R and Bens, S and Schneppenheim, R and Kool, M and Stelczer, Gábor and Hortobágyi, Tibor and Hauser, Péter}, doi = {10.1002/pbc.26173}, journal-iso = {PEDIATR BLOOD CANCER}, journal = {PEDIATRIC BLOOD & CANCER}, volume = {64}, unique-id = {3104826}, issn = {1545-5009}, abstract = {Atypical teratoid/rhabdoid tumor (AT/RT), a highly malignant brain tumor in young children, usually arises de novo and has only rarely been described as a secondary malignancy. Here, we present a case of a child with glioblastoma, who was treated postoperatively by a combination of temozolomide, irradiation, and bevacizumab. AT/RT was diagnosed as a secondary tumor, 2.5 years following primary diagnosis. The child died 13 months after the diagnosis of AT/RT. This case demonstrates that malignant gliomas may give rise to AT/RT. It also emphasizes the diagnostic value of a repeated tumor biopsy in the recurrence setting.}, year = {2017}, eissn = {1545-5017}, pages = {96-99}, orcid-numbers = {Bozzai, Barbara/0000-0002-8128-0328; Stelczer, Gábor/0000-0003-4984-6165; Hortobágyi, Tibor/0000-0001-5732-7942; Hauser, Péter/0000-0002-8307-8975} } @article{MTMT:3094750, title = {High expression of DNA methyltransferases in primary human medulloblastoma}, url = {https://m2.mtmt.hu/api/publication/3094750}, author = {Pócza, Tímea and Krenács, Tibor and Turányi, Eszter and Csáthy, J and Jakab, Zsuzsanna and Hauser, Péter}, doi = {10.5114/fn.2016.60365}, journal-iso = {FOLIA NEUROPATHOL}, journal = {FOLIA NEUROPATHOLOGICA}, volume = {54}, unique-id = {3094750}, issn = {1641-4640}, year = {2016}, eissn = {1509-572X}, pages = {105-113}, orcid-numbers = {Krenács, Tibor/0000-0001-9164-065X; Jakab, Zsuzsanna/0000-0002-8231-0357; Hauser, Péter/0000-0002-8307-8975} } @article{MTMT:3023608, title = {Corticobasal Syndrome Due to Superficial Siderosis Caused by Thalamic Cavernoma}, url = {https://m2.mtmt.hu/api/publication/3023608}, author = {Bihari, J and Hornyák, Csilla and Szőke, Kristóf and Vajda, János and Bagó, Attila György and Varallyay, G and Turányi, Eszter and Rozsa, I and Debreczeni, Róbert and Bereczki, Dániel and Kovács, Tibor}, doi = {10.1176/appi.neuropsych.15080196}, journal-iso = {J NEUROPSYCH CLIN N}, journal = {JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES}, volume = {28}, unique-id = {3023608}, issn = {0895-0172}, year = {2016}, eissn = {1545-7222}, pages = {e15-e16}, orcid-numbers = {Hornyák, Csilla/0000-0003-1273-5883; Szőke, Kristóf/0000-0001-5289-7508; Debreczeni, Róbert/0000-0001-5115-2125; Bereczki, Dániel/0000-0002-8374-0500; Kovács, Tibor/0000-0002-8603-8848} } @article{MTMT:2946462, title = {Evaluation of the good tumor response of embryonal tumor with abundant neuropil and true rosettes (ETANTR).}, url = {https://m2.mtmt.hu/api/publication/2946462}, author = {Mózes, Petra and Hauser, Péter and Hortobágyi, Tibor and Benyó, Gábor and Peták, István and Garami, Miklós and Cserháti, Adrienn and Bartyik, Katalin and Bognár, László and Nagy, Zoltán and Turányi, Eszter and Hideghéty, Katalin}, doi = {10.1007/s11060-015-1938-3}, journal-iso = {J NEURO-ONCOL}, journal = {JOURNAL OF NEURO-ONCOLOGY}, volume = {126}, unique-id = {2946462}, issn = {0167-594X}, abstract = {The embryonal tumor with abundant neuropil and true rosettes is a rare and highly malignant variant of embryonal brain tumors. It usually affects infants and young children under the age of 4 years and exhibits a very aggressive course with a dismal prognosis. For the 68 cases reported to date the mean age at diagnosis was 25.42 months (range 3-57 months). Survival data are available for 48 children (including our case): the median overall survival is 13.0 months, though 6 (9 %) of the children have had a relative long survival (>30 months). The aggressive combined treatment, involving primary surgical tumor removal, adjuvant polychemotherapy, including high-dose chemotherapy with stem cell transplantation, radiotherapy and radiochemotherapy, might play an important role in the longer survival. We have performed a literature review and we present here a multimodal-treated case of a 2- year-old girl with a long survival, who was reoperated when recurrence occurred. The residual tumor demonstrated a good response to temozolomide radiochemotherapy (craniospinal axis + boost) and followed by maintenance temozolomide. The described complex aggressive treatment option might be considered for future cases of this tumor entity.}, year = {2016}, eissn = {1573-7373}, pages = {99-105}, orcid-numbers = {Mózes, Petra/0000-0002-2411-7719; Hauser, Péter/0000-0002-8307-8975; Hortobágyi, Tibor/0000-0001-5732-7942; Peták, István/0000-0003-0422-9286; Garami, Miklós/0000-0003-4298-2746; Hideghéty, Katalin/0000-0001-7080-2365} } @article{MTMT:2937994, title = {Evolution of Flow-Diverter Endothelialization and Thrombus Organization in Giant Fusiform Aneurysms after Flow Diversion: A Histopathologic Study.}, url = {https://m2.mtmt.hu/api/publication/2937994}, author = {Szikora, István and Turányi, Eszter and Marosfői, Miklós}, doi = {10.3174/ajnr.A4336}, journal-iso = {AM J NEURORADIOL}, journal = {AMERICAN JOURNAL OF NEURORADIOLOGY}, volume = {36}, unique-id = {2937994}, issn = {0195-6108}, abstract = {BACKGROUND AND PURPOSE: Treatment of giant fusiform aneurysms with flow diverters has been associated with a relatively high rate of complications. Our goal was to study the evolution of flow-diverter endothelialization and thrombus organization at different time points after flow-diverter treatment in giant fusiform aneurysms to better understand reasons for flow-diverter thrombosis and delayed aneurysm ruptures. MATERIALS AND METHODS: Two giant anterior and 2 posterior circulation aneurysms, all of which had partially thrombosed before treatment, were studied. An unruptured, untreated posterior circulation aneurysm was used as a control. Each specimen was removed at 7 days or at 6, 9, or 13 months after flow-diverter treatment. The 3 patients who survived longer than 7 days were followed up by angiography and MR imaging. Formaldehyde-fixed paraffin-embedded sections were stained by using H&E, Van Gieson elastic, CD34, h-Caldesmon, and Picrosirius stains and studied by light microscopy. RESULTS: According to angiography, aneurysms were found to be obliterated partially at 6 and 9 months and completely at 13 months. MR imaging revealed that mass effect remained unchanged in each case. Sections of the flow diverter within the normal parent artery were covered by an endothelialized fibrous layer as early as 6 months, but there was no tissue coverage or endothelialization seen even at 13 months inside the aneurysm itself. Each treated aneurysm had a thin wall with complete lack of smooth muscle cells. No signs of thrombus organization were found at any of the time points studied. CONCLUSIONS: Endothelialization of the flow diverter in giant fusiform aneurysms may not occur and thrombus organization may not be initiated inside these aneurysms for as long as 1 year, which explains delayed flow-diverter thrombosis and the possibility of delayed ruptures.}, year = {2015}, eissn = {1936-959X}, pages = {1716-1720}, orcid-numbers = {Szikora, István/0000-0003-3730-3278; Marosfői, Miklós/0000-0001-8202-1603} } @article{MTMT:2932578, title = {Search for comorbidities before the surgery of aortic stenosis.}, url = {https://m2.mtmt.hu/api/publication/2932578}, author = {Pump, Ágnes and Robert, B and Turányi, Eszter}, doi = {10.1093/eurheartj/ehu399}, journal-iso = {EUR HEART J}, journal = {EUROPEAN HEART JOURNAL}, volume = {36}, unique-id = {2932578}, issn = {0195-668X}, year = {2015}, eissn = {1522-9645}, pages = {2471-2471} } @article{MTMT:2859803, title = {Az agydaganatok molekuláris diagnosztikája}, url = {https://m2.mtmt.hu/api/publication/2859803}, author = {Reiniger, Lilla and Hanzély, Z and Bálint, Katalin and Turányi, Eszter}, journal-iso = {KLINIKAI ONKOLÓGIA}, journal = {KLINIKAI ONKOLÓGIA}, volume = {2}, unique-id = {2859803}, issn = {2064-5058}, year = {2015}, pages = {51-55}, orcid-numbers = {Reiniger, Lilla/0000-0003-2248-4264} } @article{MTMT:2821045, title = {Expression of proliferation markers Ki67, cyclin A, geminin and aurora-kinase A in primary breast carcinomas and corresponding distant metastases.}, url = {https://m2.mtmt.hu/api/publication/2821045}, author = {Tőkés, Anna-Mária and Szász, Attila Marcell and Geszti, F and Lukacs, LV and Kenessey, István and Turányi, Eszter and Meggyesházi, Nóra and Molnár, István Artúr and Fillinger, János and Soltesz, I and Bálint, Katalin and Hanzely, Z and Arató, Gabriella and Szendrői, Miklós and Kulka, Janina}, doi = {10.1136/jclinpath-2014-202607}, journal-iso = {J CLIN PATHOL}, journal = {JOURNAL OF CLINICAL PATHOLOGY}, volume = {68}, unique-id = {2821045}, issn = {0021-9746}, abstract = {AIMS: To assess the expression of the following cell cycle regulatory proteins in primary metastatic breast carcinomas (MBCs) and on availability in matched distant metastases (DMs): Ki67, cyclin A, geminin and aurora-kinase A (aurkA); and to compare the expression of these markers in early MBC (EMBC) and late MBC separated into groups according to median time point on metastatic event occurred (28 months). METHODS: The expression of the above mentioned markers was analysed in a total of 47 primary MBCs and 59 DMs (out of which 37 were pairs) by immunohistochemistry. Fourteen breast carcinomas with no relapse over a 10-year follow-up period were utilised as control cases (CBC). RESULTS: Among the MBCs, 22 metastasised to the bone, 4 to the lung and 21 to the central nervous system (CNS). Geminin (p<0.001) and Ki67 (p=0.001) were increased in the MBCs while aurkA and cyclin A showed no difference when compared with CBCs. There were no differences between aurkA, cyclin A and geminin expression in MBCs and DMs in general. Expression of Ki67 was, however, elevated (p=0.027) in DMs. In CNS metastases all markers showed elevated expression as compared to MBCs. In bone metastases, geminin was lower (p<0.001) compared with primary MBCs. In the metastases of the lung, the evaluated markers did not show different expression. According to the median follow-up until the metastatic event, Ki67 was found to be significantly elevated in EMBC (p=0.018). CONCLUSIONS: Ki67 index and geminin distinguish a fraction of MBC with worse prognosis, showing increased levels in the latter in comparison to CBC being tumour-free over a 10-year follow-up period. Ki67 could possibly identify a group of MBCs that develop early DMs.}, keywords = {Aged; Adult; Female; Middle Aged; Humans; immunohistochemistry; Hungary; Predictive Value of Tests; Retrospective Studies; Aged, 80 and over; Risk Factors; Time Factors; *Cell Proliferation; Disease-Free Survival; Kaplan-Meier Estimate; Tissue Array Analysis; Ki-67 Antigen/*analysis; Lung Neoplasms/enzymology/secondary; Geminin/*analysis; Cyclin A/*analysis; Central Nervous System Neoplasms/enzymology/secondary; Carcinoma/*enzymology/mortality/*secondary/therapy; Breast Neoplasms/*enzymology/mortality/*pathology/therapy; Bone Neoplasms/enzymology/secondary; Aurora Kinase A/*analysis}, year = {2015}, eissn = {1472-4146}, pages = {274-282}, orcid-numbers = {Tőkés, Anna-Mária/0000-0002-9581-7536; Szász, Attila Marcell/0000-0003-2739-4196; Kenessey, István/0000-0002-6963-8489; Szendrői, Miklós/0000-0002-3762-244X; Kulka, Janina/0000-0001-6498-5943} } @article{MTMT:2836367, title = {SYMPTOMATIC SUBEPENDYMOMAS OF THE VENTRICLES. REVIEW OF TWENTY CONSECUTIVE CASES}, url = {https://m2.mtmt.hu/api/publication/2836367}, author = {Vitanovics, Dusan and Áfra, Dénes and Nagy, Gábor and Hanzely, Z and Turányi, Eszter and Banczerowski, Péter}, journal-iso = {IDEGGYOGY SZEMLE}, journal = {IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE}, volume = {67}, unique-id = {2836367}, issn = {0019-1442}, year = {2014}, eissn = {2498-6208}, pages = {415-419}, orcid-numbers = {Nagy, Gábor/0000-0001-8831-3340; Banczerowski, Péter/0000-0003-2144-5298} } @article{MTMT:2748825, title = {Expression of proliferation markers Aurora kinase A, geminin, Cyclin A and Ki67 in primary breast carcinomas and corresponding distant metastases}, url = {https://m2.mtmt.hu/api/publication/2748825}, author = {Tokes, A and Szász, Attila Marcell and Kenessey, István and Lukacs, L V and Turányi, Eszter and Meggyesházi, Nóra and Harsanyi, L and Arató, Gabriella and Szendrői, Miklós and Kulka, J}, journal-iso = {EUR J CANCER}, journal = {EUROPEAN JOURNAL OF CANCER}, volume = {50}, unique-id = {2748825}, issn = {0959-8049}, year = {2014}, eissn = {1879-2995}, pages = {S193-S193}, orcid-numbers = {Szász, Attila Marcell/0000-0003-2739-4196; Kenessey, István/0000-0002-6963-8489; Szendrői, Miklós/0000-0002-3762-244X} }