@article{MTMT:34538356, title = {Effectiveness of SARS-CoV-2 primary vaccines and boosters in patients with type 2 diabetes mellitus in Hungary (HUN-VE 4 Study)}, url = {https://m2.mtmt.hu/api/publication/34538356}, author = {Molnár, Gergő Attila and Vokó, Zoltán and Sütő, Gábor and Rokszin, György Aurél and Nagy, Dávid and Surján, György and Surján, Orsolya and Nagy, Péter and Kenessey, István and Wéber, András and Pálosi, Mihály and Müller, Cecília and Kásler, Miklós and Wittmann, István and Kiss, Zoltán}, doi = {10.1136/bmjdrc-2023-003777}, journal-iso = {BMJ OPEN DIAB RES CA}, journal = {BMJ OPEN DIABETES RESEARCH & CARE}, volume = {12}, unique-id = {34538356}, abstract = {Introduction Type 2 diabetes mellitus is a risk factor for severe COVID-19 infection and is associated with increased risk of complications. The present study aimed to investigate effectiveness and persistence of different COVID vaccines in persons with or without diabetes during the Delta wave in Hungary.Research design and methods Data sources were the national COVID-19 registry data from the National Public Health Center and the National Health Insurance Fund on the total Hungarian population. The adjusted incidence rate ratios and corresponding 95% CIs were derived from a mixed-effect negative binomial regression model.Results A population of 672 240 cases with type 2 diabetes and a control group of 2 974 102 non-diabetic persons free from chronic diseases participated. Unvaccinated elderly persons with diabetes had 2.68 (95% CI 2.47 to 2.91) times higher COVID-19-related mortality rate as the ‘healthy’ controls. Primary immunization effectively equalized the risk of COVID-19 mortality between the two groups. Vaccine effectiveness declined over time, but the booster restored the effectiveness against mortality to over 90%. The adjusted vaccine effectiveness of the primary Pfizer-BioNTech against infection in the 14–120 days of postvaccination period was 71.6 (95% CI 66.3 to 76.1)% in patients aged 65–100 years with type 2 diabetes and 64.52 (95% CI 59.2 to 69.2)% in the controls. Overall, the effectiveness tended to be higher in individuals with diabetes than in controls. The booster vaccines could restore vaccine effectiveness to over 80% concerning risk of infection (eg, patients with diabetes aged 65–100 years: 89.1 (88.1–89.9)% with Pfizer-on-Pfizer, controls 65–100 years old: 86.9 (85.8–88.0)% with Pfizer-on-Pfizer, or patients with diabetes aged 65–100 years: 88.3 (87.2–89.2)% with Pfizer-on-Sinopharm, controls 65–100 years old: 87.8 (86.8–88.7)% with Pfizer-on-Sinopharm).Conclusions Our data suggest that people with type 2 diabetes may have even higher health gain when getting vaccinated as compared with non-diabetic persons, eliminating the marked, COVID-19-related excess risk of this population. Boosters could restore protection.Data are available upon reasonable request.}, year = {2024}, eissn = {2052-4897}, orcid-numbers = {Molnár, Gergő Attila/0000-0001-6052-5907; Vokó, Zoltán/0000-0002-1004-1848; Surján, György/0000-0001-5836-7647; Nagy, Péter/0000-0003-3393-235X; Kenessey, István/0000-0002-6963-8489; Wéber, András/0000-0003-1605-8226; Kásler, Miklós/0000-0002-7235-8787; Kiss, Zoltán/0000-0002-4752-8529} } @misc{MTMT:34655963, title = {Az erdélyi székelyek alpopuláció-szintű vizsgálata nagy felbontású autoszomális marker adatok alkalmazásával}, url = {https://m2.mtmt.hu/api/publication/34655963}, author = {Bánfai, Zsolt and Ádám, Valerián and Sümegi, Katalin and Szabó, András and Büki, Gergely and Magyari, Lili and Hadzsiev, Kinga and Kásler, Miklós and Melegh, Béla}, unique-id = {34655963}, year = {2023}, orcid-numbers = {Kásler, Miklós/0000-0002-7235-8787} } @article{MTMT:34411671, title = {Waning of SARS-CoV-2 Vaccine Effectiveness in COPD Patients. Lessons from the Delta Variant}, url = {https://m2.mtmt.hu/api/publication/34411671}, author = {Polivka, Lőrinc and Vályi-Nagy, István and Szekanecz, Zoltán and Bogos, Krisztina and Vágó, Hajnalka and Kamondi, Anita and Fekete, Ferenc and Szlavik, Janos and Surjan, György and Surjan, Orsolya and Nagy, Péter and Schaff, Zsuzsa and Kiss, Zoltán and Müller, Cecilia and Kásler, Miklós and Müller, Veronika}, doi = {10.3390/vaccines11121786}, journal-iso = {VACCINES-BASEL}, journal = {VACCINES (BASEL)}, volume = {11}, unique-id = {34411671}, abstract = {Although the COVID-19 pandemic is profoundly changing, data on the effect of vaccination and duration of protection against infection and severe disease can still be advantageous, especially for patients with COPD, who are more vulnerable to respiratory infections. The Hungarian COVID-19 registry was retrospectively investigated for risk of infection and hospitalization by time since the last vaccination, and vaccine effectiveness (VE) was calculated in adults with COPD diagnosis and an exact-matched control group during the Delta variant of concern (VOC) wave in Hungary (September–December 2021). For the matching, sex, age, major co-morbidities, vaccination status, and prior infection data were obtained on 23 August 2021. The study population included 373,962 cases divided into COPD patients (age: 66.67 ± 12.66) and a 1:1 matched group (age: 66.73 ± 12.67). In both groups, the female/male ratio was 52.2:47.7, respectively. Among the unvaccinated, there was no difference between groups in risk for infection or hospitalization. Regarding vaccinated cases, in the COPD group, a slightly faster decline in effectiveness was noted for hospitalization prevention, although in both groups, the vaccine lost its significant effect between 215 and 240 days after the last dose of vaccination. Based on a time-stratified multivariate Cox analysis of the vaccinated cases, the hazard was constantly higher in the COPD group, with an HR of 1.09 (95%: 1.05–1.14) for infection and 1.87 (95% CI: 1.59–2.19) for hospitalization. In our study, COPD patients displayed lower vaccine effectiveness against SARS-CoV-2 infection and hospitalization but a similar waning trajectory, as vaccines lost their preventive effect after 215 days. These data emphasize revaccination measures in the COPD patient population.}, keywords = {COPD; Vaccine effectiveness; COVID-19; VE; Waning}, year = {2023}, eissn = {2076-393X}, orcid-numbers = {Polivka, Lőrinc/0009-0004-9576-2776; Vágó, Hajnalka/0000-0002-3568-3572; Kamondi, Anita/0000-0001-9860-730X; Nagy, Péter/0000-0003-3393-235X; Schaff, Zsuzsa/0000-0002-6429-8059; Kiss, Zoltán/0000-0002-4752-8529; Kásler, Miklós/0000-0002-7235-8787; Müller, Veronika/0000-0002-1398-3187} } @article{MTMT:33551270, title = {Characterization of Danube Swabian population samples on a high-resolution genome-wide basis}, url = {https://m2.mtmt.hu/api/publication/33551270}, author = {Bánfai, Zsolt and Kövesdi, Erzsébet and Sümegi, Katalin and Büki, Gergely and Szabó, András and Magyari, Lili and Ádám, Valerián and Pálos, Ferenc and Miseta, Attila János and Kásler, Miklós and Melegh, Béla}, doi = {10.1186/s12864-022-09092-5}, journal-iso = {BMC GENOMICS}, journal = {BMC GENOMICS}, volume = {24}, unique-id = {33551270}, issn = {1471-2164}, year = {2023}, eissn = {1471-2164}, orcid-numbers = {Miseta, Attila János/0000-0002-7984-3347; Kásler, Miklós/0000-0002-7235-8787} } @book{MTMT:34757822, title = {Életközelben: : interjúk a miniszterrel 2020.05.28-2022.03.26}, url = {https://m2.mtmt.hu/api/publication/34757822}, editor = {Balogh, Andrea Johanna and Gazsó, L. Ferenc}, publisher = {EMMI}, unique-id = {34757822}, year = {2022}, orcid-numbers = {Kásler, Miklós/0000-0002-7235-8787} } @misc{MTMT:33697346, title = {Magyar válaszok a pandémiára}, url = {https://m2.mtmt.hu/api/publication/33697346}, author = {Kásler, Miklós}, unique-id = {33697346}, year = {2022}, orcid-numbers = {Kásler, Miklós/0000-0002-7235-8787} } @article{MTMT:33257861, title = {The genetic legacy of the Hunyadi descendants}, url = {https://m2.mtmt.hu/api/publication/33257861}, author = {Neparáczki, Endre and Kis, Luca and Maróti, Zoltán and Kovács, Bence and Varga, Gergely István and Makoldi, Miklós Zsombor and Pamjav, Horolma and Teiszler, Éva and Tihanyi, Balázs and Nagy, Péter L. and Maár, Kitti and Gyenesei, Attila and Schütz, Oszkár and Dudás, Eszter and Török, Tibor and Pascuttini-Juraga, Vesna and Peharda, Ivančica and Vizi, László Tamás and Horváth-Lugossy, Gábor and Kásler, Miklós}, doi = {10.1016/j.heliyon.2022.e11731}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {8}, unique-id = {33257861}, abstract = {The Hunyadi family is one of the most influential families in the history of Central Europe in the 14th–16th centuries. The family’s prestige was established by Johannes Hunyadi, a Turk-beater who rose to the position of governor of the Kingdom of Hungary. His second son, Matthias Hunyadi, became the elected ruler of the Kingdom of Hungary in 1458. The Hunyadi family had unknown origin. Moreover, Matthias failed to found a dynasty because of lacking a legitimate heir and his illegitimate son Johannes Corvinus was unable to obtain the crown. His grandson, Christophorus Corvinus, died in childhood, thus the direct male line of the family ended. In the framework of on interdisciplinary research, we have determined the whole genome sequences of Johannes Corvinus and Christophorus Corvinus by next-generation sequencing technology. Both of them carried the Y-chromosome haplogroup is E1b1b1a1b1a6a1c ~, which is widespread in Eurasia. The father-son relationship was verified using the classical STR method and whole genome data. Christophorus Corvinus belongs to the rare, sporadically occurring T2c1þ146 mitochondrial haplogroup, most frequent around the Mediterranean, while his father belongs to the T2b mitochondrial haplogroup, widespread in Eurasia, both are consistent with the known origin of the mothers. Archaeogenomic analysis indicated that the Corvinus had an ancient European genome composition. Based on the reported genetic data, it will be possible to identify all the other Hunyadi family member, whose only known grave site is known, but who are resting assorted with several other skeletons.}, keywords = {ancient genomes; Hunyadi; Corvinus; Hungarian Nobel family}, year = {2022}, eissn = {2405-8440}, orcid-numbers = {Neparáczki, Endre/0000-0003-3466-0368; Kis, Luca/0000-0002-1021-2854; Maróti, Zoltán/0000-0002-0515-117X; Kovács, Bence/0000-0002-4915-1462; Varga, Gergely István/0000-0001-9073-5788; Teiszler, Éva/0000-0002-2077-4308; Tihanyi, Balázs/0000-0001-5124-4468; Nagy, Péter L./0000-0002-7461-8415; Maár, Kitti/0000-0002-1207-6569; Schütz, Oszkár/0000-0001-5521-3044; Török, Tibor/0000-0002-2128-1126; Vizi, László Tamás/0000-0003-2623-131X; Kásler, Miklós/0000-0002-7235-8787} } @misc{MTMT:33241655, title = {A Magyarországon alkalmazott koronavírus vakcinák hatékonysága és tartóssága 2-es típusú cukorbetegekben : a Hun-Ve 4 vizsgálat}, url = {https://m2.mtmt.hu/api/publication/33241655}, author = {Kiss, Zoltán and Vokó, Zoltán and Sütő, Gábor and Molnár, Gergely Attila and Nagy, Dávid and Surján, György and Surján, Orsolya and Nagy, Péter and Kenessey, István and Wéber, András and Pálosi, Mihály and Müller, Cecília and Kásler, Miklós and Wittmann, István}, unique-id = {33241655}, year = {2022}, orcid-numbers = {Surján, György/0000-0001-5836-7647; Nagy, Péter/0000-0003-3393-235X; Kenessey, István/0000-0002-6963-8489; Wéber, András/0000-0003-1605-8226; Kásler, Miklós/0000-0002-7235-8787} } @misc{MTMT:33241545, title = {A koronavírus fertőzés incidenciája, és a fertőzéssel kapcsolatos halálozás 2-es típusú diabeteses betegekben : Hun-Cov-Diab 1 tanulmány}, url = {https://m2.mtmt.hu/api/publication/33241545}, author = {Sütő, Gábor and Vokó, Zoltán and Laczy, Boglárka and Molnár, Gergő Attila and Kiss, Zoltán and Nagy, Dávid and Surján, György and Surján, Orsolya and Nagy, Péter and Kenessey, István and Wéber, András and Pálosi, Mihály and Müller, Cecília and Kásler, Miklós and Wittmann, István}, unique-id = {33241545}, year = {2022}, orcid-numbers = {Molnár, Gergő Attila/0000-0001-6052-5907; Surján, György/0000-0001-5836-7647; Nagy, Péter/0000-0003-3393-235X; Kenessey, István/0000-0002-6963-8489; Wéber, András/0000-0003-1605-8226; Kásler, Miklós/0000-0002-7235-8787} } @article{MTMT:33097331, title = {Comparison of Cancer Survival Trends in Hungary in the Periods 2001–2005 and 2011–2015 According to a Population-Based Cancer Registry}, url = {https://m2.mtmt.hu/api/publication/33097331}, author = {Kenessey, István and Szőke, Georgina and Dobozi, Mária and Szatmári, István and Wéber, András and Fogarassy, György and Nagy, Péter and Kásler, Miklós and Polgár, Csaba and Fogarassyné Vathy, Ágnes}, doi = {10.3389/pore.2022.1610668}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {28}, unique-id = {33097331}, issn = {1219-4956}, abstract = {Background: Assessment of population-based cancer survival may provide the most valuable feedback about the effectiveness of oncological surveillance and treatment.}, year = {2022}, eissn = {1532-2807}, orcid-numbers = {Kenessey, István/0000-0002-6963-8489; Wéber, András/0000-0003-1605-8226; Nagy, Péter/0000-0003-3393-235X; Kásler, Miklós/0000-0002-7235-8787; Polgár, Csaba/0000-0001-7245-0762; Fogarassyné Vathy, Ágnes/0000-0002-5524-1675} }