TY - THES AU - Sáska, Zsófia TI - Izomalt segédanyag alkalmazása granulátum és tabletta előállítása céljából PB - Semmelweis Egyetem PY - 2013 SP - 110 DO - 10.14753/SE.2013.1813 UR - https://m2.mtmt.hu/api/publication/2340515 ID - 2340515 LA - Hungarian DB - MTMT ER - TY - GEN AU - Sáska, Zsófia AU - Dredán, Judit AU - Bertalanné Balogh, Emese AU - Antal, István TI - Izomalt-tartalmú kéreg granulátumok előállítása és vizsgálata faktoriális kísérletterv segítségével CY - 2012. szeptember 27-29. PY - 2012 UR - https://m2.mtmt.hu/api/publication/2090148 ID - 2090148 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sáska, Zsófia AU - Dredán, Judit AU - Luhn, O AU - Bertalanné Balogh, Emese AU - Shafir, G AU - Antal, István TI - Evaluation of the impact of mixing speed on the compressibility and compactibility of paracetamol-isomalt containing granules with factorial design JF - POWDER TECHNOLOGY J2 - POWDER TECHNOL VL - 213 PY - 2011 IS - 1-3 SP - 132 EP - 140 PG - 9 SN - 0032-5910 DO - 10.1016/j.powtec.2011.07.019 UR - https://m2.mtmt.hu/api/publication/1690284 ID - 1690284 AB - The aim of the present study is to evaluate the effect of a new formulation parameter on the characteristics of dosage form and manufacturing process. In our previous work the effects of isomalt and compression force on compaction and tablet properties were investigated. In this research paper the particles were agglomerated with purified water without using other binders. To set up the 33 type factorial design a new independent variable - mixing speed (X2) - was added to paracetamol:isomalt ratio in granules (X1) and to compression force during the tabletting process (X3). Each of these variables was examined at three levels to characterize their power and interactions. As granule's properties mass flow, densities and particle size were investigated. From the aspect of compression process lubrication coefficient and friction work were the evaluated response variables. As tablet characteristics tablet resistance to crushing and tensile strength were studied. The results indicated that the agglomeration process did not need any other binders to obtain granules with good quality. Moreover, the addition of mixing speed as a new independent variable was appropriate, since it had significant effect among others on the particle size distribution of the granules and on tablet characteristics. According to the results of the tablet quality tests the optimal mixing speed at granulation is needed which offers not only sufficient homogeneity of the granules but also appropriate tablet characteristics. Furthermore, the enhancing effect of isomalt on the compaction of granules and on the tablet characteristics is observed. © 2011 Elsevier B.V. All rights reserved. LA - English DB - MTMT ER - TY - GEN AU - Sáska, Zsófia AU - Dredán, Judit AU - Bertalanné Balogh, Emese AU - Antal, István TI - Izomalt, mint kötőanyag hatása paracetamol-tartalmú granulátumok préselhetőségére PY - 2010 UR - https://m2.mtmt.hu/api/publication/2092647 ID - 2092647 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sáska, Zsófia AU - Dredán, Judit AU - Bertalanné Balogh, Emese AU - Luhn, O AU - Shafir, G AU - Antal, István TI - Effect of isomalt as novel binding agent on compressibility of poorly compactable paracetamol evaluated by factorial design JF - POWDER TECHNOLOGY J2 - POWDER TECHNOL VL - 201 PY - 2010 IS - 2 SP - 123 EP - 129 PG - 7 SN - 0032-5910 DO - 10.1016/j.powtec.2010.03.009 UR - https://m2.mtmt.hu/api/publication/1487285 ID - 1487285 AB - Tablets containing paracetamol were prepared by wet granulation. The model drug, paracetamol (API) and the diluent, milled isomalt (IM) were applied in different ratios where the granulation liquid was kept constant in each sample. The purpose of the study was to investigate the effect of wet granulation with milled isomalt on the tabletting properties of poorly compressible paracetamol. The results of tabletting process and the tablet characteristics were evaluated with 32 type face-centered full factorial design. The API:IM ratio (X1) and compression force (X2) were selected as independent variables. The dependent variables were as follows: the parameters of the tabletting process - lubrication coefficient (R-value), relative elasticity, friction work - and characteristics of the dosage form such as tablet hardness, friability, disintegration time, tensile strength. The results indicated that milled isomalt has an advantageous effect on both the process of compression and the tablet characteristics - due to its binder properties. Furthermore an optimal composition of the API and the diluent is to be found according to the compression process and the dosage form. © 2010 Elsevier B.V. LA - English DB - MTMT ER - TY - GEN AU - Sáska, Zsófia AU - Dredán, Judit AU - Bertalanné Balogh, Emese AU - Oliver, Luhn AU - Klebovich, Imre AU - Antal, István TI - Kötőanyag hatásának jellemzése a nehezen préselhető paracetamol tablettázhatóságára PY - 2009 UR - https://m2.mtmt.hu/api/publication/1496699 ID - 1496699 LA - Hungarian DB - MTMT ER - TY - GEN AU - Dredán, Judit AU - Kállai-Szabó, Nikolett AU - Sáska, Zsófia AU - Klebovich, Imre AU - Antal, István TI - Bevonó polimer keverékek fizikai, fizikai-kémiai vizsgálata PY - 2009 UR - https://m2.mtmt.hu/api/publication/1496691 ID - 1496691 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Sáska, Zsófia AU - Dredán, Judit AU - Bertalanné Balogh, Emese AU - Oliver, Luhn AU - Klebovich, Imre AU - Antal, István TI - Kötőanyag hatásának jellemzése a nehezen préselhető paracetamol tablettázhatóságára JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 53 PY - 2009 IS - Suppl 1. SP - S101 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/1491314 ID - 1491314 N1 - Abstr. P-73 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Dredán, Judit AU - Kállai-Szabó, Nikolett AU - Sáska, Zsófia AU - Klebovich, Imre AU - Antal, István TI - Bevonó polimer keverékek fizikai, fizikai-kémiai vizsgálata JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 53 PY - 2009 IS - Suppl 1. SP - S92 EP - S93 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/1491304 ID - 1491304 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Török, Tamás AU - Rácz, D AU - Sáska, Zsófia AU - Dávid, A Z AU - Tábi, Tamás AU - Zillikens, S AU - Nada, S A AU - Klebovich, Imre AU - Gyires, Klára AU - Magyar, Kálmán TI - Reverse Na+/Ca2+-exchange mediated Ca2+-entry and noradrenaline release in Na+-loaded peripheral sympathetic nerves JF - NEUROCHEMISTRY INTERNATIONAL J2 - NEUROCHEM INT VL - 53 PY - 2008 IS - 6-8 SP - 338 EP - 345 PG - 8 SN - 0197-0186 DO - 10.1016/j.neuint.2008.08.009 UR - https://m2.mtmt.hu/api/publication/1485437 ID - 1485437 N1 - Megjegyzés-10050052 FU: The National Scientific Research Foundation [1020, T017749, TS042595]; : The Health Science Council [237/96, 141/2003]; Semmelweis University : [G6]; Hungarian Academy of Sciences FX: We thank to Professor A.F. Brading (Department of Pharmacology, The : University of Oxford, U.K) for critical reading and discussion of the : manuscript. We also thank to Mrs. Agnes Gaborhazy for technical and Ms. : Erzsebet Horvath for secretarial assistance. This work was supported in : part by the following grants: The National Scientific Research : Foundation (OTKA, grant nos.: 1020, T017749, TS042595), The Health : Science Council (ETT, grant nos.: 237/96, 141/2003), Semmelweis : University (ETK-SOTE, grant no.: G6) and by a Grant from the Hungarian : Academy of Sciences provided to the "Neurochemical Research Group of : Semmelweis University". Megjegyzés-10065066 FU: The National Scientific Research Foundation [1020, T017749, TS042595]; : The Health Science Council [237/96, 141/2003]; Semmelweis University : [G6]; Hungarian Academy of Sciences FX: We thank to Professor A.F. Brading (Department of Pharmacology, The : University of Oxford, U.K) for critical reading and discussion of the : manuscript. We also thank to Mrs. Agnes Gaborhazy for technical and Ms. : Erzsebet Horvath for secretarial assistance. This work was supported in : part by the following grants: The National Scientific Research : Foundation (OTKA, grant nos.: 1020, T017749, TS042595), The Health : Science Council (ETT, grant nos.: 237/96, 141/2003), Semmelweis : University (ETK-SOTE, grant no.: G6) and by a Grant from the Hungarian : Academy of Sciences provided to the "Neurochemical Research Group of : Semmelweis University". Megjegyzés-10070049 FU: The National Scientific Research Foundation [1020, T017749, TS042595]; : The Health Science Council [237/96, 141/2003]; Semmelweis University : [G6]; Hungarian Academy of Sciences FX: We thank to Professor A.F. Brading (Department of Pharmacology, The : University of Oxford, U.K) for critical reading and discussion of the : manuscript. We also thank to Mrs. Agnes Gaborhazy for technical and Ms. : Erzsebet Horvath for secretarial assistance. This work was supported in : part by the following grants: The National Scientific Research : Foundation (OTKA, grant nos.: 1020, T017749, TS042595), The Health : Science Council (ETT, grant nos.: 237/96, 141/2003), Semmelweis : University (ETK-SOTE, grant no.: G6) and by a Grant from the Hungarian : Academy of Sciences provided to the "Neurochemical Research Group of : Semmelweis University". Megjegyzés-21528563 Chemicals/CAS: 4 aminopyridine, 1003-40-3, 504-24-5; calcium, 7440-70-2; cocaine, 50-36-2, 53- 21-4, 5937-29-1; corticosterone, 50-22-6; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; omega conotoxin, 92078-76-7; veratridine, 71-62-5; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium, 7440-70-2; Norepinephrine, 51-41-2; Potassium Channel Blockers; Sodium Channels; Sodium, 7440-23-5; Sodium-Calcium Exchanger; Veratridine, 71-62-5 Manufacturers: Sigma Megjegyzés-21528584 Chemicals/CAS: 4 aminopyridine, 1003-40-3, 504-24-5; calcium, 7440-70-2; cocaine, 50-36-2, 53-21-4, 5937-29-1; corticosterone, 50-22-6; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; omega conotoxin, 92078-76-7; veratridine, 71-62-5; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium, 7440-70-2; Norepinephrine, 51-41-2; Potassium Channel Blockers; Sodium Channels; Sodium, 7440-23-5; Sodium-Calcium Exchanger; Veratridine, 71-62-5 Manufacturers: Sigma Megjegyzés-21528602 Chemicals/CAS: 4 aminopyridine, 1003-40-3, 504-24-5; calcium, 7440-70-2; cocaine, 50-36-2, 53- 21-4, 5937-29-1; corticosterone, 50-22-6; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; omega conotoxin, 92078-76-7; veratridine, 71-62-5; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium, 7440-70-2; Norepinephrine, 51-41-2; Potassium Channel Blockers; Sodium Channels; Sodium, 7440-23-5; Sodium-Calcium Exchanger; Veratridine, 71-62-5 Manufacturers: Sigma Megjegyzés-21528690 Chemicals/CAS: 4 aminopyridine, 1003-40-3, 504-24-5; calcium, 7440-70-2; cocaine, 50-36-2, 53- 21-4, 5937-29-1; corticosterone, 50-22-6; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; omega conotoxin, 92078-76-7; veratridine, 71-62-5; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium, 7440-70-2; Norepinephrine, 51-41-2; Potassium Channel Blockers; Sodium Channels; Sodium, 7440-23-5; Sodium-Calcium Exchanger; Veratridine, 71-62-5 Manufacturers: Sigma Megjegyzés-21528552 Chemicals/CAS: 4 aminopyridine, 1003-40-3, 504-24-5; calcium, 7440-70-2; cocaine, 50-36-2, 53-21-4, 5937-29-1; corticosterone, 50-22-6; neomycin, 11004-65-2, 1404-04-2, 1405-10-3, 8026-22-0; omega conotoxin, 92078-76-7; veratridine, 71-62-5; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium, 7440-70-2; Norepinephrine, 51-41-2; Potassium Channel Blockers; Sodium Channels; Sodium, 7440-23-5; Sodium-Calcium Exchanger; Veratridine, 71-62-5 Manufacturers: Sigma AB - [3H]noradrenaline ([3H]NA) released from sympathetic nerves in the isolated main pulmonary artery of the rabbit was measured in response to field stimulation (2 Hz, 1 ms, 60 V for 3 min) in the presence of uptake blockers (cocaine, 3 × 10-5 M and corticosterone, 5 × 10-5 M). The [3H]NA-release was fully blocked by the combined application of the selective and irreversible 'N-type' voltage-sensitive Ca2+-channel (VSCC)-blocker ω-conotoxin (ω-CgTx) GVIA (10-8 M) and the 'non-selective' VSCC-blocker aminoglycoside antibiotic neomycin (3 × 10-3 M). Na+-loading (Na+-pump inhibition by K+-free perfusion) was required to elicit further NA-release after blockade of VSCCs (ω-CgTx GVIA + neomycin). In K+-free solution, in the absence of functioning VSCCs (ω-CgTx GVIA + neomycin), the fast Na+-channel activator veratridine (10-5 M) further potentiated the nerve-evoked release of [3H]NA. This NA-release was significantly inhibited by KB-R7943, and fully blocked by C ao2 + - removal. However, Li+-substitution was surprisingly ineffective. The non-selective K+-channel blocker 4-aminopyridine (4-AP, 10-4 M) also further potentiated the nerve-evoked release of NA in K+-free solution. This potentiated release was concentration-dependently inhibited by KB-R7943, significantly inhibited by Li+-substitution and abolished by C ao2 + - removal. It is concluded that in Na+-loaded sympathetic nerves, in which the VSCCs are blocked, the reverse Na+/Ca2+-exchange-mediated Ca2+-entry is responsible for transmitter release on nerve-stimulation. Theoretically we suppose that the fast Na+-channel and the exchanger proteins are close to the vesicle docking sites. © 2008 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER -