@mastersthesis{MTMT:2340515,
	title = {Izomalt segédanyag alkalmazása granulátum és tabletta előállítása céljából},
	url = {https://m2.mtmt.hu/api/publication/2340515},
	author = {Sáska, Zsófia},
	doi = {10.14753/SE.2013.1813},
	publisher = {Semmelweis Egyetem},
	unique-id = {2340515},
	year = {2013}
}

@misc{MTMT:2090148,
	title = {Izomalt-tartalmú kéreg granulátumok előállítása és vizsgálata faktoriális kísérletterv segítségével},
	url = {https://m2.mtmt.hu/api/publication/2090148},
	author = {Sáska, Zsófia and Dredán, Judit and Bertalanné Balogh, Emese and Antal, István},
	unique-id = {2090148},
	year = {2012},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Bertalanné Balogh, Emese/0000-0002-1127-3923; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:1690284,
	title = {Evaluation of the impact of mixing speed on the compressibility and compactibility of paracetamol-isomalt containing granules with factorial design},
	url = {https://m2.mtmt.hu/api/publication/1690284},
	author = {Sáska, Zsófia and Dredán, Judit and Luhn, O and Bertalanné Balogh, Emese and Shafir, G and Antal, István},
	doi = {10.1016/j.powtec.2011.07.019},
	journal-iso = {POWDER TECHNOL},
	journal = {POWDER TECHNOLOGY},
	volume = {213},
	unique-id = {1690284},
	issn = {0032-5910},
	abstract = {The aim of the present study is to evaluate the effect of a new formulation parameter on the characteristics of dosage form and manufacturing process. In our previous work the effects of isomalt and compression force on compaction and tablet properties were investigated. In this research paper the particles were agglomerated with purified water without using other binders. To set up the 33 type factorial design a new independent variable - mixing speed (X2) - was added to paracetamol:isomalt ratio in granules (X1) and to compression force during the tabletting process (X3). Each of these variables was examined at three levels to characterize their power and interactions. As granule's properties mass flow, densities and particle size were investigated. From the aspect of compression process lubrication coefficient and friction work were the evaluated response variables. As tablet characteristics tablet resistance to crushing and tensile strength were studied. The results indicated that the agglomeration process did not need any other binders to obtain granules with good quality. Moreover, the addition of mixing speed as a new independent variable was appropriate, since it had significant effect among others on the particle size distribution of the granules and on tablet characteristics. According to the results of the tablet quality tests the optimal mixing speed at granulation is needed which offers not only sufficient homogeneity of the granules but also appropriate tablet characteristics. Furthermore, the enhancing effect of isomalt on the compaction of granules and on the tablet characteristics is observed. © 2011 Elsevier B.V. All rights reserved.},
	keywords = {PARACETAMOL; compaction; Wet granulation; Isomalt; Factorial design},
	year = {2011},
	eissn = {1873-328X},
	pages = {132-140},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Bertalanné Balogh, Emese/0000-0002-1127-3923; Antal, István/0000-0002-5434-201X}
}

@misc{MTMT:2092647,
	title = {Izomalt, mint kötőanyag hatása paracetamol-tartalmú granulátumok préselhetőségére},
	url = {https://m2.mtmt.hu/api/publication/2092647},
	author = {Sáska, Zsófia and Dredán, Judit and Bertalanné Balogh, Emese and Antal, István},
	unique-id = {2092647},
	year = {2010},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Bertalanné Balogh, Emese/0000-0002-1127-3923; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:1487285,
	title = {Effect of isomalt as novel binding agent on compressibility of poorly compactable paracetamol evaluated by factorial design},
	url = {https://m2.mtmt.hu/api/publication/1487285},
	author = {Sáska, Zsófia and Dredán, Judit and Bertalanné Balogh, Emese and Luhn, O and Shafir, G and Antal, István},
	doi = {10.1016/j.powtec.2010.03.009},
	journal-iso = {POWDER TECHNOL},
	journal = {POWDER TECHNOLOGY},
	volume = {201},
	unique-id = {1487285},
	issn = {0032-5910},
	abstract = {Tablets containing paracetamol were prepared by wet granulation. The model drug, paracetamol (API) and the diluent, milled isomalt (IM) were applied in different ratios where the granulation liquid was kept constant in each sample. The purpose of the study was to investigate the effect of wet granulation with milled isomalt on the tabletting properties of poorly compressible paracetamol. The results of tabletting process and the tablet characteristics were evaluated with 32 type face-centered full factorial design. The API:IM ratio (X1) and compression force (X2) were selected as independent variables. The dependent variables were as follows: the parameters of the tabletting process - lubrication coefficient (R-value), relative elasticity, friction work - and characteristics of the dosage form such as tablet hardness, friability, disintegration time, tensile strength. The results indicated that milled isomalt has an advantageous effect on both the process of compression and the tablet characteristics - due to its binder properties. Furthermore an optimal composition of the API and the diluent is to be found according to the compression process and the dosage form. © 2010 Elsevier B.V.},
	keywords = {ARTICLE; DESIGN; PARACETAMOL; CRYSTALLIZATION; compaction; elasticity; tensile strength; Binders; drug dosage form; Dosage Forms; tablet hardness; tablet friability; tablet compression; tablet manufacture; drug granulation; tablet property; tablet disintegration; Granulation; Tabletting; R value; Optimal composition; Model drugs; Independent variables; Full factorial design; Friction work; Dependent variables; Compression process; Compression force; Binding agent; Binder properties; Wet granulation; Isomalt; Factorial design; Compressibility; Binder},
	year = {2010},
	eissn = {1873-328X},
	pages = {123-129},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Bertalanné Balogh, Emese/0000-0002-1127-3923; Antal, István/0000-0002-5434-201X}
}

@misc{MTMT:1496699,
	title = {Kötőanyag hatásának jellemzése a nehezen préselhető paracetamol tablettázhatóságára},
	url = {https://m2.mtmt.hu/api/publication/1496699},
	author = {Sáska, Zsófia and Dredán, Judit and Bertalanné Balogh, Emese and Oliver, Luhn and Klebovich, Imre and Antal, István},
	unique-id = {1496699},
	year = {2009},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Bertalanné Balogh, Emese/0000-0002-1127-3923; Klebovich, Imre/0000-0003-1672-5172; Antal, István/0000-0002-5434-201X}
}

@misc{MTMT:1496691,
	title = {Bevonó polimer keverékek fizikai, fizikai-kémiai vizsgálata},
	url = {https://m2.mtmt.hu/api/publication/1496691},
	author = {Dredán, Judit and Kállai-Szabó, Nikolett and Sáska, Zsófia and Klebovich, Imre and Antal, István},
	unique-id = {1496691},
	year = {2009},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Klebovich, Imre/0000-0003-1672-5172; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:1491314,
	title = {Kötőanyag hatásának jellemzése a nehezen préselhető paracetamol tablettázhatóságára},
	url = {https://m2.mtmt.hu/api/publication/1491314},
	author = {Sáska, Zsófia and Dredán, Judit and Bertalanné Balogh, Emese and Oliver, Luhn and Klebovich, Imre and Antal, István},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {53},
	unique-id = {1491314},
	issn = {0017-6036},
	year = {2009},
	pages = {S101},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Bertalanné Balogh, Emese/0000-0002-1127-3923; Klebovich, Imre/0000-0003-1672-5172; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:1491304,
	title = {Bevonó polimer keverékek fizikai, fizikai-kémiai vizsgálata},
	url = {https://m2.mtmt.hu/api/publication/1491304},
	author = {Dredán, Judit and Kállai-Szabó, Nikolett and Sáska, Zsófia and Klebovich, Imre and Antal, István},
	journal-iso = {GYÓGYSZERÉSZET},
	journal = {GYÓGYSZERÉSZET},
	volume = {53},
	unique-id = {1491304},
	issn = {0017-6036},
	year = {2009},
	pages = {S92-S93},
	orcid-numbers = {Dredán, Judit/0000-0001-5278-8053; Kállai-Szabó, Nikolett/0000-0002-8164-3993; Klebovich, Imre/0000-0003-1672-5172; Antal, István/0000-0002-5434-201X}
}

@article{MTMT:1485437,
	title = {Reverse Na+/Ca2+-exchange mediated Ca2+-entry and noradrenaline release in Na+-loaded peripheral sympathetic nerves},
	url = {https://m2.mtmt.hu/api/publication/1485437},
	author = {Török, Tamás and Rácz, D and Sáska, Zsófia and Dávid, A Z and Tábi, Tamás and Zillikens, S and Nada, S A and Klebovich, Imre and Gyires, Klára and Magyar, Kálmán},
	doi = {10.1016/j.neuint.2008.08.009},
	journal-iso = {NEUROCHEM INT},
	journal = {NEUROCHEMISTRY INTERNATIONAL},
	volume = {53},
	unique-id = {1485437},
	issn = {0197-0186},
	abstract = {[3H]noradrenaline ([3H]NA) released from sympathetic nerves in the isolated main pulmonary artery of the rabbit was measured in response to field stimulation (2 Hz, 1 ms, 60 V for 3 min) in the presence of uptake blockers (cocaine, 3 × 10-5 M and corticosterone, 5 × 10-5 M). The [3H]NA-release was fully blocked by the combined application of the selective and irreversible 'N-type' voltage-sensitive Ca2+-channel (VSCC)-blocker ω-conotoxin (ω-CgTx) GVIA (10-8 M) and the 'non-selective' VSCC-blocker aminoglycoside antibiotic neomycin (3 × 10-3 M). Na+-loading (Na+-pump inhibition by K+-free perfusion) was required to elicit further NA-release after blockade of VSCCs (ω-CgTx GVIA + neomycin). In K+-free solution, in the absence of functioning VSCCs (ω-CgTx GVIA + neomycin), the fast Na+-channel activator veratridine (10-5 M) further potentiated the nerve-evoked release of [3H]NA. This NA-release was significantly inhibited by KB-R7943, and fully blocked by C ao2 + - removal. However, Li+-substitution was surprisingly ineffective. The non-selective K+-channel blocker 4-aminopyridine (4-AP, 10-4 M) also further potentiated the nerve-evoked release of NA in K+-free solution. This potentiated release was concentration-dependently inhibited by KB-R7943, significantly inhibited by Li+-substitution and abolished by C ao2 + - removal. It is concluded that in Na+-loaded sympathetic nerves, in which the VSCCs are blocked, the reverse Na+/Ca2+-exchange-mediated Ca2+-entry is responsible for transmitter release on nerve-stimulation. Theoretically we suppose that the fast Na+-channel and the exchanger proteins are close to the vesicle docking sites. © 2008 Elsevier Ltd. All rights reserved.},
	keywords = {Animals; Male; NOREPINEPHRINE; RABBITS; calcium; CORTICOSTERONE; ARTICLE; SODIUM; priority journal; controlled study; Dose-Response Relationship, Drug; nonhuman; animal tissue; animal experiment; Calcium Channel Blockers; Sodium Channels; nerve stimulation; Rabbit; outcome assessment; SODIUM-CALCIUM EXCHANGER; 4 aminopyridine; Oryctolagus cuniculus; Calcium Signaling; Adrenergic Fibers; Pulmonary Artery; sympathetic nerve; cocaine; salt loading; Heliothis zea virus 1; Potassium Channel Blockers; Calcium Channels, N-Type; sodium calcium exchange; noradrenalin release; veratridine; omega conotoxin; neomycin; 2 [2 [4 (4 nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate; Voltage-sensitive Na+-channel; Voltage-sensitive Ca2+-channel; Reverse Na+/Ca2+-exchange; Rabbit main pulmonary artery; Na+-pump; Delayed rectifier K+-channel; [3H]noradrenaline release},
	year = {2008},
	eissn = {1872-9754},
	pages = {338-345},
	orcid-numbers = {Török, Tamás/0000-0002-4436-3239; Tábi, Tamás/0000-0001-5343-0205; Klebovich, Imre/0000-0003-1672-5172; Gyires, Klára/0000-0002-4718-2345; Magyar, Kálmán/0000-0002-1852-3577}
}