TY  - JOUR
AU  - Verma, S.
AU  - Wanner, C.
AU  - Zwiener, I.
AU  - Ofstad, A.P.
AU  - George, J.T.
AU  - Fitchett, D.
AU  - Zinman, B.
ED  - EMPA-REG, OUTCOME Investigators / Collaborative Organization
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamás, Gyula / Collaborator
TI  - Influence of Microvascular Disease on Cardiovascular Events in Type 2 Diabetes
JF  - JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
J2  - J AM COLL CARDIOL
VL  - 73
PY  - 2019
IS  - 21
SP  - 2780
EP  - 2782
PG  - 3
SN  - 0735-1097
DO  - 10.1016/j.jacc.2019.03.002
UR  - https://m2.mtmt.hu/api/publication/31300303
ID  - 31300303
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zinman, Bernard
AU  - Inzucchi, Silvio E
AU  - Wanner, Christoph
AU  - Hehnke, Uwe
AU  - George, Jyothis T
AU  - Johansen, Odd Erik
AU  - Fitchett, David
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamás, Gyula / Collaborator
TI  - Empagliflozin in women with type 2 diabetes and cardiovascular disease - an analysis of EMPA-REG OUTCOME®
JF  - DIABETOLOGIA
J2  - DIABETOLOGIA
VL  - 61
PY  - 2018
IS  - 7
SP  - 1522
EP  - 1527
PG  - 6
SN  - 0012-186X
DO  - 10.1007/s00125-018-4630-2
UR  - https://m2.mtmt.hu/api/publication/31307246
ID  - 31307246
N1  - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada            
            Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States            
            Department of Medicine, Division of Nephrology, Würzburg University Clinic, Würzburg, Germany            
            Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany            
            Boehringer Ingelheim Norway KS, Drengsrudbekken 8, PO Box 405, Asker, N-1373, Norway            
            Division of Cardiology, St Michael’s Hospital, University of Toronto, Toronto, ON, Canada            
            Cited By :32            
            Export Date: 19 November 2021            
            CODEN: DBTGA            
            Correspondence Address: Johansen, O.E.; Boehringer Ingelheim Norway KS, Drengsrudbekken 8, PO Box 405, Norway; email: odd_erik.johansen@boehringer-ingelheim.com            
            Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; empagliflozin, 864070-44-0; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8; metformin, 1115-70-4, 657-24-9; glucoside, 50986-29-3; glycosylated hemoglobin, 9062-63-9; Benzhydryl Compounds; Biomarkers; Blood Glucose; empagliflozin; Glucosides; Glycated Hemoglobin A; hemoglobin A1c protein, human; Hypoglycemic Agents
AB  - The global epidemic of type 2 diabetes affects women and men equally; however, the relative impact on the cardiovascular (CV) system appears greater for women than men when compared with peers without diabetes. Furthermore, women are often under-represented in CV outcome trials, resulting in less certainty about the impact of CV prevention therapies across the sexes. The EMPA-REG OUTCOME® trial, which included 28.5% women, found that empagliflozin, given in addition to standard of care, reduced the risk of CV death by 38%, heart failure (HF) hospitalisation by 35% and a composite endpoint for incident or worsening nephropathy by 39%. Here we report a secondary analysis of the trial to determine the relative effects of empagliflozin in women vs men.The population studied were individuals with type 2 diabetes (HbA1c 53-86 mmol/mol [7-10%] and eGFR >30 ml min-1 [1.73 m]-2), with established atherosclerotic CV disease. Individuals were randomised to receive empagliflozin 10 mg or 25 mg, or placebo once daily in addition to standard of care, and followed. The trial continued until ≥691 individuals had experienced an adjudicated event included in the primary outcome. All CV outcome events, including HF hospitalisations and deaths were prospectively adjudicated by blinded clinical events committees.At baseline, the demographic profile of the 2004 women (age ± standard deviation 63.6 ± 8.8 years) compared with the 5016 men (age 63.0 ± 8.6 years) in the trial was largely similar, with the exception that LDL-cholesterol was numerically higher in women (2.5 ± 1.0 vs 2.1 ± 0.9 mmol/l), consistent with lower rates of lipid-lowering therapies (75.4% vs 83.2%). Women were also less likely to have smoked (31.5% vs 69.9%). The annualised incidence rate for women in the placebo group was numerically lower than in men for CV death (1.58% vs 2.19%), numerically higher for HF hospitalisation (1.75% vs 1.33%) and similar for renal events (7.22% vs 7.75%). We did not detect any effect modification by sex within the statistical power restrictions of the analysis for CV death, HF hospitalisation and incident or worsening nephropathy (interaction p values 0.32, 0.20 and 0.85, respectively). Compared with placebo, empagliflozin increased the rates of genital infections in both women (2.5% vs 10.0%) and men (1.5% vs 2.6%).CV death, HF hospitalisation and incident or worsening nephropathy rate reductions induced by empagliflozin were not different between women and men.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Fitchett, D
AU  - Butler, J
AU  - van de Borne, P
AU  - Zinman, B
AU  - Lachin, JM
AU  - Wanner, C
AU  - Woerle, HJ
AU  - Hantel, S
AU  - George, JT
AU  - Johansen, OE
AU  - Inzucchi, SE
ED  - EMPA-REG, OUTCOME trial investigators / Collaborative Organization
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamás, Gyula / Collaborator
TI  - Effects of empagliflozin on risk for cardiovascular death and heart failure hospitalization across the spectrumof heart failure risk in the EMPA-REG OUTCOME (R) trial
JF  - EUROPEAN HEART JOURNAL
J2  - EUR HEART J
VL  - 39
PY  - 2018
IS  - 5
SP  - 363
EP  - 370
PG  - 8
SN  - 0195-668X
DO  - 10.1093/eurheartj/ehx511
UR  - https://m2.mtmt.hu/api/publication/31209141
ID  - 31209141
N1  - Cited By :100            
            Export Date: 25 April 2020            
            CODEN: EHJOD            
            Correspondence Address: Fitchett, D.; Division of Cardiology, St. Michael's Hospital, 30 Bond St, Canada; email: fitchettd@smh.ca            
            Chemicals/CAS: empagliflozin, 864070-44-0; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Sodium-Glucose Transporter 2 Inhibitors
Cited By :100            
            Export Date: 26 April 2020            
            CODEN: EHJOD            
            Correspondence Address: Fitchett, D.; Division of Cardiology, St. Michael's Hospital, 30 Bond St, Canada; email: fitchettd@smh.ca            
            Chemicals/CAS: empagliflozin, 864070-44-0; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Sodium-Glucose Transporter 2 Inhibitors
Cited By :101            
            Export Date: 4 May 2020            
            CODEN: EHJOD            
            Correspondence Address: Fitchett, D.; Division of Cardiology, St. Michael's Hospital, 30 Bond St, Canada; email: fitchettd@smh.ca            
            Chemicals/CAS: empagliflozin, 864070-44-0; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Sodium-Glucose Transporter 2 Inhibitors
AB  - Aims Empagliflozin reduced the risk of cardiovascular (CV) death and heart failure (HF) hospitalizations in patients with type 2 diabetes (T2D) and established CV disease (CVD) in the EMPA-REG OUTCOME (R) trial. We investigated whether the benefit of empagliflozin was observed across the spectrum of HF risk. Methods and results Seven thousand and twenty patients with T2D (HbA1c 7-10% and eGFR > 30 mL/min/1.73 m(2)) were treated with empagliflozin 10 or 25 mg, or placebo once daily and followed for median 3.1 years. In patients without HF at baseline (89.9%), we derived the 5-year risk for incident HF using the 9-variable Health ABC HF Risk score [classified as low-to-average (<10%), high (10-20%), and very high (>= 20%)]. Overall, 67.2% of the population had low-to-average, 24.2% high, and 5.1% very high 5-year HF risk. Across these groups, the effect on CV death and HF hospitalization with empagliflozin was consistent [hazard ratio 0.71 (95% confidence interval: 0.52, 0.96), 0.52 (0.36, 0.75), and 0.55 (0.30, 1.00), respectively]. Effects on CV death in the ostensibly highest HF risk group (HF at baseline and/or incident HF during the trial) in whom 37.9% of the overall CV deaths occurred, was also beneficial [0.67 (0.47, 0.97)], yet, similar benefits were seen in the lower risk patients. Conclusion In patients with T2D and established CVD, a sizeable proportion without HF at baseline are at high or very high risk for HF outcomes, indicating the need for active case finding in this patient population. Empagliflozin consistently improved HF outcomes both in patients at low or high HF risk.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wanner, Christoph
AU  - Lachin, John M
AU  - Inzucchi, Silvio E
AU  - Fitchett, David
AU  - Mattheus, Michaela
AU  - George, Jyothis
AU  - Woerle, Hans J
AU  - Broedl, Uli C
AU  - von Eynatten, Maximilian
AU  - Zinman, Bernard
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamás, Gyula / Collaborator
TI  - Empagliflozin and Clinical Outcomes in Patients With Type 2 Diabetes Mellitus, Established Cardiovascular Disease, and Chronic Kidney Disease
JF  - CIRCULATION
J2  - CIRCULATION
VL  - 137
PY  - 2018
IS  - 2
SP  - 119
EP  - 129
PG  - 11
SN  - 0009-7322
DO  - 10.1161/CIRCULATIONAHA.117.028268
UR  - https://m2.mtmt.hu/api/publication/31209130
ID  - 31209130
N1  - Comprehensive Heart Failure Center, Renal Division, University of Wuerzburg and Hospital, Germany            
            Biostatistics Center, George Washington University, Rockville, MD, United States            
            Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States            
            St. Michael's Hospital, Division of Cardiology, University of Toronto, Canada            
            Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim, Germany            
            Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada            
            Division of Endocrinology, University of Toronto, Canada            
            Würzburg University Clinic, Oberdürrbacherstrasse 6, Würzburg, 97080, Germany            
            Cited By :137            
            Export Date: 25 April 2020            
            CODEN: CIRCA            
            Correspondence Address: Wanner, C.; Würzburg University Clinic, Oberdürrbacherstrasse 6, Germany; email: wanner_c@ukw.de            
            Chemicals/CAS: empagliflozin, 864070-44-0; hemoglobin, 9008-02-0; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8; uric acid, 69-93-2; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Sodium-Glucose Transporter 2 Inhibitors
Comprehensive Heart Failure Center, Renal Division, University of Wuerzburg and Hospital, Germany            
            Biostatistics Center, George Washington University, Rockville, MD, United States            
            Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States            
            St. Michael's Hospital, Division of Cardiology, University of Toronto, Canada            
            Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim, Germany            
            Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada            
            Division of Endocrinology, University of Toronto, Canada            
            Würzburg University Clinic, Oberdürrbacherstrasse 6, Würzburg, 97080, Germany            
            Cited By :138            
            Export Date: 26 April 2020            
            CODEN: CIRCA            
            Correspondence Address: Wanner, C.; Würzburg University Clinic, Oberdürrbacherstrasse 6, Germany; email: wanner_c@ukw.de            
            Chemicals/CAS: empagliflozin, 864070-44-0; hemoglobin, 9008-02-0; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8; uric acid, 69-93-2; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Sodium-Glucose Transporter 2 Inhibitors
Comprehensive Heart Failure Center, Renal Division, University of Wuerzburg and Hospital, Germany            
            Biostatistics Center, George Washington University, Rockville, MD, United States            
            Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States            
            St. Michael's Hospital, Division of Cardiology, University of Toronto, Canada            
            Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim, Germany            
            Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada            
            Division of Endocrinology, University of Toronto, Canada            
            Würzburg University Clinic, Oberdürrbacherstrasse 6, Würzburg, 97080, Germany            
            Cited By :140            
            Export Date: 1 May 2020            
            CODEN: CIRCA            
            Correspondence Address: Wanner, C.; Würzburg University Clinic, Oberdürrbacherstrasse 6, Germany; email: wanner_c@ukw.de            
            Chemicals/CAS: empagliflozin, 864070-44-0; hemoglobin, 9008-02-0; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8; uric acid, 69-93-2; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Sodium-Glucose Transporter 2 Inhibitors
Comprehensive Heart Failure Center, Renal Division, University of Wuerzburg and Hospital, Germany            
            Biostatistics Center, George Washington University, Rockville, MD, United States            
            Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States            
            St. Michael's Hospital, Division of Cardiology, University of Toronto, Canada            
            Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim, Germany            
            Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada            
            Division of Endocrinology, University of Toronto, Canada            
            Würzburg University Clinic, Oberdürrbacherstrasse 6, Würzburg, 97080, Germany            
            Cited By :141            
            Export Date: 4 May 2020            
            CODEN: CIRCA            
            Correspondence Address: Wanner, C.; Würzburg University Clinic, Oberdürrbacherstrasse 6, Germany; email: wanner_c@ukw.de            
            Chemicals/CAS: empagliflozin, 864070-44-0; hemoglobin, 9008-02-0; hemoglobin A1c, 62572-11-6; insulin, 9004-10-8; uric acid, 69-93-2; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Sodium-Glucose Transporter 2 Inhibitors
AB  - Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, reduced cardiovascular morbidity and mortality in patients with type 2 diabetes mellitus and established cardiovascular disease in the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients). Urinary glucose excretion with empagliflozin decreases with declining renal function, resulting in less potency for glucose lowering in patients with kidney disease. We investigated the effects of empagliflozin on clinical outcomes in patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease.Patients with type 2 diabetes mellitus, established cardiovascular disease, and estimated glomerular filtration rate (eGFR) ≥30 mL·min-1·1.73 m-2 at screening were randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, or placebo once daily in addition to standard of care. We analyzed cardiovascular death, hospitalization for heart failure, all-cause hospitalization, and all-cause mortality in patients with prevalent kidney disease (defined as eGFR <60 mL·min-1·1.73 m-2 and/or urine albumin-creatinine ratio >300 mg/g) at baseline. Additional analyses were performed in subgroups by baseline eGFR (<45, 45-<60, 60-<90, ≥90 mL·min-1·1.73 m-2) and baseline urine albumin-creatinine ratio (>300, 30-≤300, <30 mg/g).Of 7020 patients treated, 2250 patients had prevalent kidney disease at baseline, of whom 67% had a diagnosis of type 2 diabetes mellitus for >10 years, 58% were receiving insulin, and 84% were taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. In patients with prevalent kidney disease at baseline, empagliflozin reduced the risk of cardiovascular death by 29% compared with placebo (hazard ratio [HR], 0.71; 95% confidence interval [CI], 0.52-0.98), the risk of all-cause mortality by 24% (HR, 0.76; 95% CI, 0.59-0.99), the risk of hospitalization for heart failure by 39% (HR, 0.61; 95% CI, 0.42-0.87), and the risk of all-cause hospitalization by 19% (HR, 0.81; 95% CI, 0.72-0.92). Effects of empagliflozin on these outcomes were consistent across categories of eGFR and urine albumin-creatinine ratio at baseline and across the 2 doses studied. The adverse event profile of empagliflozin in patients with eGFR <60 mL·min-1·1.73 m-2 was consistent with the overall trial population.Empagliflozin improved clinical outcomes and reduced mortality in vulnerable patients with type 2 diabetes mellitus, established cardiovascular disease, and chronic kidney disease.URL: https://www.clinicaltrials.gov. Unique identifier: NCT01131676.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wanner, Christoph
AU  - Heerspink, Hiddo J. L.
AU  - Zinman, Bernard
AU  - Inzucchi, Silvio E.
AU  - Koitka-Weber, Audrey
AU  - Mattheus, Michaela
AU  - Hantel, Stefan
AU  - Woerle, Hans-Juergen
AU  - Broedl, Uli C.
AU  - von Eynatten, Maximilian
AU  - Groop, Per-Henrik
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamás, Gyula / Collaborator
TI  - Empagliflozin and Kidney Function Decline in Patients with Type 2 Diabetes: A Slope Analysis from the EMPA-REG OUTCOME Trial
JF  - JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
J2  - J AM SOC NEPHROL
VL  - 29
PY  - 2018
IS  - 11
SP  - 2755
EP  - 2769
PG  - 15
SN  - 1046-6673
DO  - 10.1681/ASN.2018010103
UR  - https://m2.mtmt.hu/api/publication/30703833
ID  - 30703833
AB  - Background Empagliflozin slowed the progression of CKD in patients with type 2 diabetes and cardiovascular disease in the EMPA-REG OUTCOME Trial. In a prespecified statistical approach, we assessed treatment differences in kidney function by analyzing slopes of eGFR changes.Methods Participants (n=7020) were randomized (1:1:1) to empagliflozin 10 mg/d, empagliflozin 25 mg/d, or placebo added to standard of care. We calculated eGFR slopes using random-intercept/random-coefficient models for prespecified study periods: treatment initiation (baseline to week 4), chronic maintenance treatment (week 4 to last value on treatment), and post-treatment (last value on treatment to follow-up).Results Compared with placebo, empagliflozin was associated with uniform shifts in individual eGFR slopes across all periods. On treatment initiation, adjusted mean slope (eGFR change per week, ml/min per 1.73 m(2)) decreased with empagliflozin (-0.77; 95% confidence interval, -0.83 to -0.71; placebo: 0.01; 95% confidence interval, -0.08 to 0.10; P<0.001). However, annual mean slope (ml/min per 1.73 m(2) per year) did not decline with empagliflozin during chronic treatment (empagliflozin: 0.23; 95% confidence interval, 0.05 to 0.40; placebo: -1.46; 95% confidence interval, -1.74 to -1.17; P<0.001). After drug cessation, the adjusted mean eGFR slope (ml/min per 1.73 m(2) per week) increased and mean eGFR returned toward baseline level only in the empagliflozin group (0.56; 95% confidence interval, 0.49 to 0.62; placebo -0.02; 95% confidence interval, -0.12 to 0.08; P<0.001). Results were consistent across patient subgroups at higher CKD risk.Conclusions The hemodynamic effects of empagliflozin, associated with reduction in intraglomerular pressure, may contribute to long-term preservation of kidney function.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kaku, Kohei
AU  - Lee, Jisoo
AU  - Mattheus, Michaela
AU  - Kaspers, Stefan
AU  - George, Jyothis
AU  - Woerle, Hans-Juergen
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamás, Gyula / Collaborator
TI  - Empagliflozin and Cardiovascular Outcomes in Asian Patients With Type 2 Diabetes and Established Cardiovascular Disease ― Results From EMPA-REG OUTCOME® ―
JF  - CIRCULATION JOURNAL: OFFICIAL JOURNAL OF THE JAPANESE CIRCULATION SOCIETY
J2  - CIRC J
VL  - 81
PY  - 2017
IS  - 2
SP  - 227
EP  - 234
PG  - 8
SN  - 1346-9843
DO  - 10.1253/circj.CJ-16-1148
UR  - https://m2.mtmt.hu/api/publication/31308918
ID  - 31308918
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Zinman, Bernard
AU  - Inzucchi, Silvio E
AU  - Lachin, John M
AU  - Wanner, Christoph
AU  - Fitchett, David
AU  - Kohler, Sven
AU  - Mattheus, Michaela
AU  - Biomath, Dipl
AU  - Woerle, Hans J
AU  - Broedl, Uli C
AU  - Johansen, Odd Erik
AU  - Albers, Gregory W
AU  - Diener, Hans Christoph
ED  - EMPA, REG OUTCOME Investigators / Collaborative Organization
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamás, Gyula / Collaborator
TI  - Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk
JF  - STROKE
J2  - STROKE
VL  - 48
PY  - 2017
IS  - 5
SP  - 1218
EP  - 1225
PG  - 31
SN  - 0039-2499
DO  - 10.1161/STROKEAHA.116.015756
UR  - https://m2.mtmt.hu/api/publication/26756488
ID  - 26756488
N1  - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 60 Murray St, Box 17, Toronto, ON M5T 3L9, Canada            
            Division of Endocrinology, University of Toronto, Canada            
            St Michael's Hospital, Division of Cardiology, University of Toronto, Canada            
            Section of Endocrinology, Yale University School of Medicine, New Haven, CT, United States            
            Biostatistics Center, George Washington University, Rockville, MD, United States            
            Comprehensive Heart Failure Center and Renal Division, University of Wuerzburg and Hospital, Germany            
            Boehringer Ingelheim Pharma GmbH and Co. KG, Ingelheim, Germany            
            Boehringer Ingelheim Norway KS, Asker, Norway            
            Department of Neurology and Neurological Sciences, Stanford Stroke CenterCA, United States            
            Department of Neurology and Stroke Center, University Hospital Essen, Germany            
            Cited By :81            
            Export Date: 25 November 2021            
            CODEN: SJCCA            
            Correspondence Address: Zinman, B.; Lunenfeld-Tanenbaum Research Institute, 60 Murray St, Box 17, Canada; email: zinman@lunenfeld.ca            
            Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; empagliflozin, 864070-44-0; glucoside, 50986-29-3; Benzhydryl Compounds; empagliflozin; Glucosides; Hypoglycemic Agents
AB  - Background and Purpose-In the EMPA-REG OUTCOME trial (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients), empagliflozin added to standard of care in patients with type 2 diabetes mellitus and high cardiovascular risk reduced the risk of 3-point major adverse cardiovascular events, driven by a reduction in cardiovascular mortality, with no significant difference between empagliflozin and placebo in risk of myocardial infarction or stroke. In a modified intent-to-treat analysis, the hazard ratio for stroke was 1.18 (95% confidence interval, 0.89-1.56; P= 0.26). We further investigated cerebrovascular events.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Wanner, Christoph
AU  - Inzucchi, Silvio E.
AU  - Lachin, John M.
AU  - Fitchett, David
AU  - von Eynatten, Maximilian
AU  - Mattheus, Michaela
AU  - Johansen, Odd Erik
AU  - Woerle, Hans J.
AU  - Broedl, Uli C.
AU  - Zinman, Bernard
ED  - Aizenberg, D / Collaborator
ED  - Ulla, M / Collaborator
ED  - Waitman, J / Collaborator
ED  - De Loredo, L / Collaborator
ED  - Farías, J / Collaborator
ED  - Fideleff, H / Collaborator
ED  - Lagrutta, M / Collaborator
ED  - Maldonado, N / Collaborator
ED  - Colombo, H / Collaborator
ED  - Ferre Pacora, F / Collaborator
ED  - Wasserman, A / Collaborator
ED  - Maffei, L / Collaborator
ED  - Lehman, R / Collaborator
ED  - Selvanayagam, J / Collaborator
ED  - d’Emden, M / Collaborator
ED  - Fasching, P / Collaborator
ED  - Paulweber, B / Collaborator
ED  - Toplak, H / Collaborator
ED  - Luger, A / Collaborator
ED  - Drexel, H / Collaborator
ED  - Prager, R / Collaborator
ED  - Schnack, C / Collaborator
ED  - Schernthaner, G / Collaborator
ED  - Fliesser Görzer, E / Collaborator
ED  - Kaser, S / Collaborator
ED  - Scheen, A / Collaborator
ED  - Van Gaal, L / Collaborator
ED  - Hollanders, G / Collaborator
ED  - Kockaerts, Y / Collaborator
ED  - Capiau, L / Collaborator
ED  - Chachati, A / Collaborator
ED  - Persu, A / Collaborator
ED  - Hermans, M / Collaborator
ED  - Vantroyen, D / Collaborator
ED  - Vercammen, C / Collaborator
ED  - Van de Borne, P / Collaborator
ED  - Benhalima, K / Collaborator
ED  - Mathieu, C / Collaborator
ED  - Lienart, F / Collaborator
ED  - Mortelmans, J / Collaborator
ED  - Strivay, M / Collaborator
ED  - Vereecken, G / Collaborator
ED  - Keymeulen, B / Collaborator
ED  - Lamkanfi, F / Collaborator
ED  - Chacra, A / Collaborator
ED  - Eliaschewitz, F / Collaborator
ED  - Zanella, M / Collaborator
ED  - Faludi, A / Collaborator
ED  - Bertolami, M / Collaborator
ED  - Hayashida, C / Collaborator
ED  - Nunes Salles, J / Collaborator
ED  - Monte, O / Collaborator
ED  - Dinato, M / Collaborator
ED  - Manenti, E / Collaborator
ED  - Rassi, N / Collaborator
ED  - Halpern, A / Collaborator
ED  - Lima Filho, M / Collaborator
ED  - Ayoub, J / Collaborator
ED  - Felicio, J / Collaborator
ED  - Borges, J / Collaborator
ED  - Gross, J / Collaborator
ED  - Sgarbi, J / Collaborator
ED  - Betti, R / Collaborator
ED  - Tiburcio, A / Collaborator
ED  - Purisch, S / Collaborator
ED  - Schmid, H / Collaborator
ED  - Takahashi, M / Collaborator
ED  - Castro, M / Collaborator
ED  - Rea, R / Collaborator
ED  - Hissa, M / Collaborator
ED  - Geloneze Neto, B / Collaborator
ED  - Saraiva, J / Collaborator
ED  - Henein, S / Collaborator
ED  - Lochnan, H / Collaborator
ED  - Imran, S A / Collaborator
ED  - Clayton, D / Collaborator
ED  - Bayly, K / Collaborator
ED  - Berlingieri, J / Collaborator
ED  - Boucher, P / Collaborator
ED  - Chan, Y / Collaborator
ED  - Gupta, M / Collaborator
ED  - Chehayeb, R / Collaborator
ED  - Ouellett, A / Collaborator
ED  - Ur, E / Collaborator
ED  - Woo, V / Collaborator
ED  - St Amour, E / Collaborator
ED  - Terront Lozano, M / Collaborator
ED  - Yupanqui Lozno, H / Collaborator
ED  - Urina, M / Collaborator
ED  - Lopez Jaramillo, P / Collaborator
ED  - Jaramillo, N / Collaborator
ED  - Sanchez, G / Collaborator
ED  - Pérez, G / Collaborator
ED  - Tusek, S / Collaborator
ED  - Mirosevic, G / Collaborator
ED  - Goldoni, V / Collaborator
ED  - Jurisic Erzen, D / Collaborator
ED  - Balasko, A / Collaborator
ED  - Balic, S / Collaborator
ED  - Drvodelic Sunic, E / Collaborator
ED  - Canecki-Varzic, Silvija / Collaborator
ED  - Machkova, M / Collaborator
ED  - Weiner, P / Collaborator
ED  - Lastuvka, J / Collaborator
ED  - Olsovsky, J / Collaborator
ED  - Krarup, T / Collaborator
ED  - Ridderstråle, M / Collaborator
ED  - Tarnow, L / Collaborator
ED  - Sætre Lihn, A / Collaborator
ED  - Christensen, P / Collaborator
ED  - Juhl, H / Collaborator
ED  - Urhammer, S / Collaborator
ED  - Lund, P / Collaborator
ED  - Adojaan, B / Collaborator
ED  - Jakovlev, U / Collaborator
ED  - Lanno, R / Collaborator
ED  - Lubi, M / Collaborator
ED  - Marandi, T / Collaborator
ED  - Gouet, D / Collaborator
ED  - Courrèges, J / Collaborator
ED  - Zaoui, P / Collaborator
ED  - Choukroun, G / Collaborator
ED  - Petit, C / Collaborator
ED  - Formagne, L / Collaborator
ED  - Estour, B / Collaborator
ED  - Mabire, P / Collaborator
ED  - Daugenet, C / Collaborator
ED  - Lemarie, B / Collaborator
ED  - Clavel, S / Collaborator
ED  - Aure, P / Collaborator
ED  - Remaud, P / Collaborator
ED  - Halimi, J / Collaborator
ED  - Hadjadj, S / Collaborator
ED  - Couffinhal, T / Collaborator
ED  - Glonti, S / Collaborator
ED  - Metreveli, D / Collaborator
ED  - Lominadze, Z / Collaborator
ED  - Giorgadze, E / Collaborator
ED  - Burtchuladze, T / Collaborator
ED  - Javashvili, L / Collaborator
ED  - Kurashvili, G / Collaborator
ED  - Kurashvili, R / Collaborator
ED  - Virsaladze, D / Collaborator
ED  - Nadareishvili, L / Collaborator
ED  - Khomasuridze, A / Collaborator
ED  - Cahill, T / Collaborator
ED  - Green, F / Collaborator
ED  - MacRury, S / Collaborator
ED  - Waldron, M / Collaborator
ED  - Middleton, A / Collaborator
ED  - McKnight, J / Collaborator
ED  - Pearson, E / Collaborator
ED  - Butler, M / Collaborator
ED  - Choksi, M / Collaborator
ED  - Caldwell, I / Collaborator
ED  - Farmer, I / Collaborator
ED  - Wyatt, N / Collaborator
ED  - Patrick, J / Collaborator
ED  - O'Brien, I / Collaborator
ED  - Devers, M / Collaborator
ED  - Bousboulas, S / Collaborator
ED  - Pappas, S / Collaborator
ED  - Piaditis, G / Collaborator
ED  - Vryonidou, A / Collaborator
ED  - Tentolouris, N / Collaborator
ED  - Karamitsos, K / Collaborator
ED  - Manes, C / Collaborator
ED  - Benroubi, M / Collaborator
ED  - Avramidis, I / Collaborator
ED  - Ozaki, R / Collaborator
ED  - Tan, K / Collaborator
ED  - Siu, S / Collaborator
ED  - Ip, T / Collaborator
ED  - Tsang, C / Collaborator
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
ED  - Salamon, C / Collaborator
ED  - Gerő, László / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabák, Ádám / Collaborator
ED  - Tamás, Gyula / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Ghaisas, N / Collaborator
ED  - Bantwal, G / Collaborator
ED  - Mohan, V / Collaborator
ED  - Gupta, J / Collaborator
ED  - Sadhu, N / Collaborator
ED  - Kulkarni, A / Collaborator
ED  - Garg, N / Collaborator
ED  - Reddy, S / Collaborator
ED  - Deshpande, N / Collaborator
ED  - Gutlapalli, K / Collaborator
ED  - Pillai, M / Collaborator
ED  - Premchand, R / Collaborator
ED  - Badgandi, M / Collaborator
ED  - Jain, S / Collaborator
ED  - Aravind, S / Collaborator
ED  - Shamanna, P / Collaborator
ED  - Pandey, A / Collaborator
ED  - Gupta, S / Collaborator
ED  - Pramono, B / Collaborator
ED  - Dante Saksono, H / Collaborator
ED  - Agung, P / Collaborator
ED  - Djoko Wahono, S / Collaborator
ED  - Suastika, K / Collaborator
ED  - Tanggo, Y / Collaborator
ED  - Juwana, Y / Collaborator
ED  - Siswanto, B / Collaborator
ED  - Adawi, F / Collaborator
ED  - Efrati, S / Collaborator
ED  - Mazen, E / Collaborator
ED  - Bashkin, A / Collaborator
ED  - Herskovits, T / Collaborator
ED  - Jaffe, A / Collaborator
ED  - Schiff, E / Collaborator
ED  - Wainstein, J / Collaborator
ED  - Taddei, S / Collaborator
ED  - Aiello, A / Collaborator
ED  - Arca, M / Collaborator
ED  - Calabro, P / Collaborator
ED  - Cignarelli, M / Collaborator
ED  - Fioretto, P / Collaborator
ED  - Marchesini Reggiani, G / Collaborator
ED  - Gnasso, A / Collaborator
ED  - Marchionni, N / Collaborator
ED  - Marsilii, A / Collaborator
ED  - Bucci, M / Collaborator
ED  - Mezzetti, A / Collaborator
ED  - Pozzilli, P / Collaborator
ED  - Colivicchi, F / Collaborator
ED  - Santini, M / Collaborator
ED  - Moro, E / Collaborator
ED  - Semplicini, A / Collaborator
ED  - Toscano, V / Collaborator
ED  - Fucili, A / Collaborator
ED  - Monno, S / Collaborator
ED  - Furui, K / Collaborator
ED  - Higashiue, S / Collaborator
ED  - Hiramatsu, N / Collaborator
ED  - Kawamitsu, K / Collaborator
ED  - Takenaka, T / Collaborator
ED  - Takahashi, H / Collaborator
ED  - Hojo, F / Collaborator
ED  - Onishi, Y / Collaborator
ED  - Izumino, K / Collaborator
ED  - Okubo, M / Collaborator
ED  - Wakida, Y / Collaborator
ED  - Kondo, Y / Collaborator
ED  - Hieshima, K / Collaborator
ED  - Jinnouchi, H / Collaborator
ED  - Suzuki, A / Collaborator
ED  - Ito, M / Collaborator
ED  - Park, S / Collaborator
ED  - Kim, Y / Collaborator
ED  - Hong, T / Collaborator
ED  - Park, H / Collaborator
ED  - Gwon, H / Collaborator
ED  - Kim, H / Collaborator
ED  - Kang, K / Collaborator
ED  - Lee, S / Collaborator
ED  - Jeong, M / Collaborator
ED  - Seung, K / Collaborator
ED  - Lim, D / Collaborator
ED  - Rha, S / Collaborator
ED  - Tahk, S / Collaborator
ED  - Yang, J / Collaborator
ED  - Yoon, J / Collaborator
ED  - Shin, M / Collaborator
ED  - Kim, D / Collaborator
ED  - Jeong, J / Collaborator
ED  - Nik Ahmad, N / Collaborator
ED  - Mustafa, N / Collaborator
ED  - Wan Mohamed, W / Collaborator
ED  - Fung, Y / Collaborator
ED  - Abdul Ghani, R / Collaborator
ED  - Chandramouli, A / Collaborator
ED  - Chee, K / Collaborator
ED  - Abdul Kadir, K / Collaborator
ED  - Ling, K / Collaborator
ED  - Abu Hassan, M / Collaborator
ED  - Foo, S / Collaborator
ED  - Garcia Hernandez, P / Collaborator
ED  - Aguilar Salinas, C / Collaborator
ED  - Vidrio Velazquez, M / Collaborator
ED  - Flores, F / Collaborator
ED  - Alpizar Salazar, M / Collaborator
ED  - Micher Escalante, D / Collaborator
ED  - Garcia Soria, M / Collaborator
ED  - Cardona Muñoz, E / Collaborator
ED  - Storms, G / Collaborator
ED  - Schaper, N / Collaborator
ED  - Kooy, A / Collaborator
ED  - Krekels, M / Collaborator
ED  - vab Bemmel, T / Collaborator
ED  - Verhoeven, R / Collaborator
ED  - Mulder, H / Collaborator
ED  - Oldenburg Ligtenberg, P / Collaborator
ED  - Gonkel, F / Collaborator
ED  - de Jong, A / Collaborator
ED  - van Soest, J / Collaborator
ED  - Viergever, P / Collaborator
ED  - Mevissen, H / Collaborator
ED  - Lochorn, G / Collaborator
ED  - Zwiers, G / Collaborator
ED  - Hoogslag, P / Collaborator
ED  - Ronner, E / Collaborator
ED  - Nierop, P / Collaborator
ED  - Al Windy, N / Collaborator
ED  - Kragten, J / Collaborator
ED  - Dekelver, P / Collaborator
ED  - Benatar, J / Collaborator
ED  - Krebs, J / Collaborator
ED  - Scott, R / Collaborator
ED  - Heggen, E / Collaborator
ED  - Berz, A / Collaborator
ED  - Fossum, C / Collaborator
ED  - Hurtig, U / Collaborator
ED  - Langslet, G / Collaborator
ED  - Baranowski, M / Collaborator
ED  - Sparby, J / Collaborator
ED  - Karlsson, T / Collaborator
ED  - Delgado Torres, C / Collaborator
ED  - Rodriguez Escudero, A / Collaborator
ED  - Lisson, R / Collaborator
ED  - Allemant Maldonado, A / Collaborator
ED  - Gallardo Rojas, W / Collaborator
ED  - Gonzales Bravo, L / Collaborator
ED  - Lema Osores, J / Collaborator
ED  - Farfan, J / Collaborator
ED  - Zapata, L / Collaborator
ED  - Godoy Junchaya, J / Collaborator
ED  - Roldan Concha, Y / Collaborator
ED  - Urquiaga Calderon, J / Collaborator
ED  - Sy, R / Collaborator
ED  - Tan, G / Collaborator
ED  - Aquitania, G / Collaborator
ED  - De Los Santos, G / Collaborator
ED  - Panelo, A / Collaborator
ED  - Roderos, O / Collaborator
ED  - Rosales, R / Collaborator
ED  - Toledo, R / Collaborator
ED  - Liwag, A / Collaborator
ED  - Ramoncito, H / Collaborator
ED  - Skokowska, E / Collaborator
ED  - Krzyzagorska, E / Collaborator
ED  - Ogorek, M / Collaborator
ED  - Wojnowski, L / Collaborator
ED  - Spyra, J / Collaborator
ED  - Konieczny, M / Collaborator
ED  - Piesiewicz, W / Collaborator
ED  - Kus, W / Collaborator
ED  - Ocicka Kozakiewicz, A / Collaborator
ED  - Orlowska Kunikowska, E / Collaborator
ED  - Zmuda, W / Collaborator
ED  - Duarte, S / Collaborator
ED  - Leitão, A / Collaborator
ED  - Monteiro, P / Collaborator
ED  - Rita, H / Collaborator
ED  - Salgado, V / Collaborator
ED  - Pinto, L / Collaborator
ED  - Queirós, J / Collaborator
ED  - Teixeira, J / Collaborator
ED  - Rogado, C / Collaborator
ED  - Duarte, R / Collaborator
ED  - Sobral do Rosário, F / Collaborator
ED  - Silva, A / Collaborator
ED  - Andrade, L / Collaborator
ED  - Velez, M / Collaborator
ED  - Brazão, M / Collaborator
ED  - Istratoaie, O / Collaborator
ED  - Lichiardopol, R / Collaborator
ED  - Catrinoiu, D / Collaborator
ED  - Militaru, C / Collaborator
ED  - Zetu, C / Collaborator
ED  - Barbonta, D / Collaborator
ED  - Cosma, D / Collaborator
ED  - Crisan, C / Collaborator
ED  - Pop, L / Collaborator
ED  - Esip, V / Collaborator
ED  - Arutyunov, G / Collaborator
ED  - Boyarkin, M / Collaborator
ED  - Agafyina, A / Collaborator
ED  - Vorokhobina, N / Collaborator
ED  - Petunina, N / Collaborator
ED  - Libov, I / Collaborator
ED  - Zalevskaya, A / Collaborator
ED  - Nikolaev, K Y / Collaborator
ED  - Barbarash, O / Collaborator
ED  - Potemkin, V / Collaborator
ED  - Bystrova, A / Collaborator
ED  - Krasilnikova, E / Collaborator
ED  - Barbarich, V / Collaborator
ED  - Chumakova, G / Collaborator
ED  - Tarasov, N / Collaborator
ED  - Meleshkevich, T / Collaborator
ED  - Zateyshchikov, D / Collaborator
ED  - Lantseva, O / Collaborator
ED  - Belenkiy, D / Collaborator
ED  - Obrezan, A / Collaborator
ED  - Rossolko, L / Collaborator
ED  - Fillipova, E / Collaborator
ED  - Yakhontova, P / Collaborator
ED  - Khokhlov, A / Collaborator
ED  - Tan, R / Collaborator
ED  - Sum, C / Collaborator
ED  - Chang, H / Collaborator
ED  - Distiller, L / Collaborator
ED  - Pretorius, M / Collaborator
ED  - Nortje, H / Collaborator
ED  - Mitha, E / Collaborator
ED  - Burgess, L / Collaborator
ED  - Blignaut, S / Collaborator
ED  - Venter, T / Collaborator
ED  - Moodley, R / Collaborator
ED  - Lombaard, J / Collaborator
ED  - Govind, U / Collaborator
ED  - Naidoo, V / Collaborator
ED  - Mookadam, M / Collaborator
ED  - Engelbrecht, J / Collaborator
ED  - Omar, M / Collaborator
ED  - Jurgens, J / Collaborator
ED  - Podgorski, G / Collaborator
ED  - Vawda, H / Collaborator
ED  - Naidoo, D / Collaborator
ED  - Emanuel, S / Collaborator
ED  - Roodt, A / Collaborator
ED  - Amod, A / Collaborator
ED  - Van Zyl, L / Collaborator
ED  - Segura, J / Collaborator
ED  - Brito, M / Collaborator
ED  - Fernandez Cruz, A / Collaborator
ED  - Artola, S / Collaborator
ED  - Iglesias, R / Collaborator
ED  - Toural, E / Collaborator
ED  - Garcia Ortiz, L / Collaborator
ED  - Saban, J / Collaborator
ED  - Mesa, J / Collaborator
ED  - Vidal, J / Collaborator
ED  - Linares, J / Collaborator
ED  - del Cañizo, F / Collaborator
ED  - Rigla, M / Collaborator
ED  - Suarez, C / Collaborator
ED  - Llorente, I / Collaborator
ED  - Moreno, B / Collaborator
ED  - Antoli, A / Collaborator
ED  - Gomez Peralta, F / Collaborator
ED  - Iglesias, M / Collaborator
ED  - Pereg, V / Collaborator
ED  - de Teresa, L / Collaborator
ED  - Camafort, M / Collaborator
ED  - Trescoli, C / Collaborator
ED  - Satarasinghe, R / Collaborator
ED  - Somasundaram, N / Collaborator
ED  - Siyambalapitiya, S / Collaborator
ED  - Antonypillai, C / Collaborator
ED  - Bulugahapitiya, D / Collaborator
ED  - Medagama, U / Collaborator
ED  - Huang, C / Collaborator
ED  - Lu, Y / Collaborator
ED  - Hwang, J / Collaborator
ED  - Chiang, C / Collaborator
ED  - Wen, M / Collaborator
ED  - Chen, J / Collaborator
ED  - Lai, W / Collaborator
ED  - Chang, K / Collaborator
ED  - Wang, J / Collaborator
ED  - Yeh, H / Collaborator
ED  - Kriangsak, P / Collaborator
ED  - Deerochanawong, C / Collaborator
ED  - Suwanwalaikorn, S / Collaborator
ED  - Mangklabruks, A / Collaborator
ED  - Kaewsuwanna, P / Collaborator
ED  - Piyayotai, D / Collaborator
ED  - Iabluchanskyi, M / Collaborator
ED  - Samoylov, O / Collaborator
ED  - Godlevska, O / Collaborator
ED  - Kovalyova, O / Collaborator
ED  - Voloshyna, O / Collaborator
ED  - Tseluyko, V / Collaborator
ED  - Zotov, S / Collaborator
ED  - Vykhovanyuk, I / Collaborator
ED  - Dulgeroff, A / Collaborator
ED  - Mayfield, R / Collaborator
ED  - Zaniewski Singh, M / Collaborator
ED  - Ullal, J / Collaborator
ED  - Aloi, J / Collaborator
ED  - De La Rosa, R / Collaborator
ED  - Mosely, J / Collaborator
ED  - Wittmer, B / Collaborator
ED  - Aronoff, S / Collaborator
ED  - Rosenfeld, J / Collaborator
ED  - Seidner, M / Collaborator
ED  - Warren, M / Collaborator
ED  - Fishman, N / Collaborator
ED  - Weiss, R / Collaborator
ED  - Arif, A / Collaborator
ED  - Sandberg, M / Collaborator
ED  - Lewis, D / Collaborator
ED  - Ball, E / Collaborator
ED  - Graf, R / Collaborator
ED  - Breton, C / Collaborator
ED  - Tamayo, R / Collaborator
ED  - Richards, R / Collaborator
ED  - Cefalu, W / Collaborator
ED  - Uwaifo, G / Collaborator
ED  - Zayour, D / Collaborator
ED  - Hoffman, J / Collaborator
ED  - Fitz Patrick, D / Collaborator
ED  - Khan, B / Collaborator
ED  - Blaze, K / Collaborator
ED  - Bressler, P / Collaborator
ED  - Halpern, S / Collaborator
ED  - Chappell, D / Collaborator
ED  - Bergenstal, R / Collaborator
ED  - Cuddihy, R / Collaborator
ED  - Matfin, G / Collaborator
ED  - Freedman, Z / Collaborator
ED  - Gonzalez Campoy, J / Collaborator
ED  - Lerman, S / Collaborator
ED  - Rendell, M / Collaborator
ED  - Sitar, S / Collaborator
ED  - Reeves, M / Collaborator
ED  - Howard, T / Collaborator
ED  - Soufer, J / Collaborator
ED  - Miranda Palma, B / Collaborator
ED  - Laliotis, A / Collaborator
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ED  - Teltser, M / Collaborator
ED  - Hurley, D / Collaborator
ED  - Morawski, E / Collaborator
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ED  - Welch, M / Collaborator
ED  - Goytia Leos, D / Collaborator
ED  - Syed, M / Collaborator
ED  - Kowaloff, E / Collaborator
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ED  - Peniston, J / Collaborator
ED  - Brockmyre, A / Collaborator
ED  - First, B / Collaborator
ED  - Feld, L / Collaborator
ED  - Huffman, D / Collaborator
ED  - Nassim, O / Collaborator
ED  - Gottschlich, G / Collaborator
ED  - Patel, A / Collaborator
ED  - Knopke, C / Collaborator
ED  - Hernandez, M / Collaborator
ED  - Diaz, J / Collaborator
ED  - Giugliano, G / Collaborator
ED  - Nicasio, J / Collaborator
ED  - Eagerton, D / Collaborator
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ED  - Reed, J / Collaborator
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ED  - Levins, P / Collaborator
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ED  - Naidu, J / Collaborator
ED  - Lindenbaum, J / Collaborator
ED  - Jacks, R / Collaborator
ED  - Hammond, G / Collaborator
ED  - Arena, C / Collaborator
ED  - Saxman, K / Collaborator
ED  - Mach, M / Collaborator
ED  - Kerstein, H / Collaborator
ED  - Kereiakes, D / Collaborator
ED  - Wahlen, J / Collaborator
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ED  - Rothman, J / Collaborator
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ED  - Rosenstock, J / Collaborator
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ED  - Navarro, J / Collaborator
ED  - Colfer, H / Collaborator
ED  - Mokshagundam, S / Collaborator
ED  - Shandilya, L / Collaborator
ED  - Connery, L / Collaborator
ED  - Wysham, C / Collaborator
ED  - Dela Llana, A / Collaborator
ED  - Jardula, M / Collaborator
ED  - MacAdams, M / Collaborator
ED  - Flippo, G / Collaborator
ED  - Heurich, E / Collaborator
ED  - Curtis, C / Collaborator
ED  - Sanders, D / Collaborator
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ED  - Osea, E / Collaborator
ED  - Mahood, K / Collaborator
ED  - Feldman, G / Collaborator
ED  - Eder, F / Collaborator
ED  - Riley, E / Collaborator
ED  - Jain, M / Collaborator
ED  - Fowler, W / Collaborator
ED  - Shepard, M / Collaborator
ED  - Schear, M / Collaborator
ED  - Barker, B / Collaborator
ED  - Strout, C / Collaborator
ED  - Obiekwe, O / Collaborator
ED  - Shanik, M / Collaborator
ED  - Green, C / Collaborator
ED  - Blakney, E / Collaborator
ED  - Roberson, K / Collaborator
ED  - Bretton, E / Collaborator
ED  - Pish, R / Collaborator
ED  - Kaveh, K / Collaborator
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ED  - Barager, W / Collaborator
ED  - Soldyshev, R / Collaborator
ED  - Austin, B / Collaborator
ED  - Parmar, P / Collaborator
ED  - Simpson, R / Collaborator
ED  - Chauhan, A / Collaborator
ED  - Kasper, J / Collaborator
ED  - Burr, R / Collaborator
ED  - Patel, N / Collaborator
ED  - Mariano, H / Collaborator
ED  - Pluto, T / Collaborator
ED  - Bratcher, C / Collaborator
ED  - Juarez, M / Collaborator
ED  - Levinson, L / Collaborator
ED  - Awad, A / Collaborator
ED  - Longshaw, K / Collaborator
ED  - Hoffman, K / Collaborator
ED  - Richwine, R / Collaborator
ED  - Molter, D / Collaborator
ED  - Boscia, J / Collaborator
ED  - Kowalyk, S / Collaborator
ED  - Lemis, P / Collaborator
ED  - Liss, J / Collaborator
ED  - Orr, R / Collaborator
ED  - Riser, J / Collaborator
ED  - Wood, J / Collaborator
ED  - Ubani, A / Collaborator
ED  - Paine, W / Collaborator
ED  - Hassani, F / Collaborator
ED  - Miranda, F / Collaborator
ED  - Hansen, V / Collaborator
ED  - Farris, N / Collaborator
ED  - Bowden, R / Collaborator
ED  - Ajani, D / Collaborator
ED  - Maw, K / Collaborator
ED  - Andersen, J / Collaborator
ED  - Bergman, B / Collaborator
ED  - Dunmyer, S / Collaborator
ED  - Brandon, D / Collaborator
ED  - Anderson, M / Collaborator
ED  - Bononi, P / Collaborator
ED  - Prawer, J / Collaborator
ED  - Seidman, B / Collaborator
ED  - Cruz, H / Collaborator
ED  - Wilks, K / Collaborator
ED  - DiSanto, L / Collaborator
ED  - Buynak, R / Collaborator
ED  - Christensen, T / Collaborator
ED  - Denker, P / Collaborator
ED  - Koppel, W / Collaborator
ED  - Stedman, M / Collaborator
ED  - Lewy Alterbaum, L / Collaborator
ED  - Karim, S / Collaborator
ED  - Shapiro, J / Collaborator
ED  - Gardner, T / Collaborator
ED  - Oskin, T / Collaborator
ED  - Gabra, N / Collaborator
ED  - Malano, J / Collaborator
ED  - Welty, F K / Collaborator
ED  - Parhofer, K G / Collaborator
ED  - Pedersen, T R / Collaborator
ED  - Lees, K R / Collaborator
ED  - Clayton, T / Collaborator
ED  - Pocock, S / Collaborator
ED  - Palmer, M / Collaborator
ED  - Clemmensen, P / Collaborator
ED  - Grande, P / Collaborator
ED  - Pehrson, S / Collaborator
ED  - Januzzi, J / Collaborator
ED  - Wood, M J / Collaborator
ED  - Petrie, M / Collaborator
ED  - Sairanen, T / Collaborator
ED  - Tatlisumak, T / Collaborator
ED  - Soinne, L / Collaborator
ED  - Kase, C / Collaborator
ED  - Turan, T / Collaborator
ED  - Watkins, P / Collaborator
ED  - Lewis, J / Collaborator
ED  - Freston, J / Collaborator
ED  - Schenker, S / Collaborator
ED  - Heist, R / Collaborator
ED  - Lee, R J / Collaborator
ED  - Natale, R B / Collaborator
ED  - Sullivan, R J / Collaborator
ED  - Buchbinder, E I / Collaborator
ED  - Chodak, G / Collaborator
ED  - Schumacher, M / Collaborator
ED  - Schmoor, C / Collaborator
ED  - Hieke, S / Collaborator
ED  - Fasching, P / Collaborator
ED  - Paulweber, B / Collaborator
ED  - Toplak, H / Collaborator
ED  - Luger, A / Collaborator
ED  - Drexel, H / Collaborator
ED  - Prager, R / Collaborator
ED  - Schnack, C / Collaborator
ED  - Schernthaner, G / Collaborator
ED  - Fliesser Goerzer, E / Collaborator
ED  - Kaser, S / Collaborator
ED  - Scheen, A / Collaborator
ED  - Van Gaal, L / Collaborator
ED  - Hollanders, G / Collaborator
ED  - Kockaerts, Y / Collaborator
ED  - Capiau, L / Collaborator
ED  - Chachati, A / Collaborator
ED  - Persu, A / Collaborator
ED  - Hermans, M / Collaborator
ED  - Vantroyen, D / Collaborator
ED  - Vercammen, C / Collaborator
ED  - Van de Borne, P / Collaborator
ED  - Mathieu, C / Collaborator
ED  - Benhalima, K / Collaborator
ED  - Lienart, F / Collaborator
ED  - Mortelmans, J / Collaborator
ED  - Strivay, M / Collaborator
ED  - Vereecken, G / Collaborator
ED  - Keymeulen, B / Collaborator
ED  - Lamkanfi, F / Collaborator
ED  - Chacra, A / Collaborator
ED  - Eliaschewitz, F / Collaborator
ED  - Zanella, M / Collaborator
ED  - Faludi, A / Collaborator
ED  - Bertolami, M / Collaborator
ED  - Hayashida, C / Collaborator
ED  - Nunes Salles, J / Collaborator
ED  - Monte, O / Collaborator
ED  - Dinato, M / Collaborator
ED  - Manenti, E / Collaborator
ED  - Rassi, N / Collaborator
ED  - Halpern, A / Collaborator
ED  - Lima Filho, M / Collaborator
ED  - Ayoub, J / Collaborator
ED  - Felicio, J / Collaborator
ED  - Borges, J / Collaborator
ED  - Gross, J / Collaborator
ED  - Sgarbi, J / Collaborator
ED  - Betti, R / Collaborator
ED  - Tiburcio, A / Collaborator
ED  - Purisch, S / Collaborator
ED  - Schmid, H / Collaborator
ED  - Takahashi, M / Collaborator
ED  - Castro, M / Collaborator
ED  - Rea, R / Collaborator
ED  - Hissa, M / Collaborator
ED  - Geloneze Neto, B / Collaborator
ED  - Saraiva, J / Collaborator
ED  - Henein, S / Collaborator
ED  - Lochnan, H / Collaborator
ED  - Imran, S / Collaborator
ED  - Clayton, D / Collaborator
ED  - Bayly, K / Collaborator
ED  - Berlingieri, J / Collaborator
ED  - Boucher, P / Collaborator
ED  - Chan, Y / Collaborator
ED  - Gupta, M / Collaborator
ED  - Chehayeb, R / Collaborator
ED  - Ouellett, A / Collaborator
ED  - Ur, E / Collaborator
ED  - Woo, V / Collaborator
ED  - Zinman, B / Collaborator
ED  - St Amour, E / Collaborator
ED  - Terront Lozano, M / Collaborator
ED  - Yupanqui Lozno, H / Collaborator
ED  - Urina, M / Collaborator
ED  - Lopez Jaramillo, P / Collaborator
ED  - Jaramillo, N / Collaborator
ED  - Sanchez, G / Collaborator
ED  - Perez, G / Collaborator
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ED  - Mirosevic, G / Collaborator
ED  - Goldoni, V / Collaborator
ED  - Jurisic Erzen, D / Collaborator
ED  - Balasko, A / Collaborator
ED  - Balic, S / Collaborator
ED  - Drvodelic Sunic, E / Collaborator
ED  - Varzic, S / Collaborator
ED  - Machkova, M / Collaborator
ED  - Weiner, P / Collaborator
ED  - Lastuvka, J / Collaborator
ED  - Olsovsky, J / Collaborator
ED  - Krarup, T / Collaborator
ED  - Ridderstrale, M / Collaborator
ED  - Tarnow, L / Collaborator
ED  - Boesgaard, T / Collaborator
ED  - Lihn, A / Collaborator
ED  - Christensen, P / Collaborator
ED  - Juhl, H / Collaborator
ED  - Urhammer, S / Collaborator
ED  - Lund, P / Collaborator
ED  - Adojaan, B / Collaborator
ED  - Jakovlev, U / Collaborator
ED  - Lanno, R / Collaborator
ED  - Lubi, M / Collaborator
ED  - Marandi, T / Collaborator
ED  - Gouet, D / Collaborator
ED  - Courreges, J / Collaborator
ED  - Zaoui, P / Collaborator
ED  - Choukroun, G / Collaborator
ED  - Petit, C / Collaborator
ED  - Formagne, L / Collaborator
ED  - Estour, B / Collaborator
ED  - Mabire, P / Collaborator
ED  - Daugenet, C / Collaborator
ED  - Lemarie, B / Collaborator
ED  - Clavel, S / Collaborator
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ED  - Glonti, S / Collaborator
ED  - Metreveli, D / Collaborator
ED  - Lominadze, Z / Collaborator
ED  - Giorgadze, E / Collaborator
ED  - Burtchuladze, T / Collaborator
ED  - Javashvili, L / Collaborator
ED  - Kurashvili, G / Collaborator
ED  - Kurashvili, R / Collaborator
ED  - Virsaladze, D / Collaborator
ED  - Nadareishvili, L / Collaborator
ED  - Khomasuridze, A / Collaborator
ED  - Cahill, T / Collaborator
ED  - Green, F / Collaborator
ED  - MacRury, S / Collaborator
ED  - Waldron, M / Collaborator
ED  - Middleton, A / Collaborator
ED  - McKnight, J / Collaborator
ED  - Pearson, E / Collaborator
ED  - Butler, M / Collaborator
ED  - Choksi, M / Collaborator
ED  - Caldwell, I / Collaborator
ED  - Farmer, I / Collaborator
ED  - Wyatt, N / Collaborator
ED  - Patrick, J / Collaborator
ED  - O'Brien, I / Collaborator
ED  - Devers, M / Collaborator
ED  - Bousboulas, S / Collaborator
ED  - Pappas, S / Collaborator
ED  - Piaditis, G / Collaborator
ED  - Vryonidou, A / Collaborator
ED  - Tentolouris, N / Collaborator
ED  - Karamitsos, K / Collaborator
ED  - Manes, C / Collaborator
ED  - Benroubi, M / Collaborator
ED  - Avramidis, I / Collaborator
ED  - Ozaki, R / Collaborator
ED  - Tan, K / Collaborator
ED  - Siu, S / Collaborator
ED  - Tsang, C / Collaborator
ED  - Dudas, M / Collaborator
ED  - Nagy, K / Collaborator
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ED  - Ip, T / Collaborator
ED  - Geroo, L / Collaborator
ED  - Patkay, J / Collaborator
ED  - Tabak, A / Collaborator
ED  - Juhasz, F / Collaborator
ED  - Szentpeteri, I / Collaborator
ED  - Tamas, G / Collaborator
ED  - Ghaisas, N / Collaborator
ED  - Bantwal, G / Collaborator
ED  - Mohan, V / Collaborator
ED  - Gupta, J / Collaborator
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ED  - Garg, N / Collaborator
ED  - Reddy, S / Collaborator
ED  - Deshpande, N / Collaborator
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ED  - Pillai, M / Collaborator
ED  - Premchand, R / Collaborator
ED  - Badgandi, M / Collaborator
ED  - Jain, S / Collaborator
ED  - Aravind, S / Collaborator
ED  - Shamanna, P / Collaborator
ED  - Pandey, A / Collaborator
ED  - Gupta, S / Collaborator
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ED  - Saksono, H / Collaborator
ED  - Agung, P / Collaborator
ED  - Wahono,, S Suastika, K / Collaborator
ED  - Tanggo, Y / Collaborator
ED  - Juwana, Y / Collaborator
ED  - Siswanto, B / Collaborator
ED  - Adawi, F / Collaborator
ED  - Efrati, S / Collaborator
ED  - Mazen, E / Collaborator
ED  - Bashkin, A / Collaborator
ED  - Herskovits, T / Collaborator
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ED  - Aiello, A / Collaborator
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ED  - Cignarelli, M / Collaborator
ED  - Fioretto, P / Collaborator
ED  - Reggiani, G / Collaborator
ED  - Gnasso, A / Collaborator
ED  - Marchionni, N / Collaborator
ED  - Marsilii, A / Collaborator
ED  - Bucci, M / Collaborator
ED  - Mezzetti, A / Collaborator
ED  - Pozzilli, P / Collaborator
ED  - Colivicchi, F / Collaborator
ED  - Santini, M / Collaborator
ED  - Moro, E / Collaborator
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ED  - Semplicini, A / Collaborator
ED  - Monno, S / Collaborator
ED  - Furui, K / Collaborator
ED  - Higashiue, S / Collaborator
ED  - Hiramatsu, N / Collaborator
ED  - Kawamitsu, K / Collaborator
ED  - Takenaka, T / Collaborator
ED  - Takahashi, H / Collaborator
ED  - Hojo, F / Collaborator
ED  - Onishi, Y / Collaborator
ED  - Izumino, K / Collaborator
ED  - Okubo, M / Collaborator
ED  - Wakida, Y / Collaborator
ED  - Kondo, Y / Collaborator
ED  - Hieshima, K / Collaborator
ED  - Jinnouchi, H / Collaborator
ED  - Suzuki, A / Collaborator
ED  - Ito, M / Collaborator
ED  - Park, S / Collaborator
ED  - Kim, Y / Collaborator
ED  - Hong, T / Collaborator
ED  - Park, H / Collaborator
ED  - Gwon, H / Collaborator
ED  - Kim, H / Collaborator
ED  - Kang, K / Collaborator
ED  - Jeong, M / Collaborator
ED  - Seung, K / Collaborator
ED  - Lim, D / Collaborator
ED  - Rha, S / Collaborator
ED  - Tahk, S / Collaborator
ED  - Yang, J / Collaborator
ED  - Yoon, J / Collaborator
ED  - Shin, M / Collaborator
ED  - Kim, D / Collaborator
ED  - Jeong, J / Collaborator
ED  - Ahmad,, N Mustafa, N / Collaborator
ED  - Mohamed, W / Collaborator
ED  - Fung, Y / Collaborator
ED  - Ghani, R / Collaborator
ED  - Chandramouli, A / Collaborator
ED  - Chee, K / Collaborator
ED  - Kadir, K / Collaborator
ED  - Ling, K / Collaborator
ED  - Abu Hassan, M / Collaborator
ED  - Foo, S / Collaborator
ED  - Lee, S / Collaborator
ED  - Garcia Hernandez, P / Collaborator
ED  - Aguilar Salinas, C / Collaborator
ED  - Vidrio Velazquez, M / Collaborator
ED  - Flores, F / Collaborator
ED  - Alpizar Salazar, M / Collaborator
ED  - Micher Escalante, D / Collaborator
ED  - Garcia Soria, M / Collaborator
ED  - Cardona Munoz, E / Collaborator
ED  - Storms, G / Collaborator
ED  - Schaper, N / Collaborator
ED  - Kooy, A / Collaborator
ED  - Krekels, M / Collaborator
ED  - van Bemmel, T / Collaborator
ED  - Verhoeven, R / Collaborator
ED  - Mulder, H / Collaborator
ED  - Oldenburg Ligtenberg, P / Collaborator
ED  - Gonkel, F / Collaborator
ED  - de Jong, A / Collaborator
ED  - van Soest, J / Collaborator
ED  - Viergever, P / Collaborator
ED  - Mevissen, H / Collaborator
ED  - Lochorn, G / Collaborator
ED  - Zwiers, G / Collaborator
ED  - Hoogslag, P / Collaborator
ED  - Ronner, E / Collaborator
ED  - Nierop, P / Collaborator
ED  - Al Windy, N / Collaborator
ED  - Kragten, J / Collaborator
ED  - Dekelver, P / Collaborator
ED  - Benatar, J / Collaborator
ED  - Krebs, J / Collaborator
ED  - Scott, R / Collaborator
ED  - Heggen, E / Collaborator
ED  - Berz, A / Collaborator
ED  - Fossum, C / Collaborator
ED  - Hurtig, U / Collaborator
ED  - Langslet, G / Collaborator
ED  - Baranowski, M / Collaborator
ED  - Sparby, J / Collaborator
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ED  - Delgado Torres, C / Collaborator
ED  - Rodriguez Escudero, A / Collaborator
ED  - Lisson, R / Collaborator
ED  - Allemant Maldonado, A / Collaborator
ED  - Gallardo Rojas, W / Collaborator
ED  - Gonzales Bravo, L / Collaborator
ED  - Lema Osores, J / Collaborator
ED  - Farfan, J / Collaborator
ED  - Zapata, L / Collaborator
ED  - Godoy Junchaya, J / Collaborator
ED  - Roldan Concha, Y / Collaborator
ED  - Urquiaga Calderon, J / Collaborator
ED  - Sy, R / Collaborator
ED  - Tan, G / Collaborator
ED  - Aquitania, G / Collaborator
ED  - De Los Santos, G / Collaborator
ED  - Panelo, A / Collaborator
ED  - Roderos, O / Collaborator
ED  - Rosales, R / Collaborator
ED  - Toledo, R / Collaborator
ED  - Liwag, A / Collaborator
ED  - Ramoncito, H / Collaborator
ED  - Skokowska, E / Collaborator
ED  - Krzyzagorska, E / Collaborator
ED  - Ogorek, M / Collaborator
ED  - Wojnowski, L / Collaborator
ED  - Spyra, J / Collaborator
ED  - Konieczny, M / Collaborator
ED  - Piesiewicz, W / Collaborator
ED  - Kus, W / Collaborator
ED  - Ocicka Kozakiewicz, A / Collaborator
ED  - Orlowska Kunikowska, E / Collaborator
ED  - Zmuda, W / Collaborator
ED  - Duarte, S / Collaborator
ED  - Leitao, A / Collaborator
ED  - Monteiro, P / Collaborator
ED  - Rita, H / Collaborator
ED  - Salgado, V / Collaborator
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ED  - Teixeira, J / Collaborator
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ED  - Duarte, R / Collaborator
ED  - Sobral do Rosario, F / Collaborator
ED  - Silva, A / Collaborator
ED  - Andrade, L / Collaborator
ED  - Velez, M / Collaborator
ED  - Brazao, M / Collaborator
ED  - Istratoaie, O / Collaborator
ED  - Lichiardopol, R / Collaborator
ED  - Catrinoiu, D / Collaborator
ED  - Militaru, C / Collaborator
ED  - Zetu, C / Collaborator
ED  - Barbonta, D / Collaborator
ED  - Cosma, D / Collaborator
ED  - Crisan, C / Collaborator
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ED  - Khetagurova, F / Collaborator
ED  - Petrov, A / Collaborator
ED  - Arutyunov, G / Collaborator
ED  - Boyarkin, M / Collaborator
ED  - Agafyina, A / Collaborator
ED  - Vorokhobina, N / Collaborator
ED  - Petunina, N / Collaborator
ED  - Libov, I / Collaborator
ED  - Zalevskaya, A / Collaborator
ED  - Nikolaev, K / Collaborator
ED  - Barbarash, O / Collaborator
ED  - Potemkin, V / Collaborator
ED  - Bystrova, A / Collaborator
ED  - Krasilnikova, E / Collaborator
ED  - Barbarich, V / Collaborator
ED  - Chumakova, G / Collaborator
ED  - Tarasov, N / Collaborator
ED  - Meleshkevich, T / Collaborator
ED  - Zateyshchikov, D / Collaborator
ED  - Lantseva, O / Collaborator
ED  - Belenkiy, D / Collaborator
ED  - Obrezan, A / Collaborator
ED  - Rossolko, L / Collaborator
ED  - Fillipova, E / Collaborator
ED  - Yakhontova, P / Collaborator
ED  - Khokhlov, A / Collaborator
ED  - Tan, R / Collaborator
ED  - Sum, C / Collaborator
ED  - Chang, H / Collaborator
ED  - Distiller, L / Collaborator
ED  - Pretorius, M / Collaborator
ED  - Nortje, H / Collaborator
ED  - Mitha, E / Collaborator
ED  - Burgess, L / Collaborator
ED  - Blignaut, S / Collaborator
ED  - Venter, T / Collaborator
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ED  - Lombaard, J / Collaborator
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ED  - Amod, A / Collaborator
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ED  - Segura, J / Collaborator
ED  - Brito, M / Collaborator
ED  - Fernandez Cruz, A / Collaborator
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ED  - Iglesias, R / Collaborator
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ED  - Linares, J / Collaborator
ED  - del Canizo, F / Collaborator
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ED  - Suarez, C / Collaborator
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ED  - Gomez Peralta, F / Collaborator
ED  - Iglesias, M / Collaborator
ED  - Pereg, V / Collaborator
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ED  - Satarasinghe, R / Collaborator
ED  - Somasundaram, N / Collaborator
ED  - Siyambalapitiya, S / Collaborator
ED  - Antonypillai, C / Collaborator
ED  - Bulugahapitiya, D / Collaborator
ED  - Medagama, U / Collaborator
ED  - Huang, C / Collaborator
ED  - Lu, Y / Collaborator
ED  - Hwang, J / Collaborator
ED  - Chiang, C / Collaborator
ED  - Wen, M / Collaborator
ED  - Chen, J / Collaborator
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ED  - Chang, K / Collaborator
ED  - Wang, J / Collaborator
ED  - Yeh, H / Collaborator
ED  - Kriangsak, P / Collaborator
ED  - Deerochanawong, C / Collaborator
ED  - Suwanwalaikorn, S / Collaborator
ED  - Mangklabruks, A / Collaborator
ED  - Kaewsuwanna, P / Collaborator
ED  - Piyayotai, D / Collaborator
ED  - Iabluchanskyi, M / Collaborator
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ED  - Godlevska, O / Collaborator
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ED  - Voloshyna, O / Collaborator
ED  - Tseluyko, V / Collaborator
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ED  - Vykhovanyuk, I / Collaborator
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ED  - Ball, E / Collaborator
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ED  - Welch, M / Collaborator
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ED  - Peniston, J / Collaborator
ED  - Brockmyre, A / Collaborator
ED  - First, B / Collaborator
ED  - Feld, L / Collaborator
ED  - Huffman, D / Collaborator
ED  - Nassim, O / Collaborator
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ED  - Hernandez, M / Collaborator
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ED  - Giugliano, G / Collaborator
ED  - Nicasio, J / Collaborator
ED  - Eagerton, D / Collaborator
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ED  - Reed, J / Collaborator
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ED  - Hippert, R / Collaborator
ED  - Sofley, C Jr / Collaborator
ED  - Alzohaili, O / Collaborator
ED  - Levins, P / Collaborator
ED  - Anspach, R / Collaborator
ED  - Shah, S / Collaborator
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ED  - Lindenbaum, J / Collaborator
ED  - Jacks, R / Collaborator
ED  - Hammond, G / Collaborator
ED  - Arena, C / Collaborator
ED  - Saxman, K / Collaborator
ED  - Mach, M / Collaborator
ED  - Kerstein, H / Collaborator
ED  - Kereiakes, D / Collaborator
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ED  - Bittar, N / Collaborator
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ED  - Shandilya, L / Collaborator
ED  - Connery, L / Collaborator
ED  - Wysham, C / Collaborator
ED  - Dela Llana, A / Collaborator
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ED  - MacAdams, M / Collaborator
ED  - Flippo, G / Collaborator
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ED  - Feldman, G / Collaborator
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ED  - Fowler, W / Collaborator
ED  - Jain, M / Collaborator
ED  - Shepard, M / Collaborator
ED  - Schear, M / Collaborator
ED  - Barker, B / Collaborator
ED  - Strout, C / Collaborator
ED  - Obiekwe, O / Collaborator
ED  - Shanik, M / Collaborator
ED  - Green, C / Collaborator
ED  - Blakney, E / Collaborator
ED  - Roberson, K / Collaborator
ED  - Bretton, E / Collaborator
ED  - Pish, R / Collaborator
ED  - Kaveh, K / Collaborator
ED  - Maynard, B / Collaborator
ED  - Barager, W / Collaborator
ED  - Soldyshev, R / Collaborator
ED  - Austin, B / Collaborator
ED  - Parmar, P / Collaborator
ED  - Simpson, R / Collaborator
ED  - Chauhan, A / Collaborator
ED  - Kasper, J / Collaborator
ED  - Burr, R / Collaborator
ED  - Patel, N / Collaborator
ED  - Mariano, H / Collaborator
ED  - Pluto, T / Collaborator
ED  - Bratcher, C / Collaborator
ED  - Juarez, M / Collaborator
ED  - Levinson, L / Collaborator
ED  - Awad, A / Collaborator
ED  - Longshaw, K / Collaborator
ED  - Hoffman, K / Collaborator
ED  - Richwine, R / Collaborator
ED  - Molter, D / Collaborator
ED  - Boscia, J / Collaborator
ED  - Kowalyk, S / Collaborator
ED  - Lemis, P / Collaborator
ED  - Liss, J / Collaborator
ED  - Orr, R / Collaborator
ED  - Riser, J / Collaborator
ED  - Wood, J / Collaborator
ED  - Ubani, A / Collaborator
ED  - Paine, W / Collaborator
ED  - Hassani, F / Collaborator
ED  - Miranda, F / Collaborator
ED  - Hansen, V / Collaborator
ED  - Hansen, Val R / Collaborator
ED  - Farris, N / Collaborator
ED  - Bowden, R / Collaborator
ED  - Ajani, D / Collaborator
ED  - Maw, K / Collaborator
ED  - Andersen, J / Collaborator
ED  - Bergman, B / Collaborator
ED  - Dunmyer, S / Collaborator
ED  - Brandon, D / Collaborator
ED  - Anderson, M / Collaborator
ED  - Bononi, P / Collaborator
ED  - Prawer, J / Collaborator
ED  - Seidman, B / Collaborator
ED  - Cruz, H / Collaborator
ED  - Wilks, K / Collaborator
ED  - DiSanto, L / Collaborator
ED  - Buynak, R / Collaborator
ED  - Christensen, T / Collaborator
ED  - Denker, P / Collaborator
ED  - Koppel, W / Collaborator
ED  - Stedman, M / Collaborator
ED  - Lewy Alterbaum, L / Collaborator
ED  - Karim, S / Collaborator
ED  - Shapiro, J / Collaborator
ED  - Gardner, T / Collaborator
ED  - Oskin, T / Collaborator
ED  - Gabra, N / Collaborator
ED  - Malano, J / Collaborator
TI  - Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
JF  - NEW ENGLAND JOURNAL OF MEDICINE
J2  - NEW ENGL J MED
VL  - 375
PY  - 2016
IS  - 4
SP  - 323
EP  - 334
PG  - 12
SN  - 0028-4793
DO  - 10.1056/NEJMoa1515920
UR  - https://m2.mtmt.hu/api/publication/31230059
ID  - 31230059
AB  - BACKGROUND Diabetes confers an increased risk of adverse cardiovascular and renal events. In the EMPA-REG OUTCOME trial, empagliflozin, a sodium-glucose cotransporter 2 inhibitor, reduced the risk of major adverse cardiovascular events in patients with type 2 diabetes at high risk for cardiovascular events. We wanted to determine the long-term renal effects of empagliflozin, an analysis that was a prespecified component of the secondary microvascular outcome of that trial. METHODS We randomly assigned patients with type 2 diabetes and an estimated glomerular filtration rate of at least 30 ml per minute per 1.73 m(2) of body-surface area to receive either empagliflozin (at a dose of 10 mg or 25 mg) or placebo once daily. Prespecified renal outcomes included incident or worsening nephropathy (progression to macroalbuminuria, doubling of the serum creatinine level, initiation of renal-replacement therapy, or death from renal disease) and incident albuminuria. RESULTS Incident or worsening nephropathy occurred in 525 of 4124 patients (12.7%) in the empagliflozin group and in 388 of 2061 (18.8%) in the placebo group (hazard ratio in the empagliflozin group, 0.61; 95% confidence interval, 0.53 to 0.70; P<0.001). Doubling of the serum creatinine level occurred in 70 of 4645 patients (1.5%) in the empagliflozin group and in 60 of 2323 (2.6%) in the placebo group, a significant relative risk reduction of 44%. Renal-replacement therapy was initiated in 13 of 4687 patients (0.3%) in the empagliflozin group and in 14 of 2333 patients (0.6%) in the placebo group, representing a 55% lower relative risk in the empagliflozin group. There was no significant between-group difference in the rate of incident albuminuria. The adverse-event profile of empagliflozin in patients with impaired kidney function at baseline was similar to that reported in the overall trial population. CONCLUSIONS In patients with type 2 diabetes at high cardiovascular risk, empagliflozin was associated with slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care. (Funded by the Boehringer Ingelheim and Eli Lilly and Company Diabetes Alliance; EMPA-REG OUTCOME ClinicalTrials.gov number, NCT01131676.)
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kun, Attila
AU  - Tabák, Ádám
AU  - Sudár, Z
AU  - Tornóczky, J
AU  - Vargha, P
AU  - Kerényi, Z
AU  - Tamás, Gyula
TI  - Teljes körű GDM-szűrés értékelése a WHO és az IADPSG kritériumrendszere alapján
JF  - DIABETOLOGIA HUNGARICA
J2  - DIABETOLOGIA HUNGARICA
VL  - 22
PY  - 2014
SP  - 201
EP  - 206
PG  - 6
SN  - 1217-372X
UR  - https://m2.mtmt.hu/api/publication/3078519
ID  - 3078519
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Szabó, E
AU  - Szili-Janicsek, Zsófia
AU  - Fürst, Á
AU  - Magenheim, Rita
AU  - Tänczer, Tímea
AU  - Kósa, János
AU  - Tamás, Gyula
AU  - Tabák, Ádám
TI  - Serum adiponectin levels in women with previous gestational diabetes
JF  - DIABETOLOGIA
J2  - DIABETOLOGIA
VL  - 56
PY  - 2013
IS  - Suppl. 1
SP  - S513
EP  - S513
SN  - 0012-186X
UR  - https://m2.mtmt.hu/api/publication/2404281
ID  - 2404281
LA  - English
DB  - MTMT
ER  -