TY  - CHAP
AU  - Horváth, Csaba
AU  - Takács, István
ED  - Takács, István
TI  - Kalcium-anyagcsere zavarai, osteoporosis
T2  - Belgyógyászat 1 tantárgyi jegyzet
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316122
PY  - 2024
SP  - 170
EP  - 185
PG  - 16
UR  - https://m2.mtmt.hu/api/publication/34817497
ID  - 34817497
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Takács, István
ED  - Takács, István
TI  - A mellékpajzsmirigy betegségei
T2  - Belgyógyászat 1 tantárgyi jegyzet
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316122
PY  - 2024
SP  - 70
EP  - 72
PG  - 3
UR  - https://m2.mtmt.hu/api/publication/34804137
ID  - 34804137
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Takács, István
ED  - Takács, István
TI  - Pajzsmirigyhormon-adaptációs szindróma (nonthyroidal illness – PASz)
T2  - Belgyógyászat 1 tantárgyi jegyzet
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316122
PY  - 2024
SP  - 68
EP  - 69
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/34804134
ID  - 34804134
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Bakos, Bence
AU  - Takács, István
ED  - Takács, István
TI  - Hyperthyreosis
T2  - Belgyógyászat 1 tantárgyi jegyzet
PB  - Semmelweis Kiadó
CY  - Budapest
SN  - 9789633316122
PY  - 2024
SP  - 46
EP  - 49
PG  - 4
UR  - https://m2.mtmt.hu/api/publication/34803088
ID  - 34803088
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - BOOK
ED  - Takács, István
TI  - Belgyógyászat 1 tantárgyi jegyzet
PB  - Semmelweis Kiadó
CY  - Budapest
PY  - 2024
SP  - 442
SN  - 9789633316122
UR  - https://m2.mtmt.hu/api/publication/34802851
ID  - 34802851
N1  - Az e-könyv feltéve: 2024. április 14.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Bojtor, Bence
AU  - Vaszilkó, Mihály Tamás
AU  - Ármós, Richárd Levente
AU  - Tóbiás, Bálint
AU  - Podani, János
AU  - Szentpéteri, Szófia Katalin
AU  - Balla, Bernadett
AU  - Lengyel, Balazs
AU  - Pikó, Henriett
AU  - Illés, Anett
AU  - Kiss, András
AU  - Putz, Zsuzsanna
AU  - Takács, István
AU  - Kósa, János
AU  - Lakatos, Péter
TI  - Analysis of SIRT1 Gene SNPs and Clinical Characteristics in Medication-Related Osteonecrosis of the Jaw
JF  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2  - INT J MOL SCI
VL  - 25
PY  - 2024
IS  - 7
PG  - 11
SN  - 1661-6596
DO  - 10.3390/ijms25073646
UR  - https://m2.mtmt.hu/api/publication/34795043
ID  - 34795043
AB  - Certain genetic factors, including single-nucleotide polymorphisms (SNPs) in the SIRT1 gene, have been linked to medication-related osteonecrosis of the jaw (MRONJ). This study examined four SNPs in the SIRT1 gene and implemented multivariate statistical analysis to analyze genetic and clinical factors in MRONJ patients. Genomic DNA was isolated from peripheral blood samples of 63 patients of European origin treated for MRONJ, and four SNP genotypes in the gene encoding the SIRT-1 protein were determined by Sanger sequencing. The allele frequencies measured in the MRONJ population were compared with allele frequencies measured in the European population in the National Center for Biotechnology Information Allele Frequency Aggregator (NCBI ALFA) database. Genetic and clinical factors were examined with multivariate statistical analysis. A C:A allele distribution ratio of 77.8:22.2 was measured in the rs932658 SNP. In the ALFA project, a C:A allele distribution ratio of 59.9:40.1 was detected in the European population, which was found to be a significant difference (p = 4.5 × 10−5). Multivariate statistical analysis revealed a positive correlation (0.275) between the genotype of SNP rs932658 and the number of stages improved during appropriate MRONJ therapy. It is concluded that allele A in SNP rs932658 in the SIRT1 gene acts as a protective factor in MRONJ.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Pikó, Henriett
AU  - Illés, Anett
AU  - Nagy, Sándor
AU  - Beke, Artúr
AU  - Árvai, Kristóf
AU  - Elekes, Tibor
AU  - Ferdinandyné Horváth, Emese
AU  - Ferenczy, Miklós
AU  - Mosonyi, Péter
AU  - Lukács, Valéria
AU  - Klujber, Valéria
AU  - Török, Olga
AU  - Kiss, Zsuzsanna
AU  - P Tardy, Erika
AU  - Tidrenczel, Zsolt
AU  - Tóbiás, Bálint
AU  - Balla, Bernadett
AU  - Lakatos, Péter
AU  - Kósa, János
AU  - Takács, István
TI  - Az első hazai tapasztalatok összegzése kromoszomális microarray-analízis és teljesexom-szekvenálás módszerekkel a magzati diagnosztikában
JF  - ORVOSI HETILAP
J2  - ORV HETIL
VL  - 165
PY  - 2024
IS  - 14
SP  - 523
EP  - 530
PG  - 8
SN  - 0030-6002
DO  - 10.1556/650.2024.33028
UR  - https://m2.mtmt.hu/api/publication/34780698
ID  - 34780698
AB  - Bevezetés: Az elmúlt évtized egyik jelentős technológiai újdonsága az ún. ’high-throughput’ molekuláris genetikai vizsgálati módszerek – mint a kromoszomális microarray-analízis (chromosomal microarray analysis, CMA) és a teljesexom-szekvenálás (whole-exome sequencing, WES) – elterjedése a praenatalis diagnosztikában. Célkitűzés: Az elmúlt 5 évben munkacsoportunk több mint 252 praenatalis vizsgálatot végzett hazai laboratóriumi háttérrel, amelyek indikációját különböző súlyosságú strukturális magzati ultrahangeltérések képezték. A klasszikus citogenetikai vizsgálatok eredményétől függően végeztük el a nagy felbontású CMA- és WES-analíziseket a praenatalis diagnosztika érdekében. Módszer: A CMA-vizsgálatokat a „GeneChip System 3000 Instrument” platformmal végeztük az SNP-alapú komparatív hibridizálás módszerével. Az általunk elvégzett újgenerációs szekvenálás során a teljes humán exom szekvenciájának meghatározása IonTorrent és Illumina platformokkal történt. Eredmények: Összesen 252 magzati CMA-vizsgálatot végeztünk, és 42%-ban mutattunk ki valamilyen hiányt vagy többletet, ebből 22%-ban igazoltunk kóros eltérést. 42 esetben végeztünk WES-t, amelyből 9 esetben (21,4%) azonosítottunk kóros eltérést az öröklésmenetet támogató, a magzati fenotípussal feltételezhetően összefüggésben lévő, a ClinVar adatbázis vagy az ACMG-klasszifikáció alapján. Megbeszélés: Tekintettel arra, hogy a magzati fenotípus értékelése közvetett, a praenatalis CMA- és WES-elemzésnek elsősorban a magzati ultrahangvizsgálat során azonosítható strukturális anomáliákkal összefüggő génekre, kromoszomális régiókra kell korlátozódnia. A szülők vizsgálata mind a CMA-, mind a WES-analízisek során kiemelt jelentőséggel bír, főleg azokban az esetekben, amelyeknél a kapott eltérés nem hozható egyértelmű összefüggésbe az ultrahangeltérésekkel. Következtetés: Fontos meghatározni azokat a paramétereket, amelyek alapján a magzati mintában talált kópiaszám-eltéréseket és WES-vizsgálattal igazolt variánsokat a leletben közöljük (figyelembe véve a nemzetközi ajánlásokat). Ezek alapján a praenatalis klinikai genetikai tanácsadáskor sokkal használhatóbb információk adhatók. Orv Hetil. 2024; 165(14): 523–530.
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Takács, István
AU  - Mezősi, Emese
AU  - Soto, Alfonso
AU  - Kamenický, Peter
AU  - Figueres, Lucile
AU  - Galvez Moreno, Maria Angeles
AU  - Lemoine, Sandrine
AU  - Borson-Chazot, Francoise
AU  - Capel, Ismael
AU  - Ouldrouis, Taha
AU  - Lucas, Nadège
AU  - Allas, Soraya
AU  - Sumeray, Mark
AU  - Ovize, Michel
AU  - Mannstadt, Michael
TI  - An Open-Label Phase 2 Study of Eneboparatide, a Novel PTH Receptor 1 Agonist, in Hypoparathyroidism
JF  - JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
J2  - J CLIN ENDOCR METAB
PY  - 2024
SN  - 0021-972X
DO  - 10.1210/clinem/dgae121
UR  - https://m2.mtmt.hu/api/publication/34729561
ID  - 34729561
AB  - Hypoparathyroidism is a rare disorder characterized by a deficiency in parathyroid hormone (PTH) resulting in hypocalcemia, hyperphosphatemia, and hypercalciuria. Eneboparatide is an investigational peptide agonist of the PTH1 receptor for the treatment of chronic hypoparathyroidism (HP).To evaluate the efficacy, safety, and tolerability of eneboparatide in HP patients.Open-label, phase 2 study.Twenty-eight patients (21 women, 7 men), mean age (range): 58 years (28-72), with HP were enrolled into 2 consecutive cohorts (C1, n = 12, and C2, n = 16).Following an optimization period, daily subcutaneous injections of eneboparatide were administered for 3 months at 20 µg/day (C1) or 10 µg/day (C2) starting dose. Conventional therapy was progressively removed and eneboparatide could be titrated up to 60 µg (C1) or 80 µg (C2).Proportion of patients achieving independence from conventional therapy, albumin-adjusted serum calcium (ADsCa), 24-h urine calcium (uCa), serum bone turnover markers (s-CTX and P1NP), bone mineral density (BMD), and adverse events (AEs).After 3 months,  ≥ 88% patients achieved independence from conventional therapy while mean ADsCa was maintained within target range (7.8-9 mg/dL). Eneboparatide induced a rapid and sustained reduction of mean 24-hour uCa, even among patients with hypercalciuria. Bone turnover markers slightly increased and BMD remained unchanged, consistent with progressive resumption of physiologic bone turnover. Eneboparatide was well tolerated with no serious AEs.Eneboparatide allowed independence from conventional therapy and maintenance of serum calcium within a target range, while normalizing uCa excretion and producing a balanced resumption of bone turnover.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Tuttle, Katherine R
AU  - Hauske, Sibylle J
AU  - Canziani, Maria Eugenia
AU  - Caramori, Maria Luiza
AU  - Cherney, David
AU  - Cronin, Lisa
AU  - Heerspink, Hiddo J L
AU  - Hugo, Christian
AU  - Nangaku, Masaomi
AU  - Rotter, Ricardo Correa
AU  - Silva, Arnold
AU  - Shah, Shimoli V
AU  - Sun, Zhichao
AU  - Urbach, Dorothea
AU  - de Zeeuw, Dick
AU  - Rossing, Peter
ED  - Tuttle, Katherine R / Collaborator
ED  - Hauske, Sibylle J / Collaborator
ED  - Canziani, Maria Eugenia / Collaborator
ED  - Caramori, Maria Luiza / Collaborator
ED  - Cherney, David / Collaborator
ED  - Cronin, Lisa / Collaborator
ED  - Heerspink, Hiddo J L / Collaborator
ED  - Hugo, Christian / Collaborator
ED  - Nangaku, Masaomi / Collaborator
ED  - Rotter, Ricardo Correa / Collaborator
ED  - Silva, Arnold / Collaborator
ED  - Shah, Shimoli V / Collaborator
ED  - Sun, Zhichao / Collaborator
ED  - Urbach, Dorothea / Collaborator
ED  - de Zeeuw, Dick / Collaborator
ED  - Rossing, Peter / Collaborator
ED  - Szeto, Cheuk Chun / Collaborator
ED  - Echeverri, Diego / Collaborator
ED  - Martin, Edouard / Collaborator
ED  - Yee, Ming Li / Collaborator
ED  - Wah, William / Collaborator
ED  - Wang, Ray / Collaborator
ED  - Chacko, Bobby / Collaborator
ED  - Swaminathan, Shriram / Collaborator
ED  - MacIsaac, Richard / Collaborator
ED  - Hashimura, Hikaru / Collaborator
ED  - Ward, Glenn / Collaborator
ED  - De Vusser, Katrien / Collaborator
ED  - Claes, Kathleen / Collaborator
ED  - Kuypers, Dirk / Collaborator
ED  - Meijers, Björn / Collaborator
ED  - Van Craenenbroeck, Amaryllis / Collaborator
ED  - Hilbrands, Robert / Collaborator
ED  - Debroye, Corinne / Collaborator
ED  - Wissing, Karl Martin / Collaborator
ED  - Jadoul, Michel / Collaborator
ED  - Demoulin, Nathalie / Collaborator
ED  - Treille De Grandsaigne, Serge / Collaborator
ED  - Beklevic, Ishak / Collaborator
ED  - Marcoux, Diane / Collaborator
ED  - Liénart, Fabienne / Collaborator
ED  - Daper, Claude / Collaborator
ED  - De Brouckere, Véronique / Collaborator
ED  - Heureux, Mercédès / Collaborator
ED  - Felicio, Joao / Collaborator
ED  - Felicio, Karem Mileo / Collaborator
ED  - Leite, Daniella / Collaborator
ED  - Melo, Franciane / Collaborator
ED  - Queiroz, Natercia / Collaborator
ED  - Souza, Ana Carolina / Collaborator
ED  - Vieira, Jocyelle / Collaborator
ED  - Franco, Roberto / Collaborator
ED  - Mendes, Adriana / Collaborator
ED  - Picolli, Giovana / Collaborator
ED  - Canani, Luis Henrique / Collaborator
ED  - Sartori, Carla / Collaborator
ED  - Valenti, Adriana / Collaborator
ED  - Eliaschewitz, Freddy / Collaborator
ED  - Bona, Renata / Collaborator
ED  - Franco, Denise / Collaborator
ED  - Ludovico Costa de Castro, Denise / Collaborator
ED  - Magalhaes, Vanessa / Collaborator
ED  - Oliveira, Marcelo / Collaborator
ED  - Sampaio, Célia Regina / Collaborator
ED  - Visconti, Guilherme / Collaborator
ED  - Halpern, Bruno / Collaborator
ED  - Nihei, Camila / Collaborator
ED  - Pessoa, Bruna / Collaborator
ED  - Seraphim, Carlos / Collaborator
ED  - Santos, Daniel / Collaborator
ED  - Brito, Claudia / Collaborator
ED  - Douverny, Joao / Collaborator
ED  - Colella, Marina / Collaborator
ED  - Gazeta, Cristina / Collaborator
ED  - Vercia, Monique / Collaborator
ED  - Watanabe, Renato / Collaborator
ED  - Temelkova, Theodora / Collaborator
ED  - Kjurkchiev, Dimo / Collaborator
ED  - Statkova, Silviya / Collaborator
ED  - Popov, Iliya / Collaborator
ED  - Radeva, Radosveta / Collaborator
ED  - Arabadzhiev, Lachezar / Collaborator
ED  - Binova, Mariya / Collaborator
ED  - Bosilkov, Aleksandar / Collaborator
ED  - Koleva-Stoicheva, Neli / Collaborator
ED  - Ivanov, Ivaylo / Collaborator
ED  - Ivanova, Zornitsa / Collaborator
ED  - Kotseva, Viktoria / Collaborator
ED  - Spasov, Petar / Collaborator
ED  - Tsvetkov, Ivaylo / Collaborator
ED  - Jolly, Shivinder / Collaborator
ED  - Bailey, Gordon / Collaborator
ED  - Ye, Zhiming / Collaborator
ED  - Niu, Jianying / Collaborator
ED  - Li, Hongmei / Collaborator
ED  - Wu, Qing / Collaborator
ED  - Liao, Bing / Collaborator
ED  - Hao, Chuanming / Collaborator
ED  - Lai, Lingyun / Collaborator
ED  - Xu, Yunyu / Collaborator
ED  - Zhang, Min / Collaborator
ED  - Li, Yiwen / Collaborator
ED  - Liu, Bo / Collaborator
ED  - Shao, Lina / Collaborator
ED  - Chen, Wei / Collaborator
ED  - Wu, Haishan / Collaborator
ED  - Pirchala, Marian / Collaborator
ED  - Skarpova, Iva / Collaborator
ED  - Hraskova, Marketa / Collaborator
ED  - Soukupova, Simoneta / Collaborator
ED  - Veberova, Lucie / Collaborator
ED  - Drasnar, Tomas / Collaborator
ED  - Falc, Matej / Collaborator
ED  - Racz, Blazej / Collaborator
ED  - Votocek, Stepan / Collaborator
ED  - Weissova, Danica / Collaborator
ED  - Syc-Krivanova, Lenka / Collaborator
ED  - Slezak, Dagmar / Collaborator
ED  - Kantola, Ilkka / Collaborator
ED  - Nieminen, Sakari / Collaborator
ED  - Anttonen, Milla / Collaborator
ED  - Taurio, Jyrki / Collaborator
ED  - Lahtela, Jorma / Collaborator
ED  - Tsimihodimos, Vasileios / Collaborator
ED  - Balafa, Olga / Collaborator
ED  - Dounousi, Evangelia / Collaborator
ED  - Sakkou, Sissy / Collaborator
ED  - Tentolouris, Nikolaos / Collaborator
ED  - Siafarikas, Christos / Collaborator
ED  - Siami, Evangelia / Collaborator
ED  - Doupis, Ioannis / Collaborator
ED  - Angelopoulos, Theodoros / Collaborator
ED  - Georgoulias, Christodoulos / Collaborator
ED  - Pall, Denes / Collaborator
ED  - Esze, Regina / Collaborator
ED  - Kobling, Tamas / Collaborator
ED  - Varadi, Zita / Collaborator
ED  - Zsiros, Noemi / Collaborator
ED  - Vass, Viktor / Collaborator
ED  - Balo, Timea / Collaborator
ED  - Csanyi, Erika / Collaborator
ED  - Ory, Ivan / Collaborator
ED  - Pall, Istvan / Collaborator
ED  - Patai, Valentina / Collaborator
ED  - Zeak, Zsuzsanna / Collaborator
ED  - Takács, István / Collaborator
ED  - Pethő, Ákos / Collaborator
ED  - Szili, Balázs / Collaborator
ED  - Korányi, László / Collaborator
ED  - Bezzegh, Katalin / Collaborator
ED  - Pauer, Jozsef / Collaborator
ED  - Peterfai, Eva / Collaborator
ED  - Konyves, Laszlo / Collaborator
ED  - Szoke, Brigitta / Collaborator
ED  - Hajdu, Csaba / Collaborator
ED  - Kalman, Krisztina / Collaborator
ED  - Yadav, Raj / Collaborator
ED  - Saxena, Navneet / Collaborator
ED  - Bhattacharya, Meenakshi / Collaborator
ED  - Sharma, Bal / Collaborator
ED  - Thomas, Nihal / Collaborator
ED  - K, Felix Jebasingh / Collaborator
ED  - Kapoor, Nitin / Collaborator
ED  - Kurian, Mathews E / Collaborator
ED  - Paul, Jinson / Collaborator
ED  - Ramesh, Priyadharshini / Collaborator
ED  - Varghese, Sheeba / Collaborator
ED  - Shibusawa, Nobuyuki / Collaborator
ED  - Nishi, Hiroshi / Collaborator
ED  - Noritake, Nobuyasu / Collaborator
ED  - Oda, Takashi / Collaborator
ED  - Okamoto, Hideki / Collaborator
ED  - Kasuga, Hirotake / Collaborator
ED  - Hori, Hiroshi / Collaborator
ED  - Ito, Yukiko / Collaborator
ED  - Mizukoshi, Toshihiro / Collaborator
ED  - Ishii, Hideto / Collaborator
ED  - Han, Seung Hyeok / Collaborator
ED  - Kim, Hyung Woo / Collaborator
ED  - Oh, Kook-Hwan / Collaborator
ED  - Han, Seung Seok / Collaborator
ED  - Han, Sang Youb / Collaborator
ED  - Cha, Dae Ryong / Collaborator
ED  - Cha, Jin Joo / Collaborator
ED  - Kwon, Soon-Kil / Collaborator
ED  - Cho, Hyunjeong / Collaborator
ED  - Kim, Hye-Young / Collaborator
ED  - Kim, Sun Moon / Collaborator
ED  - Lee, Jung Pyo / Collaborator
ED  - Lee, Jeonghwan / Collaborator
ED  - Lee, Li Yuan / Collaborator
ED  - Chang, Meng Lee / Collaborator
ED  - Laang, Shian Tuck / Collaborator
ED  - Tan, Zhao Zhi / Collaborator
ED  - Ahmad Rosdi, Hajar / Collaborator
ED  - Mohammad Ismail, Siti Hafizah / Collaborator
ED  - Simatherai, Devamalar / Collaborator
ED  - Tay, Ju Fan / Collaborator
ED  - Wong, Eddie Fook Sem / Collaborator
ED  - Yakob, Suryati / Collaborator
ED  - Abdul Sukur, Noorhafini / Collaborator
ED  - Anuar, Amalina / Collaborator
ED  - Md Rasid, Syaliza / Collaborator
ED  - Mushaddik, Irma Liyana / Collaborator
ED  - Mustafar, Ruslinda / Collaborator
ED  - Abu Shamsi, Muhammad Yusuf / Collaborator
ED  - Fong, Voon Ken / Collaborator
ED  - Kamaruzaman, Lydia / Collaborator
ED  - Mohd, Rozita / Collaborator
ED  - Wan Daud, Wan Rohaslizan / Collaborator
ED  - Wan Hassan, Wan Hasnul Halimi / Collaborator
ED  - Ab Hamid, Suhaidarwani / Collaborator
ED  - Abdullah, Muhammad Nabil / Collaborator
ED  - Yusoff, Mohd Yusran / Collaborator
ED  - Ramanathan, G R Letchuman / Collaborator
ED  - Lee, Kim Yen / Collaborator
ED  - Wan Ismail, Wan Fadhilah / Collaborator
ED  - Morales Villegas, Enrique / Collaborator
ED  - Ramirez Baez, Rubria / Collaborator
ED  - Vital Lopez, Jorge / Collaborator
ED  - Arias Delgadillo, Cristhian / Collaborator
ED  - Herrera Marmolejo, Marisol / Collaborator
ED  - Parra Perez, Rosa / Collaborator
ED  - Alpizar Salazar, Melchor / Collaborator
ED  - Flores Montealegre, Ana / Collaborator
ED  - Galvan Magaña, Jose / Collaborator
ED  - Gutierrez Tlapale, Minerva / Collaborator
ED  - Reyes Munguia, Daniela / Collaborator
ED  - Witczak, Bartlomiej / Collaborator
ED  - Gøransson, Lasse / Collaborator
ED  - Strand Thorsen, Inga / Collaborator
ED  - Caringal, Clodoaido / Collaborator
ED  - Villardo, Mario / Collaborator
ED  - Toledo, Ronaldo / Collaborator
ED  - Dijamco, Emerlinda Fausto / Collaborator
ED  - De Asis, Norman Cornelio / Collaborator
ED  - Kuizon, Angelica / Collaborator
ED  - Catindig, Elizabeth Ann / Collaborator
ED  - Perez, Ronald / Collaborator
ED  - Aquitania, Grace / Collaborator
ED  - Pableo, Jimrie David / Collaborator
ED  - Sanchez, Jay Karlou / Collaborator
ED  - Czernecka, Ewa / Collaborator
ED  - Cegiel, Aleksandra / Collaborator
ED  - Knychas, Dorota / Collaborator
ED  - Ochnio, Malgorzata / Collaborator
ED  - Kuligowska-Jakubowska, Monika / Collaborator
ED  - Cesarz, Marek / Collaborator
ED  - Kowalewska-Celejewska, Milena / Collaborator
ED  - Masajtis-Zagajewska, Anna / Collaborator
ED  - Jankowski, Lukasz / Collaborator
ED  - Ojrzanowski, Marcin / Collaborator
ED  - Olszewska-Jander, Magdalena / Collaborator
ED  - Skokowska, Ewa / Collaborator
ED  - Giermakowska-Samek, Malgorzata / Collaborator
ED  - Luchowska, Elzbieta / Collaborator
ED  - Patkowska, Renata / Collaborator
ED  - Sekulska, Marzenna / Collaborator
ED  - Marczuk-Krynicka, Dorota / Collaborator
ED  - Marciniak, Andrzej / Collaborator
ED  - Barwijuk, Michal / Collaborator
ED  - Myslicki, Marcin / Collaborator
ED  - Siek, Michal / Collaborator
ED  - Wronska, Danuta / Collaborator
ED  - Tomsia-Goncerz, Jadwiga / Collaborator
ED  - Wronski, Krzysztof / Collaborator
ED  - Junik, Roman / Collaborator
ED  - Dzialak, Szymon / Collaborator
ED  - Kurlapska, Ewelina / Collaborator
ED  - Malecha, Wieslaw / Collaborator
ED  - Suwala, Szymon / Collaborator
ED  - Branco, Patrícia / Collaborator
ED  - Birne, Rita / Collaborator
ED  - Raposo, João / Collaborator
ED  - Ferreira, Marta / Collaborator
ED  - Alexandrino, Henrique / Collaborator
ED  - Alves, Helena / Collaborator
ED  - Correia, Sara / Collaborator
ED  - Oliveira, Maria João / Collaborator
ED  - Ramalho, Diogo / Collaborator
ED  - Tavares, Patricia / Collaborator
ED  - Coetzee, Kathleen / Collaborator
ED  - Blignaut, Sue / Collaborator
ED  - Viljoen, Winifred / Collaborator
ED  - Potgieter, Elsje / Collaborator
ED  - Malherbe, Elmien / Collaborator
ED  - Ortiz Arduán, Alberto / Collaborator
ED  - Goma Garcés, Elena / Collaborator
ED  - Pérez, María / Collaborator
ED  - Santamaría, Rafael / Collaborator
ED  - López López, Isabel / Collaborator
ED  - Pendón de Mier, Victoria / Collaborator
ED  - Rodelo Haad, Cristian / Collaborator
ED  - Marques, María / Collaborator
ED  - Domènech, Esther / Collaborator
ED  - Portoles, Josep Maria / Collaborator
ED  - Soler, María José / Collaborator
ED  - Agraz, Irene / Collaborator
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ED  - Alvarez, German / Collaborator
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ED  - Fernandez, Juan / Collaborator
ED  - Bruce, Kendaling / Collaborator
ED  - Cuellar, Juan / Collaborator
ED  - Ranz Y Alvarez, Maria / Collaborator
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ED  - Pautasso, Mauro / Collaborator
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ED  - Sinha, Dhananjay / Collaborator
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ED  - Pazos, Fabiola / Collaborator
ED  - Gacutan-Liwag, Aretha / Collaborator
ED  - Duszynska, Malgorzata / Collaborator
ED  - Antkowiak-Piatyszek, Karolina / Collaborator
ED  - Konieczny, Grzegorz / Collaborator
ED  - Sidorowicz-Bialynicka, Anna / Collaborator
ED  - Ciesiolkiewicz-Wojcik, Agnieszka / Collaborator
ED  - Dwojak, Marek / Collaborator
ED  - Szymkowiak, Katarzyna / Collaborator
ED  - Gorczyca-Siudak, Daria / Collaborator
ED  - Janik-Palazzolo, Marzena / Collaborator
ED  - Siudak, Lukasz / Collaborator
ED  - Opiela, Jaroslaw / Collaborator
ED  - Iwanow, Dariusz / Collaborator
ED  - Solkiewicz, Monika / Collaborator
ED  - Sipinska-Surzynska, Malgorzata / Collaborator
ED  - Olszanecka-Glinianowicz, Magdalena / Collaborator
ED  - Rozmilowska, Izabela / Collaborator
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ED  - Prozesky, Hans / Collaborator
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ED  - Alvarisqueta, Andrés / Collaborator
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ED  - Suarez, Gabriel / Collaborator
ED  - Hernandez Gauna, Adrian / Collaborator
ED  - Pereyra, Alejandro / Collaborator
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ED  - Gelersztein, Elizabeth / Collaborator
ED  - Campestri, Gina / Collaborator
ED  - Gonzalez Santos, Maria / Collaborator
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ED  - Igarzabal, Cecilia / Collaborator
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TI  - Efficacy and safety of aldosterone synthase inhibition with and without empagliflozin for chronic kidney disease. a randomised, controlled, phase 2 trial
TS  - a randomised, controlled, phase 2 trial
JF  - LANCET
J2  - LANCET
VL  - 403
PY  - 2024
IS  - 10424
SP  - 379
EP  - 390
PG  - 12
SN  - 0140-6736
DO  - 10.1016/S0140-6736(23)02408-X
UR  - https://m2.mtmt.hu/api/publication/34452050
ID  - 34452050
AB  - Excess aldosterone accelerates chronic kidney disease progression. This phase 2 clinical trial assessed BI 690517, an aldosterone synthase inhibitor, for efficacy, safety, and dose selection.This was a multinational, randomised, controlled, phase 2 trial. People aged 18 years or older with an estimated glomerular filtration rate (eGFR) of 30 to less than 90 mL/min/1·73 m2, a urine albumin to creatinine ratio (UACR) of 200 to less than 5000 mg/g, and serum potassium of 4·8 mmol/L or less, taking an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker, were enrolled. Participants were randomly assigned (1:1) to 8 weeks of empagliflozin or placebo run-in, followed by a second randomisation (1:1:1:1) to 14 weeks of treatment with once per day BI 690517 at doses of 3 mg, 10 mg, or 20 mg, or placebo. Study participants, research coordinators, investigators, and the data coordinating centre were masked to treatment assignment. The primary endpoint was the change in UACR measured in first morning void urine from baseline (second randomisation) to the end of treatment. This study is registered with ClinicalTrials.gov (NCT05182840) and is completed.Between Feb 18 and Dec 30, 2022, of the 714 run-in participants, 586 were randomly assigned to receive BI 690517 or placebo. At baseline, 33% (n=196) were women, 67% (n=390) were men, 42% (n=244) had a racial identity other than White, and mean participant age was 63·8 years (SD 11·3). Mean baseline eGFR was 51·9 mL/min/1·73 m2 (17·7) and median UACR was 426 mg/g (IQR 205 to 889). Percentage change in first morning void UACR from baseline to the end of treatment at week 14 was -3% (95% CI -19 to 17) with placebo, -22% (-36 to -7) with BI 690517 3 mg, -39% (-50 to -26) with BI 690517 10 mg, and -37% (-49 to -22) with BI 690517 20 mg monotherapy. BI 690517 produced similar UACR reductions when added to empagliflozin. Investigator-reported hyperkalaemia occurred in 10% (14/146) of those in the BI 690517 3 mg group, 15% (22/144) in the BI 690517 10 mg group, and 18% (26/146) in the BI 690517 20 mg group, and in 6% (nine of 147) of those receiving placebo, with or without empagliflozin. Most participants with hyperkalaemia did not require intervention (86% [72/84]). Adrenal insufficiency was an adverse event of special interest reported in seven of 436 study participants (2%) receiving BI 690517 and one of 147 participants (1%) receiving matched placebo. No treatment-related deaths occurred during the study.BI 690517 dose-dependently reduced albuminuria with concurrent renin-angiotensin system inhibition and empagliflozin, suggesting an additive efficacy for chronic kidney disease treatment without unexpected safety signals.Boehringer Ingelheim.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ungvári, Zoltán István
AU  - Tabák, Ádám
AU  - Ádány, Róza
AU  - Purebl, György
AU  - Kaposvári, Csilla
AU  - Fazekas-Pongor, Vince
AU  - Csípő, Tamás
AU  - Szarvas, Zsófia
AU  - Horváth, Krisztián
AU  - Mukli, Péter
AU  - Balog, Piroska
AU  - Bódizs, Róbert
AU  - Ujma, Przemyslaw Péter
AU  - Stauder, Adrienne
AU  - Belsky, Daniel W.
AU  - Kovács, Illés
AU  - Yabluchanskiy, Andriy
AU  - Maier, Andrea B.
AU  - Moizs, Mariann
AU  - Östlin, Piroska
AU  - Yon, Yongjie
AU  - Varga, Péter
AU  - Vokó, Zoltán
AU  - Papp, Magor Csongor
AU  - Takács, István
AU  - Vásárhelyi, Barna
AU  - Torzsa, Péter
AU  - Ferdinandy, Péter
AU  - Csiszar, Anna
AU  - Benyó, Zoltán
AU  - Szabó, Attila
AU  - Bednárikné Dörnyei, Gabriella
AU  - Kivimäki, Mika
AU  - Kellermayer, Miklós
AU  - Merkely, Béla Péter
TI  - The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging
JF  - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)
J2  - GEROSCIENCE
VL  - 46
PY  - 2024
IS  - 1
SP  - 191
EP  - 218
PG  - 28
SN  - 2509-2715
DO  - 10.1007/s11357-023-01018-7
UR  - https://m2.mtmt.hu/api/publication/34425939
ID  - 34425939
N1  - International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary            
            Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Department of Health Promotion Sciences, The Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States            
            Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            UCL Brain Sciences, University College London, London, United Kingdom            
            Department of Internal Medicine and Oncology, Semmelweis University, Faculty of Medicine, Budapest, Hungary            
            HUN-REN-UD Public Health Research Group, Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary            
            Institute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            Robert N. Butler Columbia Aging Center, Columbia University, New York, NY, United States            
            Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States            
            Department of Ophthalmology, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            Department of Ophthalmology, Weill Cornell Medical College, New York City, NY, United States            
            Department of Clinical Ophthalmology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary            
            Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore            
            Centre for Healthy Longevity, National University Health System, Singapore, Singapore            
            Department of Human Movement Sciences, @AgeAmsterdam, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, Netherlands            
            Ministry of Interior of Hungary, Budapest, Hungary            
            WHO Regional Office for Europe, Copenhagen, Denmark            
            Clinical Center, Semmelweis University, Budapest, Hungary            
            Center for Health Technology Assessment, Semmelweis University, Budapest, Hungary            
            Department of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            Department of Family Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            Department of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            HUN-REN-SU Cerebrovascular and Neurocognitive Diseases Research Group, Budapest, Hungary            
            First Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            HUN-REN-SU Pediatrics and Nephrology Research Group, Semmelweis University, Budapest, Hungary            
            Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary            
            Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary            
            Heart and Vascular Center, Semmelweis University, Budapest, Hungary            
            Cited By :1            
            Export Date: 29 February 2024            
            Correspondence Address: Ungvari, Z.; International Training Program in Geroscience/Healthy Aging Program, Hungary; email: Zoltan-Ungvari@ouhsc.edu            
            Correspondence Address: Adany, R.; International Training Program in Geroscience/Healthy Aging Program, Hungary
AB  - The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.
LA  - English
DB  - MTMT
ER  -