@article{MTMT:34741829, title = {Expert Opinion on Current Trends in the Use of Insulin in the Management of People with Type 2 Diabetes from the South-Eastern European Region and Israel.}, url = {https://m2.mtmt.hu/api/publication/34741829}, author = {Tabák, Ádám and Kempler, Péter and Guja, Cristian and Eldor, Roy and Haluzik, Martin and Klupa, Tomasz and Papanas, Nikolaos and Stoian, Anca Pantea and Mankovsky, Boris}, doi = {10.1007/s13300-024-01556-z}, journal-iso = {DIABTHERAP}, journal = {DIABETES THERAPY}, volume = {In press}, unique-id = {34741829}, issn = {1869-6953}, abstract = {Despite the availability of various antihyperglycaemic therapies and comprehensive guidelines, glycaemic control in diabetes management has not improved significantly during the last decade in the real-world clinical setting. Treatment inertia arising from a complex interplay among patient-, clinician- and healthcare-system-related factors is the prime reason for this suboptimal glycaemic control. Also, the key factor leading to inadequate glycaemic levels remains limited communication between healthcare professionals (HCPs) and people with type 2 diabetes (PwT2D). Early insulin administration has several advantages including reduced glucotoxicity, high efficacy and preserved β-cell mass/function, leading to lowering the risk of diabetes complications. The current publication is based on consensus of experts from the South-Eastern European region and Israel who reviewed the existing evidence and guidelines for the treatment of PwT2D. Herein, the experts emphasised the timely use of insulin, preferably second-generation basal insulin (BI) analogues and intensification using basal-plus therapy, as the most-potent glucose-lowering treatment choice in the real-world clinical setting. Despite an increase in the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), the experts urged timely insulin initiation for inadequate glycaemic control in PwT2D. Furthermore, the combination of BI and GLP-1 RA addressing both fasting plasma glucose and post-prandial excursions as a free- or fixed-ratio combination was identified to reduce treatment complexity and burden. To minimise discontinuation and improve adherence, the experts reiterated quality, regular interactions and discussions between HCPs and PwT2D/carers for their involvement in the diabetes management decision-making process. Clinicians and HCPs should consider the opinions of the experts in accordance with the most recent recommendations for diabetes management.}, keywords = {ISRAEL; clinical practice; Titration; Type 2 diabetes; INTENSIFICATION; Insulin initiation; South-Eastern European region}, year = {2024}, eissn = {1869-6961}, pages = {In press}, orcid-numbers = {Tabák, Ádám/0000-0002-6234-3936; Kempler, Péter/0000-0002-6072-8832} } @article{MTMT:34425939, title = {The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging}, url = {https://m2.mtmt.hu/api/publication/34425939}, author = {Ungvári, Zoltán István and Tabák, Ádám and Ádány, Róza and Purebl, György and Kaposvári, Csilla and Fazekas-Pongor, Vince and Csípő, Tamás and Szarvas, Zsófia and Horváth, Krisztián and Mukli, Péter and Balog, Piroska and Bódizs, Róbert and Ujma, Przemyslaw Péter and Stauder, Adrienne and Belsky, Daniel W. and Kovács, Illés and Yabluchanskiy, Andriy and Maier, Andrea B. and Moizs, Mariann and Östlin, Piroska and Yon, Yongjie and Varga, Péter and Vokó, Zoltán and Papp, Magor Csongor and Takács, István and Vásárhelyi, Barna and Torzsa, Péter and Ferdinandy, Péter and Csiszar, Anna and Benyó, Zoltán and Szabó, Attila and Bednárikné Dörnyei, Gabriella and Kivimäki, Mika and Kellermayer, Miklós and Merkely, Béla Péter}, doi = {10.1007/s11357-023-01018-7}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34425939}, issn = {2509-2715}, abstract = {The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.}, year = {2024}, eissn = {2509-2723}, pages = {191-218}, orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039; Tabák, Ádám/0000-0002-6234-3936; Purebl, György/0000-0002-9750-2001; Fazekas-Pongor, Vince/0000-0002-6405-4003; Szarvas, Zsófia/0000-0002-0022-5053; Mukli, Péter/0000-0003-4355-8103; Balog, Piroska/0000-0001-5025-8649; Bódizs, Róbert/0000-0001-5341-060X; Ujma, Przemyslaw Péter/0000-0002-7981-3009; Stauder, Adrienne/0000-0002-0358-3657; Kovács, Illés/0000-0001-5763-0482; Vokó, Zoltán/0000-0002-1004-1848; Takács, István/0000-0002-7810-4833; Vásárhelyi, Barna/0000-0003-0055-7346; Torzsa, Péter/0000-0002-8148-4961; Ferdinandy, Péter/0000-0002-6424-6806; Benyó, Zoltán/0000-0001-6015-0359; Szabó, Attila/0000-0001-7321-9861; Bednárikné Dörnyei, Gabriella/0000-0001-7007-6252; Kellermayer, Miklós/0000-0002-5553-6553; Merkely, Béla Péter/0000-0001-6514-0723} } @article{MTMT:34163215, title = {The effect of COVID-19 vaccination status on all-cause mortality in patients hospitalised with COVID-19 in Hungary during the delta wave of the pandemic}, url = {https://m2.mtmt.hu/api/publication/34163215}, author = {Horváth, Viktor József and Békeffy, Magdolna Zsófia and Németh, Zsuzsanna and Szelke, Emese and Fazekas-Pongor, Vince and Hajdú, Noémi and Svébis, Márk Márton and Pintér, József and Domján, Beatrix Annamária and Mészáros, Szilvia and Körei, Anna Erzsébet and Kézdi, Árpád and Kocsis, Ibolya and Kristóf, Katalin and Kempler, Péter and Rozgonyi, Ferenc and Takács, István and Tabák, Ádám}, doi = {10.1007/s11357-023-00931-1}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {46}, unique-id = {34163215}, issn = {2509-2715}, abstract = {The high mortality of patients with coronavirus disease 2019 (COVID-19) is effectively reduced by vaccination. However, the effect of vaccination on mortality among hospitalised patients is under-researched. Thus, we investigated the effect of a full primary or an additional booster vaccination on in-hospital mortality among patients hospitalised with COVID-19 during the delta wave of the pandemic. This retrospective cohort included all patients (n = 430) admitted with COVID-19 at Semmelweis University Department of Medicine and Oncology in 01/OCT/2021–15/DEC/2021. Logistic regression models were built with COVID-19-associated in-hospital/30 day-mortality as outcome with hierarchical entry of predictors of vaccination, vaccination status, measures of disease severity, and chronic comorbidities. Deceased COVID-19 patients were older and presented more frequently with cardiac complications, chronic kidney disease, and active malignancy, as well as higher levels of inflammatory markers, serum creatinine, and lower albumin compared to surviving patients (all p < 0.05). However, the rates of vaccination were similar (52–55%) in both groups. Based on the fully adjusted model, there was a linear decrease of mortality from no/incomplete vaccination (ref) through full primary (OR 0.69, 95% CI: 0.39–1.23) to booster vaccination (OR 0.31, 95% CI 0.13–0.72, p = 0.006). Although unadjusted mortality was similar among vaccinated and unvaccinated patients, this was explained by differences in comorbidities and disease severity. In adjusted models, a full primary and especially a booster vaccination improved survival of patients hospitalised with COVID-19 during the delta wave of the pandemic. Our findings may improve the quality of patient provider discussions at the time of admission.}, year = {2024}, eissn = {2509-2723}, pages = {1881-1894}, orcid-numbers = {Horváth, Viktor József/0000-0002-7888-2651; Békeffy, Magdolna Zsófia/0009-0005-5659-9758; Németh, Zsuzsanna/0000-0003-2586-6639; Szelke, Emese/0000-0002-8514-3451; Fazekas-Pongor, Vince/0000-0002-6405-4003; Svébis, Márk Márton/0000-0002-6624-9621; Mészáros, Szilvia/0000-0002-4871-6986; Körei, Anna Erzsébet/0000-0001-6201-2961; Kocsis, Ibolya/0000-0003-3128-2832; Kristóf, Katalin/0000-0002-5189-4636; Kempler, Péter/0000-0002-6072-8832; Takács, István/0000-0002-7810-4833; Tabák, Ádám/0000-0002-6234-3936} } @article{MTMT:34440559, title = {Cost-Effectiveness of Bariatric Surgery in Patients Living with Obesity and Type 2 Diabetes}, url = {https://m2.mtmt.hu/api/publication/34440559}, author = {Kovács, Gábor and Mohos, Elemér and Kis, János Tibor and Tabák, Ádám and Gerendy, Péter and Pettkó, Judit and Nagy, Dávid and Győrbíró, Dávid and Kaló, Zoltán}, doi = {10.1155/2023/9686729}, journal-iso = {J DIABETES RES}, journal = {JOURNAL OF DIABETES RESEARCH}, volume = {2023}, unique-id = {34440559}, issn = {2314-6745}, abstract = {Aims. The favourable effects of bariatric surgeries on body weight reduction and glucose control have been demonstrated in several studies. Additionally, the cost-effectiveness of bariatric surgeries has been confirmed in several analyses. The aim of the current analysis was to demonstrate the cost-effectiveness of bariatric surgeries in obese patients with type 2 diabetes in Hungary compared to conventional diabetes treatments based on economic modelling of published clinical trial results. Materials and Methods. Patients entered the simulation model at the age of 45 with kg/m2 and type 2 diabetes. The model was performed from the public payer’s perspective, comparing sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) procedures to conventional care of diabetes. The results were provided separately for three BMI categories. Results. The base-case analysis demonstrated that both surgery types were dominant; i.e., they saved 17 064 to 24 384 Euro public payer expenditures and resulted in improved health outcomes (1.36 to 1.50 quality-adjusted life years gain (QALY)) in the three BMI categories. Bariatric surgeries extended the life expectancy and the disease-free survival times of all the investigated diabetes complications. All the scenario analyses confirmed the robustness of the base-case analysis, such that bariatric surgeries remained dominant compared to conventional diabetes treatments. Conclusion. The results of this cost-effectiveness analysis highlight the importance of bariatric surgeries as alternatives to conventional diabetes treatments in the obese population. Therefore, it is strongly recommended that a wider population has access to these surgeries in Hungary.}, year = {2023}, eissn = {2314-6753}, orcid-numbers = {Kovács, Gábor/0000-0001-7900-0676; Tabák, Ádám/0000-0002-6234-3936; Kaló, Zoltán/0000-0001-7762-2607} } @article{MTMT:34411481, title = {Effect of school lockdown due to the COVID-19 pandemic on screen time among adolescents in Hungary: a longitudinal analysis}, url = {https://m2.mtmt.hu/api/publication/34411481}, author = {Major, Dávid and Fazekas-Pongor, Vince and Pártos, Katalin and Tabák, Ádám and Ungvári, Zoltán István and Eörsi, Dániel and Árva, Dorottya and Terebessy, András}, doi = {10.3389/fpubh.2023.1233024}, journal-iso = {FRONT PUBLIC HEALTH}, journal = {FRONTIERS IN PUBLIC HEALTH}, volume = {11}, unique-id = {34411481}, year = {2023}, eissn = {2296-2565}, orcid-numbers = {Major, Dávid/0000-0002-6108-9745; Fazekas-Pongor, Vince/0000-0002-6405-4003; Tabák, Ádám/0000-0002-6234-3936; Ungvári, Zoltán István/0000-0002-6035-6039; Árva, Dorottya/0000-0003-3964-2708; Terebessy, András/0000-0001-6080-8114} } @article{MTMT:34401876, title = {Survival and longevity of European rulers: geographical influences and exploring potential factors, including the Mediterranean diet — a historical analysis from 1354 to the twentieth century}, url = {https://m2.mtmt.hu/api/publication/34401876}, author = {Madarász, Bálint and Fazekas-Pongor, Vince and Szarvas, Zsófia and Fekete, Mónika and Varga, János Tamás and Tarantini, Stefano and Csiszar, Anna and Lionetti, Vincenzo and Tabák, Ádám and Ungvári, Zoltán István and Forrai, Judit}, doi = {10.1007/s11357-023-00957-5}, journal-iso = {GEROSCIENCE}, journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)}, volume = {2023}, unique-id = {34401876}, issn = {2509-2715}, abstract = {Significant regional variability in lifespan in Europe is influenced by environmental factors and lifestyle behaviors, including diet. This study investigates the impact of geographical region on the lifespan of European rulers spanning from the fourteenth century to the present day. By analyzing historical records and literature, we aim to identify region-specific dietary patterns and lifestyle factors that may have contributed to longer lifespans among rulers. The hypothesis to be tested is that rulers from Southern European countries, where the traditional Mediterranean diet is consumed by the local people, may exhibit longer lifespans compared to rulers from other regions, due to the well-documented health benefits associated with this dietary pattern. We extracted comprehensive information for each ruler, encompassing their sex, birth and death dates, age, age of enthronement, duration of rulership, country, and cause of death (natural vs. non-natural). To determine their nationality, we coded rulers based on their hypothetical present-day residence (2023). Utilizing the EuroVoc Geographical classification, we categorized the countries into four regions: Northern, Western, Southern, Central and Eastern Europe. While Cox regression models did not find significant differences in survival rates among regions, further analysis stratified by time periods revealed intriguing trends. Contrary to our initial predictions, the Northern region displayed better survival rates compared to the Southern region between 1354 and 1499, whereas survival rates were similar across regions from 1500 to 1749. However, after 1750, all regions, except the Southern region, exhibited significantly improved survival rates, suggesting advancements in healthcare and lifestyle factors. These findings underscore the dynamic influence of both region and time period on health and longevity. Interestingly, despite the prevalence of the Mediterranean diet in the Southern region of Europe, rulers from this region did not demonstrate longer lifespans compared to their counterparts in other regions. This suggests that additional lifestyle factors may have played a more prominent role in their longevity. In conclusion, our study sheds light on the intricate relationship between region, time period, and lifespan among European rulers. Although the Mediterranean diet is often associated with health benefits, our findings indicate that it alone may not account for differences in ruler longevity across regions. Further research is warranted to explore the impact of other lifestyle factors on the health and lifespan of European rulers throughout history.}, year = {2023}, eissn = {2509-2723}, orcid-numbers = {Madarász, Bálint/0000-0002-7110-6692; Fazekas-Pongor, Vince/0000-0002-6405-4003; Szarvas, Zsófia/0000-0002-0022-5053; Fekete, Mónika/0000-0001-8632-2120; Varga, János Tamás/0000-0002-8552-1336; Tarantini, Stefano/0000-0001-5627-1430; Tabák, Ádám/0000-0002-6234-3936; Ungvári, Zoltán István/0000-0002-6035-6039; Forrai, Judit/0000-0002-4749-4672} } @{MTMT:34265399, title = {Obesity and Cognitive Decline}, url = {https://m2.mtmt.hu/api/publication/34265399}, author = {Tabák, Ádám and Fazekas-Pongor, Vince and Tarantini, Stefano and Balasubramanian, Priya and Csiszar, Anna and Ungvári, Zoltán István}, booktitle = {Handbook of Obesity - Volume 1}, doi = {10.1201/9781003437673-66}, unique-id = {34265399}, year = {2023}, pages = {572-580}, orcid-numbers = {Tabák, Ádám/0000-0002-6234-3936; Fazekas-Pongor, Vince/0000-0002-6405-4003; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039} } @{MTMT:34231568, title = {Royal food and longevity: did the mediterranean diet provide longer lifespan among the european nobility?}, url = {https://m2.mtmt.hu/api/publication/34231568}, author = {Madarász, Bálint and Fazekas-Pongor, Vince and Szarvas, Zsófia and Fekete, Mónika and Varga, János Tamás and Tarantini, Stefano and Csiszar, Anna and Lionetti, Vincenzo and Tabák, Ádám and Ungvári, Zoltán István and Forrai, Judit}, booktitle = {Nutrition and Health Science}, unique-id = {34231568}, year = {2023}, pages = {26-28}, orcid-numbers = {Madarász, Bálint/0000-0002-7110-6692; Fazekas-Pongor, Vince/0000-0002-6405-4003; Szarvas, Zsófia/0000-0002-0022-5053; Fekete, Mónika/0000-0001-8632-2120; Varga, János Tamás/0000-0002-8552-1336; Tarantini, Stefano/0000-0001-5627-1430; Tabák, Ádám/0000-0002-6234-3936; Ungvári, Zoltán István/0000-0002-6035-6039; Forrai, Judit/0000-0002-4749-4672} } @article{MTMT:34166920, title = {A bariátriai műtétek egészségpolitikai szerepe a 2-es típusú cukorbetegségben szenvedő elhízott betegek ellátásában}, url = {https://m2.mtmt.hu/api/publication/34166920}, author = {Kovács, Gábor and Mohos, Elemér and Kis, János Tibor and Tabák, Ádám and Gerendy, Péter and Dózsa, Csaba and Dózsa, Katalin Mária and Pettkó, Judit and Ujhelyi, Krisztina and Kaló, Zoltán}, doi = {10.53020/IME-2023-302}, journal-iso = {IME}, journal = {IME}, volume = {22}, unique-id = {34166920}, issn = {1588-6387}, abstract = {Annak ellenére, hogy a 2-es típusú cukorbetegségben szenvedő elhízott betegek kezelése népegészségügyi prioritás, és a bariátriai műtétek jelentős egészségnyereséget és egészségügyi költségmegtakarítását eredményeznek e betegeknél, ezek a műtétek csak a magán egészségügyi szektorban elérhetőek egy szűk vagyonos réteg számára. Számos akadály gátolja az elhízott cukorbetegeknél végzett bariátriai műtétek széles körű elterjedését, így az egészségpolitikai döntéshozók támogatásának hiánya, a bariátriai műtétek szerepének meghatározatlansága az egészségügyi rendszerben, ebből következően az ilyen műtétek közfinanszírozásának hiánya, közfinanszírozott kapacitások korlátozottsága, valamint a szakmai kompetenciák kidolgozatlansága. A szerzők ezen korlátok áthidalására tesznek konszenzusos javaslatot.}, keywords = {elhízás; 2-es típusú diabetes; bariátriai műtét; obezitás}, year = {2023}, eissn = {1789-9974}, pages = {12-20}, orcid-numbers = {Kovács, Gábor/0000-0001-7900-0676; Kis, János Tibor/0009-0003-0415-797X; Tabák, Ádám/0000-0002-6234-3936; Dózsa, Csaba/0000-0003-4884-7537; Dózsa, Katalin Mária/0000-0001-5369-7372; Kaló, Zoltán/0000-0001-7762-2607} } @article{MTMT:34150278, title = {The impact of COVID-19 infection before the vaccination era on the hospitalized patients requiring hemodialysis: a single-center retrospective cohort}, url = {https://m2.mtmt.hu/api/publication/34150278}, author = {Pethő, Ákos and Kevei, Péter and Juha, Márk and Kóczy, Ágnes and Ledó, Nóra and Tislér, András and Takács, István and Tabák, Ádám}, doi = {10.1080/0886022X.2023.2251593}, journal-iso = {RENAL FAILURE}, journal = {RENAL FAILURE}, volume = {45}, unique-id = {34150278}, issn = {0886-022X}, year = {2023}, eissn = {1525-6049}, orcid-numbers = {Pethő, Ákos/0000-0001-9776-9841; Juha, Márk/0000-0002-4967-7608; Ledó, Nóra/0000-0002-2439-9218; Tislér, András/0000-0002-1265-1869; Takács, István/0000-0002-7810-4833; Tabák, Ádám/0000-0002-6234-3936} }