@article{MTMT:35425111,
	title = {Periodic limb movements in sleep in patients using antidepressants},
	url = {https://m2.mtmt.hu/api/publication/35425111},
	author = {Marey, H. and Chai, A. and Bikov, András},
	doi = {10.1016/j.smrv.2024.102011},
	journal-iso = {SLEEP MED REV},
	journal = {SLEEP MEDICINE REVIEWS},
	volume = {79},
	unique-id = {35425111},
	issn = {1087-0792},
	year = {2025},
	eissn = {1532-2955},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X}
}

@article{MTMT:35626887,
	title = {Triple inhaled therapy in asthma: Beliefs, behaviours and doubts},
	url = {https://m2.mtmt.hu/api/publication/35626887},
	author = {Bagnasco, D. and Ansotegui, I. and Baiardini, I. and Benfante, A. and Bernstein, J.A. and Bikov, András and Bondi, B. and Boulet, L.P. and Panaitescu, C. and Canonica, G.W. and Chong-Neto, H. and Dubuske, L. and El-Owaidy, R. and Ferraris, M. and Filipovic, M. and Gonzalez-Barcala, F.J. and Guidos, Fogelbach G. and Ivancevich, J.C. and Jusufovic, E. and Kowal, K. and Lantieri, F. and Mahboub, B. and Mihaicuta, S. and Mincarini, M. and Nedeva, D. and Novakova, P. and Novakova, S. and Nunes, C. and Ricchiuto, F.R. and Santus, P. and Scichilone, N. and Steiropoulos, P. and Tiotiu, A. and Tomasello, A. and Virchow, J.C. and Yadav, R. and Zunino, S. and Braido, F.},
	doi = {10.1016/j.pupt.2024.102333},
	journal-iso = {PULM PHARMACOL THER},
	journal = {PULMONARY PHARMACOLOGY & THERAPEUTICS},
	volume = {87},
	unique-id = {35626887},
	issn = {1094-5539},
	abstract = {Long-acting muscarinic antagonists (LAMA) in association with inhaled corticosteroids (ICS) plus long-acting beta-2 agonists (LABA) are recommended by the GINA report as further option in step 4 and first choice in step 5 treatment. Despite consistent evidence of its efficacy and safety, inhaled triple therapy (ITT) is still not largely used in patients with asthma. With the aim to explore belief and behaviours of asthma specialists, an ad hoc survey has been developed by a panel of Interasma Scientific Network (INESnet) experts and subsequently defined by two Delphi rounds among an international group of physicians. The questionnaire has been distributed through Interasma social media between June and September 2023. Besides a descriptive analysis, to assess the responses gathered from the questionnaire, Spearman's non-parametric statistical method was employed. Totally, three hundred fourteen questionnaires were completed. Clinicians' attitudes and behaviours toward timing and methodologies adopted in prescribing ITT, were analysed. 35.7 % specialists consider ITT as a relevant therapeutic option, 61.8 % that is second option after reaching high dose of ICS-LABA and 89.2 % agreed that optimization of inhaled therapy should be attempted before the use of biological drugs. Persistent flow limitation and high reversibility are considered predictive factors of response. Specialists consider ITT a resource in asthma management. Although its efficacy in decreasing exacerbation rate and improving lung function were well known, the survey revealed persistent uncertainties among clinicians in positioning it highlighting the need for further measures to effectively integrate research findings into day-to-day clinical practice. © 2024 The Authors},
	year = {2024},
	eissn = {1522-9629},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X}
}

@article{MTMT:35472722,
	title = {Innovating Respiratory Diagnostics: The Game-Changing Role of Biomarkers},
	url = {https://m2.mtmt.hu/api/publication/35472722},
	author = {Dragonieri, Silvano and Bikov, András},
	doi = {10.3390/jcm13195850},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {35472722},
	year = {2024},
	eissn = {2077-0383},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X}
}

@article{MTMT:35436011,
	title = {The Effect of Opioids and Benzodiazepines on Exacerbation Rate and Overall Survival in Patients with Chronic Obstructive Pulmonary Disease on Long-Term Non-Invasive Ventilation †},
	url = {https://m2.mtmt.hu/api/publication/35436011},
	author = {Chai, A. and Csoma, Balázs and Lázár, Zsófia and Bentley, A. and Bikov, András},
	doi = {10.3390/jcm13185624},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {35436011},
	abstract = {Background: There is a growing concern that opioids and benzodiazepines can depress the respiratory drive and could contribute to worsening respiratory failure and higher exacerbation frequency in COPD. However, the relationship between the exacerbation rate and medication taken is poorly understood in patients with chronic respiratory failure due to COPD. Methods: As part of a service evaluation project, we analysed 339 patients with COPD who were established on long-term non-invasive ventilation (LT-NIV) at our tertiary centre. We investigated the relationship between benzodiazepine and opioid prescription and clinical outcomes as well as their impact on the exacerbation rate and overall survival following setup. Results: Before LT-NIV setup, 40 patients took benzodiazepines and 99 patients took opioids. Neither benzodiazepine nor opioid use was associated with changes in daytime blood gases, overnight hypoxia or annual exacerbations before NIV setup, but patients taking opioids were more breathless as assessed by modified Medical Research Council scores (3.91 ± 0.38 vs. 3.65 ± 0.73, p < 0.01). Long-term NIV significantly reduced the number of yearly exacerbations (from 3.0/2.0–5.0/ to 2.8/0.71–4.57/, p < 0.01) in the whole cohort, but the effect was limited in those who took benzodiazepines (from 3.0/2.0–7.0/ to 3.5/1.2–5.5/) or opioids (3.0/2.0–6.0/ to 3.0/0.8–5.5/). Benzodiazepine use was associated with reduced exacerbation-free survival and overall survival (both p < 0.05). However, after adjustment with relevant covariates, the relationship with exacerbation-free survival became insignificant (p = 0.12). Opioids were not associated with adverse outcomes. Conclusions: Benzodiazepines and opiates are commonly taken in this cohort. Whilst they do not seem to contribute to impaired gas exchange pre-setup, they, especially benzodiazepines, may limit the benefits of LT-NIV. © 2024 by the authors.},
	keywords = {Aged; Adult; Female; Middle Aged; Male; PH; PREVALENCE; ARTICLE; human; Survival Rate; questionnaire; major clinical study; controlled study; cohort analysis; clinical feature; disease severity; clonazepam; nitrazepam; clobazam; Benzodiazepines; drug effect; benzodiazepine derivative; DIAZEPAM; Patient Selection; body mass; Forced Expiratory Volume; scoring system; disease exacerbation; dyspnea; anxiety; TRAMADOL; overall survival; respiratory failure; follow up; oxybutynin; HYPOXIA; COPD; drug use; opiate; chronic obstructive lung disease; codeine; Opioids; prescription; Clinical outcome; Hypercapnia; oxygen tension; carbon dioxide tension; lorazepam; temazepam; morphine sulfate; methadone; blood gas; buprenorphine; oxycodone; forced vital capacity; tertiary care center; Noninvasive ventilation; Non-invasive ventilation; Charlson Comorbidity Index},
	year = {2024},
	eissn = {2077-0383},
	orcid-numbers = {Csoma, Balázs/0000-0002-9425-1219; Lázár, Zsófia/0000-0003-2444-9040; Bikov, András/0000-0002-8983-740X}
}

@article{MTMT:35434262,
	title = {Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Obstructive Sleep Apnea Syndrome Management: A Narrative Review},
	url = {https://m2.mtmt.hu/api/publication/35434262},
	author = {Dragonieri, S. and Portacci, A. and Quaranta, V.N. and Carratu, P. and Lazar, Z. and Carpagnano, G.E. and Bikov, András},
	doi = {10.3390/diseases12090224},
	journal-iso = {DISEASES},
	journal = {DISEASES},
	volume = {12},
	unique-id = {35434262},
	year = {2024},
	eissn = {2079-9721},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X}
}

@article{MTMT:35306010,
	title = {Religiosity and Health Outcomes in a Cohort of Romanian Patients Hospitalized for COVID-19},
	url = {https://m2.mtmt.hu/api/publication/35306010},
	author = {Frent, S. and Popovici, A.-F. and Balan, A. and Cerbu, B. and Marincu, I. and Mihaicuta, S. and Bikov, András},
	doi = {10.1007/s10943-024-02120-6},
	journal-iso = {J RELIG HEALTH},
	journal = {JOURNAL OF RELIGION & HEALTH},
	volume = {in press},
	unique-id = {35306010},
	issn = {0022-4197},
	abstract = {There is a growing body of evidence for the interrelation between health status and religious beliefs. Our aim was to evaluate the level of religiosity in patients hospitalized for COVID-19 and to assess the link between religiosity and measurable health outcomes. This was an observational, single-center study which included patients with moderate-to-severe forms of COVID-19. A total of 112 patients were enrolled in the study, of whom 77 were highly religious (CRS-15 score ≥ 4) and 35 non-highly religious (CRS-15 score < 4). There was no difference in demographics or prevalence of comorbidities between the two groups. Furthermore, we found no difference between groups in radiological extension of lung lesions, length of hospital stays, or ICU need; however, in-hospital mortality rate was significantly lower in highly religious group (1% vs. 14%, p = 0.005). Serum ferritin level at admission was significantly lower (p = 0.03) and prevalence of post-COVID-19 pulmonary sequelae significantly higher in highly religious group (p = 0.02). © The Author(s) 2024.},
	keywords = {MORTALITY; hospitalization; religiosity; COVID-19},
	year = {2024},
	eissn = {1573-6571},
	pages = {in press},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X}
}

@article{MTMT:35070555,
	title = {What has the ESADA Registry Contributed to the Current OSA Knowledge?},
	url = {https://m2.mtmt.hu/api/publication/35070555},
	author = {Bikov, András and Mihaicuta, S.},
	doi = {10.1016/j.arbres.2024.06.002},
	journal-iso = {ARCH BRONCONEUMOL},
	journal = {ARCHIVOS DE BRONCONEUMOLOGIA},
	unique-id = {35070555},
	issn = {0300-2896},
	year = {2024},
	eissn = {1579-2129},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X}
}

@article{MTMT:34854037,
	title = {Long-Term Adherence to Continuous Positive Airway Pressure in Patients with Obstructive Sleep Apnoea Set Up in a Complete Remote Pathway: A Single-Centre Service Evaluation Project},
	url = {https://m2.mtmt.hu/api/publication/34854037},
	author = {Bikov, András and Bentley, Andrew and Csoma, Balázs and Smith, Nicola and Morris, Bryn and Bokhari, Saba},
	doi = {10.3390/jcm13102891},
	journal-iso = {J CLIN MED},
	journal = {JOURNAL OF CLINICAL MEDICINE},
	volume = {13},
	unique-id = {34854037},
	abstract = {Background: Continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep apnoea (OSA). Maintaining adherence to CPAP in the long term is a clinical problem, and numerous factors have been identified that impact adherence. Although fully remote diagnostic and CPAP services were frequently utilised during the COVID-19 pandemic for patients with OSA, long-term adherence data have not been published. The aim of this service evaluation project was to describe the long-term adherence to CPAP. We also analysed factors that are associated with it. Methods: two-hundred and eighty patients diagnosed with OSA and set up on CPAP remotely during the first wave of the COVID-19 pandemic as part of routine clinical practice were analysed. Results: One-hundred and seven patients (38%) were fully adherent to CPAP at 24 months, determined by at least 4 h of usage on at least 70% of the days. Of the factors analysed, body mass index, disease severity, driving status and the presence of depression were related to long-term adherence (all p < 0.05). Conclusions: with the likelihood of future pandemics similar to COVID-19, our data provide evidence that fully remote pathways for management of patients with OSA can be designed and be sustainable with good long-term adherence.},
	year = {2024},
	eissn = {2077-0383},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X; Csoma, Balázs/0000-0002-9425-1219}
}

@article{MTMT:34771062,
	title = {Platelet count and platelet-to-lymphocyte ratio at the onset of a severe COPD exacerbation are unrelated to the time till the next moderate or severe relapse},
	url = {https://m2.mtmt.hu/api/publication/34771062},
	author = {Schønberg-Moe, A. and Csoma, Balázs and Bikov, András and Müller, Veronika and Lázár, Zsófia},
	doi = {10.1016/j.advms.2024.03.003},
	journal-iso = {ADV MED SCI-POLAND},
	journal = {ADVANCES IN MEDICAL SCIENCES},
	volume = {69},
	unique-id = {34771062},
	issn = {1896-1126},
	year = {2024},
	eissn = {1898-4002},
	pages = {160-166},
	orcid-numbers = {Csoma, Balázs/0000-0002-9425-1219; Bikov, András/0000-0002-8983-740X; Müller, Veronika/0000-0002-1398-3187; Lázár, Zsófia/0000-0003-2444-9040}
}

@article{MTMT:34664932,
	title = {Bacterial Vaccinations in Patients with Chronic Obstructive Pulmonary Disease},
	url = {https://m2.mtmt.hu/api/publication/34664932},
	author = {Paróczai, Dóra and Burián, Katalin and Bikov, András},
	doi = {10.3390/vaccines12020213},
	journal-iso = {VACCINES-BASEL},
	journal = {VACCINES (BASEL)},
	volume = {12},
	unique-id = {34664932},
	abstract = {Chronic obstructive pulmonary disease (COPD) is a frequent, often progressive, chronic disease of the lungs. Patients with COPD often have impaired immunity; therefore, they are prone to chest infections, such as pneumonia or bronchitis. Acute exacerbations of COPD are major events that accelerate disease progression, contributing to its symptoms’ burden, morbidity, and mortality. Both pneumonia and acute exacerbations in COPD are caused by bacteria against which there are effective vaccinations. Although the number of randomised controlled studies on bacterial vaccinations in COPD is limited, national and international guidelines endorse specific vaccinations in patients with COPD. This review will summarise the different types of vaccinations that prevent pneumonia and COPD exacerbations. We also discuss the results of early phase studies. We will mainly focus on Streptococcus pneumoniae, as this bacterium was predominantly investigated in COPD. However, we also review studies investigating vaccinations against Haemophilus influenzae, Moraxella catarrhalis, and Bordetella pertussis.},
	year = {2024},
	eissn = {2076-393X},
	orcid-numbers = {Paróczai, Dóra/0000-0001-6792-6789; Burián, Katalin/0000-0003-1300-2374; Bikov, András/0000-0002-8983-740X}
}