TY - JOUR AU - Wappler-Guzzetta, Edina Amalia AU - Margittai, Éva AU - Veszelyi, Krisztina Nóra AU - Pickard, Shanel AU - Merwin, Caroline AU - Molvarec, Attila AU - Czegle, Ibolya TI - Subcellular Stress Markers in Epithelial Ovarian Cancer JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 27 PY - 2026 IS - 1 PG - 45 SN - 1661-6596 DO - 10.3390/ijms27010342 UR - https://m2.mtmt.hu/api/publication/36833696 ID - 36833696 N1 - Funding Agency and Grant Number: University of California; Semmelweis University Funding text: The APC was funded by Semmelweis University and University of California. AB - Epithelial ovarian cancer is one of the most lethal gynecological malignancies worldwide. Its development strongly depends on several genetic and environmental factors, with metabolic components and cellular redox homeostasis alterations playing a significant a role in its development and disease progression. In this review, we summarize the contribution of mitochondrial and endoplasmic reticulum (ER) stress in the pathogenesis of epithelial ovarian cancer along with their role as potential biomarkers and therapeutic targets, including proteins of glucose metabolism, mitochondrial fission and fusion, mitophagy, membrane-associated ring-CH-type finger 5 (MARCH5), A-kinase anchoring proteins (AKAPs), proteins regulating mitochondrial Ca2+ homeostasis, mitochondrial unfolded protein response (UPRmt) proteins, activating transcription factors (ATFs), CCAAT enhancer binding protein (C/EBP) homologous protein (CHOP), ‘mitokines’, GRP75, and GRP78. Although many of these potential targets are in preclinical phase, they have a high potential to become valuable alternative or additive treatments for epithelial ovarian cancers. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Viola AU - Gelley, András AU - Margittai, Éva AU - Bagci, Buket AU - Wappler-Guzzetta, Edina Amalia AU - Czegle, Ibolya TI - Mitochondrial Stress in Helicobacter pylori Infection and Associated Malignancies: A Review JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 15 PY - 2026 IS - 3 PG - 38 SN - 2076-3921 DO - 10.3390/antiox15030285 UR - https://m2.mtmt.hu/api/publication/36983788 ID - 36983788 N1 - Varga Viola; Gelley András megosztott első szerző AB - Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations in these malignancies are less documented. Mitochondria are key organelles, maintaining cellular homeostasis under normal and pathological conditions. They regulate complex cellular processes and play a key role in carcinogenesis and cancer progression in H. pylori-associated malignancies. This review summarizes the role of mitochondrial stress in H. pylori infection, gastric cancer, and MALT lymphoma. LA - English DB - MTMT ER - TY - JOUR AU - Gelley, András AU - Kéri, Noémi AU - Birinyi, Péter AU - Lakné Komka, Kinga AU - Hardy, Vajk AU - Döngölő, László AU - Szeli, Dóra AU - Czegle, Ibolya TI - Optimizing the Routine Use of Clinical Guidelines by Addition of Supplements (Probiotics and/or Bismuth) to Helicobacter pylori Eradication Protocols in a Clarithromycin Resistant and Tetracycline/Bismuth Naive Area: A Real-World Data Retrospective Analysis of 402 Cases (2016–24) in a Single Gastroenterology Unit JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 14 PY - 2025 IS - 9 PG - 20 SN - 2079-6382 DO - 10.3390/antibiotics14090870 UR - https://m2.mtmt.hu/api/publication/36310539 ID - 36310539 AB - Background: The official current guideline for Helicobacter pylori (H. pylori) eradication is to use tetracycline–bismuth-based protocols as first line treatment due to the increasing incidence of clarithromycin resistance in the last decade. The unavailability of tetracycline and bismuth-containing medicines, however, is an issue in many countries, limiting the routine use of these protocols. The value of using additional probiotics in eradication protocols is also unclear. Direct comparison data on the effect of available bismuth compounds and different probiotic strains on eradication outcome are limited. Goal: The aim of our investigation was to find optimal eradication protocols, supplementations and treatment duration for routine clinical use in our gastroenterology unit, located in a highly clarithromycin-resistant and tetracycline–bismuth-naïve area. Materials and Methods: We conducted a retrospective real-world data analysis of 402 H. pylori positive patients between 2016 and 2024. H. pylori infection was diagnosed using histological examination of gastroscopy samples obtained from the gastric antrum. For the evaluation of treatment success or failure, 14C breath tests and stool H. pylori antigen tests were performed. Data on patient characteristics and treatment protocols were collected from our electronic patient record system, and treatment success was compared between the different treatment regimes. Results: Despite the regional clarithromycin resistance, supplementing clarithromycin-based regimens with bismuth and probiotic during the 14-day treatment duration showed a high and comparable cure rate when compared to tetracycline-based regimens, which are the current first-line therapies. When tetracycline-based combination is available, it is recommended to use it with an additional probiotic to achieve the best possible outcome. Comparison of the effect of available bismuth preparations on treatment success showed no significant difference. Generally, probiotic-containing protocols are more successful, compared to those treatments without this supplement. There was no statistical difference in the cure rates amongst the four probiotic strains used, where sample size allowed statistical analysis. Furthermore, supplementation with probiotics Lactobacillus reuteri ATCC PTA 6475 or Lactobacillus reuteri Protectis® DSM 17938 showed promising high treatment success rates (85.2% and 100.0%, respectively) in our study. LA - English DB - MTMT ER - TY - CONF AU - Gelley, András AU - Kéri, Noémi AU - Birinyi, Péter AU - Lakné Komka, Kinga AU - Hardy, Vajk AU - Döngolő, László AU - Szeli, Dóra AU - Czegle, Ibolya TI - Optimizing the Routine Use of Clinical Guidelines by Addition of Supplements (Probiotics and/or Bismuth) to Helicobacter pylori Eradication Protocols in a Clarithromycin Resistant and Tetracycline/Bismuth Naive Area: A Real-World Data Retrospective Analysis of 402 Cases (2016–24) in a Single Gastroenterology Unit T2 - 5th International Conference on Advanced Pharmacology & Toxicology Research SN - 9781917892285 PY - 2025 SP - 25 EP - 26 PG - 2 UR - https://m2.mtmt.hu/api/publication/36481075 ID - 36481075 LA - English DB - MTMT ER - TY - JOUR AU - Gelley, András AU - Kéri, Noémi AU - Birinyi, Péter AU - Lakné Komka, Kinga AU - Hardy, Vajk AU - Döngölő, László AU - Szeli, Dóra AU - Czegle, Ibolya TI - HELICOBACTER PYLORI ERADIKÁCIÓS PROTOKOLLOK OPTIMALIZÁLÁSA BIZMUT ÉS PROBIOTIKUM KIEGÉSZÍTÉSSEL KLARITROMICIN-REZISZTENS, TETRACIKLIN–BIZMUT-NAIV RÉGIÓBAN 402 ESET REAL-WORLD RETROSPEKTÍV ELEMZÉSE ALAPJÁN JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 78 PY - 2025 IS - 5-6 SP - 328 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/36481123 ID - 36481123 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Veszelyi, Krisztina Nóra AU - Czegle, Ibolya AU - Varga, Viola AU - Németh, Csilla Emese AU - Besztercei, Balázs AU - Margittai, Éva TI - Subcellular Localization of Thioredoxin/Thioredoxin Reductase System—A Missing Link in Endoplasmic Reticulum Redox Balance JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 12 PG - 20 SN - 1661-6596 DO - 10.3390/ijms25126647 UR - https://m2.mtmt.hu/api/publication/35052153 ID - 35052153 AB - The lumen of the endoplasmic reticulum (ER) is usually considered an oxidative environment; however, oxidized thiol-disulfides and reduced pyridine nucleotides occur there parallelly, indicating that the ER lumen lacks components which connect the two systems. Here, we investigated the luminal presence of the thioredoxin (Trx)/thioredoxin reductase (TrxR) proteins, capable of linking the protein thiol and pyridine nucleotide pools in different compartments. It was shown that specific activity of TrxR in the ER is undetectable, whereas higher activities were measured in the cytoplasm and mitochondria. None of the Trx/TrxR isoforms were expressed in the ER by Western blot analysis. Co-localization studies of various isoforms of Trx and TrxR with ER marker Grp94 by immunofluorescent analysis further confirmed their absence from the lumen. The probability of luminal localization of each isoform was also predicted to be very low by several in silico analysis tools. ER-targeted transient transfection of HeLa cells with Trx1 and TrxR1 significantly decreased cell viability and induced apoptotic cell death. In conclusion, the absence of this electron transfer chain may explain the uncoupling of the redox systems in the ER lumen, allowing parallel presence of a reduced pyridine nucleotide and a probably oxidized protein pool necessary for cellular viability. LA - English DB - MTMT ER - TY - JOUR AU - Czegle, Ibolya AU - Huang, C. AU - Soria, P.G. AU - Purkiss, D.W. AU - Shields, A. AU - Wappler-Guzzetta, E.A. TI - The Role of Genetic Mutations in Mitochondrial-Driven Cancer Growth in Selected Tumors: Breast and Gynecological Malignancies JF - LIFE-BASEL J2 - LIFE-BASEL VL - 13 PY - 2023 IS - 4 PG - 56 SN - 2075-1729 DO - 10.3390/life13040996 UR - https://m2.mtmt.hu/api/publication/33803455 ID - 33803455 LA - English DB - MTMT ER - TY - JOUR AU - Czegle, Ibolya TI - A refIuxbetegség (GERD) kezelési stratégiája és aktuális kérdései JF - MAGYAR CSALÁDORVOSOK LAPJA J2 - MAGYAR CSALÁDORVOSOK LAPJA VL - 2023 PY - 2023 IS - 3 SP - 12 EP - 14 PG - 3 SN - 1789-607X UR - https://m2.mtmt.hu/api/publication/35137518 ID - 35137518 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Czegle, Ibolya AU - Gray, A.L. AU - Wang, M. AU - Liu, Y. AU - Wang, J. AU - Wappler-Guzzetta, E.A. TI - Mitochondria and their relationship with common genetic abnormalities in hematologic malignancies JF - LIFE-BASEL J2 - LIFE-BASEL VL - 11 PY - 2021 IS - 12 PG - 56 SN - 2075-1729 DO - 10.3390/life11121351 UR - https://m2.mtmt.hu/api/publication/32587732 ID - 32587732 LA - English DB - MTMT ER - TY - JOUR AU - Molvarec, Attila AU - Czegle, Ibolya TI - Menopause and its management: A review JF - DEVELOPMENTS IN HEALTH SCIENCES J2 - DEV HEALTH SCI VL - 4 PY - 2021 IS - 2 SP - 38 EP - 41 PG - 4 SN - 2630-9378 DO - 10.1556/2066.2021.00050 UR - https://m2.mtmt.hu/api/publication/32819161 ID - 32819161 LA - English DB - MTMT ER -