@article{MTMT:34430365,
	title = {Phenol-Soluble Modulin α3 Stimulates Autophagy in HaCaT Keratinocytes},
	url = {https://m2.mtmt.hu/api/publication/34430365},
	author = {Dernovics, Áron and Seprényi, György and Rázga, Zsolt and Ayaydin, Ferhan and Veréb, Zoltán and Megyeri, Klára},
	doi = {10.3390/biomedicines11113018},
	journal-iso = {BIOMEDICINES},
	journal = {BIOMEDICINES},
	volume = {11},
	unique-id = {34430365},
	year = {2023},
	eissn = {2227-9059},
	orcid-numbers = {Rázga, Zsolt/0000-0003-4717-8482; Veréb, Zoltán/0000-0002-9518-2155}
}

@CONFERENCE{MTMT:34154565,
	title = {Radiosensitizing effect of metal nanoparticles in combination with histone deacetylase inhibitors},
	url = {https://m2.mtmt.hu/api/publication/34154565},
	author = {Igaz, Nóra and Szőke, Krisztina and Bocz, Csenge and Kovács, Dávid and Rónavári, Andrea and Szabó, Emilia Rita and Polanek, Róbert and Buhala, Andrea and Vizler, Csaba and Tiszlavicz, László and Rázga, Zsolt and Hideghéty, Katalin and Kónya, Zoltán and Csontné Kiricsi, Mónika},
	booktitle = {FAMÉ 2023},
	unique-id = {34154565},
	year = {2023},
	pages = {75-76},
	orcid-numbers = {Igaz, Nóra/0000-0003-1580-4397; Rónavári, Andrea/0000-0001-7054-0975; Szabó, Emilia Rita/0000-0003-3611-2066; Polanek, Róbert/0000-0003-3645-8331; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Hideghéty, Katalin/0000-0001-7080-2365; Kónya, Zoltán/0000-0002-9406-8596; Csontné Kiricsi, Mónika/0000-0002-8416-2052}
}

@article{MTMT:34085614,
	title = {Herpes Simplex Virus Infection Alters the Immunological Properties of Adipose-Tissue-Derived Mesenchymal-Stem Cells},
	url = {https://m2.mtmt.hu/api/publication/34085614},
	author = {Kun-Varga, Anikó and Konczné Gubán, Barbara and Miklós, Vanda and Parvaneh, Shahram and Guba, Melinda and Szűcs, Diána and Monostori, Tamás and Varga, János and Varga, Ákos and Rázga, Zsolt and Csörgő Sándorné Bata, Zsuzsanna and Kemény, Lajos and Megyeri, Klára and Veréb, Zoltán},
	doi = {10.3390/ijms241511989},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34085614},
	issn = {1661-6596},
	abstract = {The proper functioning of mesenchymal stem cells (MSCs) is of paramount importance for the homeostasis of the body. Inflammation and infection can alter the function of MSCs, which can also affect the regenerative potential and immunological status of tissues. It is not known whether human herpes simplex viruses 1 and 2 (HSV1 and HSV2), well-known human pathogens that can cause lifelong infections, can induce changes in MSCs. In non-healing ulcers, HSV infection is known to affect deeper tissue layers. In addition, HSV infection can recur after initially successful cell therapies. Our aim was to study the response of adipose-derived MSCs (ADMSCs) to HSV infection in vitro. After confirming the phenotype and differentiation capacity of the isolated cells, we infected the cells in vitro with HSV1-KOS, HSV1-532 and HSV2 virus strains. Twenty-four hours after infection, we examined the gene expression of the cells via RNA-seq and RT-PCR; detected secreted cytokines via protein array; and determined autophagy via Western blot, transmission electron microscopy (TEM) and fluorescence microscopy. Infection with different HSV strains resulted in different gene-expression patterns. In addition to the activation of pathways characteristic of viral infections, distinct non-immunological pathways (autophagy, tissue regeneration and differentiation) were also activated according to analyses with QIAGEN Ingenuity Pathway Analysis, Kyoto Encyclopedia of Genes and Genome and Genome Ontology Enrichment. Viral infections increased autophagy, as confirmed via TEM image analysis, and also increased levels of the microtubule-associated protein light chain 3 (LC3B) II protein. We identified significantly altered accumulation for 16 cytokines involved in tissue regeneration and inflammation. Our studies demonstrated that HSV infection can alter the viability and immunological status of ADMSCs, which may have implications for ADMSC-based cell therapies. Alterations in autophagy can affect numerous processes in MSCs, including the inhibition of tissue regeneration as well as pathological differentiation.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Rázga, Zsolt/0000-0003-4717-8482; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743; Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155}
}

@article{MTMT:34067381,
	title = {Phase-separated ribosome-nascent chain complexes in genotoxic stress response},
	url = {https://m2.mtmt.hu/api/publication/34067381},
	author = {Szatmári, Orsolya and Nagy-Mikó, Bence and Györkei, Ádám and Varga, Dániel and H. Kovács, Bálint Barna and Igaz, Nóra and Bognár, Bence and Rázga, Zsolt and Nagy, Gábor and Zsindely, Nóra and Bodai, László and Papp, Balázs and Erdélyi, Miklós and Csontné Kiricsi, Mónika and Blastyák, András and Collart, Martine A and Boros, Imre Miklós and Villanyi, Zoltan},
	doi = {10.1261/rna.079755.123},
	journal-iso = {RNA},
	journal = {RNA-A PUBLICATION OF THE RNA SOCIETY},
	volume = {29},
	unique-id = {34067381},
	issn = {1355-8382},
	abstract = {Assemblysomes are EDTA- and RNase-resistant ribonucleoprotein (RNP) complexes of paused ribosomes with protruding nascent polypeptide chains. They have been described in yeast and human cells for the proteasome subunit Rpt1, and the disordered N-terminal part of the nascent chain was found to be indispensable for the accumulation of the Rpt1-RNP into assemblysomes. Motivated by this, to find other assemblysome-associated RNPs we used bioinformatics to rank subunits of Saccharomyces cerevisiae protein complexes according to their N-terminal disorder propensity. The results revealed that gene products involved in DNA repair are enriched among the top candidates. The Sgs1 DNA helicase was chosen for experimental validation. We found that indeed nascent chains of Sgs1 form EDTA-resistant RNP condensates, assemblysomes by definition. Moreover, upon exposure to UV, SGS1 mRNA shifted from assemblysomes to polysomes, suggesting that external stimuli are regulators of assemblysome dynamics. We extended our studies to human cell lines. The BLM helicase, ortholog of yeast Sgs1, was identified upon sequencing assemblysome-associated RNAs from the MCF7 human breast cancer cell line, and mRNAs encoding DNA repair proteins were overall enriched. Using the radiation-resistant A549 cell line, we observed by transmission electron microscopy that 1,6-hexanediol, an agent known to disrupt phase-separated condensates, depletes ring ribosome structures compatible with assemblysomes from the cytoplasm of cells and makes the cells more sensitive to X-ray treatment. Taken together these findings suggest that assemblysomes may be a component of the DNA damage response from yeast to human.},
	year = {2023},
	eissn = {1469-9001},
	pages = {1557-1574},
	orcid-numbers = {Varga, Dániel/0000-0003-0391-5057; Igaz, Nóra/0000-0003-1580-4397; Rázga, Zsolt/0000-0003-4717-8482; Nagy, Gábor/0000-0001-5464-1135; Zsindely, Nóra/0000-0002-6189-3100; Bodai, László/0000-0001-8411-626X; Erdélyi, Miklós/0000-0002-9501-5752; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Boros, Imre Miklós/0000-0001-8504-9687}
}

@CONFERENCE{MTMT:34657419,
	title = {Defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis by the impaired regulation of PMCA activity},
	url = {https://m2.mtmt.hu/api/publication/34657419},
	author = {Madácsy, Tamara and Varga, Árpád and Csákány-Papp, Noémi and Tél, Bálint and Pallagi, Petra and Szabó, Viktória and Kiss, Aletta Kata and Fanczal, Júlia and Rakonczay, Zoltán and Tiszlavicz, László and Rázga, Zsolt and Hohweiler, Meike and Kleger, Alexander and Gray, Mike and Hegyi, Péter and Maléth, József},
	booktitle = {European Cystic Fibrosis Society 17th ECFS Basic Science Conference},
	unique-id = {34657419},
	year = {2022},
	pages = {135},
	orcid-numbers = {Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Csákány-Papp, Noémi/0000-0002-3614-2698; Tél, Bálint/0000-0003-2066-6494; Pallagi, Petra/0000-0001-8906-0840; Szabó, Viktória/0000-0001-6547-9102; Kiss, Aletta Kata/0000-0001-6404-1555; Fanczal, Júlia/0000-0001-7356-3857; Rakonczay, Zoltán/0000-0002-1499-3416; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Hegyi, Péter/0000-0003-0399-7259; Maléth, József/0000-0001-5768-3090}
}

@article{MTMT:33261227,
	title = {Abnormal type VII collagen expression in non-lesional psoriatic skin},
	url = {https://m2.mtmt.hu/api/publication/33261227},
	author = {Konczné Gubán, Barbara and Flink, Lili Borbála and Bozó, Renáta and Danis, Judit and Rázga, Zsolt and Koncz, Balázs and Széll, Márta and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna},
	doi = {10.1016/j.jid.2022.09.386},
	journal-iso = {J INVEST DERMATOL},
	journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
	volume = {142},
	unique-id = {33261227},
	issn = {0022-202X},
	year = {2022},
	eissn = {1523-1747},
	pages = {S244-S244},
	orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Danis, Judit/0000-0002-0270-5309; Rázga, Zsolt/0000-0003-4717-8482; Széll, Márta/0000-0002-0730-714X; Kemény, Lajos/0000-0002-2119-9501; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743}
}

@article{MTMT:33190130,
	title = {Abnormal type VII collagen expression in non-lesional psoriatic skin},
	url = {https://m2.mtmt.hu/api/publication/33190130},
	author = {Konczné Gubán, Barbara and Flink, Lili Borbála and Bozó, Renáta and Danis, Judit and Rázga, Zsolt and Koncz, Balázs and Széll, Márta and Kemény, Lajos and Csörgő Sándorné Bata, Zsuzsanna},
	journal-iso = {BVSZ},
	journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE},
	volume = {98},
	unique-id = {33190130},
	issn = {0006-7768},
	year = {2022},
	eissn = {2064-261X},
	pages = {190-190},
	orcid-numbers = {Bozó, Renáta/0000-0003-4242-2474; Danis, Judit/0000-0002-0270-5309; Rázga, Zsolt/0000-0003-4717-8482; Széll, Márta/0000-0002-0730-714X; Csörgő Sándorné Bata, Zsuzsanna/0000-0002-3732-1743}
}

@article{MTMT:32800045,
	title = {Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis.},
	url = {https://m2.mtmt.hu/api/publication/32800045},
	author = {Madácsy, Tamara and Varga, Árpád and Csákány-Papp, Noémi and Tél, Bálint and Pallagi, Petra and Szabó, Viktória and Kiss, Aletta Kata and Fanczal, Júlia and Rakonczay, Zoltán and Tiszlavicz, László and Rázga, Zsolt and Hohwieler, Meike and Kleger, Alexander and Gray, Mike and Hegyi, Péter and Maléth, József},
	doi = {10.1007/s00018-022-04287-1},
	journal-iso = {CELL MOL LIFE SCI},
	journal = {CELLULAR AND MOLECULAR LIFE SCIENCES},
	volume = {79},
	unique-id = {32800045},
	issn = {1420-682X},
	abstract = {Alcoholic pancreatitis and hepatitis are frequent, potentially lethal diseases with limited treatment options. Our previous study reported that the expression of CFTR Cl- channel is impaired by ethanol in pancreatic ductal cells leading to more severe alcohol-induced pancreatitis. In addition to determining epithelial ion secretion, CFTR has multiple interactions with other proteins, which may influence intracellular Ca2+ signaling. Thus, we aimed to investigate the impact of ethanol-mediated CFTR damage on intracellular Ca2+ homeostasis in pancreatic ductal epithelial cells and cholangiocytes. Human and mouse pancreas and liver samples and organoids were used to study ion secretion, intracellular signaling, protein expression and interaction. The effect of PMCA4 inhibition was analyzed in a mouse model of alcohol-induced pancreatitis. The decreased CFTR expression impaired PMCA function and resulted in sustained intracellular Ca2+ elevation in ethanol-treated and mouse and human pancreatic organoids. Liver samples derived from alcoholic hepatitis patients and ethanol-treated mouse liver organoids showed decreased CFTR expression and function, and impaired PMCA4 activity. PMCA4 co-localizes and physically interacts with CFTR on the apical membrane of polarized epithelial cells, where CFTR-dependent calmodulin recruitment determines PMCA4 activity. The sustained intracellular Ca2+ elevation in the absence of CFTR inhibited mitochondrial function and was accompanied with increased apoptosis in pancreatic epithelial cells and PMCA4 inhibition increased the severity of alcohol-induced AP in mice. Our results suggest that improving Ca2+ extrusion in epithelial cells may be a potential novel therapeutic approach to protect the exocrine pancreatic function in alcoholic pancreatitis and prevent the development of cholestasis in alcoholic hepatitis.},
	keywords = {CFTR; Ca2+ signaling; Alcoholic pancreatitis; Alcoholic Hepatitis; Epithelial ion secretion},
	year = {2022},
	eissn = {1420-9071},
	orcid-numbers = {Madácsy, Tamara/0000-0001-5598-9723; Varga, Árpád/0000-0002-2379-139X; Csákány-Papp, Noémi/0000-0002-3614-2698; Tél, Bálint/0000-0003-2066-6494; Pallagi, Petra/0000-0001-8906-0840; Szabó, Viktória/0000-0001-6547-9102; Kiss, Aletta Kata/0000-0001-6404-1555; Fanczal, Júlia/0000-0001-7356-3857; Rakonczay, Zoltán/0000-0002-1499-3416; Tiszlavicz, László/0000-0003-1134-6587; Rázga, Zsolt/0000-0003-4717-8482; Hegyi, Péter/0000-0003-0399-7259; Maléth, József/0000-0001-5768-3090}
}

@misc{MTMT:32783378,
	title = {Phase separated ribosome nascent chain complexes paused in translation are capable to continue expression of proteins playing role in genotoxic stress response upon DNA damage},
	url = {https://m2.mtmt.hu/api/publication/32783378},
	author = {Szatmári, Orsolya and Györkei, Á and Varga, Dániel and H. Kovács, Bálint Barna and Igaz, Nóra and Német, K and Bagi, N and Nagy-Mikó, B and Balogh, D and Rázga, Zsolt and Erdélyi, Miklós and Papp, B and Csontné Kiricsi, Mónika and Blastyák, A and Collart, MA and Boros, Imre Miklós and Villanyi, Zoltan},
	doi = {10.1101/2022.03.16.484567},
	unique-id = {32783378},
	year = {2022},
	orcid-numbers = {Varga, Dániel/0000-0003-0391-5057; Igaz, Nóra/0000-0003-1580-4397; Rázga, Zsolt/0000-0003-4717-8482; Erdélyi, Miklós/0000-0002-9501-5752; Csontné Kiricsi, Mónika/0000-0002-8416-2052; Boros, Imre Miklós/0000-0001-8504-9687}
}

@article{MTMT:32489937,
	title = {Indoleamine 2,3-Dioxygenase Cannot Inhibit Chlamydia trachomatis Growth in HL-60 Human Neutrophil Granulocytes},
	url = {https://m2.mtmt.hu/api/publication/32489937},
	author = {Virók, Dezső and Tömösi, Ferenc and Keller-Pintér, Anikó and Szabó, Kitti and Bogdanov, Anita and Póliska, Szilárd and Rázga, Zsolt and Bruszel, Bella and Cseh, Zsuzsanna and Kókai, Dávid and Paróczai, Dóra and Endrész, Valéria and Janáky, Tamás and Burián, Katalin},
	doi = {10.3389/fimmu.2021.717311},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {12},
	unique-id = {32489937},
	issn = {1664-3224},
	year = {2021},
	eissn = {1664-3224},
	orcid-numbers = {Tömösi, Ferenc/0000-0002-6657-5777; Keller-Pintér, Anikó/0000-0002-4105-8458; Szabó, Kitti/0000-0002-1177-2036; Bogdanov, Anita/0000-0003-3067-8835; Rázga, Zsolt/0000-0003-4717-8482; Endrész, Valéria/0000-0002-9402-3857; Janáky, Tamás/0000-0002-6466-8283; Burián, Katalin/0000-0003-1300-2374}
}