TY - JOUR AU - Rein, P. AU - Keczer, Bánk AU - Horváth, Miklós AU - Gellért, Bálint AU - Marjai, Tamás AU - Benke, Márton AU - Tóth, E. AU - Szűcs, Ákos AU - Szijártó, Attila AU - Hritz, István TI - Az endoszkópos ultrahang diagnosztikus érzékenysége kiemelkedő a hasnyálmirigy térfoglalások vizsgálatában JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 9 PY - 2023 IS - Suppl. 1 SP - 98 EP - 99 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/34806236 ID - 34806236 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Benke, Márton AU - Zeöld, Anikó AU - Kittel, Ágnes AU - Khamari, Delaram AU - Hritz, István AU - Horváth, Miklós AU - Keczer, Bánk AU - Borka, Katalin AU - Szűcs, Ákos AU - Wiener, Zoltán TI - MiR-200b categorizes patients into pancreas cystic lesion subgroups with different malignant potential JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-023-47129-1 UR - https://m2.mtmt.hu/api/publication/34371433 ID - 34371433 AB - Extracellular vesicles (EV) carry their cargo in a membrane protected form, however, their value in early diagnostics is not well known. Although pancreatic cysts are heterogeneous, they can be clustered into the larger groups of pseudocysts (PC), and serous and mucinous pancreatic cystic neoplasms (S-PCN and M-PCN, respectively). In contrast to PCs and S-PCNs, M-PCNs may progress to malignant pancreatic cancers. Since current diagnostic tools do not meet the criteria of high sensitivity and specificity, novel methods are urgently needed to differentiate M-PCNs from other cysts. We show that cyst fluid is a rich source of EVs that are positive and negative for the EV markers CD63 and CD81, respectively. Whereas we found no difference in the EV number when comparing M-PCN with other pancreatic cysts, our EV-based biomarker identification showed that EVs from M-PCNs had a higher level of miR-200b. We also prove that not only EV-derived, but also total cyst fluid miR-200b discriminates patients with M-PCN from other pancreatic cysts with a higher sensitivity and specificity compared to other diagnostic methods, providing the possibility for clinical applications. Our results show that measuring miR-200b in cyst fluid-derived EVs or from cyst fluid may be clinically important in categorizing patients. LA - English DB - MTMT ER - TY - JOUR AU - Budai, Bettina Katalin AU - Schultz, Leona AU - Szűcs, Ákos AU - Benke, Márton AU - Kaposi, Pál AU - Szijártó, Attila AU - Maurovich-Horvat, Pál AU - Dudás, Ibolyka TI - A pancreas cystosus neoplasiák fotonszámláló detektor CT felvételeinek radiomikai elemzése – a virtuális nem kontrasztos és a valódi natív sorozatok kvantitatív összehasonlítása JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 9 PY - 2023 IS - Suppl. 1 SP - 70 EP - 71 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/33998941 ID - 33998941 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Budai, Bettina Katalin AU - Molnár, Dániel AU - Szűcs, Ákos AU - Benke, Márton AU - Kaposi, Pál AU - Szijártó, Attila AU - Maurovich-Horvat, Pál AU - Dudás, Ibolyka TI - A nagy felbontású fotonszámláló detektor CT vizsgálat szerepe a cisztikus pancreas léziók diagnosztikájában JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 9 PY - 2023 IS - Suppl. 1 SP - 70 EP - 70 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/33998900 ID - 33998900 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Czakó, László AU - Gyökeres, Tibor Zoltán AU - Hritz, István AU - Madácsy, László AU - Illés, Dóra AU - Szepes, Zoltán AU - Dubravcsik, Zsolt AU - Péterfi, Zoltán AU - Nagy, András AU - Szűcs, Ákos AU - Vincze, Áron TI - Epeút- és epehólyag-gyulladás: diagnosztikus kritériumok és terápia [Cholangitis and cholecystitis: diagnostic criteria and management] JF - ORVOSI HETILAP J2 - ORV HETIL VL - 164 PY - 2023 IS - 20 SP - 770 EP - 787 PG - 18 SN - 0030-6002 DO - 10.1556/650.2023.32770 UR - https://m2.mtmt.hu/api/publication/33842885 ID - 33842885 N1 - Belgyógyászati Klinika, Gasztroenterológiai Osztály, Általános Orvostudományi Kar, Szegedi Tudományegyetem, Szeged, Hungary Gasztroenterológiai Osztály, ÉSzak-Pesti Centrumkórház - Honvédkórház, Budapest, Hungary Sebészeti, Transzplantációs és Gasztroenterológiai Klinika, Általános Orvostudományi Kar, Semmelweis Egyetem, Budapest, Hungary Endo-Kapszula Magánorvosi Centrum, Székesfehérvár, Hungary Gasztroenterológiai Osztály, Bács-Kiskun Megyei Oktatókórház, Kecskemét, Hungary I. Belgyógyászati Klinika, Általános Orvostudományi Kar, Pécsi Tudományegyetem, Pécs, Hungary Radiológiai Klinika, Általános Orvostudományi Kar, Szegedi Tudományegyetem, Szeged, Hungary Export Date: 7 September 2023 CODEN: ORHEA Correspondence Address: László, C.Pf. 469, Hungary; email: czako.laszlo@med.u-szeged.hu AB - In developed countries, diseases of the gallbladder and the biliary tract count as some of the most frequent gastrointestinal disorders. The inflammation of the gallbladder/biliary tree is a potentially severe, even lethal condition that requires rapid diagnosis and early multidisciplinary approach to be treated. Although the frequency of these diseases is high, the treatment is not unified in Hungary yet. The aim of the evidence-based recommendation is to clarify the diagnostic criteria and severity grading of these diseases and to highlight the indications and rules of proper application of the numerous available therapeutic interventions. The recent guideline is based on the consensus of the Board members of the Endoscopic Section of the Hungarian Gastroenterology Society in contribution with renown experts of surgery, infectology as well as interventional radiology and it counts as a clear and easy applicable guide during the all-day healthcare practice. Our guidelines are based on Tokyo guidelines established on the basis of the consensus reached in the International Consensus Meeting held in Tokyo which were revised in 2013 (TG13) and in 2018 (TG18). Orv Hetil. 2023; 164(20): 770-787. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gellért, Bálint AU - Horváth, Miklós AU - Péter, Zoltán AU - Miheller, Pál AU - Dudás, Ibolyka AU - Benke, Márton AU - Marjai, Tamás AU - Szűcs, Ákos AU - Szijártó, Attila AU - Hritz, István TI - Ampullaris neoplasiak kezelése – kié a beteg? JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 8 PY - 2022 IS - Suppl. 1 SP - 77 EP - 78 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/33635672 ID - 33635672 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Keczer, Bánk AU - Benke, Márton AU - Marjai, Tamás AU - Horváth, Miklós AU - Miheller, Pál AU - Szűcs, Ákos AU - Harsányi, László AU - Szijártó, Attila AU - Hritz, István TI - Quantitative Software Analysis of Endoscopic Ultrasound Images of Pancreatic Cystic Lesions JF - DIAGNOSTICS J2 - DIAGNOSTICS VL - 12 PY - 2022 IS - 9 PG - 11 SN - 2075-4418 DO - 10.3390/diagnostics12092105 UR - https://m2.mtmt.hu/api/publication/33108464 ID - 33108464 N1 - Export Date: 25 January 2024 AB - Endoscopic ultrasonography (EUS) is the most accurate imaging modality for the evaluation of different types of pancreatic cystic lesions. Our aim was to analyze EUS images of pancreatic cystic lesions using an image processing software. We specified the echogenicity of the lesions by measuring the gray value of pixels inside the selected areas. The images were divided into groups (serous cystic neoplasm /SCN/, intraductal papillary mucinous neoplasms and mucinous cystic neoplasms /Non-SCN/ and Pseudocyst) according to the pathology results of the lesions. Overall, 170 images were processed by the software: 81 in Non-SCN, 30 in SCN and 59 in Pseudocyst group. The mean gray value of the entire lesion in the Non-SCN group was significantly higher than in the SCN group (27.8 vs. 18.8; p < 0.0005). The area ratio in the SCN, Non-SCN and Pseudocyst groups was 57%, 39% and 61%, respectively; significantly lower in the Non-SCN group than in the SCN or Pseudocyst groups (p < 0.0005 and p < 0.0005, respectively). The lesion density was also significantly higher in the Non-SCN group compared to the SCN or Pseudocyst groups (4186.6/mm2 vs. 2833.8/mm2 vs. 2981.6/mm2; p < 0.0005 and p < 0.0005, respectively). The EUS image analysis process may have the potential to be a diagnostic tool for the evaluation and differentiation of pancreatic cystic lesions. LA - English DB - MTMT ER - TY - JOUR AU - Benke, Márton AU - Borbásné Farkas, Kornélia AU - Hegyi, Péter AU - Tinusz, Benedek AU - Sarlós, Patrícia AU - Erőss, Bálint Mihály AU - Szemes, Kata AU - Vörhendi, Nóra AU - Szakács, Zsolt AU - Szűcs, Ákos TI - Preoperative Serum Carbohydrate Antigen 19-9 Levels Cannot Predict the Surgical Resectability of Pancreatic Cancer : A Meta-Analysis JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 28 PY - 2022 PG - 9 SN - 1219-4956 DO - 10.3389/pore.2022.1610266 UR - https://m2.mtmt.hu/api/publication/32862713 ID - 32862713 AB - Background and Aims: Pancreatic ductal adenocarcinoma has one of the worst prognosis of all malignancies. This investigated the relationship between the preoperative serum carbohydrate antigen 19-9 and surgical resectability. Methods: A systematic search was performed in three databases (MEDLINE, EMBASE, and Web of Science) to compare the surgical resectability of pancreatic ductal adenocarcinoma in patients with high and low preoperative serum carbohydrate antigen 19-9 values. The receiving operating characteristic curves were constructed and the weighted mean differences for preoperative serum carbohydrate antigen 19-9 levels of resectable and unresectable groups of patients were calculated. The PROSPERO registration number is CRD42019132522. Results: Results showed that there was a significant difference in resectability between the low and high carbohydrate antigen 19-9 groups. Six out of the eight studies utilised receiver operating characteristic curves in order to find the cut-off preoperative carbohydrate antigen 19-9 levels marking unresectability. The overall result from the pooled area under curve values from the receiver operating characteristic curves was 0.794 (CI: 0.694-0.893), showing that the preoperative carbohydrate antigen 19-9 level is a "fair" marker of resectability. The result of the pooled weighted mean differences was 964 U/ml (p < 0.001) showing that there is a significant carbohydrate antigen 19-9 difference between the resectable and unresectable groups. Based on the results of the I-squared test, the result was 87.4%, accounting for "considerable" heterogeneity within the population. Conclusion: Carbohydrate antigen 19-9 is not a reliable marker of unresectability, it should not be used on its own in surgical decision-making. LA - English DB - MTMT ER - TY - JOUR ED - Hahn, Oszkár / Collaborator ED - Szijártó, Attila / Collaborator ED - Pekli, Damján / Collaborator ED - Fülöp, András / Collaborator ED - Kokas, Bálint András / Collaborator ED - Bárdos, Dávid / Collaborator ED - Andras, Csilla / Collaborator ED - Bartek, Peter / Collaborator ED - Battyáni, István / Collaborator ED - Bezsilla, Janos / Collaborator ED - Bodoky, György / Collaborator ED - Bursics, Attila / Collaborator ED - Dank, Magdolna / Collaborator ED - Dankovics, Zsofia / Collaborator ED - Deák, Pál Ákos / Collaborator ED - Dede, Kristof / Collaborator ED - Demeter, Gyula / Collaborator ED - Doros, Attila / Collaborator ED - Dudás, Ibolyka / Collaborator ED - Egyed, Zsofia / Collaborator ED - Farkas, Róbert / Collaborator ED - Gerlei, Zsuzsanna / Collaborator ED - Györke, Tamás / Collaborator ED - Hagymási, Krisztina / Collaborator ED - Hitre, Erika / Collaborator ED - Hőhn, József / Collaborator ED - Jancsik, Viktor / Collaborator ED - Káposztás, Zsolt / Collaborator ED - Kiraly, Istvan / Collaborator ED - Loderer, Tamas / Collaborator ED - Nagy, Endre / Collaborator ED - Olah, Attila / Collaborator ED - Pajor, Peter / Collaborator ED - Papp, András / Collaborator ED - Pár, Gabriella / Collaborator ED - Patyanik, Mihaly / Collaborator ED - Petrányi, Ágota Eszter / Collaborator ED - Petri, András / Collaborator ED - Piros, László / Collaborator ED - Schuller, Janos / Collaborator ED - Sikorszki, Laszlo / Collaborator ED - Szabó, József / Collaborator ED - Székely, Eszter / Collaborator ED - Szombati, Andrea / Collaborator ED - Torday, László / Collaborator ED - Toth, Judit / Collaborator ED - Toth, Lajos Barna / Collaborator ED - Dósa, Edit / Collaborator ED - Harsányi, László / Collaborator ED - Horváth, Zsolt / Collaborator ED - István, Gábor / Collaborator ED - Landherr, Laszlo / Collaborator ED - Lázár, György ifj / Collaborator ED - Lengyel, Gabriella / Collaborator ED - Lovey, Jozsef / Collaborator ED - Mangel, László Csaba / Collaborator ED - Maurovich-Horvat, Pál / Collaborator ED - Nemes, Balázs / Collaborator ED - Palkó, András / Collaborator ED - Schaff, Zsuzsa / Collaborator ED - Szalay, Ferenc / Collaborator ED - Szűcs, Ákos / Collaborator ED - Vereczkei, András / Collaborator ED - Lazar, Istvan / Collaborator TI - A hepatocellularis carcinoma komplex kezelése. Konszenzuskonferencia, Budapest, 2021. április 24. TS - Konszenzuskonferencia, Budapest, 2021. április 24. JF - ORVOSI HETILAP J2 - ORV HETIL VL - 162 PY - 2022 IS - Suppl. 2. SP - 2 EP - 31 PG - 30 SN - 0030-6002 DO - 10.1556/650.2021.32431 UR - https://m2.mtmt.hu/api/publication/32704404 ID - 32704404 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Keczer, Bánk AU - Miheller, Pál AU - Horváth, Miklós AU - Marjai, Tamás AU - Harsányi, László AU - Szűcs, Ákos AU - Szijártó, Attila AU - Hritz, István TI - Differentiation between pancreatic cystic lesions using image processing software (FIJI) by analyzing endoscopic ultrasonographic (EUS) images JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 7 PY - 2021 IS - Suppl. 2 SP - 44 EP - 45 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32582483 ID - 32582483 LA - English DB - MTMT ER -