TY - JOUR AU - Somogyi, Virág AU - Horváth, Tamás AU - Tóth, István AU - Bartha, Tibor AU - Frenyó V., László AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Kerti, Annamária AU - Naftolin, Frederick AU - Zsarnovszky, Attila TI - Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture JF - ACTA VETERINARIA HUNGARICA J2 - ACTA VET HUNG VL - 64 PY - 2016 IS - 4 SP - 497 EP - 513 PG - 17 SN - 0236-6290 DO - 10.1556/004.2016.046 UR - https://m2.mtmt.hu/api/publication/3159049 ID - 3159049 AB - Thyroid hormones (THs) and oestrogens are crucial in the regulation of cerebellar development. TH receptors (TRs) mediate these hormone effects and are regulated by both hormone families. We reported earlier that THs and oestradiol (E2) determine TR levels in cerebellar cell culture. Here we demonstrate the effects of low concentrations (10-10 M) of the endocrine disruptor (ED) bisphenol A (BPA) on the hormonal (THs, E2) regulation of TRα,β in rat cerebellar cell culture. Primary cerebellar cell cultures, glia-containing and glia-destroyed, were treated with BPA or a combination of BPA and E2 and/or THs. Oestrogen receptor and TH receptor mRNA and protein levels were determined by real-time qPCR and Western blot techniques. The results show that BPA alone decreases, while BPA in combination with THs and/or E2 increases TR mRNA expression. In contrast, BPA alone increased receptor protein expressions, but did not further increase them in combination with THs and/or E2. The modulatory effects of BPA were mediated by the glia; however, the degree of changes also depended on the specific hormone ligand used. The results signify the importance of the regulatory mechanisms interposed between transcription and translation and raise the possibility that BPA could act to influence nuclear hormone receptor levels independently of ligand-receptor interaction. LA - English DB - MTMT ER - TY - CONF AU - Tóth, István AU - Szabó, Csaba AU - Jócsák, Gergely AU - Somogyi, Virág AU - Kiss, Dávid Sándor AU - Bartha, Tibor AU - Frenyó V., László AU - Horváth, Tamás L AU - Zsarnovszky, Attila TI - Impact of satiety state and testosterone on the metabolic lateralization in the male rat hypothalamus T2 - 15th Annual Conference of the Hungarian Neuroscience Society PY - 2015 UR - https://m2.mtmt.hu/api/publication/3016455 ID - 3016455 LA - English DB - MTMT ER - TY - CONF AU - Jócsák, Gergely AU - Tóth, István AU - Somogyi, Virág AU - Kiss, Dávid Sándor AU - Bartha, Tibor AU - Frenyó V., László AU - Horváth, Tamás L AU - Zsarnovszky, Attila TI - Ligand-dependent estrogen and thyroid hormone receptor mRNA expression is modulated by the glia T2 - 15th Annual Conference of the Hungarian Neuroscience Society PY - 2015 UR - https://m2.mtmt.hu/api/publication/3016451 ID - 3016451 LA - English DB - MTMT ER - TY - JOUR AU - Jócsák, Gergely AU - Tóth, István AU - Somogyi, Virág AU - Kiss, Dávid Sándor AU - Bartha, Tibor AU - Frenyó V., László AU - Zsarnovszky, Attila TI - Effects of bisphenol-A on cell viability in developing cerebellar cell culture JF - ACTA PHYSIOLOGICA J2 - ACTA PHYSIOL VL - 215 PY - 2015 IS - S705 SP - 102 EP - 102 PG - 1 SN - 1748-1708 UR - https://m2.mtmt.hu/api/publication/2986861 ID - 2986861 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, István AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Somogyi, Virág AU - Bartha, Tibor AU - Frenyó V., László AU - Zsarnovszky, Attila TI - Satiety state dependent metabolic sidedness in the hypothalamus of male rats JF - ACTA PHYSIOLOGICA J2 - ACTA PHYSIOL VL - 215 PY - 2015 IS - S705 SP - 101 EP - 101 PG - 1 SN - 1748-1708 UR - https://m2.mtmt.hu/api/publication/2986856 ID - 2986856 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, István AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Somogyi, Virág AU - Toronyi, Éva AU - Bartha, Tibor AU - Frenyó V., László AU - Horváth, Tamás AU - Zsarnovszky, Attila TI - Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats. JF - PLOS ONE J2 - PLOS ONE VL - 10 PY - 2015 IS - 9 PG - 11 SN - 1932-6203 DO - 10.1371/journal.pone.0137462 UR - https://m2.mtmt.hu/api/publication/2940248 ID - 2940248 AB - Hypothalamus is the highest center and the main crossroad of numerous homeostatic regulatory pathways including reproduction and energy metabolism. Previous reports indicate that some of these functions may be driven by the synchronized but distinct functioning of the left and right hypothalamic sides. However, the nature of interplay between the hemispheres with regard to distinct hypothalamic functions is still unclear. Here we investigated the metabolic asymmetry between the left and right hypothalamic sides of ovariectomized female rats by measuring mitochondrial respiration rates, a parameter that reflects the intensity of cell and tissue metabolism. Ovariectomized (saline injected) and ovariectomized+estrogen injected animals were fed ad libitum or fasted to determine 1) the contribution of estrogen to metabolic asymmetry of hypothalamus; and 2) whether the hypothalamic asymmetry is modulated by the satiety state. Results show that estrogen-priming significantly increased both the proportion of animals with detected hypothalamic lateralization and the degree of metabolic difference between the hypothalamic sides causing a right-sided dominance during state 3 mitochondrial respiration (St3) in ad libitum fed animals. After 24 hours of fasting, lateralization in St3 values was clearly maintained; however, instead of the observed right-sided dominance that was detected in ad libitum fed animals here appeared in form of either right- or left-sidedness. In conclusion, our results revealed estrogen- and satiety state-dependent metabolic differences between the two hypothalamic hemispheres in female rats showing that the hypothalamic hemispheres drive the reproductive and satiety state related functions in an asymmetric manner. LA - English DB - MTMT ER - TY - JOUR AU - Jócsák, Gergely AU - Somogyi, Virág AU - Tóth, István AU - Goszleth, Gréta AU - Bartha, Tibor AU - Zsarnovszky, Attila TI - Endocrine distruptor effect of Bisphenol A on the developing cerebellum, through estrogen and thyroid hormone receptor expression level changes JF - ACTA PHYSIOLOGICA J2 - ACTA PHYSIOL VL - 211 PY - 2014 IS - SI 697 SP - 127 EP - 127 PG - 1 SN - 1748-1708 UR - https://m2.mtmt.hu/api/publication/2822859 ID - 2822859 N1 - SU 697 LA - English DB - MTMT ER - TY - JOUR AU - Mándoki, Míra AU - Jócsák, Gergely AU - Somogyi, Virág AU - Kiss, Dávid Sándor AU - Tóth, István AU - Bartha, Tibor TI - Use of virtual patients in teaching veterinary physiology at the Faculty of Veterinary Science, Szent Istvan University, Budapest JF - ACTA PHYSIOLOGICA J2 - ACTA PHYSIOL VL - 211 PY - 2014 IS - S 697 SP - 49 EP - 49 PG - 1 SN - 1748-1708 UR - https://m2.mtmt.hu/api/publication/2791695 ID - 2791695 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, István AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Somogyi, Virág AU - Bartha, Tibor AU - Frenyó V., László AU - Zsarnovszky, Attila TI - Metabolic lateralization in the hypothalamus: possible mechanism for cramming multiple functions into a small place JF - ACTA PHYSIOLOGICA J2 - ACTA PHYSIOL VL - 211 PY - 2014 IS - s697 SP - 148 EP - 148 PG - 1 SN - 1748-1708 UR - https://m2.mtmt.hu/api/publication/2729311 ID - 2729311 N1 - DOI: 10.1111/apha.12362 LA - English DB - MTMT ER - TY - CONF AU - Tóth, István AU - Kiss, Dávid Sándor AU - Jócsák, Gergely AU - Somogyi, Virág AU - Bartha, Tibor AU - Frenyó V., László AU - Zsarnovszky, Attila TI - Metabolic lateralization in the hypothalamus: possible mechanism for cramming multiple functions into a small place T2 - 9th FENS Forum of Neuroscience PY - 2014 UR - https://m2.mtmt.hu/api/publication/2729285 ID - 2729285 LA - English DB - MTMT ER -