@article{MTMT:3089063, title = {Comparison of individual and combined effects of four endocrine disruptors on estrogen receptor beta transcription in cerebellar cell culture: The modulatory role of estradiol and triiodo-thyronine}, url = {https://m2.mtmt.hu/api/publication/3089063}, author = {Jócsák, Gergely and Kiss, Dávid Sándor and Tóth, István and Goszleth, Gréta and Bartha, Tibor and Frenyó V., László and Horváth, Tamás and Zsarnovszky, Attila}, doi = {10.3390/ijerph13060619}, journal-iso = {INT J ENV RES PUB HE}, journal = {INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH}, volume = {13}, unique-id = {3089063}, issn = {1661-7827}, year = {2016}, eissn = {1660-4601}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:2822859, title = {Endocrine distruptor effect of Bisphenol A on the developing cerebellum, through estrogen and thyroid hormone receptor expression level changes}, url = {https://m2.mtmt.hu/api/publication/2822859}, author = {Jócsák, Gergely and Somogyi, Virág and Tóth, István and Goszleth, Gréta and Bartha, Tibor and Zsarnovszky, Attila}, journal-iso = {ACTA PHYSIOL}, journal = {ACTA PHYSIOLOGICA}, volume = {211}, unique-id = {2822859}, issn = {1748-1708}, year = {2014}, eissn = {1748-1716}, pages = {127-127}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:2728821, title = {Hypothalamic Sidedness in Mitochondrial Metabolism: New Perspectives}, url = {https://m2.mtmt.hu/api/publication/2728821}, author = {Tóth, István and Kiss, Dávid Sándor and Goszleth, Gréta and Bartha, Tibor and Frenyó V., László and Naftolin, F and Horváth, Tamás and Zsarnovszky, Attila}, doi = {10.1177/1933719114530188}, journal-iso = {REPROD SCI}, journal = {REPRODUCTIVE SCIENCES}, volume = {21}, unique-id = {2728821}, issn = {1933-7191}, year = {2014}, eissn = {1933-7205}, pages = {1492-1498}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @techreport{MTMT:2213992, title = {Biszfenol A, arzén és zearalenon hatása fejlődő patkány kisagysejtjeinek ösztrogén- és pajzsmirigyhormon receptor mRNS-ének expressziójára.}, url = {https://m2.mtmt.hu/api/publication/2213992}, author = {Tóth, István and Somogyi, Virág and Győrffy, Andrea and Goszleth, Gréta and Zsarnovszky, Attila}, unique-id = {2213992}, year = {2013}, orcid-numbers = {Tóth, István/0000-0002-0168-4753; Győrffy, Andrea/0000-0001-7110-1464} } @techreport{MTMT:2213988, title = {A mitokondriális metabolizmus hypothalamicus aszimmetriája.}, url = {https://m2.mtmt.hu/api/publication/2213988}, author = {Kiss, Dávid Sándor and Tóth, István and Goszleth, Gréta and Somogyi, Virág and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila}, unique-id = {2213988}, year = {2013}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:2845330, title = {A táplálékfölvétel fő szabályozó molekulái: a grelin, a leptin és azok kölcsönhatása : Irodalmi összefoglaló. The major regulators of feed-intake: ghrelin, leptin and their interactions. Literature review}, url = {https://m2.mtmt.hu/api/publication/2845330}, author = {Tóth, István and Goszleth, Gréta and Frenyó V., László}, journal-iso = {MAGY ALLATORVOSOK}, journal = {MAGYAR ÁLLATORVOSOK LAPJA}, volume = {134}, unique-id = {2845330}, issn = {0025-004X}, year = {2012}, pages = {504-512}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @techreport{MTMT:2213977, title = {A hipotalamikus GnRH szekréció unilaterális szabályozása.}, url = {https://m2.mtmt.hu/api/publication/2213977}, author = {Tóth, István and Kiss, Dávid Sándor and Somogyi, Virág and Goszleth, Gréta and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila}, unique-id = {2213977}, year = {2012}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @techreport{MTMT:2213971, title = {Ösztrogén- és pajzsmirigyhormon receptorok expressziójának ligandum-függő változásai a fejlődő kisagyban: kvantitatív pcr és western blot vizsgálatok.}, url = {https://m2.mtmt.hu/api/publication/2213971}, author = {Somogyi, Virág and Győrffy, Andrea and Goszleth, Gréta and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila}, unique-id = {2213971}, year = {2012}, orcid-numbers = {Győrffy, Andrea/0000-0001-7110-1464} } @techreport{MTMT:2213929, title = {Az idegvégződésekben és idegsejt-testekben lévő mitokondriumok légzésének differenciált méréséhez szükséges szubfrakcionálási metodika kidolgozása.}, url = {https://m2.mtmt.hu/api/publication/2213929}, author = {Kiss, Dávid Sándor and Tóth, István and Goszleth, Gréta and Somogyi, Virág and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila}, unique-id = {2213929}, year = {2012}, orcid-numbers = {Tóth, István/0000-0002-0168-4753} } @article{MTMT:1518622, title = {Ligand-induced changes in oestrogen and thyroid hormone receptor expression in the developing rat cerebellum: a comparative quantitative PCR and Western blot study.}, url = {https://m2.mtmt.hu/api/publication/1518622}, author = {Scalise, Trudy J and Győrffy, Andrea and Tóth, István and Kiss, Dávid Sándor and Somogyi, Virág and Goszleth, Gréta and Bartha, Tibor and Frenyó V., László and Zsarnovszky, Attila}, doi = {10.1556/AVet.2012.023}, journal-iso = {ACTA VET HUNG}, journal = {ACTA VETERINARIA HUNGARICA}, volume = {60}, unique-id = {1518622}, issn = {0236-6290}, abstract = {Oestrogen (E2) and thyroid hormones (THs) are key regulators of cerebel-lar development. Recent reports implicate a complex mechanism through which E2 and THs influence the expression levels of each other’s receptors (ERs and TRs) to precisely mediate developmental signals and modulate signal strength. We examined the modulating effects of E2 and THs on the expression levels of their receptor mRNAs and proteins in cultured cerebellar cells obtained from 7-day-old rat pups. Cerebellar granule cell cultures were treated with either E2, THs or a combination of these hormones, and resulting receptor expression levels were determined by quantitative PCR and Western blot techniques. The results were compared to non-treated controls and to samples obtained from 14-day-old in situ cerebella. Additionally, we determined the glial effects on the regulation of ER-TR expression levels. The results show that (i) ER and TR expression depends on the combined presence of E2 and THs; (ii) glial cells mediate the hormonal regu- lation of neuronal ER-TR expression, and (iii) loss of tissue integrity results in characteristic changes in ER-TR expression levels. These observations suggest that both E2 and THs, in adequate amounts, are required for the precise orchestra-tion of cerebellar development and that alterations in the ratio of E2/THs may in-fluence signalling mechanisms involved in neurodevelopment. Comparison of data from in vitro and in situ samples revealed a shift in receptor expression levels after loss of tissue integrity, suggesting that such adjusting/regenerative mecha-nisms may function after cerebellar tissue injury as well.}, year = {2012}, eissn = {1588-2705}, pages = {263-284}, orcid-numbers = {Győrffy, Andrea/0000-0001-7110-1464; Tóth, István/0000-0002-0168-4753} }