TY - JOUR AU - Csatordai, Márta AU - Benkő, Ria AU - Matuz, Mária AU - Engi, Zsófia AU - Csupor, Dezső AU - Lengyel, Csaba Attila AU - Doró, Péter TI - Trends and regional differences in antidiabetic medication use: a nationwide retrospective observational study JF - DIABETOLOGY AND METABOLIC SYNDROME J2 - DIABETOL METAB SYNDR VL - 16 PY - 2024 IS - 1 PG - 10 SN - 1758-5996 DO - 10.1186/s13098-024-01334-8 UR - https://m2.mtmt.hu/api/publication/34824725 ID - 34824725 N1 - Faculty of Pharmacy, Institute of Clinical Pharmacy, University of Szeged, Szikra utca 8, Szeged, 6725, Hungary Albert Szent-Györgyi Health Centre, Central Pharmacy, University of Szeged, Szeged, Hungary Albert Szent-Györgyi Health Centre, Department of Internal Medicine, University of Szeged, Szeged, Hungary Export Date: 3 May 2024 Correspondence Address: Doró, P.; Faculty of Pharmacy, Szikra utca 8, Hungary; email: doro.peter@szte.hu LA - English DB - MTMT ER - TY - JOUR AU - Bahar, Muhammad Akbar AU - Kusuma, Ikhwan Yuda AU - Visnyovszki, Ádám AU - Matuz, Mária AU - Benkő, Ria AU - Ferenci, Tamás AU - Szabó, Bálint Gergely AU - Hajdú, Edit AU - Pető, Zoltán AU - Csupor, Dezső TI - Favipiravir does not improve viral clearance in mild to moderate COVID-19 – a systematic review and meta-analysis of randomized controlled trials JF - HELIYON J2 - HELIYON VL - 10 PY - 2024 IS - 9 PG - 15 SN - 2405-8440 DO - 10.1016/j.heliyon.2024.e29808 UR - https://m2.mtmt.hu/api/publication/34796471 ID - 34796471 LA - English DB - MTMT ER - TY - JOUR AU - Dewi, Ni Made Amelia Ratnata AU - Benkő, Ria AU - Engi, Zsófia AU - Csupor, Dezső AU - Viola, Réka AU - Csatordai, Márta AU - Matuz, Mária TI - Pain management: opioid use in hospitals JF - EUROPEAN JOURNAL OF HOSPITAL PHARMACY-SCIENCE AND PRACTICE J2 - EUR J HOSP PHARM SCI PRACT VL - 31 PY - 2024 IS - S1 SP - A242 EP - A243 PG - 1 SN - 2047-9956 DO - 10.1136/ejhpharm-2024-eahp.501 UR - https://m2.mtmt.hu/api/publication/34791311 ID - 34791311 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Barbara AU - Horváth, Attila AU - Jójártné Laczkovich, Orsolya AU - Biró, Dalma AU - Matuz, Mária AU - Csupor, Dezső TI - Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials JF - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH J2 - PLANTA MED PY - 2024 SN - 0032-0943 DO - 10.1055/a-2283-8147 UR - https://m2.mtmt.hu/api/publication/34728728 ID - 34728728 N1 - Funding Agency and Grant Number: Ministry of Innovation and Technology of Hungary [TKP2021-EGA, TKP2021-EGA-32]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund Funding text: This work was supported by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme; project No. TKP2021-EGA-32 has been implemented with the support provided. AB - Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy. LA - English DB - MTMT ER - TY - JOUR AU - Gajdács, Márió AU - Matuz, Mária AU - Benkő, Ria AU - Pető, Zoltán AU - Hajdú, Edit TI - Correlation between Stenotrophomonas maltophilia incidence and systemic antibiotic use: A 10-year retrospective, observational study in Hungary JF - EUROPEAN JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY J2 - EUR J MICROBIOL IMMU PY - 2024 SN - 2062-509X DO - 10.1556/1886.2024.00022 UR - https://m2.mtmt.hu/api/publication/34721808 ID - 34721808 N1 - Export Date: 12 April 2024 Correspondence Address: Gajdács, M.; Department of Oral Biology and Experimental Dental Research, Tisza Lajos krt. 64-66, Hungary; email: mariopharma92@gmail.com Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: The authors are thankful for the support of the Study Group for Dental Research Methodology and Health Sciences, University of Szeged. Part of the study was presented at the 31st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Project no. TKP2021-EGA-32 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. AB - Extensive use of carbapenems may lead to selection pressure for Stenotrophomonas maltophilia (SM) in hospital environments. The aim of our study was to assess the possible association between systemic antibiotic use and the incidence of SM. A retrospective, observational study was carried out in a tertiary-care hospital in Hungary, between January 1st 2010 and December 31st 2019. Incidence-density for SM and SM resistant to trimethoprim-sulfamethoxazole (SXT) was standardized for 1000 patient-days, while systemic antibiotic use was expressed as defined daily doses (DDDs) per 100 patient-days. Mean incidence density for SM infections was 0.42/1000 patient-days; 11.08% were were resistant to SXT, the mean incidence density for SXT-resistant SM was 0.047/1000 patient-days. Consumption rate for colistin, glycopeptides and carbapenems increased by 258.82, 278.94 and 372.72% from 2010 to 2019, respectively. Strong and significant positive correlations were observed with the consumption of carbapenems (r: 0.8759; P < 0.001 and r: 0.8968; P < 0.001), SXT (r: 0.7552; P = 0.011 and r: 0.7004; P = 0.024), and glycopeptides (r: 0.7542; P = 0.012 and r: 0.8138; P < 0.001) with SM and SXT-resistant SM incidence-density/1000 patient-days, respectively. Implementation of institutional carbapenem-sparing strategies are critical in preserving these life-saving drugs, and may affect the microbial spectrum of infections in clinical settings. LA - English DB - MTMT ER - TY - JOUR AU - Kusuma, Ikhwan Yuda AU - Bahar, Muhammad Akbar AU - Nuari, Doni Anshar AU - Prabandari, Rani AU - Soeharto, Soeharto AU - Csupor, Dezső AU - Benkő, Ria AU - Matuz, Mária TI - Antibiotic knowledge assessment questionnaire in undergraduate pharmacy students: A Rasch analysis of validity evidence JF - PHARMACY EDUCATION J2 - PHARM EDUC VL - 24 PY - 2024 IS - 1 SP - 54 EP - 78 PG - 25 SN - 1560-2214 DO - 10.46542/pe.2024.241.5478 UR - https://m2.mtmt.hu/api/publication/34577678 ID - 34577678 N1 - Export Date: 28 February 2024; CODEN: PLACB AB - Background: Antibiotic knowledge is crucial for undergraduate pharmacy students who are future healthcare professionals. However, a valid and reliable instrument to assess their knowledge is scarce. This study aimed to develop and validate an Antibiotic Knowledge Assessment Questionnaire (AKAQ).Methods: The AKAQ had three domains and 29 items, encompassing general antibiotic knowledge, antibiotic resistance, and antibiotic stewardship. Rasch analysis was used to assess psychometric properties, including validity parameters (item and person fit and structural validity), reliability (person and item reliability, Cronbach’s Alpha value), item-person interaction, and item bias, using differential item functioning (DIF) based on tems.Results: This study included 500 undergraduate pharmacy students from 90 Indonesian universities. The validity of the questionnaire was demonstrated, except for one item. Person means infit and outfit for MNSQ were 1.02 and 0.95, whereas ZSTD were 0.11 and 0.08, respectively. Items means infit and outfit for MNSQ were 1.01 and 0.96, while ZSTD were 0.11 and -0.23. Item and person reliabilities were acceptable at 0.99 and 0.68. Cronbach’s alpha reliability was acceptable at 0.71. Two items were biased by term.Conclusion: The AKAQ is a valid, reliable, and standard instrument for assessing the antibiotic knowledge levels of undergraduate pharmacy students. LA - English DB - MTMT ER - TY - JOUR AU - Ruzsa, Roxána AU - Benkő, Ria AU - Hambalek, Helga AU - Papfalvi, Erika Piroska AU - Csupor, Dezső AU - Nacsa, Róbert AU - Csatordai, Márta AU - Soós, Gyöngyvér AU - Hajdú, Edit AU - Matuz, Mária TI - Hospital Antibiotic Consumption before and during the COVID-19 Pandemic in Hungary JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 13 PY - 2024 IS - 1 PG - 11 SN - 2079-6382 DO - 10.3390/antibiotics13010102 UR - https://m2.mtmt.hu/api/publication/34532941 ID - 34532941 N1 - Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szeged, 6725, Hungary University Pharmacy Albert Szent-Györgyi Health Center, University of Szeged, Szeged, 6725, Hungary Department of Emergency Medicine, Albert Szent-Györgyi Health Center, University of Szeged, Szeged, 6725, Hungary Institute of Translational Medicine, Medical School, University of Pécs, Pécs, 7624, Hungary Department of Internal Medicine Infectiology Unit, Albert Szent-Györgyi Health Centre, University of Szeged, Szeged, 6725, Hungary Export Date: 6 February 2024 Correspondence Address: Ruzsa, R.; Institute of Clinical Pharmacy, Hungary; email: roxana.ruzsa@med.u-szeged.hu Correspondence Address: Matuz, M.; Institute of Clinical Pharmacy, Hungary; email: matuz.maria@szte.hu AB - The aim of this study was to assess antibiotic use in the Hungarian hospital care sector during and before the pandemic. Aggregated systemic antibiotic (ATC: J01) utilisation data were obtained for the 2010–2021 period. Classifications and calculations were performed according to the WHO ATC/DDD index and expressed as DDD per 1000 inhabitants and per day (DID), DDD per 100 patient-days (DHPD) and DDD/discharge. A linear regression (trend analysis) was performed for the pre-COVID years (2010–2019) and a prediction interval was set up to assess whether the pandemic years’ observed utilisation fit in. Antibiotic utilisation was constant in DID before and during the pandemic (2019: 1.16; 2020: 1.21), while we observed a substantial increase in antibiotic use when expressed in DDD per 100 patient-days (2019: 23.3, 2020: 32.2) or DDD/discharge (2019: 1.83, 2020: 2.45). The observed utilisation level of penicillin combinations; first-, third- and fourth-generation cephalosporins; carbapenems; glycopeptides; nitroimidazoles and macrolides exceeded the predicted utilisation values in both pandemic years. Before the pandemic, co-amoxiclav headed the top list of antibiotic use, while during the pandemic, ceftriaxone became the most widely used antibiotic. Azithromycin moved up substantially on the top list of antibiotic use, with a 397% increase (2019: 0.45; 2020: 2.24 DHPD) in use. In summary, the pandemic had a major impact on the scale and pattern of hospital antibiotic use in Hungary. LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Benkő, Ria AU - Matuz, Mária AU - Bodó, Gabriella AU - Pető, Zoltán AU - Hajdú, Edit TI - Stenotrophomonas maltophilia epidemiológiája és az antibiotikum-fogyasztás közötti összefüggések: 10-éves korrelációs vizsgálat T2 - XV. Fiatal Higiénikusok Fóruma: Program és összefoglalók PB - Magyar Higiénikusok Társasága PY - 2023 SP - 12 EP - 12 PG - 1 UR - https://m2.mtmt.hu/api/publication/34500723 ID - 34500723 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Fésüs, Adina AU - Matuz, Mária AU - Papfalvi, Erika Piroska AU - Hambalek, Helga AU - Ruzsa, Roxána AU - Tánczos, Bence AU - Bácskay, Ildikó AU - Lekli, István AU - Illés, Árpád AU - Benkő, Ria TI - Evaluation of the Diagnosis and Antibiotic Prescription Pattern in Patients Hospitalized with Urinary Tract Infections: Single-Center Study from a University-Affiliated Hospital JF - ANTIBIOTICS J2 - ANTIBIOTICS-BASEL VL - 12 PY - 2023 IS - 12 PG - 19 SN - 2079-6382 DO - 10.3390/antibiotics12121689 UR - https://m2.mtmt.hu/api/publication/34413320 ID - 34413320 N1 - Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, H-4032, Hungary Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Debrecen, H-4032, Hungary Institute of Healthcare Industry, University of Debrecen, Debrecen, H-4032, Hungary Clinical Pharmacy Department, Faculty of Pharmacy, University of Szeged, Szeged, H-6725, Hungary Central Pharmacy, Albert Szent Györgyi Medical Center, University of Szeged, Szeged, H-6725, Hungary Department of Emergency Medicine, Albert Szent Györgyi Medical Center, University of Szeged, Szeged, H-6725, Hungary Department of Internal Medicine, Faculty of Medicine, University of Debrecen, Debrecen, H-4032, Hungary Cited By :1 Export Date: 3 May 2024 Correspondence Address: Benkő, R.; Clinical Pharmacy Department, Hungary; email: benko.ria@med.u-szeged.hu Chemicals/CAS: amikacin, 37517-28-5, 39831-55-5, 110660-83-8, 1257517-67-1; amoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; amoxicillin plus clavulanic acid, 74469-00-4, 79198-29-1; cefotaxime, 63527-52-6, 64485-93-4; ceftazidime, 72558-82-8, 73547-61-2, 78439-06-2; ceftriaxone, 73384-59-5, 74578-69-1, 104376-79-6; cefuroxime, 55268-75-2, 56238-63-2; cilastatin, 81129-83-1, 82009-34-5; cilastatin plus imipenem, 92309-29-0; ciprofloxacin, 85721-33-1, 86393-32-0, 128074-72-6, 128074-76-0, 192934-52-4, 93107-08-5, 86483-48-9, 96186-80-0; clarithromycin, 81103-11-9; clavulanic acid, 58001-44-8; cotrimoxazole, 8064-90-2; fosfomycin, 23155-02-4; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; imipenem, 64221-86-9; levofloxacin, 100986-85-4, 138199-71-0; meropenem, 96036-03-2; metronidazole, 39322-38-8, 443-48-1, 69198-10-3; moxifloxacin, 151096-09-2, 186826-86-8; nitrofurantoin, 54-87-5, 67-20-9; norfloxacin, 70458-96-7; ofloxacin, 82419-36-1; piperacillin plus tazobactam, 157044-21-8; trometamol, 1185-53-1, 77-86-1 Funding details: NKFI-143360, TKP2021-EGA-32 Funding details: TKP2021-EGA-18 Funding details: European Commission, EC Funding details: European Regional Development Fund, ERDF, GINOP-2.3.4-15-2020-00008 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: This work has been implemented with support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed by ITM NKFIA TKP2021-EGA-32, and NKFI-143360. The project is co-financed by the European Union and the European Regional Development Fund by GINOP-2.3.4-15-2020-00008. The research was also supported by the Thematic Excellence Program (TKP2021-EGA-18) of the Ministry for Innovation and Technology in Hungary. AB - UTIs (urinary tract infections) are common bacterial infections with a non-negligible hospitalization rate. The diagnosis of UTIs remains a challenge for prescribers and a common source of misdiagnosis. This retrospective observational study aimed to evaluate whether recorded diagnosis by clinicians and empirical antibiotic therapy met the EAU (European Association of Urology) guideline in patients hospitalized with UTI. The study was conducted at an internal medicine unit of a tertiary care medical center in Hungary. The diagnosis was assessed based on clinical presentation, physical examination, and laboratory (including microbiological) results, considering all the potential risk factors. Diagnosis was considered misdiagnosis when not confirmed by clinical presentation or clinical signs and symptoms. Evaluation of empirical antibiotic therapy was performed only for confirmed UTIs. Empirical treatment was considered guideline-adherent when complying with the relevant recommendations. Out of 185 patients, 41.6% failed to meet EAU-based UTI diagnosis criteria, of which 27.6% were misdiagnosed and 14.1% were ABU (asymptomatic bacteriuria). The diagnosis of urosepsis recorded at admission (9.7%, 18/185) was not confirmed either by clinical or microbiological tests in five (5/18) cases. The initial empirical therapies for UTI showed a relatively low rate (45.4%) of guideline adherence regarding agent selection. The most common guideline-non-adherent therapies were combinations with metronidazole (16.7%). Dosage appropriateness assessments showed a guideline adherence rate of 36.1%, and underdosing due to high body weight was common (9.3%). Overall (agent, route of administration, dose, duration) guideline adherence was found to be substantially low (10.2%). We found a relatively high rate of misdiagnosed UTIs. Written protocols on the ward may be crucial in reducing misdiagnosis and in optimizing antibiotic use. LA - English DB - MTMT ER - TY - JOUR AU - Szemán, Ágnes AU - Matuz, Mária AU - Benkő, Ria TI - Gyógyszeres szülésindukció, gyógyszeres tocolysis: helyi gyakorlat vs. Nemzetközi protokollok [Labor induction and tocolysis: local practice versus international guidelines] JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 93 PY - 2023 IS - S1 SP - S72 EP - S72 PG - 1 SN - 0001-6659 UR - https://m2.mtmt.hu/api/publication/34398418 ID - 34398418 LA - Hungarian DB - MTMT ER -