TY - JOUR AU - Márton, Gergely AU - Tóth, Estilla Zsófia AU - Wittner, Lucia AU - Fiáth, Richárd AU - Pinke, Domonkos Péter AU - Orbán, Gábor AU - Meszéna, Domokos AU - Pál, Ildikó AU - Győri, Edit Lelle AU - Bereczki, Zsófia AU - Kandrács, Ágnes AU - Hofer, Katharina AU - Pongrácz, Anita AU - Ulbert, István AU - Tóth, Kinga TI - The neural tissue around SU-8 implants: A quantitative in vivo biocompatibility study JF - MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS J2 - MAT SCI ENG C-MATER VL - 112 PY - 2020 PG - 15 SN - 0928-4931 DO - 10.1016/j.msec.2020.110870 UR - https://m2.mtmt.hu/api/publication/31256609 ID - 31256609 LA - English DB - MTMT ER - TY - JOUR AU - Meszéna, Domokos AU - Kerekes, Bálint Péter AU - Pál, Ildikó AU - Orbán, Gábor AU - Fiáth, Richárd AU - Holzhammer, Tobias AU - Ruther, Patrick AU - Ulbert, István AU - Márton, Gergely TI - A silicon-based spiky probe providing improved cell accessibility during in vitro slice recordings JF - SENSORS AND ACTUATORS B-CHEMICAL J2 - SENSOR ACTUAT B CHEM VL - 297 PY - 2019 PG - 10 SN - 0925-4005 DO - 10.1016/j.snb.2019.126649 UR - https://m2.mtmt.hu/api/publication/30733372 ID - 30733372 N1 - Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, H-1117, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, H-1083, Hungary Óbuda University Doctoral School on Materials Sciences and Technologies, Budapest, H-1034, Hungary Microsystem Materials Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Freiburg, D-79110, Germany BrainLinks-BrainTools Cluster of Excellence at the University of Freiburg, Freiburg, D-79110, Germany Cited By :2 Export Date: 22 March 2024 CODEN: SABCE Correspondence Address: Ulbert, I.; Institute of Cognitive Neuroscience and Psychology, Magyar tudósok körútja 2., Hungary; email: ulbert.istvan@ttk.mta.hu LA - English DB - MTMT ER - TY - JOUR AU - Bérces, Zsófia AU - Tóth, Kinga AU - Márton, Gergely AU - Pál, Ildikó AU - Kováts-Megyesi, B AU - Fekete, Zoltán AU - Ulbert, István AU - Pongrácz, Anita TI - Neurobiochemical changes in the vicinity of a nanostructured neural implant JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 6 PY - 2016 PG - 11 SN - 2045-2322 DO - 10.1038/srep35944 UR - https://m2.mtmt.hu/api/publication/3130167 ID - 3130167 LA - English DB - MTMT ER - TY - THES AU - Pál, Ildikó TI - Idegi aktivitás térbeli követésére alkalmazott optikai jelek molekuláris komponenseinek azonosítása PB - Eötvös Loránd Tudományegyetem (ELTE) PY - 2015 SP - 110 DO - 10.15476/ELTE.2015.023 UR - https://m2.mtmt.hu/api/publication/2984591 ID - 2984591 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Pál, Ildikó AU - Kardos, Julianna AU - Dobolyi, Árpád AU - Héja, László TI - Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity JF - MOLECULAR BRAIN J2 - MOL BRAIN VL - 8 PY - 2015 IS - 1 PG - 20 SN - 1756-6606 DO - 10.1186/s13041-015-0127-9 UR - https://m2.mtmt.hu/api/publication/2972587 ID - 2972587 N1 - Research Centre for Natural Sciences, Institute of Cognitive Neuroscience and Psychology, Hungarian Academy of Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary MTA-ELTE-NAP B Laboratory of Molecular and Systems Neurobiology, Budapest, H-1117, Hungary Department of Anatomy, Human Brain Tissue Bank, Semmelweis University, Budapest, H-1450, Hungary Cited By :8 Export Date: 23 April 2024 Correspondence Address: Pál, I.; Research Centre for Natural Sciences, Magyar tudósok körútja 2, Hungary AB - BACKGROUND: Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks. In spite of that, identification of their major cellular and molecular components has not been concluded so far. RESULTS: We addressed these issues by imaging spatiotemporal spreading of IOS and VSD transients initiated by Schaffer collateral stimulation in rat hippocampal slices with temporal resolution comparable to standard field potential recordings using a 464-element photodiode array. By exploring the potential neuronal and astroglial molecular players in VSD and IOS generation, we identified multiple astrocytic mechanisms that significantly contribute to the VSD signal, in addition to the expected neuronal targets. Glutamate clearance through the astroglial glutamate transporter EAAT2 has been shown to be a significant player in VSD generation within a very short (<5 ms) time-scale, indicating that astrocytes do contribute to the development of spatiotemporal VSD transients previously thought to be essentially neuronal. In addition, non-specific anion channels, astroglial K(+) clearance through Kir4.1 channel and astroglial Na(+)/K(+) ATPase also contribute to IOS and VSD transients. CONCLUSION: VSD imaging cannot be considered as a spatially extended field potential measurement with predominantly neuronal origin, instead it also reflects a fast communication between neurons and astrocytes. LA - English DB - MTMT ER - TY - JOUR AU - Hofer, Katharina AU - Kandrács, Ágnes AU - Ulbert, István AU - Pál, Ildikó AU - Szabó, Csilla AU - Héja, László AU - Wittner, Lucia TI - The hippocampal CA3 region can generate two distinct types of sharp wave-ripple complexes, in vitro. JF - HIPPOCAMPUS J2 - HIPPOCAMPUS VL - 25 PY - 2015 IS - 2 SP - 169 EP - 186 PG - 18 SN - 1050-9631 DO - 10.1002/hipo.22361 UR - https://m2.mtmt.hu/api/publication/2743439 ID - 2743439 N1 - Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 14 August 2019 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 17 August 2019 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 18 August 2019 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 12 March 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 24 April 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 15 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 18 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 25 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :8 Export Date: 28 May 2020 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Department of Comparative Psychophysiology, Institute of Cognitive Neuroscience and Psychology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary Department of Information Technology and Bionics, Péter Pázmány Catholic University, Budapest, Hungary Department of Functional Neurosurgery, National Institute of Clinical Neurosciences, Budapest, Hungary Cited By :12 Export Date: 7 September 2021 CODEN: HIPPE Correspondence Address: Wittner, L.; Institute of Cognitive Neuroscience and Psychology, Magyar Tudósok körútja 2, Hungary Chemicals/CAS: 4 aminobutyric acid, 28805-76-7, 56-12-2; glutamic acid, 11070-68-1, 138-15-8, 56-86-0, 6899-05-4; gamma-Aminobutyric Acid; Glutamic Acid Funding details: Hungarian Scientific Research Fund, OTKA, 81357 AB - Hippocampal sharp wave-ripples (SPW-Rs) occur during slow wave sleep and behavioral immobility and are thought to play an important role in memory formation. We investigated the cellular and network properties of SPW-Rs with simultaneous laminar multielectrode and intracellular recordings in a rat hippocampal slice model, using physiological bathing medium. Spontaneous SPW-Rs were generated in the dentate gyrus (DG), CA3 and CA1 regions. These events were characterized by a local field potential gradient (LFPg) transient, increased fast oscillatory activity and increased multiple unit activity (MUA). Two types of SPW-Rs were distinguished in the CA3 region based on their different LFPg and current source density (CSD) pattern. Type 1 (T1) displayed negative LFPg transient in the pyramidal cell layer, and the associated CSD sink was confined to the proximal dendrites. Type 2 (T2) SPW-Rs were characterized by positive LFPg transient in the cell layer, and showed CSD sinks involving both the apical and basal dendrites. In both types, consistent with the somatic CSD source, only a small subset of CA3 pyramidal cells fired, most pyramidal cells were hyperpolarized, while most interneurons increased firing rate before the LFPg peak. Different neuronal populations, with different proportions of pyramidal cells and distinct subsets of interneurons were activated during T1 and T2 SPW-Rs. Activation of specific inhibitory cell subsets - with the possible leading role of perisomatic interneurons - seems to be crucial to synchronize distinct ensembles of CA3 pyramidal cells finally resulting in the expression of different SPW-R activities. This suggests that the hippocampus can generate dynamic changes in its activity stemming from the same excitatory and inhibitory circuits, and so, might provide the cellular and network basis for an input-specific and activity-dependent information transmission. (c) 2014 Wiley Periodicals, Inc. LA - English DB - MTMT ER - TY - JOUR AU - Nyitrai, Gabriella AU - Keszthelyi, Tamás AU - Bóta, Attila AU - Simon, Ágnes AU - Tőke, Orsolya AU - Horváth, Gergő AU - Pál, Ildikó AU - Kardos, Julianna AU - Héja, László TI - Sodium selective ion channel formation in living cell membranes by polyamidoamine dendrimer JF - BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES J2 - BBA-BIOMEMBRANES VL - 1828 PY - 2013 IS - 8 SP - 1873 EP - 1880 PG - 8 SN - 0005-2736 DO - 10.1016/j.bbamem.2013.04.004 UR - https://m2.mtmt.hu/api/publication/2305528 ID - 2305528 N1 - Megjegyzés-23246857 N1 : Chemicals/CAScalcium ion, 14127-61-8; dipalmitoylphosphatidylcholine, 2644-64-6; silicon dioxide, 10279-57-9, 14464-46-1, 14808-60-7, 15468-32-3, 60676-86-0, 7631-86-9; sodium ion, 17341-25-2 LA - English DB - MTMT ER - TY - JOUR AU - Nyitrai, Gabriella AU - Héja, László AU - Jablonkai, István AU - Pál, Ildikó AU - Benéné Visy, Júlia AU - Kardos, Julianna TI - Polyamidoamine dendrimer impairs mitochondrial oxidation in brain tissue JF - JOURNAL OF NANOBIOTECHNOLOGY J2 - J NANOBIOTECHNOL VL - 11 PY - 2013 PG - 9 SN - 1477-3155 DO - 10.1186/1477-3155-11-9 UR - https://m2.mtmt.hu/api/publication/2305501 ID - 2305501 AB - Background: The potential nanocarrier polyamidoamine (PAMAM) generation 5 (G5-NH2) dendrimer has been shown to evoke lasting neuronal depolarization and cell death in a concentration-dependent manner. In this study we explored the early progression of G5-NH2 action in brain tissue on neuronal and astroglial cells.Results: In order to describe early mechanisms of G5-NH2 dendrimer action in brain tissue we assessed G5-NH2 trafficking, free intracellular Ca2+ and mitochondrial membrane potential (ΨMITO) changes in the rat hippocampal slice by microfluorimetry. With the help of fluorescent dye conjugated G5-NH2, we observed predominant appearance of the dendrimer in the plasma membrane of pyramidal neurons and glial cells within 30 min. Under this condition, G5-NH2 evoked robust intracellular Ca2+ enhancements and ΨMITO depolarization both in pyramidal neurons and astroglial cells. Intracellular Ca2+ enhancements clearly preceded ΨMITO depolarization in astroglial cells. Comparing activation dynamics, neurons and glia showed prevalence of lasting and transient ΨMITO depolarization, respectively. Transient as opposed to lasting ΨMITO changes to short-term G5-NH2 application suggested better survival of astroglia, as observed in the CA3 stratum radiatum area. We also showed that direct effect of G5-NH2 on astroglial ΨMITO was significantly enhanced by neuron-astroglia interaction, subsequent to G5-NH2 evoked neuronal activation.Conclusion: These findings indicate that the interaction of the PAMAM dendrimer with the plasma membrane leads to robust activation of neurons and astroglial cells, leading to mitochondrial depolarization. Distinguishable dynamics of mitochondrial depolarization in neurons and astroglia suggest that the enhanced mitochondrial depolarization followed by impaired oxidative metabolism of neurons may be the primary basis of neurotoxicity. © 2013 Nyitrai et al.; licensee BioMed Central Ltd. LA - English DB - MTMT ER - TY - JOUR AU - Pál, Ildikó AU - Nyitrai, Gabriella AU - Kardos, Julianna AU - Héja, László TI - Neuronal and Astroglial Correlates Underlying Spatiotemporal Intrinsic Optical Signal in the Rat Hippocampal Slice JF - PLOS ONE J2 - PLOS ONE VL - 8 PY - 2013 IS - 3 SN - 1932-6203 DO - 10.1371/journal.pone.0057694 UR - https://m2.mtmt.hu/api/publication/2222611 ID - 2222611 N1 - Published: March 01, 2013 Funding Agency and Grant Number: [ERA-Chemistry OTKA 102166]; [TECH-09-AI-2009-0117 NKFP NANOSEN9] Funding text: This work was supported by grants ERA-Chemistry OTKA 102166 (http://www.otka.hu/) and TECH-09-AI-2009-0117 NKFP NANOSEN9 (http://www.nih.gov.hu/). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Cited By :22 Export Date: 6 April 2021 Correspondence Address: Pál, I.; Department of Functional Pharmacology, , Budapest, Hungary; email: pal.ildiko@ttk.mta.hu LA - English DB - MTMT ER - TY - JOUR AU - Nyitrai, Gabriella AU - Kékesi, Orsolya Sára AU - Pál, Ildikó AU - Keglevich, Péter AU - Csíki, Zsuzsanna AU - Fügedi, Péter AU - Simon, Ágnes AU - Fitos, Ilona AU - Németh, Krisztina AU - Benéné Visy, Júlia AU - Tárkányi, Gábor AU - Kardos, Julianna TI - Assessing toxicity of polyamidoamine dendrimers by neuronal signaling functions JF - NANOTOXICOLOGY J2 - NANOTOXICOLOGY VL - 6 PY - 2012 IS - 6 SP - 576 EP - 586 PG - 11 SN - 1743-5390 DO - 10.3109/17435390.2011.591511 UR - https://m2.mtmt.hu/api/publication/2060849 ID - 2060849 N1 - Early Online: pp. 1-13. (2011) Funding Agency and Grant Number: Nanotransport [CRC-HAS_2009]; NANOSEN9 [TECH-09-A1-2009-0117]; [GVOP-3.2.1.-2004-04-0210/3.0] Funding text: We thank Nanotransport (CRC-HAS_2009), NANOSEN9 (TECH-09-A1-2009-0117) and GVOP-3.2.1.-2004-04-0210/3.0 projects for financial support. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper. LA - English DB - MTMT ER -