TY  - JOUR
AU  - Torma, Ferenc Gergely
AU  - Kerepesi, Csaba
AU  - Jókai, Mátyás
AU  - Bábszky, Gergely
AU  - Koltai, Erika
AU  - Ligeti, Balázs
AU  - Kalcsevszki, Regina
AU  - McGreevy, Kristen M.
AU  - Horvath, Steve
AU  - Radák, Zsolt
TI  - Alterations of the gut microbiome are associated with epigenetic age acceleration and physical fitness
JF  - AGING CELL
J2  - AGING CELL
PY  - 2024
SN  - 1474-9718
DO  - 10.1111/acel.14101
UR  - https://m2.mtmt.hu/api/publication/34693196
ID  - 34693196
N1  - Funding Agency and Grant Number: European Union; National Research, Development and Innovation Office, Hungary; National Excellence Program [126823]; National Science and Research Found [OTKA142192, TKP2021-EGA-37]; Hungarian University Sport Science, Innovation and Technology Ministry, Hungary [2021-28]; National Academy of Science, Hungary;  [RRF-2.3.1-21-2022-00004];  [OTKA146113]
            Funding text: CK was supported by the European Union project RRF-2.3.1-21-2022-00004 within the framework of the Artificial Intelligence National Laboratory, and the National Excellence Program (OTKA146113) of the National Research, Development and Innovation Office, Hungary. ZR acknowledges support from the National Excellence Program (126823) National Science and Research Found (OTKA142192) and Scientific Excellence Program TKP2021-EGA-37 at the Hungarian University Sport Science, Innovation and Technology Ministry, Hungary, as well as Post-Covid 2021-28 grant by National Academy of Science, Hungary. We thank to Szilvia Farkas (Semmelweis University, Hungary) for the valuable discussions.
AB  - Epigenetic clocks can measure aging and predict the incidence of diseases and mortality. Higher levels of physical fitness are associated with a slower aging process and a healthier lifespan. Microbiome alterations occur in various diseases and during the aging process, yet their relation to epigenetic clocks is not explored. To fill this gap, we collected metagenomic (from stool), epigenetic (from blood), and exercise‐related data from physically active individuals and, by applying epigenetic clocks, we examined the relationship between gut flora, blood‐based epigenetic age acceleration, and physical fitness. We revealed that an increased entropy in the gut microbiome of physically active middle‐aged/old individuals is associated with accelerated epigenetic aging, decreased fitness, or impaired health status. We also observed that a slower epigenetic aging and higher fitness level can be linked to altered abundance of some bacterial species often linked to anti‐inflammatory effects. Overall our data suggest that alterations in the microbiome can be associated with epigenetic age acceleration and physical fitness.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Mozaffaritabar, Soroosh
AU  - Koltai, Erika
AU  - Zhou, Lei
AU  - Bori, Zoltán
AU  - Kolonics, Attila
AU  - Kujach, Sylwester
AU  - Gu, Yaodong
AU  - Koike, Atsuko
AU  - Boros, Anita
AU  - Radák, Zsolt
TI  - PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle
JF  - JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
J2  - J PHYSIOL BIOCHEM
VL  - 2024
PY  - 2024
SN  - 1138-7548
DO  - 10.1007/s13105-024-01006-1
UR  - https://m2.mtmt.hu/api/publication/34539479
ID  - 34539479
N1  - Received25 August 2023
Accepted10 January 2024
Published23 January 2024
AB  - The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling.
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Soroosh, Mozafffaritabar
AU  - Koltai, Erika
AU  - Radák, Zsolt
TI  - The role of PGC1-A in inter-muscular lipid metabolism in exercised mice
T2  - VIII. Sporttudományi PhD Szimpózium
PB  - Magyar Testnevelési és Sporttudományi Egyetem
C1  - Budapest
PY  - 2023
SP  - 47
EP  - 48
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/34053803
ID  - 34053803
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jókai, Mátyás
AU  - Torma, Ferenc Gergely
AU  - McGreevy, Kristen M.
AU  - Koltai, Erika
AU  - Bori, Zoltán
AU  - Bábszky, Gergely
AU  - Bakonyi, Péter
AU  - Gombos, Zoltán
AU  - György, Bernadett
AU  - Aczél, Dóra Tímea
AU  - Tóth, László
AU  - Osváth, Péter
AU  - Fridvalszki, Marcell Norbert
AU  - Téglás, Tímea
AU  - Pósa, Anikó
AU  - Kujach, Sylwester
AU  - Olek, Robert
AU  - Kawamura, Takuji
AU  - Seki, Yasuhiro
AU  - Suzuki, Katsuhiko
AU  - Tanisawa, Kumpei
AU  - Goto, Sataro
AU  - Kerepesi, Csaba
AU  - Boldogh, Istvan
AU  - Ba, Xueqing
AU  - Davies, Kelvin J. A.
AU  - Horvath, Steve
AU  - Radák, Zsolt
TI  - DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation
JF  - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)
J2  - GEROSCIENCE
VL  - 45
PY  - 2023
IS  - 5
SP  - 2805
EP  - 2817
PG  - 13
SN  - 2509-2715
DO  - 10.1007/s11357-023-00826-1
UR  - https://m2.mtmt.hu/api/publication/33866054
ID  - 33866054
AB  - DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ  = 0.2, p  = 6.4E − 4, r  = 0.19, p  = 1.2E − 3), Jumpmax ( p  = 0.11, p  = 5.5E − 2, r  = 0.13, p  = 2.8E − 2), Gripmax ( ρ  = 0.17, p  = 3.5E − 3, r  = 0.16, p  = 5.6E − 3), and HDL levels ( ρ  = 0.18, p  = 1.95E − 3, r  = 0.19, p  = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p  = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cikes, Domagoj
AU  - Elsayad, Kareem
AU  - Sezgin, Erdinc
AU  - Koltai, Erika
AU  - Torma, Ferenc Gergely
AU  - Orthofer, Michael
AU  - Yarwood, Rebecca
AU  - Heinz, Leonhard X.
AU  - Sedlyarov, Vitaly
AU  - Miranda, Nasser Darwish
AU  - Taylor, Adrian
AU  - Grapentine, Sophie
AU  - al-Murshedi, Fathiya
AU  - Abot, Anne
AU  - Weidinger, Adelheid
AU  - Kutchukian, Candice
AU  - Sanchez, Colline
AU  - Cronin, Shane J. F.
AU  - Novatchkova, Maria
AU  - Kavirayani, Anoop
AU  - Schuetz, Thomas
AU  - Haubner, Bernhard
AU  - Haas, Lisa
AU  - Hagelkruys, Astrid
AU  - Jackowski, Suzanne
AU  - Kozlov, Andrey V.
AU  - Jacquemond, Vincent
AU  - Knauf, Claude
AU  - Superti-Furga, Giulio
AU  - Rullman, Eric
AU  - Gustafsson, Thomas
AU  - McDermot, John
AU  - Lowe, Martin
AU  - Radák, Zsolt
AU  - Chamberlain, Jeffrey S.
AU  - Bakovic, Marica
AU  - Banka, Siddharth
AU  - Penninger, Josef M.
TI  - Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing
JF  - NATURE METABOLISM
J2  - NAT METAB
VL  - 2023
PY  - 2023
IS  - 5
SP  - 495
SN  - 2522-5812
DO  - 10.1038/s42255-023-00791-1
UR  - https://m2.mtmt.hu/api/publication/33745909
ID  - 33745909
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cikes, Domagoj
AU  - Elsayad, Kareem
AU  - Sezgin, Erdinc
AU  - Koltai, Erika
AU  - Torma, Ferenc Gergely
AU  - Orthofer, Michael
AU  - Yarwood, Rebecca
AU  - Heinz, Leonhard X.
AU  - Sedlyarov, Vitaly
AU  - Miranda, Nasser Darwish
AU  - Taylor, Adrian
AU  - Grapentine, Sophie
AU  - al-Murshedi, Fathiya
AU  - Abot, Anne
AU  - Weidinger, Adelheid
AU  - Kutchukian, Candice
AU  - Sanchez, Colline
AU  - Cronin, Shane J. F.
AU  - Novatchkova, Maria
AU  - Kavirayani, Anoop
AU  - Schuetz, Thomas
AU  - Haubner, Bernhard
AU  - Haas, Lisa
AU  - Hagelkruys, Astrid
AU  - Jackowski, Suzanne
AU  - Kozlov, Andrey
AU  - Jacquemond, Vincent
AU  - Knauf, Claude
AU  - Superti-Furga, Giulio
AU  - Rullman, Eric
AU  - Gustafsson, Thomas
AU  - McDermot, John
AU  - Lowe, Martin
AU  - Radák, Zsolt
AU  - Chamberlain, Jeffrey S.
AU  - Bakovic, Marica
AU  - Banka, Siddharth
AU  - Penninger, Josef M.
TI  - PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing
JF  - NATURE METABOLISM
J2  - NAT METAB
VL  - 5
PY  - 2023
IS  - 3
SP  - 495
EP  - 515
PG  - 20
SN  - 2522-5812
DO  - 10.1038/s42255-023-00766-2
UR  - https://m2.mtmt.hu/api/publication/33712726
ID  - 33712726
N1  - Received 08 February 2021, Accepted 10 February 2023, Published 20 March 2023
AB  - Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases and ageing. Elucidation of pathophysiological mechanisms, as well as effective treatments for muscle diseases, represents an important goal in improving human health. Here, we show that the lipid synthesis enzyme phosphatidylethanolamine cytidyltransferase (PCYT2/ECT) is critical to muscle health. Human deficiency in PCYT2 causes a severe disease with failure to thrive and progressive weakness. pcyt2-mutant zebrafish and muscle-specific Pcyt2-knockout mice recapitulate the participant phenotypes, with failure to thrive, progressive muscle weakness and accelerated ageing. Mechanistically, muscle Pcyt2 deficiency affects cellular bioenergetics and membrane lipid bilayer structure and stability. PCYT2 activity declines in ageing muscles of mice and humans, and adeno-associated virus-based delivery of PCYT2 ameliorates muscle weakness in Pcyt2-knockout and old mice, offering a therapy for individuals with a rare disease and muscle ageing. Thus, PCYT2 plays a fundamental and conserved role in vertebrate muscle health, linking PCYT2 and PCYT2-synthesized lipids to severe muscle dystrophy and ageing.
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - György, Bernadett
AU  - Pálóczi, Krisztina
AU  - Buzás, Edit
AU  - Koltai, Erika
AU  - Radák, Zsolt
TI  - A több évtizedes testedzés hatása a humán vérből izolált extracelluláris vezikulák tartalmára
T2  - VII. SPORTTUDOMÁNYI PHD SZIMPÓZIUM - PROGRAM- ÉS ABSZTRAKTFÜZET
PY  - 2022
SP  - 24
EP  - 24
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/33022430
ID  - 33022430
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Ireland, Alex
AU  - Mittag, Uwe
AU  - Degens, Hans
AU  - Felsenberg, Dieter
AU  - Heinonen, Ari
AU  - Koltai, Erika
AU  - Korhonen, Marko T.
AU  - McPhee, Jamie S.
AU  - Mekjavic, Igor
AU  - Pisot, Rado
AU  - Rawer, Rainer
AU  - Radák, Zsolt
AU  - Simunic, Bostjan
AU  - Suominen, Harri
AU  - Rittweger, Jörn
TI  - Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes: A Longitudinal Study of Master Athletes
JF  - CALCIFIED TISSUE INTERNATIONAL
J2  - CALCIFIED TISSUE INT
VL  - 110
PY  - 2022
IS  - 2
SP  - 196
EP  - 203
PG  - 8
SN  - 0171-967X
DO  - 10.1007/s00223-021-00907-3
UR  - https://m2.mtmt.hu/api/publication/32259162
ID  - 32259162
N1  - Received12 April 2021; Accepted18 August 2021; Published09 September 2021
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Adorjánné Olajos, Andrea
AU  - Koltai, Erika
TI  - Koordinációs képességek mérésének lehetséges módszere magyar elit sportolói mintán
T2  - IV. Sport és Innováció Nemzetközi Konferencia, SPORTINNO 2021: Programfüzet absztraktokkal
PB  - Testnevelési Egyetem
C1  - Budapest
PY  - 2021
SP  - 99
EP  - 100
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/32234984
ID  - 32234984
LA  - Hungarian
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Gombos, Zoltán
AU  - Koltai, Erika
AU  - Torma, Ferenc Gergely
AU  - Bakonyi, Péter
AU  - Kolonics, Attila
AU  - Aczél, Dóra Tímea
AU  - Ditrói, Tamás
AU  - Nagy, Péter
AU  - Kawamura, Takuji
AU  - Radák, Zsolt
TI  - Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels.
JF  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
J2  - INT J MOL SCI
VL  - 22
PY  - 2021
IS  - 14
PG  - 11
SN  - 1661-6596
DO  - 10.3390/ijms22147588
UR  - https://m2.mtmt.hu/api/publication/32113803
ID  - 32113803
N1  - Funding Agency and Grant Number: National Excellence Program at the University of Physical Education, Innovation and Technology Ministry, Hungary [126823]; Scientific Excellence Program at the University of Physical Education, Innovation and Technology Ministry, Hungary [TUDFO/51757/2019-ITM]; Hungarian Thematic Excellence Program from the Hungarian National Research, Development and Innovation Office [TKP2020-NKA-26]
            Funding text: This study was supported by National Excellence Program (126823), and Scientific Excellence Program TUDFO/51757/2019-ITM, at the University of Physical Education, Innovation and Technology Ministry, Hungary. Grants awarded to Z.R., P.N. acknowledges financial support from the Hungarian Thematic Excellence Program TKP2020-NKA-26 from the Hungarian National Research, Development and Innovation Office.
AB  - Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically removed, to cause a significant overload in the remaining plantaris muscle of 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic molecular signaling pathways, NAD and H2S levels of this overload-induced hypertrophy were studied. Fourteen days of overload resulted in a significant 43% (p < 0.01) increase in the mass of plantaris muscle compared to sham operated animals. Cystathionine-β-synthase (CBS) activities and bioavailable H2S levels were not modified by overload. On the other hand, overload-induced hypertrophy of skeletal muscle was associated with increased SIRT1 (p < 0.01), Akt (p < 0.01), mTOR, S6 (p < 0.01) and suppressed sestrin 2 levels (p < 0.01), which are mostly responsible for anabolic signaling. Decreased FOXO1 and SIRT3 signaling (p < 0.01) suggest downregulation of protein breakdown and mitophagy. Decreased levels of NAD+, sestrin2, OGG1 (p < 0.01) indicate that the redox milieu of skeletal muscle after 14 days of overloading is reduced. The present investigation revealed novel cellular interactions that regulate anabolic and catabolic processes in the hypertrophy of skeletal muscle.
LA  - English
DB  - MTMT
ER  -