@article{MTMT:34539479,
	title = {PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle},
	url = {https://m2.mtmt.hu/api/publication/34539479},
	author = {Mozaffaritabar, Soroosh and Koltai, Erika and Zhou, Lei and Bori, Zoltán and Kolonics, Attila and Kujach, Sylwester and Gu, Yaodong and Koike, Atsuko and Boros, Anita and Radák, Zsolt},
	doi = {10.1007/s13105-024-01006-1},
	journal-iso = {J PHYSIOL BIOCHEM},
	journal = {JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY},
	volume = {2024},
	unique-id = {34539479},
	issn = {1138-7548},
	abstract = {The role of Peroxisome proliferator-activated receptor-gamma coactivator alpha (PGC-1α) in fat metabolism is not well known. In this study, we compared the mechanisms of muscle-specific PGC-1α overexpression and exercise-related adaptation-dependent fat metabolism. PGC-1α trained (PGC-1α Ex) and wild-trained (wt-ex) mice were trained for 10 weeks, five times a week at 30 min per day with 60 percent of their maximal running capacity. The PGC-1α overexpressed animals exhibited higher levels of Fibronectin type III domain-containing protein 5 (FNDC5), 5' adenosine monophosphate-activated protein kinase alpha (AMPK-α), the mammalian target of rapamycin (mTOR), Sirtuin 1 (SIRT1), Lon protease homolog 1 (LONP1), citrate synthase (CS), succinate dehydrogenase complex flavoprotein subunit A (SDHA), Mitofusin-1 (Mfn1), endothelial nitric oxide synthase (eNOS), Hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL), G protein-coupled receptor 41 (GPR41), and Phosphatidylcholine Cytidylyltransferase 2 (PCYT2), and lower levels of Sirtuin 3 (SIRT3) compared to wild-type animals. Exercise training increased the protein content levels of SIRT1, HSL, and ATGL in both the wt-ex and PGC-1α trained groups. PGC-1α has a complex role in cellular signaling, including the upregulation of lipid metabolism-associated proteins. Our data reveals that although exercise training mimics the effects of PGC-1α overexpression, it incorporates some PGC-1α-independent adaptive mechanisms in fat uptake and cell signaling.},
	keywords = {skeletal muscle; lipid metabolism; Exercise; Mitochondrial function; PGC-1α overexpression},
	year = {2024},
	eissn = {1877-8755},
	orcid-numbers = {Mozaffaritabar, Soroosh/0000-0003-1052-7140; Koltai, Erika/0000-0002-1370-2955; Zhou, Lei/0000-0002-8152-7896; Bori, Zoltán/0000-0003-1253-060X; Kolonics, Attila/0000-0003-3990-5336; Kujach, Sylwester/0000-0001-5520-1748; Koike, Atsuko/0009-0002-2668-7114; Boros, Anita/0000-0001-5330-9050; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:34477681,
	title = {Exercise combined with postbiotics treatment results in synergistic improvement of mitochondrial function in the brain of male transgenic mice for Alzheimer’s disease},
	url = {https://m2.mtmt.hu/api/publication/34477681},
	author = {Kolonics, Attila and Bori, Zoltán and Torma, Ferenc Gergely and Ábrahám, Dóra and Fehér, János and Radák, Zsolt},
	doi = {10.1186/s12868-023-00836-x},
	journal-iso = {BMC NEUROSCI},
	journal = {BMC NEUROSCIENCE},
	volume = {24},
	unique-id = {34477681},
	issn = {1471-2202},
	year = {2023},
	eissn = {1471-2202},
	orcid-numbers = {Kolonics, Attila/0000-0003-3990-5336; Bori, Zoltán/0000-0003-1253-060X; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:33866054,
	title = {DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation},
	url = {https://m2.mtmt.hu/api/publication/33866054},
	author = {Jókai, Mátyás and Torma, Ferenc Gergely and McGreevy, Kristen M. and Koltai, Erika and Bori, Zoltán and Bábszky, Gergely and Bakonyi, Péter and Gombos, Zoltán and György, Bernadett and Aczél, Dóra Tímea and Tóth, László and Osváth, Péter and Fridvalszki, Marcell Norbert and Téglás, Tímea and Pósa, Anikó and Kujach, Sylwester and Olek, Robert and Kawamura, Takuji and Seki, Yasuhiro and Suzuki, Katsuhiko and Tanisawa, Kumpei and Goto, Sataro and Kerepesi, Csaba and Boldogh, Istvan and Ba, Xueqing and Davies, Kelvin J. A. and Horvath, Steve and Radák, Zsolt},
	doi = {10.1007/s11357-023-00826-1},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {45},
	unique-id = {33866054},
	issn = {2509-2715},
	abstract = {DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ  = 0.2, p  = 6.4E − 4, r  = 0.19, p  = 1.2E − 3), Jumpmax ( p  = 0.11, p  = 5.5E − 2, r  = 0.13, p  = 2.8E − 2), Gripmax ( ρ  = 0.17, p  = 3.5E − 3, r  = 0.16, p  = 5.6E − 3), and HDL levels ( ρ  = 0.18, p  = 1.95E − 3, r  = 0.19, p  = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p  = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life.},
	year = {2023},
	eissn = {2509-2723},
	pages = {2805-2817},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Bábszky, Gergely/0000-0002-5939-8434; Bakonyi, Péter/0000-0002-6120-3384; György, Bernadett/0000-0002-3787-7338; Tóth, László/0000-0001-9650-1202; Fridvalszki, Marcell Norbert/0000-0001-9445-9397; Pósa, Anikó/0000-0003-2167-2888; Kerepesi, Csaba/0000-0001-9541-246X; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:31305681,
	title = {Analyses of mitochondrial biogenesis and function after Associating Liver Partition and Portal vein Ligation for Staged hepatectomy (ALPPS)},
	url = {https://m2.mtmt.hu/api/publication/31305681},
	author = {Fulop, A. and Budai, A. and Radak, Z. and Bori, Zoltán and Koltai, Erika and Tretter, L. and Horvath, G. and Lukats, A. and Szijarto, A.},
	doi = {10.1016/j.hpb.2019.10.463},
	journal-iso = {HPB},
	journal = {HPB},
	volume = {21},
	unique-id = {31305681},
	issn = {1365-182X},
	year = {2019},
	eissn = {1477-2574},
	pages = {S668-S669},
	orcid-numbers = {Bori, Zoltán/0000-0003-1253-060X; Koltai, Erika/0000-0002-1370-2955}
}

@article{MTMT:3426954,
	title = {Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model},
	url = {https://m2.mtmt.hu/api/publication/3426954},
	author = {Budai, András and Horváth, Gergő and Tretter, László and Radák, Zsolt and Koltai, Erika and Bori, Zoltán and Torma, Ferenc Gergely and Lukáts, Ákos and Röhlich, Pál and Szijártó, Attila and Fülöp, András},
	doi = {10.1002/bjs.10978},
	journal-iso = {BRIT J SURG},
	journal = {BRITISH JOURNAL OF SURGERY},
	volume = {106},
	unique-id = {3426954},
	issn = {0007-1323},
	year = {2019},
	eissn = {1365-2168},
	pages = {120-131},
	orcid-numbers = {Budai, András/0000-0002-4634-2140; Horváth, Gergő/0000-0001-5386-9509; Tretter, László/0000-0001-5638-2886; Radák, Zsolt/0000-0003-1297-6804; Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X}
}

@article{MTMT:3411071,
	title = {Master athletes have higher miR-7, SIRT3 and SOD2 expression in skeletal muscle than age-matched sedentary controls},
	url = {https://m2.mtmt.hu/api/publication/3411071},
	author = {Koltai, Erika and Bori, Zoltán and Osváth, Péter and Ihász, Ferenc and Szablics, Péter and Toth, Geza and Degens, Hans and Rittweger, Jörn and Boldogh, Istvan and Radák, Zsolt},
	doi = {10.1016/j.redox.2018.07.022},
	journal-iso = {REDOX BIOL},
	journal = {REDOX BIOLOGY},
	volume = {19},
	unique-id = {3411071},
	issn = {2213-2317},
	year = {2018},
	eissn = {2213-2317},
	pages = {46-51},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:3202563,
	title = {SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle},
	url = {https://m2.mtmt.hu/api/publication/3202563},
	author = {Koltai, Erika and Bori, Zoltán and Chabert, C and Dubouchaud, H and Naito, H and Machida, S and Davies, KJ and Murlasits, Zsolt and Fry, AC and Boldogh, I and Radák, Zsolt},
	doi = {10.1113/JP273774},
	journal-iso = {J PHYSIOL-LONDON},
	journal = {JOURNAL OF PHYSIOLOGY-LONDON},
	volume = {595},
	unique-id = {3202563},
	issn = {0022-3751},
	abstract = {Significant skeletal muscle mass guarantees functional wellbeing and is important for high level performance in many sports. Although the molecular mechanism for skeletal muscle hypertrophy has been well-studied, it still is not completely understood. In the present study, we used a functional overload model to induce plantaris muscle hypertrophy by surgically removing the soleus, and gastrocnemius muscles in rats. Two weeks of muscle ablation resulted in a 40% increase in muscle mass, which was associated with a significant increase in SIRT1 content and activity (P < 0.001). SIRT1-regulated Akt, eNOS, GLUT4 levels were also induced in hypertrophied muscles, and SIRT1 levels correlated with muscle mass, paired box protein 7 (Pax7), proliferating cell nuclear antigen (PCNA) and nicotinamide phosphoribosyltransferase (Nampt) levels. Alternatively, decreased FOXO1 and increased K48 polyubiquitination also suggest that SIRT1 could also be involved in the catabolic process of hypertrophy. Furthermore, increased levels of K63 and muscle RING finger 2 (MuRF2) protein could also be important enhancers of muscle mass. We report here that the levels of miR1 and miR133a decrease in hypertrophy and negatively correlate with muscle mass, SIRT1, and Nampt levels. Our results reveal a strong agreement between SIRT1 levels and activity, SIRT1 regulated pathways, and overload-induced hypertrophy. These findings, along with the well-known regulatory roles that SIRT1 plays in modulating both anabolic and catabolic pathways, allow us to propose the hypothesis that SIRT1 may actually play a crucial causal role in overload induced hypertrophy of skeletal muscle. This hypothesis will now require rigorous direct and functional testing. This article is protected by copyright. All rights reserved.},
	year = {2017},
	eissn = {1469-7793},
	pages = {3361-3376},
	orcid-numbers = {Koltai, Erika/0000-0002-1370-2955; Bori, Zoltán/0000-0003-1253-060X; Murlasits, Zsolt/0000-0003-4101-3417; Radák, Zsolt/0000-0003-1297-6804}
}

@article{MTMT:3207700,
	title = {Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats},
	url = {https://m2.mtmt.hu/api/publication/3207700},
	author = {Torma, Ferenc Gergely and Bori, Zoltán and Koltai, Erika and Felszeghy, Klára and Vácz, Gabriella and Koch, Lauren and Britton, Steven and Boldogh, Istvan and Radak, Zsolt},
	doi = {10.1016/j.freeradbiomed.2016.04.069},
	journal-iso = {FREE RADICAL BIO MED},
	journal = {FREE RADICAL BIOLOGY AND MEDICINE},
	volume = {96},
	unique-id = {3207700},
	issn = {0891-5849},
	year = {2016},
	eissn = {1873-4596},
	pages = {S34-S35},
	orcid-numbers = {Bori, Zoltán/0000-0003-1253-060X; Koltai, Erika/0000-0002-1370-2955; Felszeghy, Klára/0000-0002-3539-1457; Vácz, Gabriella/0000-0003-0073-2482}
}

@inbook{MTMT:31281655,
	title = {The Effects of High-Altitude Exposure on Reactive Oxygen and Nitrogen Species},
	url = {https://m2.mtmt.hu/api/publication/31281655},
	author = {Radák, Zsolt and Acs, Zoltan and Bori, Zoltán and Taylor, Albert W. and Yang, Hu},
	booktitle = {Systems Biology of Free Radicals and Antioxidants},
	doi = {10.1007/978-3-642-30018-9_28},
	unique-id = {31281655},
	year = {2014},
	pages = {407-416},
	orcid-numbers = {Radák, Zsolt/0000-0003-1297-6804; Bori, Zoltán/0000-0003-1253-060X}
}

@article{MTMT:2736493,
	title = {Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats},
	url = {https://m2.mtmt.hu/api/publication/2736493},
	author = {Torma, Ferenc Gergely and Bori, Zoltán and Koltai, Erika and Felszeghy, Klára and Vácz, Gabriella and Koch, L and Britton, S and Boldogh, I and Radák, Zsolt},
	doi = {10.1016/j.brainresbull.2014.07.003},
	journal-iso = {BRAIN RES BULL},
	journal = {BRAIN RESEARCH BULLETIN},
	volume = {107},
	unique-id = {2736493},
	issn = {0361-9230},
	abstract = {Exercise capacity and dietary restriction (DR) are linked to improved quality of life, including enhanced brain function and neuro-protection. Brain derived neurotrophic factor (BDNF) is one of the key proteins involved in the beneficial effects of exercise on brain. Low capacity runner (LCR) and high capacity runner (HCR) rats were subjected to DR in order to investigate the regulation of BDNF. HCR-DR rats out-performed other groups in a passive avoidance test. BDNF content increased significantly in the hippocampus of HCR-DR groups compared to control groups (p<0.05). The acetylation of H3 increased significantly only in the LCR-DR group. However, chip-assay revealed that the specific binding between acetylated histone H3 and BNDF promoter was increased in both LCR-DR and HCR-DR groups. In spite of these increases in binding, at the transcriptional level only, the LCR-DR group showed an increase in BDNF mRNA content. Additionally, DR also induced the activity of cAMP response element-binding protein (CREB), while the content of SIRT1 was not altered. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1alpha) was elevated in HCR-DR groups. But, based on the levels of nuclear respiratory factor-1 and cytocrome c oxidase, it appears that DR did not cause mitochondrial biogenesis. The data suggest that DR-mediated induction of BDNF levels includes chromatin remodeling. Moreover, DR does not induce mitochondrial biogenesis in the hippocampus of LCR/HCR rats. DR results in different responses to a passive avoidance test, and BDNF regulation in LCR and HCR rats.},
	year = {2014},
	eissn = {1873-2747},
	pages = {54-60},
	orcid-numbers = {Bori, Zoltán/0000-0003-1253-060X; Koltai, Erika/0000-0002-1370-2955; Felszeghy, Klára/0000-0002-3539-1457; Vácz, Gabriella/0000-0003-0073-2482; Radák, Zsolt/0000-0003-1297-6804}
}