TY - JOUR AU - Vigvári, Szabolcs József AU - Vincze, Áron AU - Solt, Jenő AU - Sipos, Dávid AU - Feiszt, Zsófia AU - Kovács, Beáta AU - Kappéter, Ágnes AU - Péterfi, Zoltán TI - Experiences with fecal microbiota transplantation in Clostridium difficile infections via upper gastrointestinal tract JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 ET - 0 PY - 2019 IS - 2 SP - 179 EP - 188 PG - 10 SN - 1217-8950 DO - 10.1556/030.65.2018.051 UR - https://m2.mtmt.hu/api/publication/30362752 ID - 30362752 AB - Dramatic changes in the epidemiology of Clostridium difficile infections have been reported from the western world in the past decade. The proportion of severe cases is significantly elevating and clinicians now have to contend with the problem of additional and more frequent episodes of recurrences including an upward trend in the mortality rate. This situation led us to investigate the possibility of the fecal microbiota transplantation (FMT). An amount of 100 ml of fecal microbiota solution was instilled into a nasojejunal (NJ) tube in 16 cases and into a nasogastric (NG) tube in 44 cases. In all of the cases, where the solution was instilled via nasojejunal tubes, the symptoms resolved within 24 h. We did not note any recurrences in this group. When the material was flushed in through nasogastric tubes, the symptoms resolved in 39 (88.64%) cases within 24 h. In this group, we have experienced a recurrent episode of C. difficile infection in five (11.36%) cases. Three of them were cured with a second transplantation. We have found that in our practice the upper gastrointestinal tract methods had the primary cure rate of 91.67%, whereas the secondary cure rate is 96.67%. When we compared the NJ and NG methods, we have found that the differences in the outcomes are not significant statistically (p = 0.3113 using Fisher's exact probability test). In conclusion, FMT proved to be very effective, particularly in recurrent infections and in cases where conventional treatment had failed. LA - English DB - MTMT ER - TY - JOUR AU - Marek, Erika AU - D'Cruz, G AU - Katz, Zoltán AU - Szilárd, István AU - Berényi, Károly AU - Feiszt, Zsófia TI - Improving asylum seekers' health awareness in a Hungarian refugee reception centre. JF - HEALTH PROMOTION INTERNATIONAL J2 - HEALTH PROMOT INT VL - 34 PY - 2019 IS - 5 SP - e36 EP - e46 PG - 11 SN - 0957-4824 DO - 10.1093/heapro/day066 UR - https://m2.mtmt.hu/api/publication/3414031 ID - 3414031 AB - Due to its long border of the European Union Schengen Area, Hungary has long been affected by the rapidly growing inward migration towards the EU, which has become more acute in recent years. Inadequate access to healthcare among migrants has been widely reported and this may be due to a vast array of factors and may result in poorer health outcomes. Between August 2014 and April 2015 a questionnaire survey was conducted among migrants from a range of countries residing in the largest Hungarian refugee reception centre to establish participants' health knowledge and access to healthcare in Hungary (medical assessment, vaccination, etc.). The survey was complemented with an educational program which aimed to increase participants' awareness of healthcare provision and to promote the prevention of the infectious diseases that are common in Europe. The results showed that half the participants (52%) had no information of healthcare provision and the majority (61%) did not participate in any medical assessment since arriving in the reception centre. Since under-immunization may be a potential risk for the re-emergence of vaccine-preventable diseases for recipient countries, it was alarming that a significant proportion of African participants (21%) reported not having received any childhood vaccinations. Data demonstrated deficiencies in participants' health knowledge and also an urgent need to address mental health problems of arriving migrants. This article offers a valuable insight into the role of health educational interventions conducted for asylum seekers in refugee reception centres and discusses a number of practical application aspects for future educational programs. LA - English DB - MTMT ER - TY - JOUR AU - Vigvári, Szabolcs József AU - Sipos, Dávid AU - Solt, Jenő AU - Vincze, Áron AU - Kocsis, Béla AU - Nemes, Zsuzsanna AU - Kappéter, Ágnes AU - Feiszt, Zsófia AU - Kovács, Beáta AU - Péterfi, Zoltán TI - Faecal microbiota transplantation for Clostridium difficile infection using a lyophilized inoculum from non-related donors: A case series involving 19 patients JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 66 PY - 2019 IS - 1 SP - 69 EP - 78 PG - 10 SN - 1217-8950 DO - 10.1556/030.64.2017.042 UR - https://m2.mtmt.hu/api/publication/3304835 ID - 3304835 N1 - Department of Infectious Diseases, 1st Department of Internal Medicine, University of Pécs, Pécs, Hungary Department of Gastroenterology, 1st Department of Internal Medicine, University of Pécs, Pécs, Hungary Department of Medical Microbiology and Immunology, University of Pécs, Pécs, Hungary Cited By :10 Export Date: 23 April 2024 Correspondence Address: Vigvári, S.; Department of Infectious Diseases, Hungary; email: szabolcs.vigvari@gmail.com AB - Faecal microbiota transplantation (FMT) has been reported to be effective in treating relapsing of refractory Clostridium difficile infections, although some practical barriers are limiting its widespread use. In this study, our objective was to evaluate the rate of resolution of diarrhea following administration of lyophilized and resolved FMT via a nasogastric (NG) tube. We recruited 19 patients suffered from laboratory-confirmed C. difficile infection. Each of them was treated by lyophilized and resolved inoculum through a NG tube. One participant succumbed following the procedure due to unrelated diseases. Out of 18 cases, 15 patients reportedly experienced a resolution of the symptoms. One patient was treated with another course of antibiotics, and two of the non-responders were successfully retreated with another course of FMT utilizing a lyophilized inoculum. Notably, no significant adverse activities were observed. In accordance to our clinical experiences, a patient will likely benefit from FMT treatment including lyophilized inoculum. LA - English DB - MTMT ER - TY - JOUR AU - Vigvári, Szabolcs József AU - Sipos, Dávid AU - Kappéter, Ágnes AU - Feiszt, Zsófia AU - Kovács, Beáta AU - Péterfi, Zoltán TI - Risk factors for Clostridium difficile infections in Baranya County, Southern Hungary JF - ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA J2 - ACTA MICROBIOL IMMUNOL HUNG VL - 65 PY - 2018 IS - 2 SP - 183 EP - 192 PG - 10 SN - 1217-8950 DO - 10.1556/030.65.2018.023 UR - https://m2.mtmt.hu/api/publication/3360067 ID - 3360067 N1 - Cited By :2 Export Date: 23 April 2024 Correspondence Address: Vigvári, S.; First Department of Internal Medicine, Hungary; email: szabolcs.vigvari@gmail.com AB - In the past decade, Clostridium difficile infections (CDIs) have become a major public health challenge. Their epidemiology has radically changed with a significant rise in the number of cases and an increase in severe episodes. Recurrence and failure of conventional treatments are very common. Furthermore, a spread of CDI has emerged in general population without the usual risk factors (unexposed to antibiotic treatment, young people, etc.). The conventional treatments (metronidazole and vancomycin) are still effective and are the first-line antibiotics with new recommendations. New therapeutic strategies are now available. Recent studies show a better efficacy of vancomycin compared with metronidazole for severe episodes. Fidaxomicin is a novel antibiotic drug with an efficacy similar to vancomycin and a lower risk of recurrence. Finally, for relapsing forms, fecal microbiota transplantation (FMT) seems to be the best option. We determined risk factors for CDI among patients treated at the infectious diseases ward of our hospital in Pecs. The study included 886 patients with CDI from 2009 to 2014. The average number of recurrent episodes was 2.16 and the proportion of severe cases was 66%. Among our patients, 726 (82%) had taken antibiotics and 769 (86.8%) had been hospitalized in the prior 3 months before developing CDI. We have found that prior statin use could be a significant risk factor of CDI (OR: 1.7765, 95% CI: 1.3966-2.2597, p < 0.0001). Finally, we present the comparative efficacy of different types of treatment (metronidazole, vancomycin, fidaxomicin, and FMT). LA - English DB - MTMT ER - TY - JOUR AU - Takács, Katalin Gyöngyi AU - Sipos, Dávid AU - Feiszt, Zsófia AU - Huszár, Judit AU - Péterfi, Zoltán TI - A széklet transzplantáció életet menthet JF - IDŐSGYÓGYÁSZAT J2 - IDŐSGYÓGYÁSZAT VL - 1 PY - 2016 IS - 1 SP - 113 EP - 113 PG - 1 SN - 2498-8057 UR - https://m2.mtmt.hu/api/publication/3122019 ID - 3122019 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ternák, Gábor AU - Édel, Zsófia AU - Feiszt, Zsófia AU - Szekeres, Júlia AU - Visegrády, Balázs AU - Wittmann, István TI - Selective Association between Cephalosporin, Quinolone, Macrolide, and Penicillin Antibiotic Consumption and Childhood Obesity in Europe JF - HEALTH (IRVINE) J2 - HEALTH (IRVINE) VL - 7 PY - 2015 IS - 10 SP - 1306 EP - 1314 PG - 9 SN - 1949-4998 DO - 10.4236/health.2015.710145 UR - https://m2.mtmt.hu/api/publication/2965979 ID - 2965979 LA - English DB - MTMT ER - TY - JOUR AU - Vigvári, Szabolcs József AU - Nemes, Zsuzsanna AU - Vincze, Áron AU - Solt, Jenő AU - Sipos, Dávid AU - Feiszt, Zsófia AU - Kovács, Beáta AU - Bartos, Barbara AU - Péterfi, Zoltán TI - Faecal microbiota transplantation in Clostridium difficile infections JF - INFECTIOUS DISEASES J2 - INFECT DIS-NOR VL - 47 PY - 2015 IS - 2 SP - 114 EP - 116 PG - 3 SN - 2374-4235 DO - 10.3109/00365548.2014.969305 UR - https://m2.mtmt.hu/api/publication/2798567 ID - 2798567 N1 - Letter LA - English DB - MTMT ER - TY - JOUR AU - Ternák, Gábor AU - Édel, Zsófia AU - Feiszt, Zsófia AU - Szekeres, Júlia AU - Visegrády, Balázs AU - Wittmann, István TI - Az antibiotikum-fogyasztás globális hatása gyermek- és felnőtt korban JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 67 PY - 2014 IS - 5 SP - 348 EP - 353 PG - 6 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/2931426 ID - 2931426 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Vigvári, Szabolcs József AU - Nemes, Zsuzsanna AU - Vincze, Áron AU - Solt, J AU - Sipos, Dávid AU - Feiszt, Zsófia AU - Kappéter, Ágnes AU - Kovács, Beáta AU - Péterfi, Zoltán TI - Clostridium difficile-fertőzések széklettranszplantációval való kezelése során nyert tapasztalataink JF - ORVOSI HETILAP J2 - ORV HETIL VL - 155 PY - 2014 IS - 44 SP - 1758 EP - 1762 PG - 5 SN - 0030-6002 DO - 10.1556/OH.2014.30020 UR - https://m2.mtmt.hu/api/publication/2765530 ID - 2765530 N1 - Export Date: 27 January 2024; CODEN: ORHEA AB - INTRODUCTION: During the past years a dramatic change has been observed in the epidemiology of Clostridium difficile infections. AIM: The aim of the authors was to investigate the possibility of the fecal microbiota transplantation and study differences, if any, in the success rate of the two different upper gastrointestinal tract method. METHOD: 100 ml of fecal microbiota solution was instilled via a nasoduodenal tube in 15 cases and a nasogastric tube in 15 cases. The authors defined the primary cure rate as the percentage of cases in which the symptoms disappeared without recurrence within 6 weeks after the first fecal microbiota transplantation, while secondary cure rate was calculated as the percentage of cases in which the symptoms resolved after the second fecal microbiota transplantation. RESULTS: It was found that fecal microbiota transplantation applied via the nasoduodenal tube resulted in a 100% primary cure rate. With the use of the nasogastric tube, the primary and secondary cure rate were 80% and 93.3%, respectively. Fecal microbiota transplantation via the upper gastrointestinal tract was found to have an overall primary cure rate of 90.0% and a secondary cure rate of 96.7%. CONCLUSIONS: Fecal microbiota transplantation proved to be very effective, particularly in recurrent infections and cases where conventional treatment failed. Orv. Hetil., 2014, 155(44), 1758-1762. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Feiszt, Zsófia TI - Malária JF - MAGYAR CSALÁDORVOSOK LAPJA J2 - MAGYAR CSALÁDORVOSOK LAPJA VL - 2011 PY - 2011 IS - 2 SP - 7 EP - 10 PG - 4 SN - 1789-607X UR - https://m2.mtmt.hu/api/publication/2429935 ID - 2429935 AB - A maláriaparazita évmilliók óta jelen van a Földön. Miután a malária terjedése szempontjából legfontosabb epidemiológiai tényezők ismertté váltak, nagy erőkkel megkezdődött a betegség elleni küzdelem. A rovarölővel impregnált hálóknak és az újonnan felfedezett antimaláriás szereknek köszönhetően jó kontrollt lehetett elérni. A kezdeti sikereket követően a malária visszaszorításában reménykedő tudományos optimizmusnak csalódnia kellett, az utóbbi években a malária eddig soha nem látott mértékben lángolt fel és új területeken hódít. Ez leginkább a gyógyszerekkel és rovarölőkkel szemben kialakult rezisztenciának, a növekvő migrációnak, a turizmusnak, valamint az éghajlatváltozásnak köszönhető. Az Anopheles szúnyog csípése során fertőződik az ember a maláriát okozó Plasmodiummal. A malária elleni védekezésnek legfontosabb részét az endémiás területeken tartózkodók profilaxisa képezi, ami rovarirtók, impregnált hálók alkalmazását és kemoprofilaxist jelent. A maláriára jellemző klinikai tünetek esetén az endémiás területről hazaérkező beteget kezelni kell, mert a malária akut, életet veszélyeztető állapot lehet. A terápiás protokollt a CDC előírásainak megfelelően kell alkalmazni. LA - Hungarian DB - MTMT ER -