TY - JOUR AU - Trivedi, Dhanisha Trivedi AU - Forssten, Maximilian Peter AU - Cao, Yang AU - Mohammad Ismail, Ahmad AU - Czeiter, Endre AU - Amrein, Krisztina AU - Kobeissy, Firas AU - Wang, Kevin K W AU - DeSoucy, Erik AU - Büki, András AU - Mohseni, Shahin TI - Screening Performance of S100B, GFAP and UCH-L1 For Intracranial Injury Within 6 hours of Injury and beyond JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 41 PY - 2024 IS - 3-4 SP - 349 EP - 358 PG - 10 SN - 0897-7151 DO - 10.1089/neu.2023.0322 UR - https://m2.mtmt.hu/api/publication/34477399 ID - 34477399 N1 - * Megosztott szerzőség AB - The Scandinavian NeuroTrauma Committee (SNC) guidelines recommend S100B as a screening tool for early detection of Traumatic brain injury (TBI) in patients presenting with an initial Glasgow coma scale (GCS) of 14-15. The objective of the current study was to compare S100B's diagnostic performance within the recommended 6-hour window after injury, compared to GFAP and UCH-L1. The secondary outcome of interest was the ability of these biomarkers in detecting traumatic intracranial pathology beyond the 6-hour mark.The Center-TBI core database (2014-2017) was queried for data pertaining to all TBI patients with an initial GCS of 14-15 who had a blood sample taken within 6 hours of injury in which the levels of S100B, GFAP, and UCH-L1 were measured. As a subgroup analysis, data involving patients with blood samples taken within 6-9 hours, and 9-12 hours were analyzed separately for diagnostic ability. The diagnostic ability of these biomarkers for detecting any intracranial injury was evaluated based on the area under the receiver operating characteristic curve (AUC). Each biomarker's sensitivity, specificity, and accuracy were also reported at the cutoff that maximized Youden's index.A total of 531 TBI patients with GCS 14-15 on admission had a blood sample taken within 6 hours, of whom 24.9% (N = 132) had radiologically confirmed intracranial injury. The AUCs of GFAP (0.86, 95% confidence interval (CI): 0.82-0.90) and UCH-L1 (0.81, 95% CI: 0.76-0.85) were statistically significantly higher than that of S100B (0.74, 95% CI: 0.69-0.79) during this time. There was no statistically significant difference in the predictive ability of S100B when sampled within 6 hours, 6-9 hours, and 9-12 hours of injury, as the p-values were >0.05 when comparing the AUCs. Overlapping AUC 95% CI suggests no benefit of a combined GFAP and UCH-L1 screening tool over GFAP during the time periods studied [ 0.87 (0.83-0.90) vs 0.86 (0.82-0.90) when sampled within 6 hours of injury, 0.83 (0.78-0.88) vs 0.83 (0.78-0.89) within 6-to-9 hours and 0.81 (0.73-0.88) vs 0.79 (0.72-0.87) within 9-12 hours].Targeted analysis of the CENTER-TBI core database, with focus on the patient category for which biomarker testing is recommended by the SNC guidelines, revealed that GFAP and UCH-L1 perform superior to S100B in predicting CT-positive intracranial lesions within 6 hours of injury. GFAP continued to exhibit superior predictive ability to S100B during the time periods studied. S100B displayed relatively unaltered screening performance beyond the diagnostic timeline provided by SNC guidelines. These findings suggest the need for a re-evaluation of the current SNC TBI guidelines. LA - English DB - MTMT ER - TY - JOUR AU - Lendvai-Emmert, Dominika AU - Magyar-Sümegi, Zsófia Dina AU - Hegedüs, Emőke AU - Szarka, Nikolett AU - Fazekas, Bálint AU - Amrein, Krisztina AU - Czeiter, Endre AU - Büki, András AU - Ungvári, Zoltán István AU - Tóth, Péter József TI - Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 14 PY - 2023 PG - 9 SN - 1664-2295 DO - 10.3389/fneur.2023.1252796 UR - https://m2.mtmt.hu/api/publication/34392087 ID - 34392087 N1 - This work was supported by grants from the National Research, Development and Innovation Office (OTKA K-134555 and OTKA FK-123798 to PT), the Hungarian Academy of Sciences Bolyai Research Scholarship (to PT), National Clinical Neuroscience Laboratory (RRF-2.3.1-21-2022-00011), the Thematic Excellence Program 2021 Health sub-program of the Ministry for Innovation and Technology in Hungary, within the framework of the EGA-16 project of the University of Pecs (to PT), the National Institute on Aging (RF1AG072295, R01AG055395, R01AG068295, and K01-AG073614), the National Institute of Neurological Disorders and Stroke (R01NS100782), the National Cancer Institute (R01CA255840). LA - English DB - MTMT ER - TY - JOUR AU - Richter, Sophie AU - Czeiter, Endre AU - Amrein, Krisztina AU - Mikolic, Ana AU - Verheyden, Jan AU - Wang, Kevin K AU - Maas, Andrew AU - Steyerberg, Ewout AU - Büki, András AU - Menon, David AU - Newcombe, Virginia TI - Prognostic Value of Serum Biomarkers in Patients With Moderate-Severe Traumatic Brain Injury, Differentiated by Marshall Computer Tomography Classification JF - JOURNAL OF NEUROTRAUMA J2 - J NEUROTRAUM VL - 40 PY - 2023 IS - 21-22 SP - 2297 EP - 2310 PG - 14 SN - 0897-7151 DO - 10.1089/neu.2023.0029 UR - https://m2.mtmt.hu/api/publication/34050791 ID - 34050791 N1 - University Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary ELKH-PTE Clinical Neuroscience MR Research Group, University of Pécs, Pécs, Hungary Department of Psychology, University of British Columbia, Vancouver, BC, Canada Rehabilitation Research Program, GF Strong Rehabilitation Centre, Vancouver, BC, Canada Research and Development, icometrix, Leuven, Belgium Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, Gainesville, FL, United States Department of Neurosurgery, Antwerp University Hospital, University of Antwerp, Edegem, Belgium Department of Biomedical Data Sciences, University Medical Centre, Leiden, Netherlands Örebro University, School of Medical Sciences, Örebro, Sweden Export Date: 1 February 2024 CODEN: JNEUE Correspondence Address: Richter, S.; University Division of Anaesthesia, Box 93, Hills Road, United Kingdom; email: sr773@cam.ac.uk Correspondence Address: Newcombe, V.F.J.; University Division of Anaesthesia, Box 93, Hills Road, United Kingdom; email: vfjn2@cam.ac.uk AB - Prognostication is challenging in traumatic brain injury (TBI) patients in whom the CT fails to fully explain a low level of consciousness. Serum biomarkers reflect the extent of structural damage in a different way than CT does, but it is unclear if biomarkers provide additional prognostic value across the range of CT abnormalities. This study aimed to determine the added predictive value of biomarkers, differentiated by imaging severity. This prognostic study used data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study (2014-2017). The analysis included patients aged ≥16 years with a moderate-severe TBI (Glasgow Coma Scale, GCS < 13) who had an acute CT and serum biomarkers obtained ≤24h of injury. Out of six protein biomarkers (GFAP, NFL, NSE, S100B, Tau, UCH-L1) the most prognostic panel was selected using lasso regression. The performance of established prognostic models (CRASH and IMPACT) was assessed before and after the addition of the biomarker panel, and compared between patients with different CT Marshall scores (Marshall score <3 versus Marshall score ≥3). Outcome was assessed at 6 months post-injury using the extended Glasgow Outcome Scale (GOSE), and dichotomized into favorable and unfavourable (GOSE <5). We included 872 patients with moderate-severe TBI. The mean age was 47 years (range 16 - 95), 647 (74%) were male and 438 (50%) had a Marshall CT score <3. The serum biomarkers GFAP, NFL, S100B and UCH-L1 provided complementary prognostic information, NSE and Tau showed no added value. The addition of the biomarker panel to established prognostic models increased the area under the curve (AUC) by 0.08 and 0.03, and the explained variation in outcome by 13-14% and 7-8%, for patients with a Marshall score of <3 and ≥3, respectively. The incremental AUC of biomarkers for individual models was significantly greater when the Marshall score was <3 compared to ≥3 (p < 0.001). Serum biomarkers improve outcome prediction after moderate-severe TBI across the range of imaging severities and especially in patients with a Marshall score <3. LA - English DB - MTMT ER - TY - CONF AU - Kolozsvári, Áron AU - Bali, Zsolt Kristóf AU - Bruszt, Nóra AU - Nagy, Lili Veronika AU - Fazekas, Bálint AU - Amrein, Krisztina AU - Czeiter, Endre AU - Büki, András AU - Hernádi, István TI - Alleviation of longterm cognitive impairment with memantine combined with alfa7 nicotic receptor ligand after repetitive mild traumatic brain injury in rats T2 - Joint Neuroscience Meeting of the Hungarian Neuroscience Society (MITT) & the Austrian Neuroscience Association (ANA) PY - 2023 SP - 136 UR - https://m2.mtmt.hu/api/publication/33704639 ID - 33704639 LA - English DB - MTMT ER - TY - JOUR AU - Kovács-Öller, Tamás AU - Zempléni, Renáta AU - Balogh, Boglárka AU - Szarka, Gergely AU - Fazekas, Bálint AU - Tengölics, Ádám Jonatán AU - Amrein, Krisztina AU - Czeiter, Endre AU - Hernádi, István AU - Büki, András AU - Völgyi, Béla TI - Traumatic Brain Injury Induces Microglial and Caspase3 Activation in the Retina JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 5 PG - 16 SN - 1661-6596 DO - 10.3390/ijms24054451 UR - https://m2.mtmt.hu/api/publication/33695777 ID - 33695777 AB - Traumatic brain injury (TBI) is among the main causes of sudden death after head trauma. These injuries can result in severe degeneration and neuronal cell death in the CNS, including the retina, which is a crucial part of the brain responsible for perceiving and transmitting visual information. The long-term effects of mild-repetitive TBI (rmTBI) are far less studied thus far, even though damage induced by repetitive injuries occurring in the brain is more common, especially amongst athletes. rmTBI can also have a detrimental effect on the retina and the pathophysiology of these injuries is likely to differ from severe TBI (sTBI) retinal injury. Here, we show how rmTBI and sTBI can differentially affect the retina. Our results indicate an increase in the number of activated microglial cells and Caspase3-positive cells in the retina in both traumatic models, suggesting a rise in the level of inflammation and cell death after TBI. The pattern of microglial activation appears distributed and widespread but differs amongst the various retinal layers. sTBI induced microglial activation in both the superficial and deep retinal layers. In contrast to sTBI, no significant change occurred following the repetitive mild injury in the superficial layer, only the deep layer (spanning from the inner nuclear layer to the outer plexiform layer) shows microglial activation. This difference suggests that alternate response mechanisms play a role in the case of the different TBI incidents. The Caspase3 activation pattern showed a uniform increase in both the superficial and deep layers of the retina. This suggests a different action in the course of the disease in sTBI and rmTBI models and points to the need for new diagnostic procedures. Our present results suggest that the retina might serve as such a model of head injuries since the retinal tissue reacts to both forms of TBI and is the most accessible part of the human brain. LA - English DB - MTMT ER - TY - JOUR AU - Richter, S. AU - Winzeck, S. AU - Czeiter, Endre AU - Amrein, Krisztina AU - Kornaropoulos, E.N. AU - Verheyden, J. AU - Sugar, G. AU - Yang, Z. AU - Wang, K. AU - Maas, A.I.R. AU - Steyerberg, E. AU - Büki, András AU - Newcombe, V.F.J. AU - Menon, D.K. TI - Serum biomarkers identify critically ill traumatic brain injury patients for MRI JF - CRITICAL CARE J2 - CRIT CARE VL - 26 PY - 2022 IS - 1 PG - 7 SN - 1364-8535 DO - 10.1186/s13054-022-04250-3 UR - https://m2.mtmt.hu/api/publication/33339230 ID - 33339230 N1 - Brief report CN: Collaborative European NeuroTrauma Efectiveness Research in Traumatic Brain Injury Magnetic Resonance Imaging (CENTER-TBI MRI) Sub-study Participants and Investigators LA - English DB - MTMT ER - TY - JOUR AU - Bockhop, Fabian AU - Zeldovich, Marina AU - Cunitz, Katrin AU - Van Praag, Dominique AU - van der Vlegel, Marjolein AU - Beissbarth, Tim AU - Hagmayer, York AU - von Steinbuechel, Nicole ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Carbayo Lozano, Guillermo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - den Boogert, Hugo / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Guoyi, Gao / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - A Gomez, Pedro / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - L Gruen, Russell / Collaborator ED - Gupta, Deepak / Collaborator ED - A Haagsma, Juanita / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - J Hutchinson, Peter / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - G Kolias, Angelos / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Kornaropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - I R Maas, Andrew / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Pisica, Dana / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Helmrich, Isabel Retel / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - RueckertMartin Rusnák, Daniel / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Singh, Ranjit D / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Steven Taylor, Mark / Collaborator ED - Te Ao, Braden / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Maria Tudora, Cristina / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - Naalt, Joukje van der / Collaborator ED - T J M van Dijck, Jeroen / Collaborator ED - van Erp, Inge A M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Hecke, Wim Van / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - van Veen, Ernest / Collaborator ED - Vande Vyvere, Thijs / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - K W Wang, Kevin / Collaborator ED - Whitehouse, Daniel / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Measurement invariance of six language versions of the post-traumatic stress disorder checklist for DSM-5 in civilians after traumatic brain injury JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 15 SN - 2045-2322 DO - 10.1038/s41598-022-20170-2 UR - https://m2.mtmt.hu/api/publication/33195955 ID - 33195955 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA); Projekt DEAL Funding text: Open Access funding enabled and organized by Projekt DEAL. CENTER-TBI was supported by the European Union 7th Framework programme (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA), and from Integra LifeSciences Corporation (USA). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. AB - Traumatic brain injury (TBI) is frequently associated with neuropsychiatric impairments such as symptoms of post-traumatic stress disorder (PTSD), which can be screened using self-report instruments such as the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5). The current study aims to inspect the factorial validity and cross-linguistic equivalence of the PCL-5 in individuals after TBI with differential severity. Data for six language groups (n ≥ 200; Dutch, English, Finnish, Italian, Norwegian, Spanish) were extracted from the CENTER-TBI study database. Factorial validity of PTSD was evaluated using confirmatory factor analyses (CFA), and compared between four concurrent structural models. A multi-group CFA approach was utilized to investigate the measurement invariance (MI) of the PCL-5 across languages. All structural models showed satisfactory goodness-of-fit with small between-model variation. The original DSM-5 model for PTSD provided solid evidence of MI across the language groups. The current study underlines the validity of the clinical DSM-5 conceptualization of PTSD and demonstrates the comparability of PCL-5 symptom scores between language versions in individuals after TBI. Future studies should apply MI methods to other sociodemographic (e.g., age, gender) and injury-related (e.g., TBI severity) characteristics to improve the monitoring and clinical care of individuals suffering from PTSD symptoms after TBI. LA - English DB - MTMT ER - TY - JOUR AU - Van Praag, Dominique L G AU - Wouters, Kristien AU - Van Den Eede, Filip AU - Wilson, Lindsay AU - Maas, Andrew I R ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew Ir / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sandor, Janos / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen Tjm / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel Pj / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin Kw / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury JF - BRAIN AND SPINE J2 - BRAIN SPINE VL - 2 PY - 2022 PG - 11 SN - 2772-5294 DO - 10.1016/j.bas.2021.100854 UR - https://m2.mtmt.hu/api/publication/33163294 ID - 33163294 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA) Funding text: The data used in preparation of this manuscript was obtained in the context of CENTER-TBI, a large collaborative research project funded by the European Union 7th Framework program (EC grant 602150) . Additional funding was obtained from the Hannelore Kohl Stiftung (Germany) , from OneMind (USA) and from Integra LifeSciences Corporation (USA) . AB - Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI).We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample.The study is part of the CENTER-TBI project (Collaborative European Neurotrauma Effectiveness Research) that aims to better characterize TBI. For this cross-sectional study, we included patients of all severities aged over 15, and a Glasgow Outcome Score Extended (GOSE) above 3. Participants were assessed at six months post-injury on the PTSD Checklist-5 (PCL-5), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test (RAVLT) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Primary analysis was a complete case analysis. Regression analyses were performed to investigate the association between the PCL-5 and cognition.Of the 1134 participants included in the complete case analysis, 13.5% screened positive for PTSD. Probable PTSD was significantly associated with higher TMT-(B-A) (OR ​= ​1.35, 95% CI: 1.14-1.60, p ​< ​.001) and lower RAVLT-delayed recall scores (OR ​= ​0.74, 95% CI: 0.61-0.91, p ​= ​.004) after controlling for age, sex, psychiatric history, baseline Glasgow Coma Scale and education.Poorer performance on cognitive tests assessing task switching and, to a lesser extent, delayed verbal recall is associated with probable PTSD in civilians who have suffered TBI. LA - English DB - MTMT ER - TY - JOUR AU - Prémusz, Viktória AU - Lendvai-Emmert, Dominika AU - Makai, Alexandra AU - Amrein, Krisztina AU - Chauhan, Shalini AU - Bódis, József AU - Kovács, Kálmán András AU - Várnagy, Ákos TI - Pre-Treatment Physical Activity Could Positively Influence Pregnancy Rates in IVF despite the Induced Oxidative Stress: A Cohort Study on Salivary 8-Hydroxy-2'-deoxyguanosine JF - ANTIOXIDANTS J2 - ANTIOXIDANTS-BASEL VL - 11 PY - 2022 IS - 8 PG - 13 SN - 2076-3921 DO - 10.3390/antiox11081586 UR - https://m2.mtmt.hu/api/publication/33070004 ID - 33070004 AB - (1) Background: This study was designed to define whether pretreatment habitual physical activity (PA)-induced oxidative stress (OS) influences outcome measures by using 8-hydroxy-2'-deoxyguanosine (8-OHdG) in saliva samples of patients undergoing in vitro fertilization (IVF). (2) Method: In this cohort study, samples were obtained from 26 patients (age: 34.6 ± 5.5 years, BMI: 25.3 ± 5.1, infertility: 51.0 ± 28.7 months) before the treatment and a follow-up of outcome measures of IVF/ICSI. The 8-OHdG was evaluated by Abcam's ELISA (ab201734), PA patterns by GPAQ-H and ActiGraph GT3X; (3) Results: The number of matured oocytes was positively influenced by the GPAQ-H recreation MET (R2 = 0.367, F = 10.994, p = 0.004; β = 0.005, p = 0.004, B Constant = 4.604) and a positive significant relationship (R2 = 0.757, F = 17.692, p < 0.001, B Constant = 1.342) was found with GPAQ-H recreational PA MET (β = 0.004, p < 0.001), and Grade 1 embryos and higher very vigorous activity (GT3X) were accompanied (R2 = 0.958, F = 408.479, p < 0.001) by higher ß-hCG levels (β = 63.703, p ≤ 0.001). Unanticipated positive correlation between 8-OHdG and ß-hCG level (R = 0.467, p = 0.028) was noticed, and there were significant differences in 8-OHdG in biochemical pregnancies (pregnant: 54.82 ± 35.56 ng/mL, non-pregnant: 30.06 ± 10.40 ng/mL, p = 0.022) as well. (4) Conclusions: Pretreatment PA could positively influence reproductive performance in IVF/ICSI despite the induced OS. However, a more sensitive biomarker and the recommended amount of activity should be further investigated. LA - English DB - MTMT ER - TY - JOUR AU - Lendvai-Emmert, Dominika AU - Emmert, Vanessza AU - Makai, Alexandra AU - Fusz, Katalin AU - Prémusz, Viktória AU - Eklicsné Lepenye, Katalin AU - Sarlós, Patrícia AU - Tóth, Péter József AU - Amrein, Krisztina AU - Tóth, Gergely Péter TI - Fecal calprotectin levels in pediatric cow's milk protein allergy JF - FRONTIERS IN PEDIATRICS J2 - FRONT PEDIATR VL - 10 PY - 2022 PG - 8 SN - 2296-2360 DO - 10.3389/fped.2022.945212 UR - https://m2.mtmt.hu/api/publication/33064876 ID - 33064876 LA - English DB - MTMT ER -