TY - JOUR AU - Bockhop, Fabian AU - Zeldovich, Marina AU - Cunitz, Katrin AU - Van Praag, Dominique AU - van der Vlegel, Marjolein AU - Beissbarth, Tim AU - Hagmayer, York AU - von Steinbuechel, Nicole ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Carbayo Lozano, Guillermo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - den Boogert, Hugo / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Guoyi, Gao / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - A Gomez, Pedro / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - L Gruen, Russell / Collaborator ED - Gupta, Deepak / Collaborator ED - A Haagsma, Juanita / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - J Hutchinson, Peter / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - G Kolias, Angelos / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Kornaropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - I R Maas, Andrew / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Pisica, Dana / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Helmrich, Isabel Retel / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - RueckertMartin Rusnák, Daniel / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Singh, Ranjit D / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Steven Taylor, Mark / Collaborator ED - Te Ao, Braden / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Maria Tudora, Cristina / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - Naalt, Joukje van der / Collaborator ED - T J M van Dijck, Jeroen / Collaborator ED - van Erp, Inge A M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Hecke, Wim Van / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - van Veen, Ernest / Collaborator ED - Vande Vyvere, Thijs / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - K W Wang, Kevin / Collaborator ED - Whitehouse, Daniel / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Measurement invariance of six language versions of the post-traumatic stress disorder checklist for DSM-5 in civilians after traumatic brain injury JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 15 SN - 2045-2322 DO - 10.1038/s41598-022-20170-2 UR - https://m2.mtmt.hu/api/publication/33195955 ID - 33195955 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA); Projekt DEAL Funding text: Open Access funding enabled and organized by Projekt DEAL. CENTER-TBI was supported by the European Union 7th Framework programme (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA), and from Integra LifeSciences Corporation (USA). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. AB - Traumatic brain injury (TBI) is frequently associated with neuropsychiatric impairments such as symptoms of post-traumatic stress disorder (PTSD), which can be screened using self-report instruments such as the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5). The current study aims to inspect the factorial validity and cross-linguistic equivalence of the PCL-5 in individuals after TBI with differential severity. Data for six language groups (n ≥ 200; Dutch, English, Finnish, Italian, Norwegian, Spanish) were extracted from the CENTER-TBI study database. Factorial validity of PTSD was evaluated using confirmatory factor analyses (CFA), and compared between four concurrent structural models. A multi-group CFA approach was utilized to investigate the measurement invariance (MI) of the PCL-5 across languages. All structural models showed satisfactory goodness-of-fit with small between-model variation. The original DSM-5 model for PTSD provided solid evidence of MI across the language groups. The current study underlines the validity of the clinical DSM-5 conceptualization of PTSD and demonstrates the comparability of PCL-5 symptom scores between language versions in individuals after TBI. Future studies should apply MI methods to other sociodemographic (e.g., age, gender) and injury-related (e.g., TBI severity) characteristics to improve the monitoring and clinical care of individuals suffering from PTSD symptoms after TBI. LA - English DB - MTMT ER - TY - JOUR AU - Van Praag, Dominique L G AU - Wouters, Kristien AU - Van Den Eede, Filip AU - Wilson, Lindsay AU - Maas, Andrew I R ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew Ir / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sandor, Janos / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Unterberg, Andreas / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen Tjm / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel Pj / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin Kw / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Neurocognitive correlates of probable posttraumatic stress disorder following traumatic brain injury JF - BRAIN AND SPINE J2 - BRAIN SPINE VL - 2 PY - 2022 PG - 11 SN - 2772-5294 DO - 10.1016/j.bas.2021.100854 UR - https://m2.mtmt.hu/api/publication/33163294 ID - 33163294 N1 - Funding Agency and Grant Number: European Union [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA) Funding text: The data used in preparation of this manuscript was obtained in the context of CENTER-TBI, a large collaborative research project funded by the European Union 7th Framework program (EC grant 602150) . Additional funding was obtained from the Hannelore Kohl Stiftung (Germany) , from OneMind (USA) and from Integra LifeSciences Corporation (USA) . AB - Neurocognitive problems associated with posttraumatic stress disorder (PTSD) can interact with impairment resulting from traumatic brain injury (TBI).We aimed to identify neurocognitive problems associated with probable PTSD following TBI in a civilian sample.The study is part of the CENTER-TBI project (Collaborative European Neurotrauma Effectiveness Research) that aims to better characterize TBI. For this cross-sectional study, we included patients of all severities aged over 15, and a Glasgow Outcome Score Extended (GOSE) above 3. Participants were assessed at six months post-injury on the PTSD Checklist-5 (PCL-5), the Trail Making Test (TMT), the Rey Auditory Verbal Learning Test (RAVLT) and the Cambridge Neuropsychological Test Automated Battery (CANTAB). Primary analysis was a complete case analysis. Regression analyses were performed to investigate the association between the PCL-5 and cognition.Of the 1134 participants included in the complete case analysis, 13.5% screened positive for PTSD. Probable PTSD was significantly associated with higher TMT-(B-A) (OR ​= ​1.35, 95% CI: 1.14-1.60, p ​< ​.001) and lower RAVLT-delayed recall scores (OR ​= ​0.74, 95% CI: 0.61-0.91, p ​= ​.004) after controlling for age, sex, psychiatric history, baseline Glasgow Coma Scale and education.Poorer performance on cognitive tests assessing task switching and, to a lesser extent, delayed verbal recall is associated with probable PTSD in civilians who have suffered TBI. LA - English DB - MTMT ER - TY - JOUR AU - van der Vlegel, Marjolein AU - Mikolić, Ana AU - Lee, Hee Quentin AU - Kaplan, Z L Rana AU - Retel, Helmrich Isabel R A AU - van Veen, Ernest AU - Andelic, Nada AU - Steinbuechel, Nicole V AU - Plass, Anne Marie AU - Zeldovich, Marina AU - Wilson, Lindsay AU - Maas, Andrew I R AU - Haagsma, Juanita A AU - Polinder, Suzanne ED - Åkerlund, Cecilia / Collaborator ED - George, Pradeep / Collaborator ED - Lanyon, Linda / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Nelson, David / Collaborator ED - Amrein, Krisztina / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Kovács, Noémi / Collaborator ED - Melegh, Béla / Collaborator ED - Nyirádi, József / Collaborator ED - Tamás, Viktória / Collaborator ED - Vámos, Zoltán / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Frisvold, Shirin / Collaborator ED - Antoni, Anna / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Beretta, Luigi / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Bartels, Ronald / Collaborator ED - Boogert, Hugo den / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Perera, Natascha / Collaborator ED - Beer, Ronny / Collaborator ED - Helbok, Raimund / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Degos, Vincent / Collaborator ED - Galanaud, Damien / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Berardino, Maurizio / Collaborator ED - Cavallo, Simona / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Rosenlund, Christina / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Majdan, Marek / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Brinck, Vibeke / Collaborator ED - Jarrett, Mike / Collaborator ED - Brooker, Joanne / Collaborator ED - Donoghue, Emma / Collaborator ED - Synnot, Anneliese / Collaborator ED - Brorsson, Camilla / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Sundström, Nina / Collaborator ED - Büki, András / Collaborator ED - Czeiter, Endre / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dixit, Abhishek / Collaborator ED - Ercole, Ari / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Menon, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Richter, Sophie / Collaborator ED - Smielewski, Peter / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Williams, Guy / Collaborator ED - Winzeck, Stefan / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Carbonara, Marco / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Zoerle, Tommaso / Collaborator ED - Stocchetti, Nino / Collaborator ED - Cameron, Peter / Collaborator ED - Gantner, Dashiell / Collaborator ED - Murray, Lynnette / Collaborator ED - Trapani, Tony / Collaborator ED - Vallance, Shirley / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Pomposo, Inigo / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Gomez, Pedro A / Collaborator ED - Lagares, Alfonso / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Huijben, Jilske / Collaborator ED - Lingsma, Hester / Collaborator ED - Nieboer, Daan / Collaborator ED - Mikolic, Ana / Collaborator ED - Polinder, Suzanne / Collaborator ED - Sewalt, Charlie / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Velt, Kimberley / Collaborator ED - Voormolen, Daphne / Collaborator ED - Wiegers, Eveline / Collaborator ED - Peul, Wilco / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Kowark, Ana / Collaborator ED - Rossaint, Rolf / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čovid, Amra / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Curry, Nicola / Collaborator ED - Stanworth, Simon / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Johnson, Faye / Collaborator ED - Dawes, Helen / Collaborator ED - Esser, Patrick / Collaborator ED - van Heugten, Caroline / Collaborator ED - De Keyser, Véronique / Collaborator ED - Maas, Andrew I R / Collaborator ED - Menovsky, Tomas / Collaborator ED - Van, der Steen Gregory / Collaborator ED - Corte, Francesco Della / Collaborator ED - Grossi, Francesca / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Karan, Mladen / Collaborator ED - Vulekovic, Petar / Collaborator ED - Dreier, Jens / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Wolf, Stefan / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Maréchal, Hugues / Collaborator ED - Fabricius, Martin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Feigin, Valery L / Collaborator ED - Jones, Kelly / Collaborator ED - Ao, Braden Te / Collaborator ED - Theadom, Alice / Collaborator ED - Foks, Kelly / Collaborator ED - Haitsma, Iain / Collaborator ED - Volovici, Victor / Collaborator ED - Furmanov, Alex / Collaborator ED - Rosenthal, Guy / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Gao, Guoyi / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Valeinis, Egils / Collaborator ED - Ziverte, Agate / Collaborator ED - Glocker, Ben / Collaborator ED - Rueckert, Daniel / Collaborator ED - Gratz, Johannes / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Roe, Cecilie / Collaborator ED - Helseth, Eirik / Collaborator ED - Roise, Olav / Collaborator ED - Horton, Lindsay / Collaborator ED - Wilson, Lindsay / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Kolias, Angelos G / Collaborator ED - Jacobs, Bram / Collaborator ED - van der Naalt, Joukje / Collaborator ED - Jankowski, Stefan / Collaborator ED - Kompanje, Erwin / Collaborator ED - Timmers, Marjolein / Collaborator ED - Laureys, Steven / Collaborator ED - Ledoux, Didier / Collaborator ED - Misset, Benoit / Collaborator ED - Lecky, Fiona / Collaborator ED - Olubukola, Otesile / Collaborator ED - Lefering, Rolf / Collaborator ED - Schäfer, Nadine / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Vega, Emmanuel / Collaborator ED - Mattern, Julia / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Maegele, Marc / Collaborator ED - Manara, Alex / Collaborator ED - Thomas, Matt / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Younsi, Alexander / Collaborator ED - McMahon, Catherine / Collaborator ED - Negru, Ancuta / Collaborator ED - Oresic, Matej / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Persona, Paolo / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rossi, Sandra / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sándor, János / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Skandsen, Toril / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Takala, Riikka / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Tenovuo, Olli / Collaborator ED - Tibboel, Dick / Collaborator ED - Tolias, Christos / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van, Hecke Wim / Collaborator ED - Van, Praag Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Wang, Kevin K W / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator TI - Health care utilization and outcomes in older adults after Traumatic Brain Injury : A CENTER-TBI study JF - INJURY: INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED J2 - INJURY VL - 53 PY - 2022 IS - 8 SP - 2774 EP - 2782 PG - 9 SN - 0020-1383 DO - 10.1016/j.injury.2022.05.009 UR - https://m2.mtmt.hu/api/publication/32899084 ID - 32899084 N1 - Funding Agency and Grant Number: CENTER-TBI study Funding text: We are grateful to all patients and investigators who partici-pated in the CENTER-TBI study. AB - The incidence of Traumatic Brain Injury (TBI) is increasingly common in older adults aged ≥65 years, forming a growing public health problem. However, older adults are underrepresented in TBI research. Therefore, we aimed to provide an overview of health-care utilization, and of six-month outcomes after TBI and their determinants in older adults who sustained a TBI.We used data from the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. In-hospital and post-hospital health care utilization and outcomes were described for patients aged ≥65 years. Ordinal and linear regression analyses were performed to identify determinants of the Glasgow Outcome Scale Extended (GOSE), health-related quality of life (HRQoL), and mental health symptoms six-months post-injury.Of 1254 older patients, 45% were admitted to an ICU with a mean length of stay of 9 days. Nearly 30% of the patients received inpatient rehabilitation. In total, 554/1254 older patients completed the six-month follow-up questionnaires. The mortality rate was 9% after mild and 60% after moderate/severe TBI, and full recovery based on GOSE was reported for 44% of patients after mild and 6% after moderate/severe TBI. Higher age and increased injury severity were primarily associated with functional impairment, while pre-injury systemic disease, psychiatric conditions and lower educational level were associated with functional impairment, lower generic and disease-specific HRQoL and mental health symptoms.The rate of impairment and disability following TBI in older adults is substantial, and poorer outcomes across domains are associated with worse preinjury health. Nonetheless, a considerable number of patients fully or partially returns to their preinjury functioning. There should not be pessimism about outcomes in older adults who survive. LA - English DB - MTMT ER - TY - JOUR AU - Sewalt, Charlie Aletta AU - Gravesteijn, Benjamin Yaël AU - Menon, David AU - Lingsma, Hester Floor AU - Maas, Andrew I R AU - Stocchetti, Nino AU - Venema, Esmee AU - Lecky, Fiona E ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Cnossen, Maryse / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, D Jamie / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Corte, Francesco Della / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew I R / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mulazzi, Davide / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Nair, Nandesh / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Noirhomme, Quentin / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Real, Ruben / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Kowark, Ana / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - Vanhaudenhuyse, Audrey / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin K W / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederik A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury : a CENTER TBI study JF - SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION AND EMERGENCY MEDICINE J2 - SCAND J TRAUMA RESUS VL - 29 PY - 2021 IS - 1 PG - 11 SN - 1757-7241 DO - 10.1186/s13049-021-00930-1 UR - https://m2.mtmt.hu/api/publication/32164324 ID - 32164324 N1 - Funding Agency and Grant Number: European Union 7th Framework program (EC Grant) [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA) Funding text: CENTER-TBI was supported by the European Union 7th Framework program (EC Grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA). AB - Prehospital care for patients with traumatic brain injury (TBI) varies with some emergency medical systems recommending direct transport of patients with moderate to severe TBI to hospitals with specialist neurotrauma care (SNCs). The aim of this study is to assess variation in levels of early secondary referral within European SNCs and to compare the outcomes of directly admitted and secondarily transferred patients.Patients with moderate and severe TBI (Glasgow Coma Scale < 13) from the prospective European CENTER-TBI study were included in this study. All participating hospitals were specialist neuroscience centers. First, adjusted between-country differences were analysed using random effects logistic regression where early secondary referral was the dependent variable, and a random intercept for country was included. Second, the adjusted effect of early secondary referral on survival to hospital discharge and functional outcome [6 months Glasgow Outcome Scale Extended (GOSE)] was estimated using logistic and ordinal mixed effects models, respectively.A total of 1347 moderate/severe TBI patients from 53 SNCs in 18 European countries were included. Of these 1347 patients, 195 (14.5%) were admitted after early secondary referral. Secondarily referred moderate/severe TBI patients presented more often with a CT abnormality: mass lesion (52% vs. 34%), midline shift (54% vs. 36%) and acute subdural hematoma (77% vs. 65%). After adjusting for case-mix, there was a large European variation in early secondary referral, with a median OR of 1.69 between countries. Early secondary referral was not associated with functional outcome (adjusted OR 1.07, 95% CI 0.78-1.69), nor with survival at discharge (1.05, 0.58-1.90).Across Europe, substantial practice variation exists in the proportion of secondarily referred TBI patients at SNCs that is not explained by case mix. Within SNCs early secondary referral does not seem to impact functional outcome and survival after stabilisation in a non-specialised hospital. Future research should identify which patients with TBI truly benefit from direct transportation. LA - English DB - MTMT ER - TY - JOUR AU - Gravesteijn, Benjamin Yael AU - Sewalt, Charlie Aletta AU - Nieboer, Daan AU - Menon, David Krishna AU - Maas, Andrew AU - Lecky, Fiona AU - Klimek, Markus AU - Lingsma, Hester Floor ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Clusmann, Hans / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Della Corte, Francesco / Collaborator ED - Boogert, Hugo den / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew I R / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Mikolic, Ana / Collaborator ED - Misset, Benoit / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin K W / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Tracheal intubation in traumatic brain injury : a multicentre prospective observational study JF - BRITISH JOURNAL OF ANAESTHESIA J2 - BRIT J ANAESTH VL - 125 PY - 2020 IS - 4 SP - 505 EP - 517 PG - 13 SN - 0007-0912 DO - 10.1016/j.bja.2020.05.067 UR - https://m2.mtmt.hu/api/publication/31396426 ID - 31396426 N1 - Funding Agency and Grant Number: European Union 7th Framework Program (EC) [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA) Funding text: European Union 7th Framework Program (EC Grant 602150). Additional funding from Hannelore Kohl Stiftung (Germany), OneMind (USA), and Integra LifeSciences Corporation (USA). The funders had no role in the study design, enrolment, collection of data, writing, or publication decisions. AB - We aimed to study the associations between pre- and in-hospital tracheal intubation and outcomes in traumatic brain injury (TBI), and whether the association varied according to injury severity.Data from the international prospective pan-European cohort study, Collaborative European NeuroTrauma Effectiveness Research for TBI (CENTER-TBI), were used (n=4509). For prehospital intubation, we excluded self-presenters. For in-hospital intubation, patients whose tracheas were intubated on-scene were excluded. The association between intubation and outcome was analysed with ordinal regression with adjustment for the International Mission for Prognosis and Analysis of Clinical Trials in TBI variables and extracranial injury. We assessed whether the effect of intubation varied by injury severity by testing the added value of an interaction term with likelihood ratio tests.In the prehospital analysis, 890/3736 (24%) patients had their tracheas intubated at scene. In the in-hospital analysis, 460/2930 (16%) patients had their tracheas intubated in the emergency department. There was no adjusted overall effect on functional outcome of prehospital intubation (odds ratio=1.01; 95% confidence interval, 0.79-1.28; P=0.96), and the adjusted overall effect of in-hospital intubation was not significant (odds ratio=0.86; 95% confidence interval, 0.65-1.13; P=0.28). However, prehospital intubation was associated with better functional outcome in patients with higher thorax and abdominal Abbreviated Injury Scale scores (P=0.009 and P=0.02, respectively), whereas in-hospital intubation was associated with better outcome in patients with lower Glasgow Coma Scale scores (P=0.01): in-hospital intubation was associated with better functional outcome in patients with Glasgow Coma Scale scores of 10 or lower.The benefits and harms of tracheal intubation should be carefully evaluated in patients with TBI to optimise benefit. This study suggests that extracranial injury should influence the decision in the prehospital setting, and level of consciousness in the in-hospital setting.NCT02210221. LA - English DB - MTMT ER - TY - JOUR AU - van Wijk, Roel P J AU - van Dijck, Jeroen T J M AU - Timmers, Marjolein AU - van Veen, Ernest AU - Citerio, Giuseppe AU - Lingsma, Hester F AU - Maas, Andrew I R AU - Menon, David K AU - Peul, Wilco C AU - Stocchetti, Nino AU - Kompanje, Erwin J O ED - Åkerlund, Cecilia / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andelic, Nada / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Audibert, Gérard / Collaborator ED - Azouvi, Philippe / Collaborator ED - Azzolini, Maria Luisa / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Beauvais, Romuald / Collaborator ED - Beer, Ronny / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Benali, Habib / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brinck, Vibeke / Collaborator ED - Brooker, Joanne / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Cabeleira, Manuel / Collaborator ED - Caccioppola, Alessio / Collaborator ED - Calappi, Emiliana / Collaborator ED - Calvi, Maria Rosa / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carbonara, Marco / Collaborator ED - Cavallo, Simona / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Ceyisakar, Iris / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Čović, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Dark, Paul / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Degos, Vincent / Collaborator ED - Corte, Francesco Della / Collaborator ED - den Boogert, Hugo / Collaborator ED - Depreitere, Bart / Collaborator ED - Đilvesi, Đula / Collaborator ED - Dixit, Abhishek / Collaborator ED - Donoghue, Emma / Collaborator ED - Dreier, Jens / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Foks, Kelly / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gantner, Dashiell / Collaborator ED - Gao, Guoyi / Collaborator ED - George, Pradeep / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giga, Lelde / Collaborator ED - Glocker, Ben / Collaborator ED - Golubovic, Jagoš / Collaborator ED - Gomez, Pedro A / Collaborator ED - Gratz, Johannes / Collaborator ED - Gravesteijn, Benjamin / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Haitsma, Iain / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Horton, Lindsay / Collaborator ED - Huijben, Jilske / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Jacobs, Bram / Collaborator ED - Jankowski, Stefan / Collaborator ED - Jarrett, Mike / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Johnson, Faye / Collaborator ED - Jones, Kelly / Collaborator ED - Karan, Mladen / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koraropoulos, Evgenios / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kowark, Ana / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledoux, Didier / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lejeune, Aurelie / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Maas, Andrew I R / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Manara, Alex / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martino, Costanza / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Misset, Benoit / Collaborator ED - Mulazzi, Davide / Collaborator ED - Muraleedharan, Visakh / Collaborator ED - Murray, Lynnette / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Newcombe, Virginia / Collaborator ED - Nieboer, Daan / Collaborator ED - Nyirádi, József / Collaborator ED - Olubukola, Otesile / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Piippo-Karjalainen, Anna / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Posti, Jussi P / Collaborator ED - Puybasset, Louis / Collaborator ED - Radoi, Andreea / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Richter, Sophie / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey V / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rueckert, Daniel / Collaborator ED - Rusnák, Martin / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Schäfer, Nadine / Collaborator ED - Schmidt, Silke / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Sewalt, Charlie / Collaborator ED - Skandsen, Toril / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi Akinrinsola / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Takala, Riikka / Collaborator ED - Tamás, Viktória / Collaborator ED - Tamosuitis, Tomas / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Ao, Braden Te / Collaborator ED - Tenovuo, Olli / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Timmers, Marjolein / Collaborator ED - Tolias, Christos / Collaborator ED - Trapani, Tony / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Vallance, Shirley / Collaborator ED - Valeinis, Egils / Collaborator ED - Vámos, Zoltán / Collaborator ED - Van der Steen, Gregory / Collaborator ED - van der Naalt, Joukje / Collaborator ED - van Dijck, Jeroen T J M / Collaborator ED - van Essen, Thomas A / Collaborator ED - Van Hecke, Wim / Collaborator ED - van Heugten, Caroline / Collaborator ED - Van Praag, Dominique / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - van Wijk, Roel P J / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Velt, Kimberley / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Volovici, Victor / Collaborator ED - von Steinbüchel, Nicole / Collaborator ED - Voormolen, Daphne / Collaborator ED - Vulekovic, Petar / Collaborator ED - Wang, Kevin K W / Collaborator ED - Wiegers, Eveline / Collaborator ED - Williams, Guy / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winzeck, Stefan / Collaborator ED - Wolf, Stefan / Collaborator ED - Yang, Zhihui / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zeiler, Frederick A / Collaborator ED - Zelinkova, Veronika / Collaborator ED - Ziverte, Agate / Collaborator ED - Zoerle, Tommaso / Collaborator TI - Informed consent procedures in patients with an acute inability to provide informed consent. Policy and practice in the CENTER-TBI study TS - Policy and practice in the CENTER-TBI study JF - JOURNAL OF CRITICAL CARE J2 - J CRIT CARE VL - 59 PY - 2020 SP - 6 EP - 15 PG - 10 SN - 0883-9441 DO - 10.1016/j.jcrc.2020.05.004 UR - https://m2.mtmt.hu/api/publication/31336762 ID - 31336762 N1 - Funding Agency and Grant Number: European Union 7th Framework program (EC) [602150]; Hannelore Kohl Stiftung (Germany); OneMind (USA); Integra LifeSciences Corporation (USA); National Institute for Health Research (UK) Funding text: CENTER-TBI was supported by the European Union 7th Framework program (EC grant 602150). Additional funding was obtained from the Hannelore Kohl Stiftung (Germany), from OneMind (USA) and from Integra LifeSciences Corporation (USA). David K. Menon was supported by a Senior Investigator Award from the National Institute for Health Research (UK). AB - Enrolling traumatic brain injury (TBI) patients with an inability to provide informed consent in research is challenging. Alternatives to patient consent are not sufficiently embedded in European and national legislation, which allows procedural variation and bias. We aimed to quantify variations in informed consent policy and practice.Variation was explored in the CENTER-TBI study. Policies were reported by using a questionnaire and national legislation. Data on used informed consent procedures were available for 4498 patients from 57 centres across 17 European countries.Variation in the use of informed consent procedures was found between and within EU member states. Proxy informed consent (N = 1377;64%) was the most frequently used type of consent in the ICU, followed by patient informed consent (N = 426;20%) and deferred consent (N = 334;16%). Deferred consent was only actively used in 15 centres (26%), although it was considered valid in 47 centres (82%).Alternatives to patient consent are essential for TBI research. While there seems to be concordance amongst national legislations, there is regional variability in institutional practices with respect to the use of different informed consent procedures. Variation could be caused by several reasons, including inconsistencies in clear legislation or knowledge of such legislation amongst researchers. LA - English DB - MTMT ER - TY - JOUR AU - Tamás, Viktória AU - Kocsor, Ferenc AU - Gyuris, Petra AU - Kovács, Noémi AU - Czeiter, Endre AU - Büki, András TI - The Young Male Syndrome – an analysis of sex, age, risk taking and mortality in patients with severe traumatic brain injuries JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 10 PY - 2019 PG - 13 SN - 1664-2295 DO - 10.3389/fneur.2019.00366 UR - https://m2.mtmt.hu/api/publication/30609629 ID - 30609629 LA - English DB - MTMT ER - TY - JOUR AU - Tamás, Viktória AU - Kovács, Noémi AU - Vajdáné Tasnádi, Emese TI - Neuropszichológiai rehabilitáció szerzett agysérülést követően JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 71 ET - 0 PY - 2018 IS - 11-12 SP - 367 EP - 374 PG - 8 SN - 0019-1442 DO - 10.18071/isz.71.0367 UR - https://m2.mtmt.hu/api/publication/30365945 ID - 30365945 AB - A neuropszichológiai rehabilitáció vagy rehabilitációs neuropszichológia az alkalmazott neuropszichológia egyik ága. Szemléletmódjában eltér a klinikai és funkcionális neuropszichológiától, habár teljességgel nem különíthető el azoktól. Egyediségét komplexitásán túl individuális, folyamatvezérelt és rendszerszemléletű jellege adja. Magyarországon a neurokognitív rehabilitációt igénylő rehabilitációs intézmények és osztályok száma egyre növekszik ugyan, de számuk még mindig kevésnek mondható, így hazánkban ez a fajta „rehabilitációs megközelítés” viszonylag kevéssé ismert. A szerzők az agysérülést szerzett egyének rehabilitációját és életminőségük javítását hangsúlyozó összefoglaló tanulmányukban a téma rendkívüli fontosságára, az ezzel kapcsolatos elméleti és gyakorlati vonatkozású ismeretekre, valamint a szemléletmódbeli változtatások, feladatok szükségességére kívánják felhívni a figyelmet. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Arnold AU - Környei, Bálint Soma AU - Kovács, Noémi AU - Rostás, Tamás AU - Büki, András AU - Dóczi, Tamás Péter AU - Bogner, Péter AU - Schwarcz, Attila TI - Both hemorrhagic and non-hemorrhagic traumatic MRI lesions are associated with the microstructural damage of the normal appearing white matter. JF - BEHAVIOURAL BRAIN RESEARCH J2 - BEHAV BRAIN RES VL - 340 PY - 2018 SP - 106 EP - 116 PG - 11 SN - 0166-4328 DO - 10.1016/j.bbr.2017.02.039 UR - https://m2.mtmt.hu/api/publication/3196136 ID - 3196136 AB - Traumatic microbleeds (TMBs) and non-hemorrhagic lesions (NHLs) on MRI are regarded as surrogate markers of diffuse axonal injury. However, the actual relation between lesional and diffuse pathology remained unclear, since lesions were related to clinical parameters, -largely influenced by extracranial factors. The aim of this study is to directly compare TMBs, NHLs and their regional features with the co-existing diffuse injury of the normal appearing white matter (NAWM) as measured by diffusion tensor imaging (DTI). Thirty-eight adults with a closed traumatic brain injury (12 mild, 4 moderate and 22 severe) who underwent susceptibility weighted imaging (SWI), T1-, T2 weighted and FLAIR MRI and routine CT were included in the study. TMB (on SWI) and NHL (on T1-, T2 weighted and FLAIR images) features and Rotterdam scores were evaluated. DTI metrics such as fractional anisotropy (FA) and mean diffusivity (MD) were measured over different NAWM regions. Clinical parameters including age; Glasgow Coma Scale; Rotterdam score; TMB and NHL features were correlated to regional NAWM diffusivity using multiple regression. Overall NHL presence and basal ganglia area TMB load was significantly, negatively correlated with the subcortical NAWM FA values (partial r=-0.37 and -0.36; p=0.006 and 0.025, respectively). The presence of any NHL, or TMBs located in the basal ganglia area indicate diffuse NAWM damage even after adjusting for clinical and CT parameters. To estimate DAI, a conventional lesional MRI pathology evaluation might at least in part substitute the use of quantitative DTI, which is yet not widely feasible in a clinical setting. LA - English DB - MTMT ER - TY - JOUR AU - Cnossen, Maryse C AU - Huijben, Jilske A AU - van der Jagt, Mathieu AU - Volovici, Victor AU - van Essen, Thomas AU - Polinder, Suzanne AU - Nelson, David AU - Ercole, Ari AU - Stocchetti, Nino AU - Citerio, Giuseppe AU - Peul, Wilco C AU - Maas, Andrew I R AU - Menon, David AU - Steyerberg, Ewout W AU - Lingsma, Hester F ED - Adams, Hadie / Collaborator ED - Alessandro, Masala / Collaborator ED - Allanson, Judith / Collaborator ED - Amrein, Krisztina / Collaborator ED - Andaluz, Norberto / Collaborator ED - Andelic, Nada / Collaborator ED - Andrea, Nanni / Collaborator ED - Andreassen, Lasse / Collaborator ED - Anke, Audny / Collaborator ED - Antoni, Anna / Collaborator ED - Ardon, Hilko / Collaborator ED - Audibert, Gérard / Collaborator ED - Auslands, Kaspars / Collaborator ED - Azouvi, Philippe / Collaborator ED - Baciu, Camelia / Collaborator ED - Bacon, Andrew / Collaborator ED - Badenes, Rafael / Collaborator ED - Baglin, Trevor / Collaborator ED - Bartels, Ronald / Collaborator ED - Barzó, Pál / Collaborator ED - Bauerfeind, Ursula / Collaborator ED - Beer, Ronny / Collaborator ED - Belda, Francisco Javier / Collaborator ED - Bellander, Bo-Michael / Collaborator ED - Belli, Antonio / Collaborator ED - Bellier, Rémy / Collaborator ED - Benali, Habib / Collaborator ED - Benard, Thierry / Collaborator ED - Berardino, Maurizio / Collaborator ED - Beretta, Luigi / Collaborator ED - Beynon, Christopher / Collaborator ED - Bilotta, Federico / Collaborator ED - Binder, Harald / Collaborator ED - Biqiri, Erta / Collaborator ED - Blaabjerg, Morten / Collaborator ED - Borgen, Lund Stine / Collaborator ED - Bouzat, Pierre / Collaborator ED - Bragge, Peter / Collaborator ED - Brazinova, Alexandra / Collaborator ED - Brehar, Felix / Collaborator ED - Brorsson, Camilla / Collaborator ED - Büki, András / Collaborator ED - Bullinger, Monika / Collaborator ED - Bučková, Veronika / Collaborator ED - Calappi, Emiliana / Collaborator ED - Cameron, Peter / Collaborator ED - Lozano, Guillermo Carbayo / Collaborator ED - Carise, Elsa / Collaborator ED - Carpenter, K / Collaborator ED - Castaño-León, Ana M / Collaborator ED - Causin, Francesco / Collaborator ED - Chevallard, Giorgio / Collaborator ED - Chieregato, Arturo / Collaborator ED - Citerio, Giuseppe / Collaborator ED - Cnossen, Maryse / Collaborator ED - Coburn, Mark / Collaborator ED - Coles, Jonathan / Collaborator ED - Cooper, Jamie D / Collaborator ED - Correia, Marta / Collaborator ED - Covic, Amra / Collaborator ED - Curry, Nicola / Collaborator ED - Czeiter, Endre / Collaborator ED - Czosnyka, Marek / Collaborator ED - Dahyot-Fizelier, Claire / Collaborator ED - Damas, François / Collaborator ED - Damas, Pierre / Collaborator ED - Dawes, Helen / Collaborator ED - De Keyser, Véronique / Collaborator ED - Corte, Francesco Della / Collaborator ED - Depreitere, Bart / Collaborator ED - Ding, Shenghao / Collaborator ED - Dippel, Diederik / Collaborator ED - Dizdarevic, Kemal / Collaborator ED - Dulière, Guy-Loup / Collaborator ED - Dzeko, Adelaida / Collaborator ED - Eapen, George / Collaborator ED - Engemann, Heiko / Collaborator ED - Ercole, Ari / Collaborator ED - Esser, Patrick / Collaborator ED - Ezer, Erzsébet / Collaborator ED - Fabricius, Martin / Collaborator ED - Feigin, Valery L / Collaborator ED - Feng, Junfeng / Collaborator ED - Foks, Kelly / Collaborator ED - Fossi, Francesca / Collaborator ED - Francony, Gilles / Collaborator ED - Frantzén, Janek / Collaborator ED - Freo, Ulderico / Collaborator ED - Frisvold, Shirin / Collaborator ED - Furmanov, Alex / Collaborator ED - Gagliardo, Pablo / Collaborator ED - Galanaud, Damien / Collaborator ED - Gao, Guoyi / Collaborator ED - Geleijns, Karin / Collaborator ED - Ghuysen, Alexandre / Collaborator ED - Giraud, Benoit / Collaborator ED - Glocker, Ben / Collaborator ED - Gomez, Pedro A / Collaborator ED - Grossi, Francesca / Collaborator ED - Gruen, Russell L / Collaborator ED - Gupta, Deepak / Collaborator ED - Haagsma, Juanita A / Collaborator ED - Hadzic, Ermin / Collaborator ED - Haitsma, Iain / Collaborator ED - Hartings, Jed A / Collaborator ED - Helbok, Raimund / Collaborator ED - Helseth, Eirik / Collaborator ED - Hertle, Daniel / Collaborator ED - Hill, Sean / Collaborator ED - Hoedemaekers, Astrid / Collaborator ED - Hoefer, Stefan / Collaborator ED - Hutchinson, Peter J / Collaborator ED - Håberg, Asta Kristine / Collaborator ED - Jacobs, Bram / Collaborator ED - Janciak, Ivan / Collaborator ED - Janssens, Koen / Collaborator ED - Jiang, Ji-Yao / Collaborator ED - Jones, Kelly / Collaborator ED - Kalala, Jean-Pierre / Collaborator ED - Kamnitsas, Konstantinos / Collaborator ED - Karan, Mladen / Collaborator ED - Karau, Jana / Collaborator ED - Katila, Ari / Collaborator ED - Kaukonen, Maija / Collaborator ED - Keeling, David / Collaborator ED - Kerforne, Thomas / Collaborator ED - Ketharanathan, Naomi / Collaborator ED - Kettunen, Johannes / Collaborator ED - Kivisaari, Riku / Collaborator ED - Kolias, Angelos G / Collaborator ED - Kolumbán, Bálint / Collaborator ED - Kompanje, Erwin / Collaborator ED - Kondziella, Daniel / Collaborator ED - Koskinen, Lars-Owe / Collaborator ED - Kovács, Noémi / Collaborator ED - Kálovits, Ferenc / Collaborator ED - Lagares, Alfonso / Collaborator ED - Lanyon, Linda / Collaborator ED - Laureys, Steven / Collaborator ED - Lauritzen, Martin / Collaborator ED - Lecky, Fiona / Collaborator ED - Ledig, Christian / Collaborator ED - Lefering, Rolf / Collaborator ED - Legrand, Valerie / Collaborator ED - Lei, Jin / Collaborator ED - Levi, Leon / Collaborator ED - Lightfoot, Roger / Collaborator ED - Lingsma, Hester / Collaborator ED - Loeckx, Dirk / Collaborator ED - Lozano, Angels / Collaborator ED - Luddington, Roger / Collaborator ED - Luijten-Arts, Chantal / Collaborator ED - Andrew, I R Maas / Collaborator ED - MacDonald, Stephen / Collaborator ED - MacFayden, Charles / Collaborator ED - Maegele, Marc / Collaborator ED - Majdan, Marek / Collaborator ED - Major, Sebastian / Collaborator ED - Manara, Alex / Collaborator ED - Manhes, Pauline / Collaborator ED - Manley, Geoffrey / Collaborator ED - Martin, Didier / Collaborator ED - Martino, Costanza / Collaborator ED - Maruenda, Armando / Collaborator ED - Maréchal, Hugues / Collaborator ED - Mastelova, Dagmara / Collaborator ED - Mattern, Julia / Collaborator ED - McMahon, Catherine / Collaborator ED - Melegh, Béla / Collaborator ED - Menon, David / Collaborator ED - Menovsky, Tomas / Collaborator ED - Morganti-Kossmann, Cristina / Collaborator ED - Mulazzi, Davide / Collaborator ED - Mutschler, Manuel / Collaborator ED - Mühlan, Holger / Collaborator ED - Negru, Ancuta / Collaborator ED - Nelson, David / Collaborator ED - Neugebauer, Eddy / Collaborator ED - Newcombe, Virginia / Collaborator ED - Noirhomme, Quentin / Collaborator ED - Nyirádi, József / Collaborator ED - Oddo, Mauro / Collaborator ED - Oldenbeuving, Annemarie / Collaborator ED - Oresic, Matej / Collaborator ED - Ortolano, Fabrizio / Collaborator ED - Palotie, Aarno / Collaborator ED - Parizel, Paul M / Collaborator ED - Patruno, Adriana / Collaborator ED - Payen, Jean-François / Collaborator ED - Perera, Natascha / Collaborator ED - Perlbarg, Vincent / Collaborator ED - Persona, Paolo / Collaborator ED - Peul, Wilco / Collaborator ED - Pichon, Nicolas / Collaborator ED - Piilgaard, Henning / Collaborator ED - Piippo, Anna / Collaborator ED - Floury, Sébastien Pili / Collaborator ED - Pirinen, Matti / Collaborator ED - Ples, Horia / Collaborator ED - Polinder, Suzanne / Collaborator ED - Pomposo, Inigo / Collaborator ED - Psota, Marek / Collaborator ED - Pullens, Pim / Collaborator ED - Puybasset, Louis / Collaborator ED - Ragauskas, Arminas / Collaborator ED - Raj, Rahul / Collaborator ED - Rambadagalla, Malinka / Collaborator ED - Rehorčíková, Veronika / Collaborator ED - Rhodes, Jonathan / Collaborator ED - Richardson, Sylvia / Collaborator ED - Ripatti, Samuli / Collaborator ED - Rocka, Saulius / Collaborator ED - Rodier, Nicolas / Collaborator ED - Roe, Cecilie / Collaborator ED - Roise, Olav / Collaborator ED - Roks, Gerwin / Collaborator ED - Romegoux, Pauline / Collaborator ED - Rosand, Jonathan / Collaborator ED - Rosenfeld, Jeffrey / Collaborator ED - Rosenlund, Christina / Collaborator ED - Rosenthal, Guy / Collaborator ED - Rossaint, Rolf / Collaborator ED - Rossi, Sandra / Collaborator ED - Rostalski, Tim / Collaborator ED - Rueckert, Daniel / Collaborator ED - de Arcaute, Felix Ruiz / Collaborator ED - Rusnák, Martin / Collaborator ED - Sacchi, Marco / Collaborator ED - Sahakian, Barbara / Collaborator ED - Sahuquillo, Juan / Collaborator ED - Sakowitz, Oliver / Collaborator ED - Sala, Francesca / Collaborator ED - Sanchez-Pena, Paola / Collaborator ED - Sanchez-Porras, Renan / Collaborator ED - Sándor, János / Collaborator ED - Santos, Edgar / Collaborator ED - Sasse, Nadine / Collaborator ED - Sasu, Luminita / Collaborator ED - Savo, Davide / Collaborator ED - Schipper, Inger / Collaborator ED - Schlößer, Barbara / Collaborator ED - Schmidt, Silke / Collaborator ED - Schneider, Annette / Collaborator ED - Schoechl, Herbert / Collaborator ED - Schoonman, Guus / Collaborator ED - Schou, Rico Frederik / Collaborator ED - Schwendenwein, Elisabeth / Collaborator ED - Schöll, Michael / Collaborator ED - Sir, Özcan / Collaborator ED - Skandsen, Toril / Collaborator ED - Smakman, Lidwien / Collaborator ED - Smeets, Dirk / Collaborator ED - Smielewski, Peter / Collaborator ED - Sorinola, Abayomi / Collaborator ED - Stamatakis, Emmanuel / Collaborator ED - Stanworth, Simon / Collaborator ED - Stegemann, Katrin / Collaborator ED - Steinbüchel, Nicole / Collaborator ED - Stevens, Robert / Collaborator ED - Stewart, William / Collaborator ED - Steyerberg, Ewout W / Collaborator ED - Stocchetti, Nino / Collaborator ED - Sundström, Nina / Collaborator ED - Synnot, Anneliese / Collaborator ED - Szabó, József / Collaborator ED - Söderberg, Jeannette / Collaborator ED - Taccone, Fabio Silvio / Collaborator ED - Tamás, Viktória / Collaborator ED - Tanskanen, Päivi / Collaborator ED - Tascu, Alexandru / Collaborator ED - Taylor, Mark Steven / Collaborator ED - Te Ao, Braden / Collaborator ED - Tenovuo, Olli / Collaborator ED - Teodorani, Guido / Collaborator ED - Theadom, Alice / Collaborator ED - Thomas, Matt / Collaborator ED - Tibboel, Dick / Collaborator ED - Tolias, Christos / Collaborator ED - Tshibanda, Jean-Flory Luaba / Collaborator ED - Tudora, Cristina Maria / Collaborator ED - Vajkoczy, Peter / Collaborator ED - Valeinis, Egils / Collaborator ED - Van Hecke, Wim / Collaborator ED - Van Praag, Dominique / Collaborator ED - Van Roost, Dirk / Collaborator ED - Van Vlierberghe, Eline / Collaborator ED - Vyvere, Thijs Vande / Collaborator ED - Vanhaudenhuyse, Audrey / Collaborator ED - Vargiolu, Alessia / Collaborator ED - Vega, Emmanuel / Collaborator ED - Verheyden, Jan / Collaborator ED - Vespa, Paul M / Collaborator ED - Vik, Anne / Collaborator ED - Vilcinis, Rimantas / Collaborator ED - Vizzino, Giacinta / Collaborator ED - Vleggeert-Lankamp, Carmen / Collaborator ED - Volovici, Victor / Collaborator ED - Vulekovic, Peter / Collaborator ED - Vámos, Zoltán / Collaborator ED - Wade, Derick / Collaborator ED - Wang, Kevin K W / Collaborator ED - Wang, Lei / Collaborator ED - Wildschut, Eno / Collaborator ED - Williams, Guy / Collaborator ED - Willumsen, Lisette / Collaborator ED - Wilson, Adam / Collaborator ED - Wilson, Lindsay / Collaborator ED - Winkler, Maren K L / Collaborator ED - Ylén, Peter / Collaborator ED - Younsi, Alexander / Collaborator ED - Zaaroor, Menashe / Collaborator ED - Zhang, Zhiqun / Collaborator ED - Zheng, Zelong / Collaborator ED - Zumbo, Fabrizio / Collaborator ED - de Lange, Stefanie / Collaborator ED - de Ruiter, Godard C W / Collaborator ED - den Boogert, Hugo / Collaborator ED - van Dijck, Jeroen / Collaborator ED - van Essen, Thomas A / Collaborator ED - van Heugten, Caroline / Collaborator ED - van der Jagt, Mathieu / Collaborator ED - van der Naalt, Joukje / Collaborator TI - Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study JF - CRITICAL CARE J2 - CRIT CARE VL - 21 PY - 2017 IS - 1 SN - 1364-8535 DO - 10.1186/s13054-017-1816-9 UR - https://m2.mtmt.hu/api/publication/31296468 ID - 31296468 N1 - Journal Article; Observational Study Division of Neurosurgery, Department of Clinical Neurosciences, Addenbrooke's Hospital and University of Cambridge, Cambridge, United Kingdom Department of Anesthesia and Intensive Care, M. Bufalini Hospital, Cesena, Italy Department of Clinical Neurosciences, Addenbrooke's Hospital and University of Cambridge, Cambridge, United Kingdom János Szentágothai Research Centre, University of Pécs, Pécs, Hungary University of Cincinnati, Cincinnati, OH, United States Division of Surgery and Clinical Neuroscience, Department of Physical Medicine and Rehabilitation, Oslo University Hospital and University of Oslo, Oslo, Norway Department of Neurosurgery, University Hospital of Northern Norway, Tromsø, Norway Department of Physical Medicine and Rehabilitation, University Hospital of Northern Norway, Tromsø, Norway Trauma Surgery, Medical University Vienna, Vienna, Austria Department of Neurosurgery, Elisabeth-Tweesteden Ziekenhuis, Tilburg, Netherlands Department of Anesthesiology and Intensive Care, University Hospital Nancy, Nancy, France Riga Eastern Clinical University Hospital, Riga, Latvia Raymond Poincare Hospital, Assistance Publique - Hopitaux de Paris, Paris, France Neurointensive Care, Niguarda Hospital, Milan, Italy Neurointensive Care, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom Department of Anesthesiology and Surgical-Trauma Intensive Care, Hospital Clinic Universitari de Valencia, Valencia, Spain Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom Department of Neurosurgery, Radboud University Medical Center, Nijmegen, Netherlands Department of Neurosurgery, University of Szeged, Szeged, Hungary Institute for Transfusion Medicine (ITM), Witten/Herdecke University, Cologne, Germany Department of Neurocritical Care, Innsbruck Medical University, Innsbruck, Austria Department of Neurosurgery and Anesthesia and Intensive Care Medicine, Karolinska University Hospital, Stockholm, Sweden NIHR Surgical Reconstruction and Microbiology Research Centre, Birmingham, United Kingdom Intensive Care Unit, CHU Poitiers, Poitiers, France Anesthesie-Réanimation, Assistance Publique - Hopitaux de Paris, Paris, France Department of Anesthesia and ICU, AOU Città della Salute e della Scienza di Torino - Orthopedic and Trauma Center, Torino, Italy Department of Anesthesiology and Intensive Care, S. Raffaele University Hospital, Milan, Italy Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany Department of Neurology, Odense University Hospital, Odense, Denmark Departments of Neuroscience and Nursing Science, Norwegian University of Science and Technology, Trondheim, Norway Department of Anesthesiology and Intensive Care, University Hospital of Grenoble, Grenoble, France BehaviourWorks Australia, Monash Sustainable Development Institute, Monash University, Clayton, Australia Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia Department of Neurosurgery, Bagdasar-Arseni Emergency Clinical Hospital, Bucharest, Romania Department of Neurosurgery, Umeå University Hospital, Umeå, Sweden Department of Neurosurgery, Univ. of Pecs and MTA-PTE Clinical Neuroscience MR Research Group Janos Szentagothai Research Centre, University of Pecs, and Hungarian Brain Research Program, Pecs, Hungary Department of Medical Psychology, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany Neuro-ICU, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia Department of Neurosurgery, Hospital of Cruces, Bilbao, Spain Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, Netherlands Department of Neurosurgery, Hospital Universitario 12 de Octubre, Madrid, Spain Department of Neuroscience, Azienda Ospedaliera Università di Padova, Padua, Italy Neurointensive Care, Azienda Ospedaliera San Gerardo di Monza, Monza, Italy School of Medicine and Surgery, Università Milano Bicocca, Milan, Italy Department of Public Health, Erasmus Medical Center-University Medical Center, Rotterdam, Netherlands Department of Anaesthesiology, University Hospital of Aachen, Aachen, Germany Department of Anesthesia and Neurointensive Care, Cambridge University Hospital NHS Foundation Trust, Cambridge, United Kingdom School of Public Health and Preventive Medicine, Monash University and The Alfred Hospital, Melbourne, Australia Radiology/MRI Department, MRC Cognition and Brain Sciences Unit, Cambridge, United Kingdom Institute of Medical Psychology and Medical Sociology, Universitätsmedizin Göttingen, Göttingen, Germany Oxford University Hospitals NHS Trust, Oxford, United Kingdom Department of Neurosurgery, Univ. of Pecs and MTA-PTE Clinical Neuroscience MR Research Group Janos Szentagothai Research Centre, University of Pecs, and Hungarian Brain Research Program (grant KTIA 13 NAP-A-II/8), Pecs, Hungary Brain Physics Lab, Division of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom Intensive Care Unit, CHR Citadelle, Liège, Belgium Intensive Care Unit, CHU de Liège, Liège, Belgium Movement Science Group, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, United Kingdom Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium Department of Anesthesia and Intensive Care, Maggiore Della Carità Hospital, Novara, Italy Department of Neurosurgery, University Hospitals Leuven, Leuven, Belgium Department of Neurosurgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands Department of Neurosurgery, Medical Faculty and Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegovina Department of Neurosurgery, Regional Medical Center dr Safet Mujic, Mostar, Bosnia and Herzegovina Division of Anaesthesia, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom Department of Anaesthesiology and Intensive Therapy, University of Pécs, Pécs, Hungary Departments of Neurology, Clinical Neurophysiology and Neuroanesthesiology, Region Hovedstaden Rigshospitalet, Copenhagen, Denmark National Institute for Stroke and Applied Neurosciences, Faculty of Health and Environmental Studies, Auckland University of Technology, Auckland, New Zealand Rehabilitation and Brain Trauma, Turku University Central Hospital and University of Turku, Turku, Finland Department of Medicine, Azienda Ospedaliera Università di Padova, Padua, Italy Department of Anesthesiology and Intensive Care, University Hospital of Northern Norway, Tromsø, Norway Department of Neurosurgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel Fundación Instituto Valenciano de Neurorrehabilitación (FIVAN), Valencia, Spain Department of Neurosurgery, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Emergency Department, CHU de Liège, Liège, Belgium Department of Computing, Imperial College London, London, United Kingdom Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Monash University, Clayton, Australia Department of Neurosurgery, Neurosciences Centre and JPN Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India Department of Neurosurgery, Erasmus Medical Center, Rotterdam, Netherlands Department of Neurosurgery, University of Cincinnati, Cincinnati, OH, United States Department of Neurosurgery, Oslo University Hospital, Oslo, Norway Department of Physiology and Pharmacology, Section of Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands Department of Medical Imaging, St. Olavs Hospital, and Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway Department of Neurology, University Medical Center Groningen, Groningen, Netherlands International Neurotrauma Research Organisation, Vienna, Austria National Institute for Stroke and Applied Neurosciences, Auckland University of Technology, Auckland, New Zealand Department of Neurosurgery, University Hospital Ghent, Ghent, Belgium Department of Neurosurgery, Clinical Centre of Vojvodina, Novi Sad, Serbia Helsinki University Central Hospital, Helsinki, Finland Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland Hungarian Brain Research Program (grant KTIA 13 NAP-A-II/8), University of Pécs, Pécs, Hungary Department of Intensive Care and Department of Ethics and Philosophy of Medicine, Erasmus Medical Center, Rotterdam, Netherlands Department of Neurological and Spinal Surgery, Markusovszky University Teaching Hospital, Szombathely, Hungary Cyclotron Research Center, University of Liège, Liège, Belgium Emergency Medicine Research in Sheffield, Health Services Research Section, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, United Kingdom Institute of Research in Operative Medicine (IFOM), Witten/Herdecke University, Cologne, Germany VP Global Project Management, Central Nervous System, ICON plc, Paris, France Department of Neurosurgery, Rambam Medical Center, Haifa, Israel Department of Anesthesiology and Intensive Care, University Hospitals Southhampton NHS Trust, Southhampton, United Kingdom IcoMetrix NV, Leuven, Belgium Cologne-Merheim Medical Center (CMMC), Department of Traumatology, Orthopedic Surgery and Sports Medicine, Witten/Herdecke University, Cologne, Germany Centrum für Schlaganfallforschung, Charité - Universitätsmedizin Berlin, Berlin, Germany Intensive Care Unit, Southmead Hospital Bristol, Bristol, United Kingdom Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States Department of Neurosurgery, CHU de Liège, Liège, Belgium Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, United Kingdom Department of Medical Genetics, University of Pécs, Pécs, Hungary National Trauma Research Institute, The Alfred Hospital, Monash University, Melbourne, Australia Department Health and Prevention, University Greifswald, Greifswald, Germany Department of Neurosurgery, Emergency County Hospital Timisoara, Timisoara, Romania Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland Department of Intensive Care, Elisabeth-Tweesteden Ziekenhuis, Tilburg, Netherlands Department of Systems Medicine, Steno Diabetes Center, Gentofte, Denmark Department of Medicine, Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Analytic and Translational Genetics Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, United States Program in Medical and Population Genetics, The Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, MA, United States Department of Radiology, Antwerp University Hospital and University of Antwerp, Edegem, Belgium Neurointenisve Care Unit, Department of Anesthesia and Intensive Care, Azienda Ospedaliera San Gerardo di Monza, Monza, Italy International Projects Management, ARTTIC, Munich, Germany Department of Anesthesia and Intensive Care, Azienda Ospedaliera Università di Padova, Padua, Italy Intensive Care Unit, CHU Dupuytren, Limoges, France Intensive Care Unit, CHRU de Besançon, Besançon, France Department of Anesthesiology and Critical Care, Pitié-Salpêtrière Teaching Hospital, Assistance Publique - Hôpitaux de Paris and University Pierre et Marie Curie, Paris, France Department of Neurosurgery, Kaunas University of Technology and Vilnius University, Vilnius, Lithuania Rezekne Hospital, Rezekne, Latvia Department of Anaesthesia, Critical Care and Pain Medicine, NHS Lothian and University of Edinburgh, Edinburgh, United Kingdom MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, United Kingdom Department of Physical Medicine and Rehabilitation, Oslo University Hospital/University of Oslo, Oslo, Norway Division of Surgery and Clinical Neuroscience, Oslo University Hospital, Oslo, Norway Department of Neurology, Elisabeth-TweeSteden Ziekenhuis, Tilburg, Netherlands The Broad Institute of MIT and Harvard, Cambridge, MA, United States Department of Neurosurgery, Odense University Hospital, Odense, Denmark Department of Neurosurgery, Vall d'Hebron University Hospital, Barcelona, Spain Klinik für Neurochirurgie, Klinikum Ludwigsburg, Ludwigsburg, Germany University Hospital Heidelberg, Heidelberg, Germany Division of Biostatistics and Epidemiology, Department of Preventive Medicine, University of Debrecen, Debrecen, Hungary Department of Trauma Surgery, Leiden University Medical Center, Leiden, Netherlands Department of Anaesthesiology and Intensive Care, AUVA Trauma Hospital, Salzburg, Austria Department of Neuroanesthesia and Neurointensive Care, Odense University Hospital, Odense, Denmark Department of Emergency Care Medicine, Radboud University Medical Center, Nijmegen, Netherlands Department of Physical Medicine and Rehabilitation, St. Olavs Hospital and Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway Neurosurgical Cooperative Holland, Department of Neurosurgery, Leiden University Medical Center and Medical Center Haaglanden, Leiden and The Hague, Netherlands Department of Neurosurgery, University of Pécs, Pécs, Hungary Universitätsmedizin Göttingen, Göttingen, Germany Division of Neurosciences Critical Care, John Hopkins University School of Medicine, Baltimore, MD, United States Department of Neuropathology, Queen Elizabeth University Hospital and University of Glasgow, Glasgow, United Kingdom Australian and New Zealand Intensive Care Research Centre, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia Cochrane Consumers and Communication Review Group, Centre for Health Communication and Participation, School of Psychology and Public Health, La Trobe University, Melbourne, Australia Department of Rehabilitation, M. Bufalini Hospital, Cesena, Italy Department of Neurosurgery, King's College London, London, United Kingdom Radiology/MRI Department, CHU de Liège, Liège, Belgium Neurologie, Neurochirurgie und Psychiatrie, Charité - Universitätsmedizin Berlin, Berlin, Germany Pauls Stradinš Clinical University Hospital, Riga, Latvia Department of Anesthesiology-Intensive Care, Lille University Hospital, Lille, France University of California, Los Angeles, Los Angeles, CA, United States Department of Neurosurgery, St. Olavs Hospital, and Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway Department of Neurosurgery, Kaunas University of Health Sciences, Kaunas, Lithuania Department of Psychiatry, University of Florida, Gainesville, FL, United States Division of Psychology, University of Stirling, Stirling, United Kingdom VTT Technical Research Centre, Tampere, Finland University of Florida, Gainesville, FL, United States Department of Neurosurgery, The HAGA Hospital, The Hague, Netherlands Center for Medical Decision Making, Department of Public Health, Erasmus MC, Rotterdam, Netherlands Department of Intensive Care, Erasmus MC, Rotterdam, Netherlands Department of Neurosurgery, Erasmus MC, Rotterdam, Netherlands Leiden University Medical Center, Department of Neurosurgery, Leiden, Netherlands Department of Physiology and Pharmacology, Section of Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden University of Cambridge, Addenbrooke's Hospital, Division of Anesthesia, Cambridge, United Kingdom University of Milan, Department of Pathophysiology and Transplants, Milan, Italy Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Department of Anesthesia and Critical Care, Neuroscience Intensive Care Unit, Milan, Italy University of Milano Bicocca, School of Medicine and Surgery, Milan, Italy Neurointensive Care Unit, San Gerardo Hospital, ASST-Monza, Monza, Italy Department of Neurosurgery, Haaglanden Medical Center, The Hague, Netherlands Antwerp University Hospital and University of Antwerp, Department of Neurosurgery, Edegem, Belgium Leiden University Medical Center, Department of Medical Statistics and Bioinformatics, Leiden, Netherlands Cited By :27 Export Date: 8 June 2020 CODEN: CRCAF Correspondence Address: Cnossen, M.C.; Center for Medical Decision Making, Department of Public Health, Erasmus MCNetherlands; email: m.c.cnossen@erasmusmc.nl Chemicals/CAS: fentanyl, 437-38-7; mannitol, 69-65-8, 87-78-5; morphine, 52-26-6, 57-27-2; propofol, 2078-54-8 Funding details: Hersenstichting Funding text 1: Data used in the preparation of this article were obtained in the context of CENTER-TBI, a large collaborative project with the support of the European Commission Seventh Framework program (602150). In addition, TvE and WCP were supported by a grant from the Dutch Brain Foundation (Hersenstichting Nederland) for the Neurotraumatology Quality Registry (Net-QuRe) study. AB - No definitive evidence exists on how intracranial hypertension should be treated in patients with traumatic brain injury (TBI). It is therefore likely that centers and practitioners individually balance potential benefits and risks of different intracranial pressure (ICP) management strategies, resulting in practice variation. The aim of this study was to examine variation in monitoring and treatment policies for intracranial hypertension in patients with TBI.A 29-item survey on ICP monitoring and treatment was developed on the basis of literature and expert opinion, and it was pilot-tested in 16 centers. The questionnaire was sent to 68 neurotrauma centers participating in the Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study.The survey was completed by 66 centers (97% response rate). Centers were mainly academic hospitals (n = 60, 91%) and designated level I trauma centers (n = 44, 67%). The Brain Trauma Foundation guidelines were used in 49 (74%) centers. Approximately 90% of the participants (n = 58) indicated placing an ICP monitor in patients with severe TBI and computed tomographic abnormalities. There was no consensus on other indications or on peri-insertion precautions. We found wide variation in the use of first- and second-tier treatments for elevated ICP. Approximately half of the centers were classified as using a relatively aggressive approach to ICP monitoring and treatment (n = 32, 48%), whereas the others were considered more conservative (n = 34, 52%).Substantial variation was found regarding monitoring and treatment policies in patients with TBI and intracranial hypertension. The results of this survey indicate a lack of consensus between European neurotrauma centers and provide an opportunity and necessity for comparative effectiveness research. LA - English DB - MTMT ER -