@article{MTMT:34521154,
	title = {Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)},
	url = {https://m2.mtmt.hu/api/publication/34521154},
	author = {Picetti, Edoardo and Demetriades, Andreas K. and Catena, Fausto and Aarabi, Bizhan and Abu-Zidan, Fikri M. and Alves, Oscar L. and Ansaloni, Luca and Armonda, Rocco A. and Badenes, Rafael and Bala, Miklosh and Balogh, Zsolt J. and Barbanera, Andrea and Bertuccio, Alessandro and Biffl, Walter L. and Bouzat, Pierre and Buki, Andras and Castano-Leon, Ana Maria and Cerasti, Davide and Citerio, Giuseppe and Coccolini, Federico and Coimbra, Raul and Coniglio, Carlo and Costa, Francesco and De Iure, Federico and Depreitere, Bart and Fainardi, Enrico and Fehlings, Michael J. and Gabrovsky, Nikolay and Godoy, Daniel Agustin and Gruen, Peter and Gupta, Deepak and Hawryluk, Gregory W. J. and Helbok, Raimund and Hossain, Iftakher and Hutchinson, Peter J. and Iaccarino, Corrado and Inaba, Kenji and Ivanov, Marcel and Kaprovoy, Stanislav and Kirkpatrick, Andrew W. and Klein, Sam and Kolias, Angelos and Konovalov, Nikolay A. and Lagares, Alfonso and Lippa, Laura and Loza-Gomez, Angelica and Luoto, Teemu M. and Maas, Andrew I. R. and Maciejczak, Andrzej and Maier, Ronald V. and Marklund, Niklas and Martin, Matthew J. and Melloni, Ilaria and Mendoza-Lattes, Sergio and Meyfroidt, Geert and Munari, Marina and Napolitano, Lena M. and Okonkwo, David O. and Otomo, Yasuhiro and Papadopoulos, Marios C. and Petr, Ondra and Peul, Wilco C. and Pudkrong, Aichholz K. and Qasim, Zaffer and Rasulo, Frank and Reizinho, Carla and Ringel, Florian and Rizoli, Sandro and Rostami, Elham and Rubiano, Andres M. and Russo, Emanuele and Sarwal, Aarti and Schwab, Jan M. and Servadei, Franco and Sharma, Deepak and Sharif, Salman and Shiban, Ehab and Shutter, Lori and Stahel, Philip F. and Taccone, Fabio S. and Terpolilli, Nicole A. and Thomé, Claudius and Tóth, Péter József and Tsitsopoulos, Parmenion P. and Udy, Andrew and Vaccaro, Alexander R. and Varon, Albert J. and Vavilala, Monica S. and Younsi, Alexander and Zackova, Monika and Zoerle, Tommaso and Robba, Chiara},
	doi = {10.1186/s13017-023-00525-4},
	journal-iso = {WJES},
	journal = {WORLD JOURNAL OF EMERGENCY SURGERY},
	volume = {19},
	unique-id = {34521154},
	issn = {1749-7922},
	abstract = {Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician’s decision making in the management of tSCI polytrauma patients. © 2024, The Author(s).},
	keywords = {Adult; Humans; human; MANAGEMENT; Consensus; Complication},
	year = {2024},
	eissn = {1749-7922}
}

@article{MTMT:34477401,
	title = {Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction},
	url = {https://m2.mtmt.hu/api/publication/34477401},
	author = {Mukli, Péter and Pinto, Camila B and Owens, Cameron D and Csípő, Tamás and Lipécz, Ágnes and Szarvas, Zsófia and Péterfi, Anna and Langley, Ana Clara da Costa Pinaffi and Hoffmeister, Jordan and Rácz, Frigyes Sámuel and Perry, Jonathan W and Tarantini, Stefano and Nyúl-Tóth, Ádám and Sorond, Farzaneh A and Yang, Yuan and James, Judith A and Kirkpatrick, Angelia C and Prodan, Calin I and Tóth, Péter József and Galindo, Juliette and Gardner, Andrew W and Sonntag, William E and Csiszar, Anna and Ungvári, Zoltán István and Yabluchanskiy, Andriy},
	doi = {10.1002/advs.202303516},
	journal-iso = {ADV SCI},
	journal = {ADVANCED SCIENCE},
	volume = {11},
	unique-id = {34477401},
	abstract = {Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load.},
	keywords = {Aging; cognitive decline; functional connectivity; Neurovascular coupling; functional near-infrared spectroscopy},
	year = {2024},
	eissn = {2198-3844},
	orcid-numbers = {Mukli, Péter/0000-0003-4355-8103; Szarvas, Zsófia/0000-0002-0022-5053; Rácz, Frigyes Sámuel/0000-0001-9077-498X; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34415989,
	title = {Preventing spontaneous cerebral microhemorrhages in aging mice : a novel approach targeting cellular senescence with ABT263/navitoclax},
	url = {https://m2.mtmt.hu/api/publication/34415989},
	author = {Faakye, Janet and Nyúl-Tóth, Ádám and Murányi, Mihály and Gulej, Rafal and Csik, Boglarka and Shanmugarama, Santny and Tarantini, Stefano and Negri, Sharon and Prodan, Calin and Mukli, Peter and Yabluchanskiy, Andriy and Conley, Shannon and Tóth, Péter József and Csiszar, Anna and Ungvári, Zoltán István},
	doi = {10.1007/s11357-023-01024-9},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {46},
	unique-id = {34415989},
	issn = {2509-2715},
	abstract = {Emerging evidence from both clinical and preclinical studies underscores the role of aging in potentiating the detrimental effects of hypertension on cerebral microhemorrhages (CMHs, or cerebral microbleeds). CMHs progressively impair neuronal function and contribute to the development of vascular cognitive impairment and dementia. There is growing evidence showing accumulation of senescent cells within the cerebral microvasculature during aging, which detrimentally affects cerebromicrovascular function and overall brain health. We postulated that this build-up of senescent cells renders the aged cerebral microvasculature more vulnerable, and consequently, more susceptible to CMHs. To investigate the role of cellular senescence in CMHs' pathogenesis, we subjected aged mice, both with and without pre-treatment with the senolytic agent ABT263/Navitoclax, and young control mice to hypertension via angiotensin-II and L-NAME administration. The aged cohort exhibited a markedly earlier onset, heightened incidence, and exacerbated neurological consequences of CMHs compared to their younger counterparts. This was evidenced through neurological examinations, gait analysis, and histological assessments of CMHs in brain sections. Notably, the senolytic pre-treatment wielded considerable cerebromicrovascular protection, effectively delaying the onset, mitigating the incidence, and diminishing the severity of CMHs. These findings hint at the potential of senolytic interventions as a viable therapeutic avenue to preempt or alleviate the consequences of CMHs linked to aging, by counteracting the deleterious effects of senescence on brain microvasculature.},
	keywords = {HYPERTENSION; CAPILLARY; cellular senescence; Cerebral microcirculation; ABT263/Navitoclax; Senolytic therapy},
	year = {2024},
	eissn = {2509-2723},
	pages = {21-37},
	orcid-numbers = {Murányi, Mihály/0000-0002-7888-9749; Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34392087,
	title = {Mild traumatic brain injury-induced persistent blood–brain barrier disruption is prevented by cyclosporine A treatment in hypertension},
	url = {https://m2.mtmt.hu/api/publication/34392087},
	author = {Lendvai-Emmert, Dominika and Magyar-Sümegi, Zsófia Dina and Hegedüs, Emőke and Szarka, Nikolett and Fazekas, Bálint and Amrein, Krisztina and Czeiter, Endre and Büki, András and Ungvári, Zoltán István and Tóth, Péter József},
	doi = {10.3389/fneur.2023.1252796},
	journal-iso = {FRONT NEUR},
	journal = {FRONTIERS IN NEUROLOGY},
	volume = {14},
	unique-id = {34392087},
	issn = {1664-2295},
	year = {2023},
	eissn = {1664-2295},
	orcid-numbers = {Fazekas, Bálint/0000-0002-8445-4100; Czeiter, Endre/0000-0002-9578-6944; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:34335003,
	title = {Inaugural State of the Union : Continuous Cerebral Autoregulation Monitoring in the Clinical Practice of Neurocritical Care and Anesthesia},
	url = {https://m2.mtmt.hu/api/publication/34335003},
	author = {Park, Soojin and Beqiri, Erta and Smielewski, Peter and Aries, Marcel},
	doi = {10.1007/s12028-023-01860-9},
	journal-iso = {NEUROCRIT CARE},
	journal = {NEUROCRITICAL CARE},
	unique-id = {34335003},
	issn = {1541-6933},
	abstract = {How continuous cerebral autoregulation (CCA) knowledge should be optimally gained and interpreted is still an active area of research and refinement. We now experience a unique situation of having indices clinically available before definitive evidence of benefit or practice guidelines, in a moment when high rates of institutional variability exist both in the application of monitoring as well as in monitoring-guided treatments. Responses from 47 international clinicians, experts in this field, were collected with polling and discussion of the results. The clinical use of CCA in critical illness was not universal among experts, with 34% not using it. Of those who use a CCA index in clinical practice, 64% use intracranial pressure-based Pressure Reactivity index (PRx). There seems to exist a considerable trust in the physiologic plausibility of CCA to guide individual arterial blood pressure and cerebral perfusion pressure therapy and provide benefit, regardless of the difficulty of proving this. A total of 59% feel the need for phase II and III prospective studies but would continue to use CCA information in their practice even if randomized controlled trials (RCTs) did not show clear clinical benefit. There was nearly universal interest to participate in an RCT, with agreement that the research community must together determine end points and interventions to reduce wasted effort and time, and that investigations should include the following: the most appropriate way of inclusion of CCA into the clinical workflow; whether CCA-guided interventions should be prophylactic, proactive; or reactive; and whether a CCA-centric (unimodal) or a multimodal monitoring-integrated tiered therapy approach should be adopted. Pediatric and neonatal populations were highlighted as having urgent need and even more plausibility than adults. On the whole, the initiative was enthusiastically embraced by the experts, with the general feeling that a strong push should be now made by the community to convert the plausible benefits of CCA monitoring, already implemented in some centers, into a more standardized and RCT-validated clinical reality.},
	year = {2023},
	eissn = {1556-0961}
}

@article{MTMT:34039024,
	title = {Imaging the time course, morphology, neuronal tissue compression, and resolution of cerebral microhemorrhages in mice using intravital two-photon microscopy : insights into arteriolar, capillary, and venular origin},
	url = {https://m2.mtmt.hu/api/publication/34039024},
	author = {Faakye, Janet and Nyúl-Tóth, Ádám and Gulej, Rafal and Csik, Boglarka and Tarantini, Stefano and Shanmugarama, Santny and Prodan, Calin and Mukli, Peter and Yabluchanskiy, Andriy and Conley, Shannon and Tóth, Péter József and Csiszar, Anna and Ungvári, Zoltán István},
	doi = {10.1007/s11357-023-00839-w},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {45},
	unique-id = {34039024},
	issn = {2509-2715},
	abstract = {Cerebral microhemorrhages (CMHs, microbleeds), a manifestation of age-related cerebral small vessel disease, contribute to the pathogenesis of cognitive decline and dementia in older adults. Histological studies have revealed that CMHs exhibit distinct morphologies, which may be attributed to differences in intravascular pressure and the size of the vessels of origin. Our study aimed to establish a direct relationship between the size/morphology of CMHs and the size/anatomy of the microvessel of origin. To achieve this goal, we adapted and optimized intravital two-photon microscopy-based imaging methods to monitor the development of CMHs in mice equipped with a chronic cranial window upon high-energy laser light-induced photodisruption of a targeted cortical arteriole, capillary, or venule. We assessed the time course of extravasation of fluorescently labeled blood and determined the morphology and size/volume of the induced CMHs. Our findings reveal striking similarities between the bleed morphologies observed in hypertension-induced CMHs in models of aging and those originating from different targeted vessels via multiphoton laser ablation. Arteriolar bleeds, which are larger (> 100 μm) and more widely dispersed, are distinguished from venular bleeds, which are smaller and exhibit a distinct diffuse morphology. Capillary bleeds are circular and smaller (< 10 μm) in size. Our study supports the concept that CMHs can occur at any location in the vascular tree, and that each type of vessel produces microbleeds with a distinct morphology. Development of CMHs resulted in immediate constriction of capillaries, likely due to pericyte activation and constriction of precapillary arterioles. Additionally, tissue displacement observed in association with arteriolar CMHs suggests that they can affect an area with a radius of ~ 50 μm to ~ 100 μm, creating an area at risk for ischemia. Longitudinal imaging of CMHs allowed us to visualize reactive astrocytosis and bleed resolution during a 30-day period. Our study provides new insights into the development and morphology of CMHs, highlighting the potential clinical implications of differentiating between the types of vessels involved in the pathogenesis of CMHs. This information may help in the development of targeted interventions aimed at reducing the risk of cerebral small vessel disease-related cognitive decline and dementia in older adults.},
	keywords = {SVD; Microbleed; VCID; SMALL VESSEL DISEASE; age-related cognitive decline},
	year = {2023},
	eissn = {2509-2723},
	pages = {2851-2872},
	orcid-numbers = {Tarantini, Stefano/0000-0001-5627-1430; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:33749702,
	title = {Huge variability in restrictions of mobilization for patients with aneurysmal subarachnoid hemorrhage - A European survey of practice},
	url = {https://m2.mtmt.hu/api/publication/33749702},
	author = {Hossain, Iftakher and Younsi, Alexander and Castaño Leon, Ana Maria and Lippa, Laura and Tóth, Péter József and Terpolilli, Nicole and Tobieson, Lovisa and Latini, Francesco and Raabe, Andreas and Depreitere, Bart and Rostami, Elham},
	doi = {10.1016/j.bas.2023.101731},
	journal-iso = {BRAIN SPINE},
	journal = {BRAIN AND SPINE},
	volume = {3},
	unique-id = {33749702},
	issn = {2772-5294},
	year = {2023},
	orcid-numbers = {Hossain, Iftakher/0000-0003-4836-1158; Younsi, Alexander/0000-0002-8218-9243; Castaño Leon, Ana Maria/0000-0002-7918-5049; Lippa, Laura/0000-0001-9920-430X; Depreitere, Bart/0000-0002-7458-0648; Rostami, Elham/0000-0003-1218-6247}
}

@article{MTMT:33742456,
	title = {Post-reperfusion acute MR diffusion in stroke is a potential predictor for clinical outcome in rats},
	url = {https://m2.mtmt.hu/api/publication/33742456},
	author = {Nagy, Szilvia Anett and Ivic, Ivan and Tóth, Péter József and Komoly, Sámuel and Kiss, Tamás and Pénzes, Máté and Málnási Csizmadia, András and Dóczi, Tamás Péter and Perlaki, Gábor and Orsi, Gergely},
	doi = {10.1038/s41598-023-32679-1},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {13},
	unique-id = {33742456},
	issn = {2045-2322},
	abstract = {Middle cerebral artery occlusion (MCAO) models show substantial variability in outcome, introducing uncertainties in the evaluation of treatment effects. Early outcome predictors would be essential for prognostic purposes and variability control. We aimed to compare apparent diffusion coefficient (ADC) MRI data obtained during MCAO and shortly after reperfusion for their potentials in acute-phase outcome prediction. Fifty-nine male rats underwent a 45-min MCAO. Outcome was defined in three ways: 21-day survival; 24 h midline-shift and neurological scores. Animals were divided into two groups: rats surviving 21 days after MCAO (survival group, n = 46) and rats dying prematurely (non-survival/NS group, n = 13). At reperfusion, NS group showed considerably larger lesion volume and lower mean ADC of the initial lesion site (p < 0.0001), while during occlusion there were no significant group differences. At reperfusion, each survival animal showed decreased lesion volume and increased mean ADC of the initial lesion site compared to those during occlusion (p < 10-6), while NS group showed a mixed pattern. At reperfusion, lesion volume and mean ADC of the initial lesion site were significantly associated with 24 h midline-shift and neurological scores. Diffusion MRI performed soon after reperfusion has a great impact in early-phase outcome prediction, and it works better than the measurement during occlusion.},
	year = {2023},
	eissn = {2045-2322},
	orcid-numbers = {Nagy, Szilvia Anett/0000-0001-6483-9209; Málnási Csizmadia, András/0000-0002-2430-8398}
}

@article{MTMT:33121609,
	title = {Neuronavigated theta burst stimulation for achieve safer tumor resection near motor speech area – case study},
	url = {https://m2.mtmt.hu/api/publication/33121609},
	author = {Sebestyén, Gabriella and Lendvai-Emmert, Dominika and Tamás, Viktória and Csendes, Márk Lajos and Magyar-Sümegi, Zsófia Dina and Tóth, Péter József and Büki, András},
	doi = {10.1016/j.clinph.2022.07.384},
	journal-iso = {CLIN NEUROPHYSIOL},
	journal = {CLINICAL NEUROPHYSIOLOGY},
	volume = {141},
	unique-id = {33121609},
	issn = {1388-2457},
	year = {2022},
	eissn = {1872-8952},
	pages = {S145-S146}
}

@article{MTMT:33064876,
	title = {Fecal calprotectin levels in pediatric cow's milk protein allergy},
	url = {https://m2.mtmt.hu/api/publication/33064876},
	author = {Lendvai-Emmert, Dominika and Emmert, Vanessza and Makai, Alexandra and Fusz, Katalin and Prémusz, Viktória and Eklicsné Lepenye, Katalin and Sarlós, Patrícia and Tóth, Péter József and Amrein, Krisztina and Tóth, Gergely Péter},
	doi = {10.3389/fped.2022.945212},
	journal-iso = {FRONT PEDIATR},
	journal = {FRONTIERS IN PEDIATRICS},
	volume = {10},
	unique-id = {33064876},
	issn = {2296-2360},
	year = {2022},
	eissn = {2296-2360},
	orcid-numbers = {Makai, Alexandra/0000-0002-1907-120X; Prémusz, Viktória/0000-0002-4059-104X; Sarlós, Patrícia/0000-0002-5086-9455}
}