TY - JOUR AU - Pusch, Gabriella AU - Debrabant, B AU - Molnár, Tihamér AU - Fehér, Gergely AU - Papp, V AU - Bánáti, Miklós János AU - Kovács, Norbert AU - Szapáry, László AU - Illés, Zsolt László TI - Early Dynamics of P-selectin and Interleukin 6 Predicts Outcomes in Ischemic Stroke JF - JOURNAL OF STROKE AND CEREBROVASCULAR DISEASES J2 - J STROKE CEREBROVASC DIS VL - 24 PY - 2015 IS - 8 SP - 1938 EP - 1947 PG - 10 SN - 1052-3057 DO - 10.1016/j.jstrokecerebrovasdis.2015.05.005 UR - https://m2.mtmt.hu/api/publication/2904461 ID - 2904461 AB - BACKGROUND: Thromboinflammatory molecules connect the prothrombotic state, endothelial dysfunction, and systemic/local inflammation in the acute phase of ischemic stroke. METHODS: We prospectively investigated (1) serial changes in the levels of thromboinflammatory biomarkers in 76 patients with acute ischemic stroke (6, 24, and 72 hours after onset); (2) compared with 44 patients with asymptomatic severe (>/=70%) carotid stenosis and 66 patients with Parkinson disease; and (3) we applied multiple regression methods, relating biological biomarkers combined with demographic data and comorbidities to poststroke infection, death, and functional outcome, and assessed the ability of the models to predict each outcome. RESULTS: Interleukin 6 (IL-6) levels and change of IL-6 concentrations by 72 hours correlated with the size of tissue damage indicated by S100B titers. Levels of IL-6 and P-selectin at 72 hours were higher in patients with large-artery versus lacunar stroke. High concentration of IL-6, monocyte chemotactic protein 1, and S100B at 6 hours were associated with poststroke infections; high concentration of IL-6, S100B, and high-sensitivity C-reactive protein (hsCRP) correlated with death. Change of P-selectin from 6 to 72 hours by 1 unit increased the incidence of poststroke infections with an odds ratio of 22.7; each 100 units of IL-6 at baseline increased the odds of death by 9 per thousand, and at 72 hours, the odds of poststroke infections by 4 per thousand. Each unit of baseline hsCRP elevated the odds of death by 7%. CONCLUSIONS: In regression models, in which biological, demographic, and comorbid factors were combined, those biological biomarkers predicted poor outcome with high accuracy, which were characterized by an increasing concentration by 72 hours. Two particular biomarkers emerged to predict outcomes besides hsCRP: early dynamic changes in the systemic levels of P-selectin and IL-6. LA - English DB - MTMT ER - TY - JOUR AU - Mike, Andrea AU - Strammer, E AU - Aradi, Mihály AU - Orsi, Gergely AU - Perlaki, Gábor AU - Hajnal, András Sándor AU - Sándor, János AU - Bánáti, Miklós János AU - Illes, E AU - Zaitsev, A AU - Herold, Róbert AU - Guttmann, CR AU - Illés, Zsolt László TI - Disconnection mechanism and regional cortical atrophy contribute to impaired processing of facial expressions and theory of mind in multiple sclerosis: a structural MRI study. JF - PLOS ONE J2 - PLOS ONE VL - 8 PY - 2013 IS - 12 PG - 10 SN - 1932-6203 DO - 10.1371/journal.pone.0082422 UR - https://m2.mtmt.hu/api/publication/2486017 ID - 2486017 AB - Successful socialization requires the ability of understanding of others' mental states. This ability called as mentalization (Theory of Mind) may become deficient and contribute to everyday life difficulties in multiple sclerosis. We aimed to explore the impact of brain pathology on mentalization performance in multiple sclerosis. Mentalization performance of 49 patients with multiple sclerosis was compared to 24 age- and gender matched healthy controls. T1- and T2-weighted three-dimensional brain MRI images were acquired at 3Tesla from patients with multiple sclerosis and 18 gender- and age matched healthy controls. We assessed overall brain cortical thickness in patients with multiple sclerosis and the scanned healthy controls, and measured the total and regional T1 and T2 white matter lesion volumes in patients with multiple sclerosis. Performances in tests of recognition of mental states and emotions from facial expressions and eye gazes correlated with both total T1-lesion load and regional T1-lesion load of association fiber tracts interconnecting cortical regions related to visual and emotion processing (genu and splenium of corpus callosum, right inferior longitudinal fasciculus, right inferior fronto-occipital fasciculus, uncinate fasciculus). Both of these tests showed correlations with specific cortical areas involved in emotion recognition from facial expressions (right and left fusiform face area, frontal eye filed), processing of emotions (right entorhinal cortex) and socially relevant information (left temporal pole). Thus, both disconnection mechanism due to white matter lesions and cortical thinning of specific brain areas may result in cognitive deficit in multiple sclerosis affecting emotion and mental state processing from facial expressions and contributing to everyday and social life difficulties of these patients. LA - English DB - MTMT ER - TY - JOUR AU - Kellermayer, B AU - Polgár, Noémi AU - Pál, József AU - Bánáti, Miklós János AU - Maász, Anita AU - Kisfali, Péter AU - Hosszú, Zsolt AU - Juhász, Annamária AU - Jensen, HB AU - Tordai, Attila AU - Rózsa, Csilla AU - Melegh, Béla AU - Illés, Zsolt László TI - Association of myasthenia gravis with polymorphisms in the gene of histamine N-methyltransferase JF - HUMAN IMMUNOLOGY J2 - HUM IMMUNOL VL - 74 PY - 2013 IS - 12 SP - 1701 EP - 1704 PG - 4 SN - 0198-8859 DO - 10.1016/j.humimm.2013.07.016 UR - https://m2.mtmt.hu/api/publication/2472794 ID - 2472794 N1 - Rapid Communication Division of Clinical and Experimental Neuroimmunology, Department of Neurology, University of Pecs, Pecs, Hungary Department of Medical Genetics, University of Pecs, Pecs, Hungary Department of Neurology, Odense University Hospital, Odense, Denmark Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark Department of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary Department of Neurology, Jahn Ferenc Teaching Hospital, Budapest, Hungary Institute of Clinical Research, University of Southern Denmark, Odense, Denmark Cited By :3 Export Date: 20 September 2019 CODEN: HUIMD Correspondence Address: Illes, Z.; Department of Neurology, Odense University Hospital, SDR. Boulevard 29, 5000 Odense C, Denmark; email: zsolt.illes@rsyd.dk Funding Agency and Grant Number: Hungarian National Research FundOrszagos Tudomanyos Kutatasi Alapprogramok (OTKA) [OTKA 77892]; Hungarian Neuroimaging Foundation; Bolyai Foundation of the Hungarian Academy of SciencesHungarian Academy of Sciences Funding text: This work was supported by grant from Hungarian National Research Fund (OTKA 77892 to Z. files) and the Hungarian Neuroimaging Foundation (to Z. Illes). N. Polgar was supported by the Bolyai Foundation of the Hungarian Academy of Sciences. Division of Clinical and Experimental Neuroimmunology, Department of Neurology, University of Pecs, Pecs, Hungary Department of Medical Genetics, University of Pecs, Pecs, Hungary Department of Neurology, Odense University Hospital, Odense, Denmark Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark Department of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary Department of Neurology, Jahn Ferenc Teaching Hospital, Budapest, Hungary Institute of Clinical Research, University of Southern Denmark, Odense, Denmark Cited By :3 Export Date: 21 February 2020 CODEN: HUIMD Correspondence Address: Illes, Z.; Department of Neurology, Odense University Hospital, SDR. Boulevard 29, 5000 Odense C, Denmark; email: zsolt.illes@rsyd.dk LA - English DB - MTMT ER - TY - JOUR AU - Bánáti, Miklós János AU - Csécsei, Péter AU - Kőszegi, Edit AU - Nielsen, HH AU - Sütő, Gábor AU - Bors, L AU - Trauninger, Anita AU - Csépány, Tünde AU - Rózsa, Csilla AU - Jakab, Gábor AU - Molnár, Tihamér AU - Berthele, A AU - Kalluri, SR AU - Berki, Tímea AU - Illés, Zsolt László TI - Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 20 PY - 2013 IS - 11 SP - 1492 EP - 1495 PG - 4 SN - 1351-5101 DO - 10.1111/ene.12072 UR - https://m2.mtmt.hu/api/publication/2228899 ID - 2228899 N1 - Megosztott első szerzőség Short Communication AB - Background: Antibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity. Methods: Antibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC). Results: Thirty-seven percentages of patients with AQP4-seropositive NMO/NMO-SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (P < 0.01, respectively). Antibodies were most common (46%) in AQP4-seropositive myelitis (P = 0.01 versus HS, P = 0.05 versus MS). Anti-gliadin and ASCA were more frequent in the AQP4-seropositive NMO-spectrum compared to controls (P = 0.01 and P < 0.05, respectively). Conclusion: Antibody responses against gastrointestinal antigens are common in MS and AQP4-seropositive NMO/NMO-SD, especially in longitudinally extensive myelitis. © 2013 EFNS. LA - English DB - MTMT ER - TY - JOUR AU - Csuka, Dorottya AU - Czirják, László AU - Hóbor, Renáta AU - Illés, Zsolt László AU - Bánáti, Miklós János AU - Rajczy, K AU - Tordai, Attila AU - Füst, György TI - Effective humoral immunity against diphtheria and tetanus in patients with systemic lupus erythematosus or myasthenia gravis JF - MOLECULAR IMMUNOLOGY J2 - MOL IMMUNOL VL - 54 PY - 2013 IS - 3-4 SP - 453 EP - 456 PG - 4 SN - 0161-5890 DO - 10.1016/j.molimm.2013.01.012 UR - https://m2.mtmt.hu/api/publication/2222753 ID - 2222753 AB - INTRODUCTION: Controversy exists about the effectiveness of vaccine-induced immune response in patients with immunoregulatory disorders. Our aim was to determine the antibody titers to diphtheria and tetanus in patients with either of two autoimmune diseases. METHODS: 279 patients with SLE (205 females, aged 45.0+/-13.8 years), 158 patients with myasthenia gravis (MG) (101 females, aged 55+/-18.7 years) and 208 healthy subjects (122 females, aged 48+/-14.6 years) were enrolled. Serum concentrations of diphtheria-antitoxin-IgG (A-DIPHTH) and tetanus-antitoxoid-IgG (A-TET) were determined with ELISA. RESULTS: Equal proportions of healthy subjects, as well as patients with SLE or MG exhibited proper antibody responses and immune protection against diphtheria and tetanus. In all three test groups, serum concentration of A-DIPHTH decreased significantly (p<0.001) with age throughout the study population, while titers of A-TET dropped only in the elderly (>60-years-old) subjects. There were no significant differences among the groups in the age-related changes of A-TET and A-DIPHTH except that in <40-years-old subjects, A-DIPHTH level was significantly (p=0.029) lower in SLE patients than in controls. CONCLUSIONS: Our findings suggest that the level of vaccine-induced immunity against diphtheria and tetanus infections in patients with SLE or MG is comparable to the healthy population. LA - English DB - MTMT ER - TY - THES AU - Bánáti, Miklós János TI - T cell responses in neurological disorders PY - 2012 UR - https://m2.mtmt.hu/api/publication/1887569 ID - 1887569 LA - English DB - MTMT ER - TY - JOUR AU - Csuka, Dorottya AU - Bánáti, Miklós János AU - Rózsa, Csilla AU - Füst, György AU - Illés, Zsolt László TI - High anti-EBNA-1 IgG levels are associated with early-onset myasthenia gravis JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 19 PY - 2012 IS - 6 SP - 842 EP - 846 PG - 5 SN - 1351-5101 DO - 10.1111/j.1468-1331.2011.03636.x UR - https://m2.mtmt.hu/api/publication/1872014 ID - 1872014 AB - Background: Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against the acethylcholine receptor (AchR) of the neuromuscular junction in the majority of patients. Methods: Here, we examined IgG antibodies against the type 1 nuclear antigen of Epstein-Barr virus (EBNA-1) in the sera of 158 patients with MG compared to 184 healthy controls. Results: Although serum concentration in the sera was not different, high anti-EBNA-1 IgG titers (above 90th percentile of the normal values) were more common in the patients (26.6 vs. 16.3%, P=0.024). In addition, high EBNA-1 IgG levels occurred more frequently amongst the 94 patients with early-onset myasthenia gravis (EOMG, 30.8%) as compared to the 64 patients with late-onset disease (LOMG, 14.1%) (P=0.021). Using multiple logistic regression, high serum concentration of the anti-EBNA-1 IgG antibodies was significantly associated with EOMG (OR: 3.17, P=0.027), even after adjustment for sex, presence/absence of anti-AchR antibodies and presence/absence of anti-Titin antibodies. Out of 39 patients with EOMG, who underwent thymectomy, 18 patients (46%) had thymoma, 6 had thymic hyperplasia (15%), and 15 patients had thymic atrophy (39%); there was no difference comparing EBNA-1 antibody titers in the sera. As no correlation was found between the titers of anti- AchR, anti-Titin, and EBNA-1 antibodies, a dysregulated heterogeneous B-cell response was unlikely to be responsible for the elevated levels of EBV-associated antibody in patients. Conclusions: In summary, our data suggest that high levels of EBNA-1 antibodies are more common in MG compared to healthy controls and are especially associated with EOMG. © 2012 The Author(s). European Journal of Neurology © 2012 EFNS. LA - English DB - MTMT ER - TY - JOUR AU - Bánáti, Miklós János AU - Csécsei, Péter AU - Kőszegi, Edit AU - Sandor, J AU - Suto, l AU - Bors, L AU - Rauninger, A AU - Csépány, Tünde AU - Rózsa, Csilla AU - Simo, M AU - Hosszu, Z AU - Jakab, G AU - Berthele, A AU - Kalluri, S R AU - Hemmer, B AU - Berki, Tímea AU - Illés, Zsolt László TI - Antibody response against antigens of gastrointestinal autoimmune disorders in patients with neuromyelitis optica spectrum diseases JF - MULTIPLE SCLEROSIS JOURNAL J2 - MULT SCLER J VL - 17 PY - 2011 IS - Suppl.10 SP - S351 SN - 1352-4585 UR - https://m2.mtmt.hu/api/publication/2230675 ID - 2230675 LA - English DB - MTMT ER - TY - JOUR AU - Bánáti, Miklós János AU - Csécsei, Péter AU - Kőszegi, Edit AU - Suto, G AU - Bors, L AU - Trauninger, A AU - Csépány, Tünde AU - Rózsa, Csilla AU - Simo, M AU - Hosszu, Z AU - Jakab, G AU - Berthele, A AU - Hemmer, B AU - Berki, Tímea AU - Illés, Zsolt László TI - ANTIBODY RESPONSE AGAINST ANTIGENS OF GASTROINTESTINAL AUTOIMMUNE DISORDERS IN PATIENTS WITH NEUROMYELITIS OPTICA SPECTRUM DISEASES JF - EUROPEAN JOURNAL OF NEUROLOGY J2 - EUR J NEUROL VL - 18 PY - 2011 IS - 2 SP - 59 EP - 59 PG - 1 SN - 1351-5101 UR - https://m2.mtmt.hu/api/publication/2230663 ID - 2230663 LA - English DB - MTMT ER - TY - JOUR AU - Bánáti, Miklós János AU - Hosszú, Zsolt AU - Trauninger, Anita AU - Szereday, László AU - Illés, Zsolt László TI - Enzyme replacement therapy induces T-cell responses in late-onset Pompe's disease JF - JOURNAL OF NEUROLOGY J2 - J NEUROL VL - 258 PY - 2011 IS - Suppl. 1 SP - 253 EP - 253 PG - 1 SN - 0340-5354 UR - https://m2.mtmt.hu/api/publication/1668483 ID - 1668483 LA - English DB - MTMT ER -