@{MTMT:31684069,
	title = {Complex regulatory role of the TRPA1 receptor in acute and chronic airway inflammation mouse models},
	url = {https://m2.mtmt.hu/api/publication/31684069},
	author = {Hajna, Zsófia Réka and Csekő, Kata and Kemény, Ágnes and Kereskai, László and Tamás, Kiss and Anikó, Perkecz and Szitter, István and Kocsis, Béla and Pintér, Erika and Helyes, Zsuzsanna},
	booktitle = {Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project},
	unique-id = {31684069},
	year = {2020},
	pages = {58-58},
	orcid-numbers = {Kemény, Ágnes/0000-0002-4523-3938; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:31345123,
	title = {Complex Regulatory Role of the TRPA1 Receptor in Acute and Chronic Airway Inflammation Mouse Models},
	url = {https://m2.mtmt.hu/api/publication/31345123},
	author = {Hajna, Zsófia Réka and Csekő, Kata and Kemény, Ágnes and Kereskai, László and Kiss, Tamás and Perkecz, Anikó and Szitter, István and Kocsis, Béla and Pintér, Erika and Helyes, Zsuzsanna},
	doi = {10.3390/ijms21114109},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31345123},
	issn = {1661-6596},
	abstract = {The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein. We investigated its involvement in acute and chronic pulmonary inflammation using Trpa1 gene-deleted (Trpa1-/-) mice. Acute pneumonitis was evoked by intranasal Escherichia coli endotoxin (lipopolysaccharide: LPS) administration, chronic bronchitis by daily cigarette smoke exposure (CSE) for 4 months. Frequency, peak inspiratory/expiratory flows, minute ventilation determined by unrestrained whole-body plethysmography were significantly greater, while tidal volume, inspiratory/expiratory/relaxation times were smaller in Trpa1-/- mice. LPS-induced bronchial hyperreactivity, myeloperoxidase activity, frequency-decrease were significantly greater in Trpa1-/- mice. CSE significantly decreased tidal volume, minute ventilation, peak inspiratory/expiratory flows in wildtypes, but not in Trpa1-/- mice. CSE remarkably increased the mean linear intercept (histopathology), as an emphysema indicator after 2 months in wildtypes, but only after 4 months in Trpa1-/- mice. Semiquantitative histopathological scores were not different between strains in either models. TRPA1 has a complex role in basal airway function regulation and inflammatory mechanisms. It protects against LPS-induced acute pneumonitis and hyperresponsiveness, but is required for CSE-evoked emphysema and respiratory deterioration. Further research is needed to determine TRPA1 as a potential pharmacological target in the lung.},
	keywords = {bronchitis; Whole body plethysmography; Emphysema; COPD; Cigarette smoke; LPS; Pneumonitis},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Kemény, Ágnes/0000-0002-4523-3938; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:3250998,
	title = {Body fat of rats of different age-groups and nutritional states: assessment by micro-CT and skinfold thickness.},
	url = {https://m2.mtmt.hu/api/publication/3250998},
	author = {Tékus, Éva and Mikó, Alexandra and Füredi, Nóra and Rostás, Ildikó and Tenk, Judit and Kiss, T and Szitter, István and Balaskó, Márta and Helyes, Zsuzsanna and Wilhelm, Márta and Pétervári, Erika},
	doi = {10.1152/japplphysiol.00884.2016},
	journal-iso = {J APPL PHYSIOL},
	journal = {JOURNAL OF APPLIED PHYSIOLOGY},
	volume = {124},
	unique-id = {3250998},
	issn = {8750-7587},
	abstract = {Obesity presents a growing public health problem. Therefore, the analysis of body composition is important in clinical practice as well as in animal research models of obesity, hence precise methods for the assessment of body fat would be essential. We aimed to evaluate in vivo abdominal micro-computed tomography scan restricted to the L1-L3 region (micro-CT(L1-L3)), a skinfold thickness-based method (STM) and post mortem body composition analysis (PMA) with regard to whole-body micro-CT scan in rats. Male Wistar rats of different age-groups (from 3 to 24 months) and nutritional states (normally fed, high-fat diet-induced obese, calorie-restricted) were used. The fat percentage was determined with micro-CT(L1-L3) and whole-body scan in anesthesized rats. Their skinfold thickness was measured in five locations with Lange caliper. Wet weights of epididymal and retroperitoneal fat pads were determined via PMA. With regard to fat mass, the strongest correlation was observed between abdominal and whole-body micro-CT. The other methods showed weaker associations with whole-body micro-CT and with each other. Micro-CT(L1-L3) and PMA showed similar age-associated increase in fat mass between 3-18 months. Micro-CT(L1-L3), STM and PMA were efficient to detect differences in fat mass values in groups of different nutritional states. Micro-CT(L1-L3) appears to be a useful method for body fat assessment in rats with reduced scanning time. In rats STM may also be a useful, low-priced, non-invasive and simple in vivo technique to assess obesity.},
	year = {2018},
	eissn = {1522-1601},
	pages = {268-275},
	orcid-numbers = {Tékus, Éva/0000-0002-3608-5312; Pétervári, Erika/0000-0002-3673-8491}
}

@article{MTMT:3244396,
	title = {Integrative characterization of chronic cigarette smoke-induced cardiopulmonary comorbidities in a mouse model},
	url = {https://m2.mtmt.hu/api/publication/3244396},
	author = {Kemény, Ágnes and Csekő, Kata and Szitter, István and Varga, Zoltán and Bencsik, Péter and Kiss, Krisztina and Halmosi, Róbert and Deres, László and Erős, Krisztián and Perkecz, A and Kereskai, László and Horváthné László, Terézia and Kiss, T and Ferdinandy, Péter and Helyes, Zsuzsanna},
	doi = {10.1016/j.envpol.2017.04.098},
	journal-iso = {ENVIRON POLLUT},
	journal = {ENVIRONMENTAL POLLUTION},
	volume = {229},
	unique-id = {3244396},
	issn = {0269-7491},
	abstract = {Cigarette smoke-triggered inflammatory cascades and consequent tissue damage are the main causes of chronic obstructive pulmonary disease (COPD). There is no effective therapy and the key mediators of COPD are not identified due to the lack of translational animal models with complex characterization. This integrative chronic study investigated cardiopulmonary pathophysiological alterations and mechanisms with functional, morphological and biochemical techniques in a 6-month-long cigarette smoke exposure mouse model. Some respiratory alterations characteristic of emphysema (decreased airway resistance: Rl; end-expiratory work and pause: EEW, EEP; expiration time: Te; increased tidal mid-expiratory flow: EF50) were detected in anaesthetized C57BL/6 mice, unrestrained plethysmography did not show changes. Typical histopathological signs were peribronchial/perivascular (PB/PV) edema at month 1, neutrophil/macrophage infiltration at month 2, interstitial leukocyte accumulation at months 3-4, and emphysema/atelectasis at months 5-6 quantified by mean linear intercept measurement. Emphysema was proven by micro-CT quantification. Leukocyte number in the bronchoalveolar lavage at month 2 and lung matrix metalloproteinases-2 and 9 (MMP-2/MMP-9) activities in months 5-6 significantly increased. Smoking triggered complex cytokine profile change in the lung with one characteristic inflammatory peak of C5a, interleukin-1alpha and its receptor antagonist (IL-1alpha, IL-1ra), monokine induced by gamma interferon (MIG), macrophage colony-stimulating factor (M-CSF), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) at months 2-3, and another peak of interferon-gamma (IFN-gamma), IL-4, 7, 13, 17, 27 related to tissue destruction. Transient systolic and diastolic ventricular dysfunction developed after 1-2 months shown by significantly decreased ejection fraction (EF%) and deceleration time, respectively. These parameters together with the tricuspid annular plane systolic excursion (TAPSE) decreased again after 5-6 months. Soluble intercellular adhesion molecule-1 (sICAM-1) significantly increased in the heart homogenates at month 6, while other inflammatory cytokines were undetectable. This is the first study demonstrating smoking duration-dependent, complex cardiopulmonary alterations characteristic to COPD, in which inflammatory cytokine cascades and MMP-2/9 might be responsible for pulmonary destruction and sICAM-1 for heart dysfunction.},
	year = {2017},
	eissn = {1873-6424},
	pages = {746-759},
	orcid-numbers = {Kemény, Ágnes/0000-0002-4523-3938; Varga, Zoltán/0000-0002-2758-0784; Bencsik, Péter/0000-0003-1936-6232; Horváthné László, Terézia/0000-0002-1635-0633; Ferdinandy, Péter/0000-0002-6424-6806}
}

@mastersthesis{MTMT:3007813,
	title = {A tachykinin rendszer és az érzőideg-végződések aktivációjának szerepe bél-és légúti gyulladásmodellekben},
	url = {https://m2.mtmt.hu/api/publication/3007813},
	author = {Szitter, István},
	publisher = {PTE},
	unique-id = {3007813},
	year = {2014}
}

@article{MTMT:2750029,
	title = {Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles.},
	url = {https://m2.mtmt.hu/api/publication/2750029},
	author = {Kun, József and Szitter, István and Kemény, Ágnes and Perkecz, A and Kereskai, László and Pohóczky, Krisztina and Vincze, Áron and Gódi, Szilárd and Szabó, Imre and Szolcsányi, János and Pintér, Erika and Helyes, Zsuzsanna},
	doi = {10.1371/journal.pone.0108164},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {9},
	unique-id = {2750029},
	issn = {1932-6203},
	abstract = {Transient Receptor Potential Ankyrin 1 (TRPA1) channels are localized on sensory nerves and several non-neural cells, but data on their functional significance are contradictory. We analysed the presence and alterations of TRPA1 in comparison with TRP Vanilloid 1 (TRPV1) at mRNA and protein levels in human and mouse intact and inflamed colons. The role of TRPA1 in a colitis model was investigated using gene-deficient mice. TRPA1 and TRPV1 expressions were investigated in human colon biopsies of healthy subjects and patients with inflammatory bowel diseases (IBD: ulcerative colitis, Crohn's disease) with quantitative PCR and immunohistochemistry. Mouse colitis was induced by oral 2% dextran-sulphate (DSS) for 10 days. For investigating the functions of TRPA1, Disease Activity Index (weight loss, stool consistency, blood content) was determined in C57BL/6-based Trpa1-deficient (knockout: KO) and wildtype (WT) mice. Sensory neuropeptides, their receptors, and inflammatory cytokines/chemokines were determined with qPCR or Luminex. In human and mouse colons TRPA1 and TRPV1 are located on epithelial cells, macrophages, enteric ganglia. Significant upregulation of TRPA1 mRNA was detected in inflamed samples. In Trpa1 KO mice, Disease Activity Index was significantly higher compared to WTs. It could be explained by the greater levels of substance P, neurokinins A and B, neurokinin 1 receptor, pituitary adenylate-cyclase activating polypeptide, vasoactive intestinal polypeptide, and also interleukin-1beta, macrophage chemoattractant protein-1, monokine induced by gamma interferon-1, tumor necrosis factor-alpha and B-lymphocyte chemoattractant in the distal colon. TRPA1 is upregulated in colitis and its activation exerts protective roles by decreasing the expressions of several proinflammatory neuropeptides, cytokines and chemokines.},
	year = {2014},
	eissn = {1932-6203},
	orcid-numbers = {Kemény, Ágnes/0000-0002-4523-3938; Pohóczky, Krisztina/0000-0003-0385-5162; Vincze, Áron/0000-0003-2217-7686; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:2505156,
	title = {Plasma somatostatin-like immunoreactivity increases in the plasma of septic patients and rats with systemic inflammatory reaction: experimental evidence for its sensory origin and protective role},
	url = {https://m2.mtmt.hu/api/publication/2505156},
	author = {Sütő, Balázs and Szitter, István and Bagoly, T and Pintér, Erika and Szolcsányi, János and Loibl, Csaba and Németh, Timea and Tánczos, Krisztián and Molnár, Tihamér and Leiner, Tamás and Varnai, B and Bardonicsek, Zs and Helyes, Zsuzsanna},
	doi = {10.1016/j.peptides.2014.01.006},
	journal-iso = {PEPTIDES},
	journal = {PEPTIDES},
	volume = {54},
	unique-id = {2505156},
	issn = {0196-9781},
	year = {2014},
	eissn = {1873-5169},
	pages = {49-57},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:2505155,
	title = {Role of neurokinin 1 receptors in dextran sulfate-induced colitis: studies with gene-deleted mice and the selective receptor antagonist netupitant},
	url = {https://m2.mtmt.hu/api/publication/2505155},
	author = {Szitter, István and Pintér, Erika and Perkecz, A and Kemény, Ágnes and Kun, József and Kereskai, László and Pietra, C and Quinn, JP and Zimmer, A and Berger, A and Paige, CJ and Helyes, Zsuzsanna},
	doi = {10.1007/s00011-014-0712-x},
	journal-iso = {INFLAMM RES},
	journal = {INFLAMMATION RESEARCH},
	volume = {63},
	unique-id = {2505155},
	issn = {1023-3830},
	year = {2014},
	eissn = {1420-908X},
	pages = {399-409},
	orcid-numbers = {Pintér, Erika/0000-0001-9898-632X; Kemény, Ágnes/0000-0002-4523-3938}
}

@misc{MTMT:2361697,
	title = {Tüdő morfometria: dohányfüst okozta szöveti elváltozások kvantitatív követése mikroCT módszerrel C57BL/6 és galanin 3 receptor (Gal3r) deficiens egerekben},
	url = {https://m2.mtmt.hu/api/publication/2361697},
	author = {Szitter, István and Barbara, K and Kiss, T and Perkecz, A and Feller, D and Helyes, Zs},
	unique-id = {2361697},
	year = {2013},
	pages = {A-0191}
}

@misc{MTMT:2361693,
	title = {A tranziens receptor potenciál ankyrin 1 (TRPA1) és vanilloid 1 (TRPV1) receptor mRNS expresszió gyulladásos bélbetegségben (IBD) és dextrán-szulfát (DSS) által indukált egér colitis modellben},
	url = {https://m2.mtmt.hu/api/publication/2361693},
	author = {Kun, J and Helyes, Zs and Szitter, István and Gódi, Sz and Szabó, I and Kemény, Á and Pohóczky, Krisztina and Perkecz, A and Pintér, E},
	unique-id = {2361693},
	year = {2013},
	pages = {A-0184},
	orcid-numbers = {Pohóczky, Krisztina/0000-0003-0385-5162}
}