@article{MTMT:34095174, title = {Migraine as a Disease Associated with Dysbiosis and Possible Therapy with Fecal Microbiota Transplantation}, url = {https://m2.mtmt.hu/api/publication/34095174}, author = {Kappéter, Ágnes and Sipos, Dávid and Varga, Adorján and Vigvári, Szabolcs József and Halda-Kiss, Bernadett and Péterfi, Zoltán}, doi = {10.3390/microorganisms11082083}, journal-iso = {MICROORGANISMS}, journal = {MICROORGANISMS}, volume = {11}, unique-id = {34095174}, issn = {2076-2607}, abstract = {Migraine is a painful neurological condition characterized by severe pain on one or both sides of the head. It may be linked to changes in the gut microbiota, which are influenced by antibiotic use and other factors. Dysbiosis, which develops and persists as a result of earlier antibiotic therapy, changes the composition of the intestinal flora, and can lead to the development of various diseases such as metabolic disorders, obesity, hematological malignancies, neurological or behavioral disorders, and migraine. Metabolites produced by the gut microbiome have been shown to influence the gut–brain axis. The use of probiotics as a dietary supplement may reduce the number and severity of migraine episodes. Dietary strategies can affect the course of migraines and are a valuable tool for improving migraine management. With fecal microbiota transplantation, gut microbial restoration is more effective and more durable. Changes after fecal microbiota transplantation were studied in detail, and many data help us to interpret the successful interventions. The microbiological alteration of the gut microflora can lead to normalization of the inflammatory mediators, the serotonin pathway, and influence the frequency and intensity of migraine pain.}, year = {2023}, eissn = {2076-2607}, orcid-numbers = {Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:34025825, title = {A széklettranszplantáció aktuális hazai helyzete}, url = {https://m2.mtmt.hu/api/publication/34025825}, author = {Péterfi, Zoltán and Varga, Adorján and Vigvári, Szabolcs József and Sipos, Dávid}, doi = {10.33570/CEUJGH.9.2.59}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34025825}, year = {2023}, eissn = {2415-9107}, pages = {59-62}, orcid-numbers = {Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:32056248, title = {How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods}, url = {https://m2.mtmt.hu/api/publication/32056248}, author = {Varga, Adorján and Kocsis, Béla and Sipos, Dávid and Kása, Péter and Vigvári, Szabolcs József and Pál, Szilárd and Dembrovszky, Fanni and Borbásné Farkas, Kornélia and Péterfi, Zoltán}, doi = {10.3389/fcimb.2021.657320}, journal-iso = {FRONT CELL INFECT MI}, journal = {FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}, volume = {11}, unique-id = {32056248}, issn = {2235-2988}, year = {2021}, eissn = {2235-2988}, orcid-numbers = {Kása, Péter/0000-0002-6134-0928; Dembrovszky, Fanni/0000-0001-6953-3591; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:30362752, title = {Experiences with fecal microbiota transplantation in Clostridium difficile infections via upper gastrointestinal tract}, url = {https://m2.mtmt.hu/api/publication/30362752}, author = {Vigvári, Szabolcs József and Vincze, Áron and Solt, Jenő and Sipos, Dávid and Feiszt, Zsófia and Kovács, Beáta and Kappéter, Ágnes and Péterfi, Zoltán}, doi = {10.1556/030.65.2018.051}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {30362752}, issn = {1217-8950}, abstract = {Dramatic changes in the epidemiology of Clostridium difficile infections have been reported from the western world in the past decade. The proportion of severe cases is significantly elevating and clinicians now have to contend with the problem of additional and more frequent episodes of recurrences including an upward trend in the mortality rate. This situation led us to investigate the possibility of the fecal microbiota transplantation (FMT). An amount of 100 ml of fecal microbiota solution was instilled into a nasojejunal (NJ) tube in 16 cases and into a nasogastric (NG) tube in 44 cases. In all of the cases, where the solution was instilled via nasojejunal tubes, the symptoms resolved within 24 h. We did not note any recurrences in this group. When the material was flushed in through nasogastric tubes, the symptoms resolved in 39 (88.64%) cases within 24 h. In this group, we have experienced a recurrent episode of C. difficile infection in five (11.36%) cases. Three of them were cured with a second transplantation. We have found that in our practice the upper gastrointestinal tract methods had the primary cure rate of 91.67%, whereas the secondary cure rate is 96.67%. When we compared the NJ and NG methods, we have found that the differences in the outcomes are not significant statistically (p = 0.3113 using Fisher's exact probability test). In conclusion, FMT proved to be very effective, particularly in recurrent infections and in cases where conventional treatment had failed.}, keywords = {nasojejunal tube; FECAL MICROBIOTA TRANSPLANTATION; nasogastric tube}, year = {2019}, eissn = {1588-2640}, pages = {179-188}, orcid-numbers = {Vincze, Áron/0000-0003-2217-7686; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:3304835, title = {Faecal microbiota transplantation for Clostridium difficile infection using a lyophilized inoculum from non-related donors: A case series involving 19 patients}, url = {https://m2.mtmt.hu/api/publication/3304835}, author = {Vigvári, Szabolcs József and Sipos, Dávid and Solt, Jenő and Vincze, Áron and Kocsis, Béla and Nemes, Zsuzsanna and Kappéter, Ágnes and Feiszt, Zsófia and Kovács, Beáta and Péterfi, Zoltán}, doi = {10.1556/030.64.2017.042}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {66}, unique-id = {3304835}, issn = {1217-8950}, abstract = {Faecal microbiota transplantation (FMT) has been reported to be effective in treating relapsing of refractory Clostridium difficile infections, although some practical barriers are limiting its widespread use. In this study, our objective was to evaluate the rate of resolution of diarrhea following administration of lyophilized and resolved FMT via a nasogastric (NG) tube. We recruited 19 patients suffered from laboratory-confirmed C. difficile infection. Each of them was treated by lyophilized and resolved inoculum through a NG tube. One participant succumbed following the procedure due to unrelated diseases. Out of 18 cases, 15 patients reportedly experienced a resolution of the symptoms. One patient was treated with another course of antibiotics, and two of the non-responders were successfully retreated with another course of FMT utilizing a lyophilized inoculum. Notably, no significant adverse activities were observed. In accordance to our clinical experiences, a patient will likely benefit from FMT treatment including lyophilized inoculum.}, year = {2019}, eissn = {1588-2640}, pages = {69-78}, orcid-numbers = {Vincze, Áron/0000-0003-2217-7686; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:30600970, title = {Treatment options of Clostridium difficile infection: our latest experiences with fecal microbiota transplant}, url = {https://m2.mtmt.hu/api/publication/30600970}, author = {Varga, Adorján and Kocsis, Béla and Sipos, Dávid and Vigvári, Szabolcs József and Kása, Péter and Pál, Szilárd and Mikó, Éva and Szereday, László and Bechtolsheim, F. and Péterfi, Zoltán}, journal-iso = {CLIN CHEM LAB MED}, journal = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE}, volume = {56}, unique-id = {30600970}, issn = {1434-6621}, year = {2018}, eissn = {1437-4331}, pages = {eA133-eA133}, orcid-numbers = {Kása, Péter/0000-0002-6134-0928; Szereday, László/0000-0002-1208-2969; Péterfi, Zoltán/0000-0001-9658-153X} } @article{MTMT:3360067, title = {Risk factors for Clostridium difficile infections in Baranya County, Southern Hungary}, url = {https://m2.mtmt.hu/api/publication/3360067}, author = {Vigvári, Szabolcs József and Sipos, Dávid and Kappéter, Ágnes and Feiszt, Zsófia and Kovács, Beáta and Péterfi, Zoltán}, doi = {10.1556/030.65.2018.023}, journal-iso = {ACTA MICROBIOL IMMUNOL HUNG}, journal = {ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA}, volume = {65}, unique-id = {3360067}, issn = {1217-8950}, abstract = {In the past decade, Clostridium difficile infections (CDIs) have become a major public health challenge. Their epidemiology has radically changed with a significant rise in the number of cases and an increase in severe episodes. Recurrence and failure of conventional treatments are very common. Furthermore, a spread of CDI has emerged in general population without the usual risk factors (unexposed to antibiotic treatment, young people, etc.). The conventional treatments (metronidazole and vancomycin) are still effective and are the first-line antibiotics with new recommendations. New therapeutic strategies are now available. Recent studies show a better efficacy of vancomycin compared with metronidazole for severe episodes. Fidaxomicin is a novel antibiotic drug with an efficacy similar to vancomycin and a lower risk of recurrence. Finally, for relapsing forms, fecal microbiota transplantation (FMT) seems to be the best option. We determined risk factors for CDI among patients treated at the infectious diseases ward of our hospital in Pecs. The study included 886 patients with CDI from 2009 to 2014. The average number of recurrent episodes was 2.16 and the proportion of severe cases was 66%. Among our patients, 726 (82%) had taken antibiotics and 769 (86.8%) had been hospitalized in the prior 3 months before developing CDI. We have found that prior statin use could be a significant risk factor of CDI (OR: 1.7765, 95% CI: 1.3966-2.2597, p < 0.0001). Finally, we present the comparative efficacy of different types of treatment (metronidazole, vancomycin, fidaxomicin, and FMT).}, year = {2018}, eissn = {1588-2640}, pages = {183-192}, orcid-numbers = {Péterfi, Zoltán/0000-0001-9658-153X} } @{MTMT:3301776, title = {Advances in fecal micriobiota transplantation}, url = {https://m2.mtmt.hu/api/publication/3301776}, author = {Vigvári, Szabolcs József and Péterfi, Zoltán}, booktitle = {Superbugs: Clostridium difficile and Klebsiella pneumoniae recognition, prevention and treatment}, unique-id = {3301776}, year = {2016}, pages = {19-38}, orcid-numbers = {Péterfi, Zoltán/0000-0001-9658-153X} } @{MTMT:3276075, title = {Európai Trauma kurzus jelentősége a sürgősségi szakember képzésben (team munka szerepe az acut sürgősségi traumatológia ellátásban=The importance of Eropean Trauma Course in training emergency care staff (the role of teamwork in acute emergency traumatology care}, url = {https://m2.mtmt.hu/api/publication/3276075}, author = {Sári, Ferenc and Gaál, Ildikó and Vigvári, Szabolcs József and Szélig, György and Verzár, Zsófia}, booktitle = {X. Pécsi Sürgősségi Napok / X. Critical Care Days in Pécs}, unique-id = {3276075}, year = {2015}, pages = {31}, orcid-numbers = {Verzár, Zsófia/0000-0001-5323-0748} } @article{MTMT:2798567, title = {Faecal microbiota transplantation in Clostridium difficile infections}, url = {https://m2.mtmt.hu/api/publication/2798567}, author = {Vigvári, Szabolcs József and Nemes, Zsuzsanna and Vincze, Áron and Solt, Jenő and Sipos, Dávid and Feiszt, Zsófia and Kovács, Beáta and Bartos, Barbara and Péterfi, Zoltán}, doi = {10.3109/00365548.2014.969305}, journal-iso = {INFECT DIS-NOR}, journal = {INFECTIOUS DISEASES}, volume = {47}, unique-id = {2798567}, issn = {2374-4235}, year = {2015}, eissn = {2374-4243}, pages = {114-116}, orcid-numbers = {Vincze, Áron/0000-0003-2217-7686; Péterfi, Zoltán/0000-0001-9658-153X} }