@CONFERENCE{MTMT:34178794,
	title = {Detection and molecular characterization of antibiotic resistant Enterobacteriaceae from hospital effluents and wastewater treatment plant},
	url = {https://m2.mtmt.hu/api/publication/34178794},
	author = {Héninger, Réka and Mutuku, Christopher and Melegh, Szilvia Zsóka and Kovács, Krisztina and Urbán, Péter and Virág, Eszter Andrea and Herczeg, Róbert and Sonnevend, Ágnes and Gyenesei, Attila and Fekete, Csaba and Gazdag, Zoltán},
	booktitle = {CEESME Central and Eastern Europe Symposium on Microbial Ecology},
	unique-id = {34178794},
	year = {2023},
	pages = {77-77},
	orcid-numbers = {Herczeg, Róbert/0000-0002-5903-0082}
}

@article{MTMT:33258723,
	title = {Plasmid sequence dataset of multidrug-resistant Enterobacterales isolated from hospital effluents and wastewater treatment plant},
	url = {https://m2.mtmt.hu/api/publication/33258723},
	author = {Mutuku, Christopher and Kutasy, Barbara Júlia and Urbán, Péter and Melegh, Szilvia Zsóka and Herczeg, Róbert and Gazdag, Zoltán and Virág, Eszter Andrea},
	doi = {10.1016/j.dib.2022.108736},
	journal-iso = {DATA BRIEF},
	journal = {DATA IN BRIEF},
	volume = {45},
	unique-id = {33258723},
	abstract = {We present plasmid sequences of 21 multidrug resistant isolates of Enterobacterales belonging to Escherichia coli (n=10), Klebsiella pneumoniae (n=9), Klebsiella oxytoca (n=1), and Citrobacter freundii (n=1). The isolates originated from effluent collected from hospital sewer pipes and from a wastewater treatment plant (WWTP) in a southwestern Hungarian city. Isolation was carried out using eosin methylene blue agar supplemented with ceftriaxone and the isolates were identified with MALDI-TOF MS. Screening for multidrug resistance was conducted by determining susceptibility to four chemical classes namely, beta-lactams, aminoglycoside, fluoroquinolone, and sulfonamide. Plasmid DNA was isolated by alkaline lysis method using the Monarch plasmid DNA miniprep kit from freshly grown pure colonies. Molecular typing and Illumina sequencing of plasmid DNA of multiresistant strains were performed. After the assembly of contigs, genes localized on plasmid sequences were determined and functionally annotated. These reconstructed plasmid sequences supplemented with gene functional annotations were deposited in the Mendeley data. Using these datasets different plasmid incompatibility groups were identified. These conjugative plasmids appear to play a key role in the transmission of multiple resistance genes in enteric bacteria via wastewater. The presented data may provide useful insight on the correlations between environmental antibiotic contamination and the development of bacterial resistance, which poses a serious public health threat.},
	keywords = {Resistance genes; plasmid; wastewater treatment plant; Enterobacterales; hospital effluents; β-lactamases},
	year = {2022},
	eissn = {2352-3409},
	orcid-numbers = {Mutuku, Christopher/0000-0001-9742-1423; Herczeg, Róbert/0000-0002-5903-0082}
}

@article{MTMT:33092180,
	title = {A state-of-the-art guide to the sterilization of thermoplastic polymers and resin materials used in the additive manufacturing of medical devices},
	url = {https://m2.mtmt.hu/api/publication/33092180},
	author = {Told, Roland and Ujfalusi, Zoltán and Péntek, Attila and Kerényi, Mónika and Bánfai, Krisztina and Vizi, András and Szabó, Péter and Melegh, Szilvia Zsóka and Bovári-Biri, Judit and Pongrácz, Judit and Maróti, Péter},
	doi = {10.1016/j.matdes.2022.111119},
	journal-iso = {MATER DESIGN},
	journal = {MATERIALS AND DESIGN},
	volume = {223},
	unique-id = {33092180},
	issn = {0264-1275},
	year = {2022},
	eissn = {1873-4197},
	orcid-numbers = {Ujfalusi, Zoltán/0000-0001-5936-7286; Kerényi, Mónika/0000-0002-5767-9662; Szabó, Péter/0000-0003-0827-3583; Pongrácz, Judit/0000-0002-0278-5556; Maróti, Péter/0000-0001-7538-0675}
}

@article{MTMT:32925509,
	title = {Occurrence of antibiotics and bacterial resistance genes in wastewater : resistance mechanisms and antimicrobial resistance control approaches},
	url = {https://m2.mtmt.hu/api/publication/32925509},
	author = {Mutuku, Christopher and Gazdag, Zoltán and Melegh, Szilvia Zsóka},
	doi = {10.1007/s11274-022-03334-0},
	journal-iso = {WORLD J MICROB BIOT},
	journal = {WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY},
	volume = {38},
	unique-id = {32925509},
	issn = {0959-3993},
	abstract = {Antimicrobial pharmaceuticals are classified as emergent micropollutants of concern, implying that even at low concentrations, long-term exposure to the environment can have significant eco-toxicological effects. There is a lack of a standardized regulatory framework governing the permissible antibiotic content for monitoring environmental water quality standards. Therefore, indiscriminate discharge of antimicrobials at potentially active concentrations into urban wastewater treatment facilities is rampant. Antimicrobials may exert selective pressure on bacteria, leading to resistance development and eventual health consequences. The emergence of clinically important multiple antibiotic-resistant bacteria in untreated hospital effluents and wastewater treatment plants (WWTPs) has been linked to the continuous exposure of bacteria to antimicrobials. The levels of environmental exposure to antibiotics and their correlation to the evolution and spread of resistant bacteria need to be elucidated to help in the formulation of mitigation measures. This review explores frequently detected antimicrobials in wastewater and gives a comprehensive coverage of bacterial resistance mechanisms to different antibiotic classes through the expression of a wide variety of antibiotic resistance genes either inherent and/or exchanged among bacteria or acquired from the reservoir of antibiotic resistance genes (ARGs) in wastewater systems. To complement the removal of antibiotics and ARGs from WWTPs, upscaling the implementation of prospective interventions such as vaccines, phage therapy, and natural compounds as alternatives to widespread antibiotic use provides a multifaceted approach to minimize the spread of antimicrobial resistance.},
	keywords = {BACTERIA; Resistance genes; antibiotics; wastewater},
	year = {2022},
	eissn = {1573-0972}
}

@article{MTMT:32873680,
	title = {Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant},
	url = {https://m2.mtmt.hu/api/publication/32873680},
	author = {Mutuku, Christopher and Melegh, Szilvia Zsóka and Kovács, Krisztina and Urbán, Péter and Virág, Eszter Andrea and Héninger, Réka and Herczeg, Róbert and Sonnevend, Ágnes and Gyenesei, Attila and Fekete, Csaba and Gazdag, Zoltán},
	doi = {10.3390/antibiotics11060776},
	journal-iso = {ANTIBIOTICS-BASEL},
	journal = {ANTIBIOTICS},
	volume = {11},
	unique-id = {32873680},
	year = {2022},
	eissn = {2079-6382},
	orcid-numbers = {Herczeg, Róbert/0000-0002-5903-0082}
}

@article{MTMT:32716546,
	title = {Molecular Characterization of MCR-1 Producing Enterobacterales Isolated in Poultry Farms in the United Arab Emirates},
	url = {https://m2.mtmt.hu/api/publication/32716546},
	author = {Sonnevend, Ágnes and Alali, Walid Q. and Mahmoud, Sara A. and Ghazawi, Akela and Bharathan, Greeshma and Melegh, Szilvia Zsóka and Rizvi, Tahir A. and Pál, Tibor},
	doi = {10.3390/antibiotics11030305},
	journal-iso = {ANTIBIOTICS-BASEL},
	journal = {ANTIBIOTICS},
	volume = {11},
	unique-id = {32716546},
	abstract = {Data on the prevalence of MCR-producing Enterobacterales of animal origin are scarce from the Arabian Peninsula. We investigated the presence and variety of such strains from fecal specimens of poultry collected in four farms in the United Arab Emirates. Colonies from ten composite samples per farm grown on colistin-supplemented plates were PCR-screened for alleles of the mcr gene. Thirty-nine isolates selected based on species, colony morphology, and plasmid profile were subjected to whole genome sequencing. The panel of their resistance and virulence genes, MLST and cgMLST were established. Transferability and incompatibility types of the MCR-plasmids were determined. mcr-1.1 positive strains were identified in 36 of the 40 samples. Thirty-four multi-drug resistant Escherichia coli of 16 different sequence types, two Escherichia albertii, two Klebsiella pneumoniae and one Salmonella minnesota were identified. Beyond various aminoglycoside, tetracycline, and co-trimoxazole resistance genes, seven of them also carried ESBL genes and one blaCMY-2. Six IncHI2, 26 IncI2 and 4 IncX4 MCR-plasmids were mobilized, in case of the IncHI2 plasmids co-transferring ampicillin, chloramphenicol and tetracycline resistance. The diversity of mcr-1 positive strains suggest a complex local epidemiology calling for a coordinated surveillance including animals, retail meat and clinical cases.},
	keywords = {Middle East; POULTRY; Multi-drug resistance; mobile colistin resistance},
	year = {2022},
	eissn = {2079-6382}
}

@{MTMT:32258096,
	title = {Antimicrobial resistance and prevalence of extended spectrum and metallo-β-lactamases in Pseudomonas aeruginosa from clinical and municipal wastewater},
	url = {https://m2.mtmt.hu/api/publication/32258096},
	author = {Mutuku, Christopher and Kovács, Krisztina and Melegh, Szilvia Zsóka and Urbán, Péter and Sonnevend, Ágnes and Fekete, Csaba and Gazdag, Zoltán},
	booktitle = {XIX. Szentágothai János Mutidiszciplináris Konferencia és Hallgatói Verseny: Absztrakt kötet = XIX. János Szentágothai Multidisciplinary Conference and Student Competition: Book of Abstracts},
	unique-id = {32258096},
	year = {2021},
	pages = {27-27}
}

@{MTMT:32131081,
	title = {Detection of Vancomycin Resistant Enterococci (VRE) from Hospital Effluents},
	url = {https://m2.mtmt.hu/api/publication/32131081},
	author = {Mutuku, Christopher and Kovács, Krisztina and Melegh, Szilvia Zsóka and Urbán, Péter and Sonnevend, Ágnes and Fekete, Csaba and Gazdag, Zoltán},
	booktitle = {Medical Conference for PhD Students and Experts of Clinical Sciences 2021},
	unique-id = {32131081},
	year = {2021},
	pages = {107-107}
}

@{MTMT:33547911,
	title = {Multiple Antimicrobial Resistance and Molecular Characterization of β-lactamases in enteric bacteria from Hospital Effluents and Wastewater Treatment Plant.},
	url = {https://m2.mtmt.hu/api/publication/33547911},
	author = {Mutuku, Christopher and Kovács, Krisztina and Melegh, Szilvia Zsóka and Héninger, Réka and Kulagin, D. and Urbán, Péter and Mestyan, Gyula. and Sonnevend, A. and Fekete, Csaba and Gazdag, Zoltán},
	booktitle = {Medical Conference for PhD Students and Experts of Clinical Sciences},
	unique-id = {33547911},
	keywords = {beta-Lactamases; Hospital effluent; WWTP; ENTERIC BACTERIA; Multiple antibiotic resistance},
	year = {2020},
	pages = {70-70}
}

@article{MTMT:31408959,
	title = {Streptococcus suis: An Underestimated Emerging Pathogen in Hungary?},
	url = {https://m2.mtmt.hu/api/publication/31408959},
	author = {Gajdács, Márió and Németh, Anita and Knausz, Márta and Barrak, Ibrahim Ádám and Stájer, Anette and Mestyán, Gyula and Melegh, Szilvia Zsóka and Nyul, Adrienn and Tóth, Ákos and Ágoston, Zsuzsanna and Zsoldiné Urbán, Edit},
	doi = {10.3390/microorganisms8091292},
	journal-iso = {MICROORGANISMS},
	journal = {MICROORGANISMS},
	volume = {8},
	unique-id = {31408959},
	issn = {2076-2607},
	year = {2020},
	eissn = {2076-2607},
	orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Barrak, Ibrahim Ádám/0000-0001-8808-1762; Stájer, Anette/0000-0003-4158-173X; Zsoldiné Urbán, Edit/0000-0002-9602-7552}
}