TY - JOUR AU - Molnár, Tihamér AU - Lehoczki, Andrea Marianna AU - Fekete, Mónika AU - Várnai, Réka AU - Zavori, Laszlo AU - Erdő-Bonyár, Szabina AU - Simon, Diána AU - Berki, Tímea AU - Csécsei, Péter AU - Ezer, Erzsébet TI - Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - In press PY - 2024 SN - 2509-2715 DO - 10.1007/s11357-024-01165-5 UR - https://m2.mtmt.hu/api/publication/34824081 ID - 34824081 N1 - * Megosztott szerzőség AB - The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution of the acute phase of infection. Among the myriad of symptoms reported by long COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond the initial viral pathology. Emerging evidence has pointed to mitochondrial dysfunction as a potential underpinning mechanism contributing to the persistence and diversity of long COVID symptoms. This review aims to synthesize current findings related to mitochondrial dysfunction in long COVID, exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances, and endothelial dysfunction. Through a comprehensive analysis of the literature, we highlight the significance of mitochondrial health in the pathophysiology of long COVID, drawing parallels with similar clinical syndromes linked to post-infectious states in other diseases where mitochondrial impairment has been implicated. We discuss potential therapeutic strategies targeting mitochondrial function, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, and emphasize the need for further research and collaborative efforts to advance our understanding and management of long COVID. This review underscores the critical role of mitochondrial dysfunction in long COVID and calls for a multidisciplinary approach to address the gaps in our knowledge and treatment options for those affected by this condition. LA - English DB - MTMT ER - TY - JOUR AU - Nörenberg, Jasper Maximilian AU - Vida, P. AU - Bösmeier, I. AU - Forró, B. AU - Nörenberg, A. AU - Buda, Á. AU - Simon, Diána AU - Erdő-Bonyár, Szabina AU - Jáksó, Pál AU - Kovács, Kálmán András AU - Mikó, Éva AU - Berki, Tímea AU - Mezősi, Emese AU - Barakonyi, Alíz TI - Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 15 PY - 2024 PG - 12 SN - 1664-3224 DO - 10.3389/fimmu.2024.1382424 UR - https://m2.mtmt.hu/api/publication/34796888 ID - 34796888 N1 - Journal Article; Research Support, Non-U.S. Gov't LA - English DB - MTMT ER - TY - JOUR AU - Simon, Diána AU - Kacsándi, Dorottya AU - Karancsiné Pusztai, Anita AU - Soós, Boglárka AU - Végh, Edit AU - Kerekes, György AU - Czókolyová, Monika AU - Szamosi, Szilvia AU - Szűcs, Gabriella AU - Prohászka, Zoltán AU - Németh, Péter AU - Berki, Tímea AU - Szekanecz, Zoltán TI - Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 6 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25063429 UR - https://m2.mtmt.hu/api/publication/34745209 ID - 34745209 N1 - * Megosztott szerzőség AB - Cardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM and IgG levels were determined by ELISA. Ultrasonography was performed to assess brachial artery flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT), and arterial pulse-wave velocity (PWV). Other variables were also evaluated at baseline and 6 and 12 months after treatment initiation. Anti-TNF therapy improved FMD in RA and PWV in AS and stabilized ccIMT. TNF inhibition increased anti-CS IgM and IgG, and possibly also anti-TOPO-F4 IgG levels. Various correlation analyses revealed that nAAbs might be independently involved in autoimmunity as well as changes in inflammation and vascular pathology over time in biologic-treated patients (p < 0.05). We also found associations between anti-TOPO-F4 IgG and anti-Hsp60 IgG (p < 0.05). Baseline nAAb levels or nAAb level changes might determine changes in CRP, disease activity, FMD, PWV, and ccIMT over time (p < 0.05). The interplay between arthritis and inflammatory atherosclerosis, as well as the effects of anti-TNF biologics on these pathologies, might independently involve nAAbs. LA - English DB - MTMT ER - TY - JOUR AU - Simon, Diána AU - Erdő-Bonyár, Szabina AU - Böröcz, Katalin AU - Balázs, Noémi AU - Badawy, Ahmed AU - Bajnok, Anna AU - Nörenberg, Jasper Maximilian AU - Litvai, Tímea AU - Várnagy, Ákos AU - Kovács, Kálmán András AU - Hantosi, Eszter AU - Mezősi, Emese AU - Németh, Péter AU - Berki, Tímea TI - Altered Levels of Natural Autoantibodies against Heat Shock Proteins in Pregnant Women with Hashimoto’s Thyroiditis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 3 PG - 9 SN - 1661-6596 DO - 10.3390/ijms25031423 UR - https://m2.mtmt.hu/api/publication/34538798 ID - 34538798 N1 - Department of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, Pécs, 7624, Hungary National Laboratory on Human Reproduction, University of Pécs, Pécs, 7624, Hungary Szentágothai Research Centre, University of Pécs, Pécs, 7624, Hungary Department of Obstetrics and Gynecology, Clinical Center, Medical School, University of Pécs, Pécs, 7624, Hungary First Department of Internal Medicine, Clinical Center, Medical School, University of Pécs, Pécs, 7624, Hungary Export Date: 19 February 2024 Correspondence Address: Erdő-Bonyár, S.; Department of Immunology and Biotechnology, Hungary; email: erdo-bonyar.szabina@pte.hu AB - The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto’s thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study’s objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP). Serum samples collected from HTP and healthy pregnant (HP) women in the first and third trimesters were tested using in-house-developed enzyme-linked immunosorbent assays (ELISAs). Our findings indicate the stability of nAAbs against CS and Hsps throughout the pregnancies of both healthy women and those with HT. However, during both trimesters, HTP patients displayed elevated levels of IgM isotype nAAbs against Hsp60 and Hsp70 compared to HP women, suggesting a regulatory role of IgM nAAbs during the pregnancies of patients with HT. Nonetheless, levels of IgG isotype nAAbs against Hsps were lower solely in the third trimester among HTP patients, resulting in a higher IgM/IgG ratio, which indicates their importance in alterations of the nAAb network during pregnancy in patients with HT. LA - English DB - MTMT ER - TY - JOUR AU - Pethő, Borbála AU - Kovács, Márton Áron AU - Simon, Diána AU - Tóth, Tünde AU - Hajnal, András Sándor AU - Csulak, Timea AU - Hebling, Dóra AU - Albert, Noémi AU - Varga, Eszter AU - Herold, Márton AU - Osváth, Péter AU - Vörös, Viktor AU - Tényi, Tamás AU - Herold, Róbert TI - Investigation of peripheral inflammatory biomarkers in association with suicide risk in major depressive disorder JF - FRONTIERS IN PSYCHIATRY J2 - FRONT PSYCHIATRY VL - 15 PY - 2024 PG - 14 SN - 1664-0640 DO - 10.3389/fpsyt.2024.1321354 UR - https://m2.mtmt.hu/api/publication/34498729 ID - 34498729 LA - English DB - MTMT ER - TY - JOUR AU - Simon, Diána AU - Erdő-Bonyár, Szabina AU - Balázs, Noémi AU - Böröcz, Katalin AU - Bajnok, Anna AU - Nörenberg, Jasper Maximilian AU - Litvai, Tímea AU - Várnagy, Ákos AU - Kovács, Kálmán András AU - Mezősi, Emese AU - Németh, Péter AU - Berki, Tímea TI - Természetes autoantitestek változásai egészséges és Hashimoto thyreoiditises nők terhessége során JF - IMMUNOLÓGIAI SZEMLE J2 - IMMUNOLÓGIAI SZEMLE VL - 15 PY - 2023 IS - 3 SP - 49 EP - 58 PG - 10 SN - 2061-0203 UR - https://m2.mtmt.hu/api/publication/34747030 ID - 34747030 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szinger, Dávid AU - Berki, Tímea AU - Németh, Péter AU - Erdő-Bonyár, Szabina AU - Simon, Diána AU - Drenjančević, Ines AU - Samardzic, Senka AU - Zelić, Marija AU - Sikora, Magdalena AU - Požgain, Arlen AU - Böröcz, Katalin TI - Following Natural Autoantibodies : Further Immunoserological Evidence Regarding Their Silent Plasticity and Engagement in Immune Activation JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 19 PG - 19 SN - 1661-6596 DO - 10.3390/ijms241914961 UR - https://m2.mtmt.hu/api/publication/34214743 ID - 34214743 N1 - Department of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, Pécs, 7624, Hungary Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, 31000, Croatia Scientific Centre for Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek, Osijek, 31000, Croatia Department of Public Health, Teaching Institute of Public Health for The Osijek-Baranja County, Osijek, 31000, Croatia Department of Microbiology, Parasitology, and Clinical Laboratory Diagnostics, Medical Faculty of Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, 31000, Croatia Export Date: 22 January 2024; Cited By: 1; Correspondence Address: K. Böröcz; Department of Immunology and Biotechnology, Clinical Center, Medical School, University of Pécs, Pécs, 7624, Hungary; email: borocz.katalin@pte.hu AB - Contradictory reports are available on vaccine-associated hyperstimulation of the immune system, provoking the formation of pathological autoantibodies. Despite being interconnected within the same network, the role of the quieter, yet important non-pathological and natural autoantibodies (nAAbs) is less defined. We hypothesize that upon a prompt immunological trigger, physiological nAAbs also exhibit a moderate plasticity. We investigated their inducibility through aged and recent antigenic triggers. Anti-viral antibodies (anti-MMR n = 1739 and anti-SARS-CoV-2 IgG n = 330) and nAAbs (anti-citrate synthase IgG, IgM n = 1739) were measured by in-house and commercial ELISAs using Croatian (Osijek) anonymous samples with documented vaccination backgrounds. The results were subsequently compared for statistical evaluation. Interestingly, the IgM isotype nAAb showed a statistically significant connection with anti-MMR IgG seropositivity (p < 0.001 in all cases), while IgG isotype nAAb levels were elevated in association with anti-SARS CoV-2 specific seropositivity (p = 0.019) and in heterogeneous vaccine regimen recipients (unvaccinated controls vector/mRNA vaccines p = 0.002). Increasing evidence supports the interplay between immune activation and the dynamic expansion of nAAbs. Consequently, further questions may emerge regarding the ability of nAAbs silently shaping the effectiveness of immunization. We suggest re-evaluating the impact of nAAbs on the complex functioning of the immunological network. LA - English DB - MTMT ER - TY - JOUR AU - Böröcz, K AU - Szinger, D AU - Simon, Diána AU - Erdő-Bonyár, S AU - Nemeth, P AU - Berki, T TI - Potential non-specific side effects of anti-viral vaccines? - A study on the suspected dynamic plasticity of natural autoantibodies in the post-COVID era JF - CLINICAL CHEMISTRY AND LABORATORY MEDICINE J2 - CLIN CHEM LAB MED VL - 61 PY - 2023 IS - 8 SP - eA108 EP - eA108 SN - 1434-6621 UR - https://m2.mtmt.hu/api/publication/34156273 ID - 34156273 LA - English DB - MTMT ER - TY - JOUR AU - Erdő-Bonyár, Szabina AU - Simon, Diána AU - Bajnok, A. AU - Nörenberg, J. AU - Sereny-Litvai, T. AU - Várnagy, Á. AU - Kovács, K. AU - Hantosi, E. AU - Mezősi, E. AU - Berki, T. TI - Multiplex anti-cytokine autoantibody detection during pregnancy JF - CLINICAL CHEMISTRY AND LABORATORY MEDICINE J2 - CLIN CHEM LAB MED VL - 61 PY - 2023 IS - 8 SP - eA91 EP - eA91 SN - 1434-6621 UR - https://m2.mtmt.hu/api/publication/34141504 ID - 34141504 LA - English DB - MTMT ER - TY - JOUR AU - Pethő, Borbála AU - Tényi, Tamás AU - Simon, Diána AU - Herold, Róbert AU - Kovács, Márton Áron TI - Perifériás gyulladásos biomarkerek vizsgálata magas szuicid rizikójú major depressziós betegekben JF - PSYCHIATRIA HUNGARICA J2 - PSYCHIATRIA HUNG VL - 38 PY - 2023 IS - Suppl. 1 SP - 83 EP - 83 PG - 1 SN - 0237-7896 UR - https://m2.mtmt.hu/api/publication/34134311 ID - 34134311 LA - Hungarian DB - MTMT ER -