@article{MTMT:34824081,
	title = {Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches},
	url = {https://m2.mtmt.hu/api/publication/34824081},
	author = {Molnár, Tihamér and Lehoczki, Andrea Marianna and Fekete, Mónika and Várnai, Réka and Zavori, Laszlo and Erdő-Bonyár, Szabina and Simon, Diána and Berki, Tímea and Csécsei, Péter and Ezer, Erzsébet},
	doi = {10.1007/s11357-024-01165-5},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {In press},
	unique-id = {34824081},
	issn = {2509-2715},
	abstract = {The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution of the acute phase of infection. Among the myriad of symptoms reported by long COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond the initial viral pathology. Emerging evidence has pointed to mitochondrial dysfunction as a potential underpinning mechanism contributing to the persistence and diversity of long COVID symptoms. This review aims to synthesize current findings related to mitochondrial dysfunction in long COVID, exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances, and endothelial dysfunction. Through a comprehensive analysis of the literature, we highlight the significance of mitochondrial health in the pathophysiology of long COVID, drawing parallels with similar clinical syndromes linked to post-infectious states in other diseases where mitochondrial impairment has been implicated. We discuss potential therapeutic strategies targeting mitochondrial function, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, and emphasize the need for further research and collaborative efforts to advance our understanding and management of long COVID. This review underscores the critical role of mitochondrial dysfunction in long COVID and calls for a multidisciplinary approach to address the gaps in our knowledge and treatment options for those affected by this condition.},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34796888,
	title = {Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential},
	url = {https://m2.mtmt.hu/api/publication/34796888},
	author = {Nörenberg, Jasper Maximilian and Vida, P. and Bösmeier, I. and Forró, B. and Nörenberg, A. and Buda, Á. and Simon, Diána and Erdő-Bonyár, Szabina and Jáksó, Pál and Kovács, Kálmán András and Mikó, Éva and Berki, Tímea and Mezősi, Emese and Barakonyi, Alíz},
	doi = {10.3389/fimmu.2024.1382424},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34796888},
	issn = {1664-3224},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Berki, Tímea/0000-0002-0134-8127; Mezősi, Emese/0000-0001-9367-3877}
}

@article{MTMT:34745209,
	title = {Natural Autoantibodies in Biologic-Treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients: Associations with Vascular Pathophysiology},
	url = {https://m2.mtmt.hu/api/publication/34745209},
	author = {Simon, Diána and Kacsándi, Dorottya and Karancsiné Pusztai, Anita and Soós, Boglárka and Végh, Edit and Kerekes, György and Czókolyová, Monika and Szamosi, Szilvia and Szűcs, Gabriella and Prohászka, Zoltán and Németh, Péter and Berki, Tímea and Szekanecz, Zoltán},
	doi = {10.3390/ijms25063429},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34745209},
	issn = {1661-6596},
	abstract = {Cardiovascular (CV) morbidity and mortality have been associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Natural autoantibodies (nAAb) are involved in innate immunity, as well as autoimmunity, inflammation, and atherosclerosis. There have not been any studies assessing the effects of biologics on nAAbs in RA and AS, also in relation to vascular pathophysiology. Fifty-three anti-TNF-treated RA and AS patients were included in a 12-month follow-up study. Anti-citrate synthase (CS) and anti-topoisomerase I fragment 4 (TOPO-F4) IgM and IgG levels were determined by ELISA. Ultrasonography was performed to assess brachial artery flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT), and arterial pulse-wave velocity (PWV). Other variables were also evaluated at baseline and 6 and 12 months after treatment initiation. Anti-TNF therapy improved FMD in RA and PWV in AS and stabilized ccIMT. TNF inhibition increased anti-CS IgM and IgG, and possibly also anti-TOPO-F4 IgG levels. Various correlation analyses revealed that nAAbs might be independently involved in autoimmunity as well as changes in inflammation and vascular pathology over time in biologic-treated patients (p < 0.05). We also found associations between anti-TOPO-F4 IgG and anti-Hsp60 IgG (p < 0.05). Baseline nAAb levels or nAAb level changes might determine changes in CRP, disease activity, FMD, PWV, and ccIMT over time (p < 0.05). The interplay between arthritis and inflammatory atherosclerosis, as well as the effects of anti-TNF biologics on these pathologies, might independently involve nAAbs.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Prohászka, Zoltán/0000-0003-1761-7982; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34538798,
	title = {Altered Levels of Natural Autoantibodies against Heat Shock Proteins in Pregnant Women with Hashimoto’s Thyroiditis},
	url = {https://m2.mtmt.hu/api/publication/34538798},
	author = {Simon, Diána and Erdő-Bonyár, Szabina and Böröcz, Katalin and Balázs, Noémi and Badawy, Ahmed and Bajnok, Anna and Nörenberg, Jasper Maximilian and Litvai, Tímea and Várnagy, Ákos and Kovács, Kálmán András and Hantosi, Eszter and Mezősi, Emese and Németh, Péter and Berki, Tímea},
	doi = {10.3390/ijms25031423},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34538798},
	issn = {1661-6596},
	abstract = {The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto’s thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study’s objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP). Serum samples collected from HTP and healthy pregnant (HP) women in the first and third trimesters were tested using in-house-developed enzyme-linked immunosorbent assays (ELISAs). Our findings indicate the stability of nAAbs against CS and Hsps throughout the pregnancies of both healthy women and those with HT. However, during both trimesters, HTP patients displayed elevated levels of IgM isotype nAAbs against Hsp60 and Hsp70 compared to HP women, suggesting a regulatory role of IgM nAAbs during the pregnancies of patients with HT. Nonetheless, levels of IgG isotype nAAbs against Hsps were lower solely in the third trimester among HTP patients, resulting in a higher IgM/IgG ratio, which indicates their importance in alterations of the nAAb network during pregnancy in patients with HT.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Bajnok, Anna/0000-0002-0647-4149; Mezősi, Emese/0000-0001-9367-3877; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34498729,
	title = {Investigation of peripheral inflammatory biomarkers in association with suicide risk in major depressive disorder},
	url = {https://m2.mtmt.hu/api/publication/34498729},
	author = {Pethő, Borbála and Kovács, Márton Áron and Simon, Diána and Tóth, Tünde and Hajnal, András Sándor and Csulak, Timea and Hebling, Dóra and Albert, Noémi and Varga, Eszter and Herold, Márton and Osváth, Péter and Vörös, Viktor and Tényi, Tamás and Herold, Róbert},
	doi = {10.3389/fpsyt.2024.1321354},
	journal-iso = {FRONT PSYCHIATRY},
	journal = {FRONTIERS IN PSYCHIATRY},
	volume = {15},
	unique-id = {34498729},
	issn = {1664-0640},
	year = {2024},
	eissn = {1664-0640}
}

@article{MTMT:34747030,
	title = {Természetes autoantitestek változásai egészséges és Hashimoto thyreoiditises nők terhessége során},
	url = {https://m2.mtmt.hu/api/publication/34747030},
	author = {Simon, Diána and Erdő-Bonyár, Szabina and Balázs, Noémi and Böröcz, Katalin and Bajnok, Anna and Nörenberg, Jasper Maximilian and Litvai, Tímea and Várnagy, Ákos and Kovács, Kálmán András and Mezősi, Emese and Németh, Péter and Berki, Tímea},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {15},
	unique-id = {34747030},
	issn = {2061-0203},
	year = {2023},
	pages = {49-58},
	orcid-numbers = {Bajnok, Anna/0000-0002-0647-4149; Mezősi, Emese/0000-0001-9367-3877; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34214743,
	title = {Following Natural Autoantibodies : Further Immunoserological Evidence Regarding Their Silent Plasticity and Engagement in Immune Activation},
	url = {https://m2.mtmt.hu/api/publication/34214743},
	author = {Szinger, Dávid and Berki, Tímea and Németh, Péter and Erdő-Bonyár, Szabina and Simon, Diána and Drenjančević, Ines and Samardzic, Senka and Zelić, Marija and Sikora, Magdalena and Požgain, Arlen and Böröcz, Katalin},
	doi = {10.3390/ijms241914961},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34214743},
	issn = {1661-6596},
	abstract = {Contradictory reports are available on vaccine-associated hyperstimulation of the immune system, provoking the formation of pathological autoantibodies. Despite being interconnected within the same network, the role of the quieter, yet important non-pathological and natural autoantibodies (nAAbs) is less defined. We hypothesize that upon a prompt immunological trigger, physiological nAAbs also exhibit a moderate plasticity. We investigated their inducibility through aged and recent antigenic triggers. Anti-viral antibodies (anti-MMR n = 1739 and anti-SARS-CoV-2 IgG n = 330) and nAAbs (anti-citrate synthase IgG, IgM n = 1739) were measured by in-house and commercial ELISAs using Croatian (Osijek) anonymous samples with documented vaccination backgrounds. The results were subsequently compared for statistical evaluation. Interestingly, the IgM isotype nAAb showed a statistically significant connection with anti-MMR IgG seropositivity (p < 0.001 in all cases), while IgG isotype nAAb levels were elevated in association with anti-SARS CoV-2 specific seropositivity (p = 0.019) and in heterogeneous vaccine regimen recipients (unvaccinated controls vector/mRNA vaccines p = 0.002). Increasing evidence supports the interplay between immune activation and the dynamic expansion of nAAbs. Consequently, further questions may emerge regarding the ability of nAAbs silently shaping the effectiveness of immunization. We suggest re-evaluating the impact of nAAbs on the complex functioning of the immunological network.},
	keywords = {IMMUNIZATION; IGG; VACCINE; PLASTICITY; Serology; ELISA; autoantibody; MMR; SARS-CoV-2; natural autoantibody; anti-viral antibody; immunological network},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34156273,
	title = {Potential non-specific side effects of anti-viral vaccines? - A study on the suspected dynamic plasticity of natural autoantibodies in the post-COVID era},
	url = {https://m2.mtmt.hu/api/publication/34156273},
	author = {Böröcz, K and Szinger, D and Simon, Diána and Erdő-Bonyár, S and Nemeth, P and Berki, T},
	journal-iso = {CLIN CHEM LAB MED},
	journal = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE},
	volume = {61},
	unique-id = {34156273},
	issn = {1434-6621},
	year = {2023},
	eissn = {1437-4331},
	pages = {eA108-eA108}
}

@article{MTMT:34141504,
	title = {Multiplex anti-cytokine autoantibody detection during pregnancy},
	url = {https://m2.mtmt.hu/api/publication/34141504},
	author = {Erdő-Bonyár, Szabina and Simon, Diána and Bajnok, A. and Nörenberg, J. and Sereny-Litvai, T. and Várnagy, Á. and Kovács, K. and Hantosi, E. and Mezősi, E. and Berki, T.},
	journal-iso = {CLIN CHEM LAB MED},
	journal = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE},
	volume = {61},
	unique-id = {34141504},
	issn = {1434-6621},
	year = {2023},
	eissn = {1437-4331},
	pages = {eA91-eA91}
}

@article{MTMT:34134311,
	title = {Perifériás gyulladásos biomarkerek vizsgálata magas szuicid rizikójú major depressziós betegekben},
	url = {https://m2.mtmt.hu/api/publication/34134311},
	author = {Pethő, Borbála and Tényi, Tamás and Simon, Diána and Herold, Róbert and Kovács, Márton Áron},
	journal-iso = {PSYCHIATRIA HUNG},
	journal = {PSYCHIATRIA HUNGARICA},
	volume = {38},
	unique-id = {34134311},
	issn = {0237-7896},
	year = {2023},
	pages = {83-83}
}