@article{MTMT:34728998,
	title = {Bőrön elhelyezkedő, metasztatizáló fej-nyaki laphámkarcinómák onkológiai szemléletű kezelésének jelentősége},
	url = {https://m2.mtmt.hu/api/publication/34728998},
	author = {Égi, Fruzsina and Greksa, Dávid and Halmos, Réka and Cifra, János and Kravják, András and Kálmán, Endre and Molnár, Krisztián and Móricz, Péter},
	journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT},
	journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT},
	volume = {70},
	unique-id = {34728998},
	issn = {0016-237X},
	year = {2024},
	pages = {26-30},
	orcid-numbers = {Móricz, Péter/0000-0001-8815-0625}
}

@article{MTMT:34477404,
	title = {Comparative analysis of EZH2, p16 and p53 expression in uterine carcinosarcomas},
	url = {https://m2.mtmt.hu/api/publication/34477404},
	author = {Makk, Evelin and Bohonyi, Noémi and Oszter, Angéla and Éles, Klára and Tornóczky, Tamás and Tóth, Arnold and Kálmán, Endre and Kovács, Krisztina},
	doi = {10.3389/pore.2023.1611547},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {29},
	unique-id = {34477404},
	issn = {1219-4956},
	abstract = {Introduction: The role of p16 and p53 immunohistochemistry in the diagnosis of rare and aggressive uterine carcinosarcoma (UCS) has been well established. However, enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a member of the polycomb group family is a relatively new biomarker, with limited published data on its significance in this tumor type. The goal of this study was to examine EZH2 expression in UCS and its components, in correlation with morphological features, and p16 and p53 staining patterns. Methods: Twenty-eight UCSs were included in the study. EZH2, p16 and p53 immunoreactivity were assessed independently by two pathologists in both tumor components (epithelial and mesenchymal). EZH2 and p16 immunostains were scored semiquantitatively: based on the percentage and intensity of tumor cell staining a binary staining index ("high- or low-expressing") was calculated. The p53 staining pattern was evaluated as wild-type or aberrant (diffuse nuclear, null, or cytoplasmic expression). Statistical tests were used to evaluate the correlation between staining patterns for all three markers and the different tumor components and histotypes. Results: High EZH2 and p16 expression and aberrant p53 patterns were present in 89.3% 78.6% and 85.7% of the epithelial component and in 78.6%, 62.5% and 82.1% of the mesenchymal component, respectively. Differences among these expression rates were not found to be significant (p > 0.05). Regarding the epithelial component, aberrant p53 pattern was found to be significantly (p = 0.0474) more frequent in the serous (100%) than in endometrioid (66.6%) histotypes. Within the mesenchymal component, p53 null expression pattern occurred significantly (p = 0.0257) more frequently in heterologous sarcoma components (71.4%) compared to the homologous histotype (18.8%). Conclusion: In conclusion, EZH2, p16 and p53 seem to play a universal role in the pathogenesis of UCS; however, a distinctive pattern of p53 expression appears to exist between the serous and endometrioid carcinoma components and also between the homologous and heterologous sarcoma components.},
	keywords = {p53; carcinosarcoma; EZH2; p16; uterine cancer},
	year = {2023},
	eissn = {1532-2807}
}

@article{MTMT:34113096,
	title = {Evaluation of the routine use of E-cadherin immunohistochemistry in the typing of breast carcinomas : results of a randomized diagnostic study},
	url = {https://m2.mtmt.hu/api/publication/34113096},
	author = {Cserni, Gábor and Kálmán, Endre and Udvarhelyi, Nóra and Papp, Eszter and Grote, Isabel and Bartels, Stephan and Christgen, Matthias and Kreipe, Hans and Kulka, Janina},
	doi = {10.1111/his.15026},
	journal-iso = {HISTOPATHOLOGY},
	journal = {HISTOPATHOLOGY},
	volume = {83},
	unique-id = {34113096},
	issn = {0309-0167},
	abstract = {Invasive lobular carcinoma (ILC) has distinct morphology and association with loss of E-cadherin function. It has special clinical and imaging features, and its proper recognition is important. Following a recent proposal, we tested the value of the routine use of E-cadherin immunohistochemistry (IHC) in recognizing ILC.Five pathologists with experience in breast pathology from four Hungarian institutions histotyped 1001 breast cancers from diagnostic core biopsies or excision specimens randomly assigned to haematoxylin and eosin (HE) diagnosis first, followed by E-cadherin IHC; or to immediate HE and E-cadherin-based diagnosis. Of 524 cases with HE diagnosis, 73(14%) were deemed uncertain. E-cadherin made the initial histological type change in 14/524 cases (2.7%), including three with confident HE-based type allocation. Use of E-cadherin immunostaining was considered useful in 88/477 cases (18%) with immediate dual assessment, and typing uncertainty went down to 5% (25/477 cases), but was not zero. Collective assessment of 171 uncertain, difficult, nonclassical cases resulted in consensus diagnosis in most cases, but 15 cases were still doubtful as concerns their proper histological type. CDH1 gene sequencing was attempted and successful in 13; pathogenic genetic alterations were identified in seven cases.The routine use of E-cadherin IHC decreases the uncertainty in typing and improves the typing accuracy at the cost of potentially redundant additional immunostains. Furthermore, this procedure does not exclude uncertainty due to E-cadherin-positive ILCs, which are occasionally difficult to confidently label as ILC, especially when the growth pattern is not classic.},
	keywords = {immunohistochemistry; breast cancer; E-CADHERIN; INVASIVE LOBULAR CARCINOMA; CDH1 mutation},
	year = {2023},
	eissn = {1365-2559},
	pages = {810-821},
	orcid-numbers = {Cserni, Gábor/0000-0003-1344-7744; Kulka, Janina/0000-0001-6498-5943}
}

@article{MTMT:34104423,
	title = {Chloroquin indukálta cardiomyopathia avagy a „pseudo-Fabry-kór” fulmináns lefolyású esete = Chloroquine- induced cardiomyopathy; a fulminant course of ‟pseudo-Fabry’s-disease”},
	url = {https://m2.mtmt.hu/api/publication/34104423},
	author = {Ezer, Péter and Kálmán, Endre and Nógrádi, Ágnes Beatrix and Vértes, Vivien and Hajdu, Máté and Cziráki, Attila and Faludi, Réka},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {52},
	unique-id = {34104423},
	issn = {0133-5596},
	year = {2022},
	eissn = {1588-0230},
	pages = {231-231}
}

@article{MTMT:33105823,
	title = {Chloroquin indukálta cardiomyopathia avagy a „pszeudo-Fabry-kór” fatális lefolyású esete},
	url = {https://m2.mtmt.hu/api/publication/33105823},
	author = {Ezer, Péter and Kálmán, Endre and Nógrádi, Ágnes Beatrix and Vértes, Vivien and Cziráki, Attila and Faludi, Réka},
	doi = {10.26430/CHUNGARICA.2022.52.5.38},
	journal-iso = {CARDIOL HUNG},
	journal = {CARDIOLOGIA HUNGARICA},
	volume = {52},
	unique-id = {33105823},
	issn = {0133-5596},
	abstract = {A chloroquint napjainkban szisztémás autoimmun kórképek kezelésére használják, autoimmun szöveti károsodást gátló és immunomoduláns hatása miatt. Ritka, ám súlyos mellékhatása a szernek, hogy restriktív cardiomyopathia-szerű képet okozhat, ami fenotípus és hisztológiai kép tekintetében egyaránt a Fabry-kór kardiális manifesztációjára emlékeztet. Munkánkban egy 73 éves nőbeteg esetét mutatjuk be, akinek fulmináns lefolyású szívelégtelensége hátterében chloroquin-cardiomyopathia állt. A beteg anamnézisében tartós chloroquinszedés szerepelt, rheumatoid arthritise miatt. 71 éves, korában harmadfokú atrioventricularis blokk miatt igényelt végleges pacemaker-implantációt. 2 évvel később kardiális dekompenzáció miatt került intézeti felvételre. Ekkor transthoracalis echokardiográfia során masszív koncentrikus bal kamrai hipertrófia, közepes fokban csökkent szisztolés balkamra-funkció és restriktív típusú mitrális beáramlási görbe volt észlelhető. A beteg a kéthetes hospitalizáció során kompenzálható volt, azonban 1 hónapon belül súlyos állapotban rehospitalizációra került sor, ami fatális kimenetelű volt. A klinikai kép és az autopsziás lelet alapján felmerült Fabry-betegség gyanúja. Tekintettel azonban a beteg tartós chloroquin szedésére, chloroquin indukálta cardiomyopathiát valószínűsítettünk. A chloroquin kardiális jellegű mellékhatásai – bár az alkalmazási előírásban említésre kerülnek – kevésbé ismertek. Ajánlásokra lenne szükség azzal kapcsolatban, hogy milyen gyakran, milyen módszerrel javasolt a tartósan chloroquint szedő betegek kardiológiai szűrése.},
	year = {2022},
	eissn = {1588-0230},
	pages = {38-44}
}

@article{MTMT:33035500,
	title = {Óriás mellkasi paraganglioma diagnosztikai nehézségei és terápiás lehetőségei.},
	url = {https://m2.mtmt.hu/api/publication/33035500},
	author = {Gulyás, Erna and Bajnok, László Zoltán and Nemes, Orsolya and Bódis, Beáta and Szukits, Sándor and Schmidt, Erzsébet and Semjén, Dávid and Kálmán, Endre and Szabados, Sándor and Kittka, Bálint and Benkő, István and Mezősi, Emese},
	doi = {10.1556/650.2022.32529},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {163},
	unique-id = {33035500},
	issn = {0030-6002},
	abstract = {Paragangliomas are mostly benign tumors originating from the sympathetic or parasympathetic ganglions, but malignant forms are also known. They are in the region of the head and neck, in the glomus caroticum, intra-abdominally as well as in the thorax. The investigation of the 39-year-old male patient began due to extremely high blood pressure, night sweats and a 10 kg weight loss. Chest CT scan described a huge mass in the right hilum, bronchoscopic sampling was inconclusive. Tumor biopsy was performed through right thoracotomy, but complete resection was not possible due to tissue adhesions and cardiac involvement. Histological examination verified paraganglioma, which was also confirmed by laboratory tests. Accordingly, somatostatin analog therapy was initiated, followed by 131I-MIBG treatment with good clinical effect. Coronary angiography confirmed that the right coronary artery contributed with two marginal branches to the blood supply of the thoracic mass. The tumor was successfully removed and after the cardio-thoracic surgery, the patient's antihypertensive therapy was stopped. There was no sign of relapse during follow-ups. During the medical investigation of severe blood pressure elevations, the possibility of paraganglioma should be considered. In these cases, invasive procedures, if not preceded by proper medication, can be fatal. By taking advantage of the ever-expanding therapeutic options and the cooperation between institutions, even patients with a giant paraganglioma can become tumor-free. Orv Hetil. 2022; 163(31): 1243-1249.},
	keywords = {CATECHOLAMINE; case report; SOMATOSTATIN ANALOG; Paraganglioma; esetismertetés; 131I-MIBG; katecholamin; szomatosztatinanalóg},
	year = {2022},
	eissn = {1788-6120},
	pages = {1243-1249},
	orcid-numbers = {Mezősi, Emese/0000-0001-9367-3877}
}

@article{MTMT:33029409,
	title = {SARS-CoV-2-fehérjék kimutatása immunhisztokémiai módszerrel emberi szövetekben.. Patológiai körvizsgálat},
	url = {https://m2.mtmt.hu/api/publication/33029409},
	author = {Pesti, Adrián István and Gyömörei, Csaba and Juhász, Péter and Kálmán, Endre and Kiss, András and Kuthi, Levente and Lotz, Gábor and Méhes, Gábor and Schaff, Zsuzsa and Tiszlavicz, László},
	doi = {10.1556/650.2022.32536},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {163},
	unique-id = {33029409},
	issn = {0030-6002},
	year = {2022},
	eissn = {1788-6120},
	pages = {975-983},
	orcid-numbers = {Pesti, Adrián István/0000-0001-6706-6221; Kiss, András/0000-0002-7453-3163; Kuthi, Levente/0000-0001-9247-6679; Lotz, Gábor/0000-0002-6921-8978; Schaff, Zsuzsa/0000-0002-6429-8059; Tiszlavicz, László/0000-0003-1134-6587}
}

@article{MTMT:33024107,
	title = {Pathological Diagnosis, Work-Up and Reporting of Breast Cancer 1st Central-Eastern European Professional Consensus Statement on Breast Cancer},
	url = {https://m2.mtmt.hu/api/publication/33024107},
	author = {Cserni, Gábor and Francz, Monika and Járay, Balázs and Kálmán, Endre and Kovács, Ilona and Krenács, Tibor and Tóth, Erika and Udvarhelyi, Nóra and Vass, László and Vörös, András and Krivokuca, Ana and Kajo, Karol and Kajová Macháleková, Katarína and Kulka, Janina},
	doi = {10.3389/pore.2022.1610373},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {28},
	unique-id = {33024107},
	issn = {1219-4956},
	abstract = {This text is based on the recommendations accepted by the 4th Hungarian Consensus Conference on Breast Cancer, modified on the basis of the international consultation and conference within the frames of the Central-Eastern European Academy of Oncology. The recommendations cover non-operative, intraoperative and postoperative diagnostics, determination of prognostic and predictive markers and the content of cytology and histology reports. Furthermore, they address some specific issues such as the current status of multigene molecular markers, the role of pathologists in clinical trials and prerequisites for their involvement, and some remarks about the future.},
	year = {2022},
	eissn = {1532-2807},
	orcid-numbers = {Cserni, Gábor/0000-0003-1344-7744; Krenács, Tibor/0000-0001-9164-065X; Tóth, Erika/0000-0003-2054-8447; Vörös, András/0000-0001-6837-0567; Kulka, Janina/0000-0001-6498-5943}
}

@article{MTMT:32849786,
	title = {High Prevalence of Non-Vaccinated Oncogenic Human Papillomavirus Genotypes in High-Grade Squamous Intraepithelial Lesions of the Cervix : Thought-Provoking Results of a Detailed HPV Genotype Analysis},
	url = {https://m2.mtmt.hu/api/publication/32849786},
	author = {Rideg, Orsolya and Dergez, Tímea and Borbásné Farkas, Kornélia and Kovács, Krisztina and Kálmán, Endre and Tornóczky, Tamás and Oszter, Angéla},
	doi = {10.3390/vaccines10050748},
	journal-iso = {VACCINES-BASEL},
	journal = {VACCINES (BASEL)},
	volume = {10},
	unique-id = {32849786},
	abstract = {Identification of HPV infection is usually performed on cytological specimens, despite the often transient virus types. HPV profile analysis of pathologically confirmed lesions can also be performed on formalin-fixed paraffin-embedded (FFPE) cone samples and should be taken as standard during follow-up. We compared HPV profiles of cytological and FFPE specimens of women diagnosed with HSIL. Archived PAP smears and FFPE cones from 49 patients were processed. For genotyping, the HPV Direct Flow CHIP test was used. All samples were positive. HPV profile agreement of the two sample types was 84.16-100%. Mono-infections occurred in 12.24% and 61.22% in PAP smears and FFPE specimens, respectively; while multi-infections were detected in 87.76% and 38.78%, respectively. The most abundant genotypes were HPVs 16, 31, and 51/33. Of all infections, 56.25% and 64.93% were caused by nonavalent vaccinated type (VT) HPVs; while 50.69% and 38.96% belonged to non-nonavalent VT HPVs, in PAP smears and FFPE specimens, respectively. Our results confirmed the importance of HPV genotyping of FFPE cone samples. We also confirmed a remarkable presence of non-vaccinated HPV types in HSIL cases indicating the importance of vaccine development.},
	keywords = {Pap Smear; HSIL; HPV Direct Flow CHIP; FFPE cone sample; HPV genotype profile; nonavalent HPV vaccine},
	year = {2022},
	eissn = {2076-393X},
	orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527}
}

@article{MTMT:32061709,
	title = {Wide Spectrum Analysis of Human Papillomavirus Genotypes in External Anogenital Warts},
	url = {https://m2.mtmt.hu/api/publication/32061709},
	author = {Rideg, Orsolya and Oszter, Angéla and Makk, Evelin and Kálmán, Endre and Borbásné Farkas, Kornélia and Tornóczky, Tamás and Kovács, Krisztina},
	doi = {10.3390/vaccines9060604},
	journal-iso = {VACCINES-BASEL},
	journal = {VACCINES (BASEL)},
	volume = {9},
	unique-id = {32061709},
	abstract = {External anogenital warts (EGW) are primarily associated with the low-risk human papillomavirus (HPV) genotypes 6 and 11, though coinfection with other low-risk and oncogenic high-risk HPV genotypes also occurs. Although there have been many studies on HPV-associated disease, the prevalence of HPV genotypes associated with EGW is not well characterized. The objective of our retrospective study was to determine the prevalence of HPV genotypes among patients diagnosed with EGW in the south-west of Hungary. Archived formalin-fixed paraffin-embedded tissues from 94 patients were processed in our study. HPV genotypes were determined, applying HPV Direct Flow CHIP test. The overall prevalence of HPV DNA in the EGW samples was 100%, yielding 131 infections among the 94 samples. Of these cases, 72.3% were mono while 27.6% were multi-infections. Out of the 131 infections, the cumulative prevalence of HPV 6 and 11 was 71%. A total of 98.9% of the samples were carrying at least one of these genotypes, while 19.1% of the cases occurred with at least one high-risk genotype. Data from our study could provide invaluable information concerning the prevalence of HPV types among patients with EGW, enabling improved assessment of the actual and future efficacy of vaccination programs, vaccine development, and forecast changes in infection patterns.},
	keywords = {PREVALENCE; HPV genotyping; external anogenital warts; multi-infection; HPV Direct Flow CHIP},
	year = {2021},
	eissn = {2076-393X},
	orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527}
}