TY  - JOUR
AU  - Kovács, Z
AU  - Jernei, Tamás
AU  - Katona, D
AU  - Kocsis, László
AU  - Csámpai, Antal
TI  - Synthesis and structure of novel ferrocene-containing β-carbolines including polycondensed derivatives with the elements of planar-, central- and conformational chirality
JF  - JOURNAL OF ORGANOMETALLIC CHEMISTRY
J2  - J ORGANOMET CHEM
VL  - 794
PY  - 2015
SP  - 125
EP  - 135
PG  - 11
SN  - 0022-328X
DO  - 10.1016/j.jorganchem.2015.07.004
UR  - https://m2.mtmt.hu/api/publication/2923890
ID  - 2923890
N1  - Institute of Chemistry, Eötvös Loránd University, P. O. B. 32Budapest-112 H-1518, Hungary            
            MTA-ELTE Research Group of Peptide Chemistry, P. O. B. 32Budapest-112 H-1518, Hungary            
            Cited By :3            
            Export Date: 5 June 2020            
            CODEN: JORCA            
            Correspondence Address: Csámpai, A.; Institute of Chemistry, Eötvös Loránd University, P. O. B. 32, Hungary
AB  - Abstract Employing tryptamine or tryptophane methylester hydrochloride and (S<inf>p</inf>)-2-formylferrocene-1-carboxylate as precursors by means of Pictet-Spengler reactions and subsequent intramolecular acylation effected by cyanuricfluoride or carbonyldiimidazole (CDI), the first representatives of ferrocene-containing β-carboline derivatives including polycyclic ferroceno/fused lactames, were prepared. In the course of CDI-mediated tandem cyclization of a tryptophane-derived carboxyferrocenyl-substituted β-carboline, a ring enlargement simultaneously taking place with the loss of the η5-C<inf>5</inf>H<inf>5</inf>Fe+ fragment of the fused ferrocene moiety, effected by the coordinating imidazole released from the reagent, led to a 4H-cyclopenta[7,8]azonino[5,4-b]indole as a minor product. The constitution and relative configuration of the new compounds with the elements of planar-, central- and conformational chirality were established by NMR methods including HMQC, HMBC and NOESY measurements supported by DFT modeling studies. © 2015 Published by Elsevier B.V.
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Szabó, Ildikó
AU  - Bősze, Szilvia
AU  - Kocsis, László
AU  - Hudecz, Ferenc
AU  - Csámpai, Antal
ED  - EvamarieHey-Hawkins, null
TI  - Synthesis and invitro cytostaticeffect of diverseferrocene-conjugateson human celllines
T2  - 13th Ferrocene Colloquium
PY  - 2015
SP  - 76
UR  - https://m2.mtmt.hu/api/publication/2893991
ID  - 2893991
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Csámpai, Antal
AU  - Kovács, Zoltán
AU  - Csókás, Dániel
AU  - Gyömöre, Ádám
AU  - Jernei, Tamás
AU  - Kocsis, László
AU  - Szabó, Ildikó
AU  - Bősze, Szilvia
AU  - Hudecz, Ferenc
ED  - EvamarieHey-Hawkins, null
TI  - Synthesis of ferrocene - based bis heterocycles with biological relevance employing sequential degradation and reconstruction of the metallocene structure
T2  - 13th Ferrocene Colloquium
PY  - 2015
SP  - 20
UR  - https://m2.mtmt.hu/api/publication/2893986
ID  - 2893986
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Castillo, G
AU  - Pribransky, Kinga
AU  - Mező, Gábor
AU  - Kocsis, László
AU  - Csámpai, Antal
AU  - Németh, Krisztina
AU  - Keresztes, Zsófia
AU  - Hianik, T
TI  - Electrochemical and Photometric Detection of Plasmin by Specific Peptide Substrate.
JF  - ELECTROANALYSIS
J2  - ELECTROANAL
VL  - 27
PY  - 2015
IS  - 3
SP  - 789
EP  - 798
PG  - 10
SN  - 1040-0397
DO  - 10.1002/elan.201400622
UR  - https://m2.mtmt.hu/api/publication/2863245
ID  - 2863245
N1  - Special Issue: Mátrafüred 2014 – International Conference on Electrochemical Sensors
AB  - We report a comparative analysis of plasmin detection by means of electrochemical biosensor and photometric assays. The biosensor has been based on ferrocene-modified peptide (Fc-P) specific to plasmin. Fc-P substrate is enzymatically cleaved by plasmin and the short fragment of peptide contained Fc is released causing decrease of redox current measured by cyclic voltammetry. The biosensor was tested in the range 1–20 nM of freshly prepared plasmin and it was highly selective (LOD=0.56±0.03 nM) demonstrating lower reaction to other proteins such as thrombin and β-casein. The concentration of plasmin has been determined also by a photometric analysis based on UV-vis spectroscopy (LOD=3.68±0.04 nM). The assay has been validated in milk samples.
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Kocsis, László
AU  - Patik, Márta
AU  - Szabó, Ildikó
AU  - Bősze, Szilvia
AU  - Csámpai, Antal
AU  - Hudecz, Ferenc
ED  - Uray, Katalin
ED  - Szabó, Ildikó
ED  - Kóczán, György
TI  - Shynthesis of novel ferrocene, chalcone and triazole containing molecules with promising results in anticancer chemotherapy
T2  - COST Action - Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells
PB  - MTA-ELTE Peptidkémiai Kutatócsoport
CY  - Budapest
SN  - 9789632845005
PY  - 2014
UR  - https://m2.mtmt.hu/api/publication/2730897
ID  - 2730897
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Kolos, Kiss
AU  - Kocsis, László
AU  - Holczbauer, Tamás
AU  - Mátyás, Czugler
AU  - Luminita, Silaghi-Dumitrescu
AU  - Antal, Csámpai
ED  - Holger, Butenschön
TI  - 2-Arylideneferroceno[e]cyclohexanones and related 3-aryl-3,3a,4,5-tetrahydroferroceno[g]indazoles: synthesis, NMR-, DFT- and x-ray analysis
T2  - 2-Arylideneferroceno[e]cyclohexanones and related 3-aryl-3,3a,4,5-tetrahydroferroceno[g]indazoles: synthesis, NMR-, DFT- and x-ray analysis
C1  - Hannover
PY  - 2013
SP  - 4
EP  - 4
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/2525033
ID  - 2525033
N1  - http://www.ak-renz.uni-hannover.de/ferrocene.html
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Kocsis, László
AU  - Kolos, KISS
AU  - Kinga, FODOR
AU  - Antal, CSÁMPAI
AU  - Luminiţa, SILAGHI-DUMITRESCU
ED  - Majdik, Cornelia
TI  - Synthesis and Spectroscopic Structure Analysis of Novel C2-Chiral Diphenothiazinyl- Salen Complexes
T2  - XVIII. Nemzetközi Vegyészkonferencia
PB  - Erdélyi Magyar Műszaki Tudományos Társaság (EMT)
C1  - Kolozsvár
T3  - Nemzetközi Vegyészkonferencia, ISSN 1843-6293
PY  - 2012
SP  - 22
EP  - 22
PG  - 1
UR  - https://m2.mtmt.hu/api/publication/2525044
ID  - 2525044
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Kocsis, László
AU  - Kiss, Kolos
AU  - FODOR, Kinga
AU  - KÁROLYI, Benedek-Imre
AU  - CSÁMPAI, Antal
AU  - LOVÁSZ, Tamás
AU  - SILAGHI-DUMITRESCU, Lum ini ţ a
ED  - Majdik, Kornélia
TI  - Synthesis and Characterization of New Phenothiazine Derivatives
T2  - 17th International Conference on Chemistry
C1  - Cluj-Napoca
PY  - 2011
UR  - https://m2.mtmt.hu/api/publication/2525036
ID  - 2525036
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - ifj, VÁRHELYI Csaba
AU  - Pokol, György
AU  - Izvekov, Vladiszlav
AU  - GÖMÖRY, Ágnes
AU  - VÁRHELYI, Csaba
AU  - Kocsis, László
ED  - Majdik, Cornelia
TI  - Aszimmetrikus kobalt(III)-komplexek etil-metil-dioximmal
T2  - XV. Nemzetközi Vegyészkonferencia
PB  - Erdélyi Magyar Műszaki Tudományos Társaság (EMT)
C1  - Kolozsvár
T3  - Nemzetközi Vegyészkonferencia, ISSN 1843-6293
PY  - 2009
UR  - https://m2.mtmt.hu/api/publication/2525041
ID  - 2525041
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Rónai, András
AU  - Szemenyei, Erzsébet
AU  - Kató, Erzsébet
AU  - Kocsis, László
AU  - Orosz, György
AU  - Al-Khrasani, Mahmoud
AU  - Tóth, Géza
TI  - Endomorphin synthesis in rat brain from intracerebroventricularly injected [H-3]-Tyr-Pro: A possible biosynthetic route for endomorphins
JF  - REGULATORY PEPTIDES
J2  - REGUL PEPTIDES
VL  - 134
PY  - 2006
IS  - 1
SP  - 54
EP  - 60
PG  - 7
SN  - 0167-0115
DO  - 10.1016/j.regpep.2005.12.004
UR  - https://m2.mtmt.hu/api/publication/1626916
ID  - 1626916
N1  - Cited By :17            
            Export Date: 29 May 2022            
            CODEN: REPPD
AB  - in spite of concentrated efforts, the biosynthetic route of mu-opioid receptor agonist brain tetrapeptide endomorphins (Tyr-Pro-Trp-Phe-NH2 and Tyr-Pro-Phe-Phe-NH2), discovered in 1997, is still obscure. We report presently that 30 min after intracerebroventricular injection of 20 or 200 mu Ci [H-3]Tyr-Pro (49.9 Ci mmol(-1)) the incorporated radioactivity was found in endomorphin-related tetra- and tripeptides in rat brain extracts. As detected by the combination of HPLC with radiodetection, a peak corresponding to endomorphin-2-OH could be identified in two of four extracts of "20 mu Ci" series. Radioactive peaks in position of Tyr, Tyr-Pro, Tyr-Pro-Phe or Tyr-Pro-Trp appeared regularly in both series and also in the "tetrapeptide cluster" constituted by endomorphins and their free carboxylic forms. In one of the four extracts in the "200 mu Ci" series a robust active peak in the position of endomorphin 2 could be detected. Intracerebroventricularly injected 100 mmol, but not 10 or 1000 nmol cold Tyr-Pro (devoid of opioid activity in vitro), caused a naloxone-reversible prolongation of tail-flick latency in rats, peaking between 15 and 30 min. We suggest that Tyr-Pro may serve as a biosynthetic precursor to endomorphin synthesis. (C) 2006 Elsevier B.V. All rights reserved.
LA  - English
DB  - MTMT
ER  -