@article{MTMT:34779108,
	title = {Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/34779108},
	author = {Gáborová, Mária and Vágvölgyi, Máté and Tayeb, Bizhar Ahmed and Minorics, Renáta and Zupkó, István and Jurček, Ondřej and Béni, Szabolcs and Kubínová, Renata and Balogh, György Tibor and Hunyadi, Attila},
	doi = {10.1021/acsomega.4c00800},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {9},
	unique-id = {34779108},
	issn = {2470-1343},
	year = {2024},
	eissn = {2470-1343},
	pages = {18495-18504},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300; Béni, Szabolcs/0000-0001-7056-6825; Balogh, György Tibor/0000-0003-3347-1880; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34691003,
	title = {17-Oxime ethers of oxidized ecdysteroid derivatives modulate oxidative stress in human brain endothelial cells and dose-dependently might protect or damage the blood-brain barrier},
	url = {https://m2.mtmt.hu/api/publication/34691003},
	author = {Vágvölgyi, Máté and Laczkó, Dávid and Santa Maria, Anaraquel and Vigh, Judit Piroska and Walter, Fruzsina and Berkecz, Róbert and Deli, Mária Anna and Tóth, Gábor and Hunyadi, Attila},
	doi = {10.1371/journal.pone.0290526},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34691003},
	issn = {1932-6203},
	abstract = {20-Hydroxyecdysone and several of its oxidized derivatives exert cytoprotective effect in mammals including humans. Inspired by this bioactivity of ecdysteroids, in the current study it was our aim to prepare a set of sidechain-modified derivatives and to evaluate their potential to protect the blood-brain barrier (BBB) from oxidative stress. Six novel ecdysteroids, including an oxime and five oxime ethers, were obtained through regioselective synthesis from a sidechain-cleaved calonysterone derivative 2 and fully characterized by comprehensive NMR techniques revealing their complete 1 H and 13 C signal assignments. Surprisingly, several compounds sensitized hCMEC/D3 brain microvascular endothelial cells to tert -butyl hydroperoxide (tBHP)-induced oxidative damage as recorded by impedance measurements. Compound 8 , containing a benzyloxime ether moiety in its sidechain, was the only one that exerted a protective effect at a higher, 10 μM concentration, while at lower (10 nM– 1 μM) concentrations it promoted tBHP-induced cellular damage. Brain endothelial cells were protected from tBHP-induced barrier integrity decrease by treatment with 10 μM of compound 8 , which also mitigated the intracellular reactive oxygen species production elevated by tBHP. Based on our results, 17-oxime ethers of oxidized ecdysteroids modulate oxidative stress of the BBB in a way that may point towards unexpected toxicity. Further studies are needed to evaluate any possible risk connected to dietary ecdysteroid consumption and CNS pathologies in which BBB damage plays an important role.},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Santa Maria, Anaraquel/0000-0003-3505-5477; Walter, Fruzsina/0000-0001-8145-2823; Berkecz, Róbert/0000-0002-9076-2177; Deli, Mária Anna/0000-0001-6084-6524; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34541373,
	title = {Thymoquinone-protoflavone hybrid molecules as potential antitumor agents},
	url = {https://m2.mtmt.hu/api/publication/34541373},
	author = {AHMED, Sara Hassan Hassan and Tayeb, Bizhar Ahmed and Gonda, Tímea and Girst, Gábor and Szőri, Kornél and Berkecz, Róbert and Zupkó, István and Minorics, Renáta and Hunyadi, Attila},
	doi = {10.1371/journal.pone.0291567},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34541373},
	issn = {1932-6203},
	abstract = {We describe herein the synthesis of eight new ester-coupled hybrid compounds from thymoquinone and protoflavone building blocks, and their bioactivity testing against multiple cancer cell lines. Among the hybrids, compound 14 showed promising activities in all cell lines studied. The highest activities were recorded against breast cancer cell lines with higher selectivity to MDA-MB-231 as compared to MCF-7. Even though the hybrids were found to be completely hydrolysed in 24 h under cell culture conditions, compound 14 demonstrated a ca. three times stronger activity against U-87 glioblastoma cells than a 1:1 mixture of its fragments. Further, compound 14 showed good tumour selectivity: it acted 4.4-times stronger on U-87 cells than on MRC-5 fibroblasts. This selectivity was much lower, only ca. 1.3-times, when the cells were co-treated with a 1:1 mixture of its non-coupled fragments. Protoflavone-thymoquinone hybrids may therefore serve as potential new antitumor leads particularly against glioblastoma.},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Szőri, Kornél/0000-0003-3337-8635; Berkecz, Róbert/0000-0002-9076-2177; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34261677,
	title = {Hybrid molecules of protoflavones and spirooxindole derivatives with selective cytotoxicity against triple-negative breast cancer cells},
	url = {https://m2.mtmt.hu/api/publication/34261677},
	author = {Girst, Gábor and Lopes, Elizabeth A. and Goncalves, Lidia M. and Espadinha, Margarida and Kúsz, Norbert and Wang, Hui-Chun and Santos, Maria M. M. and Hunyadi, Attila},
	doi = {10.1039/d3md00251a},
	journal-iso = {RSC MED CHEM},
	journal = {RSC MEDICINAL CHEMISTRY},
	volume = {14},
	unique-id = {34261677},
	abstract = {The combination of compounds with complementary bioactivities into hybrid molecules is an emerging concept in drug discovery. In this study, we aimed to synthesize new hybrid compounds based on p53-MDM2/X protein-protein interaction spiropyrazoline oxindole-based inhibitors and ataxia telangiectasia and Rad3-related (ATR) protoflavone-based inhibitors through copper(i) catalysed azide-alkyne cycloaddition. Five new hybrids were prepared along with three representative reference fragments. The compounds were tested against human breast cancer cell lines MCF-7 (hormone-dependent, wild-type p53) and MDA-MB-231 (triple-negative, mutant p53). Most of the new hybrids were more cytotoxic than their reference fragments and several showed 2-4 times selective toxicity against MDA-MB-231 cells. Relevant pharmacological benefit gained from the hybrid coupling was further confirmed by virtual combination index calculations using the Chou method. Compound 13 modulated doxorubicin-induced DNA damage response through inhibiting the ATR-dependent activation of Chk-1, while increasing the activation of Chk-2. Our results suggest that the new hybrids may serve as new leads against triple negative breast cancer.},
	year = {2023},
	eissn = {2632-8682},
	pages = {1778-1786},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34167387,
	title = {Experimental and DFT Atomistic Insights into the Mechanism of Corrosion Protection of Low-Carbon Steel in an Acidic Medium by Polymethoxyflavones from Citrus Peel Waste},
	url = {https://m2.mtmt.hu/api/publication/34167387},
	author = {Najem, Ayoub and Campos, Othon S. and Girst, Gábor and Mounir, Raji and Hunyadi, Attila and García-Antón, José and Bellaouchou, Abdelkbir and Amin, Hatem M. A. and Boudalia, Maria},
	doi = {10.1149/1945-7111/acfa69},
	journal-iso = {J ELECTROCHEM SOC},
	journal = {JOURNAL OF THE ELECTROCHEMICAL SOCIETY},
	volume = {170},
	unique-id = {34167387},
	issn = {0013-4651},
	abstract = {Developing green anticorrosive films is gaining great attention in science and engineering. Citrus fruit peels are mainly discarded as waste, although they can be an excellent repository of phytochemicals, that can be exploited as mitigating agents for corrosion. Herein, we report the high anticorrosion activity of a citrus extract for low-carbon steel in 1 M HCl solution at different temperatures. The main extract constituents were identified by MS and NMR. Two polymethoxyflavones (PMFs), namely nobiletin and heptamethoxyflavone, were identified as major constituents of the extract and the crude PMFs-based extract was investigated for corrosion protection. Using potentiodynamic polarization, weight loss and electrochemical impedance spectroscopy (EIS) methods, this extract revealed improved inhibition efficiency of 94%. The inhibition mechanism was elucidated by considering electrochemical kinetics and adsorption thermodynamics. SEM and UV–vis supported the electrochemical results. PMFs-based extract acted as a mixed-type inhibitor with a Langmuir model of adsorption. Importantly, DFT simulations provided atomic-level insights into the inhibition mechanism and unraveled donor-acceptor interactions between the methoxy groups of PMFs and iron atoms, facilitating the formation of a stable inhibition adsorption layer, and thus supporting the experimental findings. In addition to the physical barrier effect of PMF inhibitor, π -back bonding effect between PMF and steel was suggested.},
	year = {2023},
	eissn = {1945-7111},
	orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; García-Antón, José/0000-0002-0289-1324; Amin, Hatem M. A./0000-0002-9250-8658}
}

@CONFERENCE{MTMT:33963590,
	title = {Antioxidant and pharmacokinetic studies on new semi-syntheticnitrogen-containing diarylheptanoids derived from curcumin},
	url = {https://m2.mtmt.hu/api/publication/33963590},
	author = {Girst, Gábor and Balogh, György Tibor and Hunyadi, Attila},
	booktitle = {4th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrmpnpr.2023.14},
	unique-id = {33963590},
	year = {2023},
	pages = {21-21},
	orcid-numbers = {Balogh, György Tibor/0000-0001-8273-1760; Hunyadi, Attila/0000-0003-0074-3472}
}

@CONFERENCE{MTMT:33963548,
	title = {Antitrypanosomal activity of natural and semi-synthetic ecdysteroids},
	url = {https://m2.mtmt.hu/api/publication/33963548},
	author = {Háznagy, Márton Benedek and Vágvölgyi, Máté and Krishnan, Sandhya R. and Gertsch, Jürg and Hunyadi, Attila},
	booktitle = {4th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrmpnpr.2023.10},
	unique-id = {33963548},
	year = {2023},
	pages = {16-16},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Gertsch, Jürg/0000-0003-0978-1555; Hunyadi, Attila/0000-0003-0074-3472}
}

@CONFERENCE{MTMT:33963403,
	title = {Hybrid molecules of tryptophan derivatives and protoflavones totackle colon cancer},
	url = {https://m2.mtmt.hu/api/publication/33963403},
	author = {Ferreira, Ricardo J. F. and Lopes, Francisca and Girst, Gábor and Hunyadi, Attila and M. M. Santos, Maria},
	booktitle = {4th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrmpnpr.2023.4},
	unique-id = {33963403},
	year = {2023},
	pages = {10-10},
	orcid-numbers = {Ferreira, Ricardo J. F./0000-0003-2590-8229; Lopes, Francisca/0000-0002-5350-147X; Hunyadi, Attila/0000-0003-0074-3472}
}

@CONFERENCE{MTMT:33963351,
	title = {Structure elucidation of diterpenoids isolated from three Plectranthus sensu lato species},
	url = {https://m2.mtmt.hu/api/publication/33963351},
	author = {Gáborová, Mária and Vágvölgyi, Máté and Hunyadi, Attila and Béni, Szabolcs and Kubínová, Renata},
	booktitle = {4th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrmpnpr.2023.2},
	unique-id = {33963351},
	year = {2023},
	pages = {8-8},
	orcid-numbers = {Gáborová, Mária/0000-0002-2928-1219; Vágvölgyi, Máté/0000-0002-2233-9422; Hunyadi, Attila/0000-0003-0074-3472; Béni, Szabolcs/0000-0001-7056-6825}
}

@CONFERENCE{MTMT:33947701,
	title = {Thymoquinone-protoflavone hybrids},
	url = {https://m2.mtmt.hu/api/publication/33947701},
	author = {AHMED, Sara Hassan Hassan and Tayeb, Bizhar Ahmed and Gonda, Tímea and Girst, Gábor and Szőri, Kornél and Berkecz, Róbert and Zupkó, István and Minorics, Renáta and Hunyadi, Attila},
	booktitle = {4th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrmpnpr.2023.7},
	unique-id = {33947701},
	year = {2023},
	pages = {13-13},
	orcid-numbers = {AHMED, Sara Hassan Hassan/0000-0002-6642-7256; Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Szőri, Kornél/0000-0003-3337-8635; Berkecz, Róbert/0000-0002-9076-2177; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Hunyadi, Attila/0000-0003-0074-3472}
}