TY - JOUR AU - Kirschfink, M. AU - Frazer-Abel, A. AU - Bertalanné Balogh, Emese AU - Goseberg, S. AU - Weiss, N. AU - Prohászka, Zoltán TI - External quality assurance program for diagnostic complement laboratories: evaluation of the results of the past seven years JF - FRONTIERS IN IMMUNOLOGY J2 - FRONT IMMUNOL VL - 15 PY - 2024 PG - 18 SN - 1664-3224 DO - 10.3389/fimmu.2024.1368399 UR - https://m2.mtmt.hu/api/publication/34796435 ID - 34796435 LA - English DB - MTMT ER - TY - JOUR AU - Csicsák, Dóra AU - Szolláth, Rita Mariann AU - Kádár, Szabina AU - Ambrus, Rita AU - Bartos, Csilla AU - Bertalanné Balogh, Emese AU - Antal, István AU - Köteles, István AU - Tőzsér, Petra AU - Bárdos, Vivien AU - Horváth, Péter AU - Borbás, Enikő AU - Takácsné Novák, Krisztina AU - Sinkó, B. AU - Völgyi, Gergely TI - The Effect of the Particle Size Reduction on the Biorelevant Solubility and Dissolution of Poorly Soluble Drugs with Different Acid-Base Character JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 1 PG - 15 SN - 1999-4923 DO - 10.3390/pharmaceutics15010278 UR - https://m2.mtmt.hu/api/publication/33562140 ID - 33562140 LA - English DB - MTMT ER - TY - JOUR AU - Basa, Bálint AU - Jakab, Géza AU - Bertalanné Balogh, Emese AU - Borbás, Bence AU - Antal, István TI - The Application of 3D Printing in the Formulation of Personalized Drug Delivery Systems JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 179 EP - 180 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.179-180 UR - https://m2.mtmt.hu/api/publication/32496833 ID - 32496833 N1 - Poster-09 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Jakab, Géza AU - Basa, Bálint AU - Barna, Ádám AU - Kállai-Szabó, Nikolett AU - Bertalanné Balogh, Emese AU - Antal, István TI - Development and Formulation of Baicalin-loaded Self-nanoemulsifying Matrix Pellets JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 243 EP - 244 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.243-244 UR - https://m2.mtmt.hu/api/publication/32496830 ID - 32496830 N1 - Poster-40 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Barna, Ádám T AU - Sántha, Konrád AU - Kállai-Szabó, Nikolett AU - Bertalanné Balogh, Emese AU - Basa, Bálint AU - Jakab, Géza AU - Antal, István TI - Comparative Dissolution Study of Coated Pellets Containing Microcrystalline Cellulose and Lactose As Core Materials JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 177 EP - 178 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.177-178 UR - https://m2.mtmt.hu/api/publication/32496822 ID - 32496822 N1 - Poster-08 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Isameddin, Aghrbi AU - Fülöp, Viktor AU - Jakab, Géza AU - Kállai-Szabó, Nikolett AU - Bertalanné Balogh, Emese AU - Antal, István TI - Transformation of Cilostazole Nanosuspension into Nanocrystal to Increase the Product Stability and Dissolution Rate JF - ACTA PHARMACEUTICA HUNGARICA J2 - ACTA PHARM HUNG VL - 91 PY - 2021 IS - 3-4 SP - 165 EP - 166 PG - 2 SN - 0001-6659 DO - 10.33892/aph.2021.91.165-166 UR - https://m2.mtmt.hu/api/publication/32496819 ID - 32496819 N1 - P-02 - DDRS 2021 Conference, Budapest, Hungary, 15-17 November 2021 LA - English DB - MTMT ER - TY - JOUR AU - Basa, Bálint AU - Jakab, Géza AU - Kállai-Szabó, Nikolett AU - Borbás, Bence AU - Fülöp, Viktor AU - Bertalanné Balogh, Emese AU - Antal, István TI - Evaluation of Biodegradable PVA-Based 3D Printed Carriers during Dissolution JF - MATERIALS J2 - MATERIALS VL - 14 PY - 2021 IS - 6 PG - 13 SN - 1996-1944 DO - 10.3390/ma14061350 UR - https://m2.mtmt.hu/api/publication/31911988 ID - 31911988 N1 - Export Date: 4 June 2021 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7-9, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Sántha, Konrád AU - Kállai-Szabó, Nikolett AU - Fülöp, Viktor AU - Jakab, Géza AU - Gordon, Péter AU - Kállai-Szabó, Barnabás AU - Bertalanné Balogh, Emese AU - Antal, István TI - Comparative Evaluation of Pellet Cushioning Agents by Various Imaging Techniques and Dissolution Studies JF - AAPS PHARMSCITECH J2 - AAPS PHARMSCITECH VL - 22 PY - 2021 IS - 1 PG - 10 SN - 1530-9932 DO - 10.1208/s12249-020-01902-x UR - https://m2.mtmt.hu/api/publication/31793659 ID - 31793659 N1 - Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7, Budapest, 1092, Hungary Department of Electronics Technology, Budapest University of Technology and Economics, Egry J. Str. 18, Budapest, 1111, Hungary ViteCer Ltd., Ipartelepi Str. 8/b, Cegléd, 2700, Hungary Cited By :3 Export Date: 23 September 2022 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Str. 7, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu AB - Most of the commercially available pharmaceutical products for oral administration route are marketed in the tablet dosage forms. However, compression of multiparticulate systems is a challenge for the pharmaceutical research and industry, especially if the individual unit is a coated particle, as the release of the active ingredient depends on the integrity of the coating. In the present study, polymer-coated pellets tableted with different types of excipients (powder, granules, pellets) then were investigated by various tablet-destructive (microscopic) and tablet non-destructive (microfocus X-ray; microCT) imaging methods. The information obtained from the independent evaluation of the in vitro drug release profiles model is confirmed by the results obtained by image analysis, regardless of whether X-ray or stereomicroscopic images of the coated, tableted pellets were used for image analysis. The results of this study show that the novel easy-to-use, fast, and non-destructive MFX method is a good alternative to the already used microscopic image analysis methods regarding the characterization of particulates, compressed into tablets. LA - English DB - MTMT ER - TY - JOUR AU - Aghrbi, Isameddin AU - Fülöp, Viktor AU - Jakab, Géza AU - Kállai-Szabó, Nikolett AU - Bertalanné Balogh, Emese AU - Antal, István TI - Nanosuspension with improved saturated solubility and dissolution rate of cilostazol and effect of solidification on stability JF - JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY J2 - J DRUG DELIV SCI TEC VL - 61 PY - 2021 PG - 10 SN - 1773-2247 DO - 10.1016/j.jddst.2020.102165 UR - https://m2.mtmt.hu/api/publication/31641232 ID - 31641232 N1 - Cited By :6 Export Date: 25 July 2022 CODEN: JDDSA Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes E. Street 7, Hungary; email: antal.istvan@pharma.semmelweis-univ.hu LA - English DB - MTMT ER - TY - JOUR AU - Fülöp, Viktor AU - Jakab, Géza AU - Tóth, Bence AU - Bertalanné Balogh, Emese AU - Antal, István TI - Study on Optimization of Wet Milling Process for the Development of Albendazole Containing Nanosuspension with Improved Dissolution JF - PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING J2 - PERIOD POLYTECH CHEM ENG VL - 64 PY - 2020 IS - 4 SP - 401 EP - 420 PG - 20 SN - 0324-5853 DO - 10.3311/PPch.15569 UR - https://m2.mtmt.hu/api/publication/31389324 ID - 31389324 N1 - Export Date: 18 February 2021 Correspondence Address: Antal, I.; Department of Pharmaceutics, Hőgyes Endre Street 7., Hungary; email: antal.istvan@pharma.semmelweis-univ.hu AB - The main objective of this work was to show the potential of the optimization of top-down wet planetary bead milling process parameters (milling speed, process time and size of the milling medium) by Design Of Experiments (DOE) approach for the development of albendazole (ABZ) containing nanosuspension with improved dissolution. In addition, the influence of process parameters (capacity of milling container, applied volume of milling beads, size of the milling medium, milling speed, milling time) on ABZ polymorphic transition has also been investigated. The optimized, milled formula yielded ~ 145.39 times reduction in mean particle size (182.200 ± 1.3130 nm) compared to unmilled dispersion, which demonstrated 13.50 times gain in mean dissolution rate value compared to the unmilled dispersion in medium at pH = 1.2. No lag time values were observed in the dissolution kinetics of the nanosuspension in comparison with the unmilled samples. Moreover, maximal mean solubility value was also improved by 1.45 times compared to the unmilled suspension, in medium at pH = 6.8, supporting the significance of the Ostwald-Freundlich equation. Diffraction pattern comparisons have indicated a polymorphic transition of albendazole to Form II, which was more pronounced in smaller container at high milling speed values and prolonged operations LA - English DB - MTMT ER -